Breviscapine Ameliorates Fear Extinction and Anxiety in BALB/cJ Mice

Wei Liang(Wei Liang),Jing Huang(Jing Huang),Shuya Yang(Shuya Yang),Peng Huang(Peng Huang),Jun Chen(Jun Chen),Chen Chen(Chen Chen),Qun Yang(Qun Yang),Fengzhan Li(Fengzhan Li) 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3

Objective In this research, the influence of breviscapine on anxiety, fear elimination, and aggression and the potential mechanism was investigated. Methods Anxiety and locomotion were analyzed by elevated plus maze and open field test in mice. Bussey-Saksida Mouse Touch Screen Chambers were used to perform fear conditioning. Territorial aggression was assessed by resident intruder test. Protein levels were evaluated by Western blot. Breviscapine improved fear-extinction learning in BALB/cJ mice. Results Breviscapine at 20-100 mg/kg increased center cross number, total distance traveled, and velocity in a dose-dependent manner. On the other hand, breviscapine at 20-100 mg/kg decreased the immobility time in open field test. In addition, breviscapine at 20-100 mg/kg increased the ratio of time on the open arm, time on the distal parts of the open arm, and total distance traveled in elevated plus maze. Breviscapine at 100 mg/kg increased the average attack latency and decreased the number of attacks over the last 3 days of resident intruder test. In hippocampus, protein levels of postsynaptic density protein-95 and synaptophysin were elevated by breviscapine at these three doses. Conclusion The administration of breviscapine alleviates fear extinction, anxiety, and aggression, while increases locomotor in a dose-dependent manner, which might be associated with its influence on synaptic function.

Porous membranes in pressure-assisted forward osmosis: Flux behavior and potential applications

Yang Yang,Xueli Gao,Zhaokui Li,Qun Wang,Senjie Dong,Xiaojuan Wang,Zhun Ma,Leyi Wang,Xinyan Wang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-

In this work, pressured-assisted forward osmosis (PAFO) was performed using porous membranes to achieve higher fluxes. The effects of additional pressure and membrane orientation on membrane performance were investigated. When ultralow additional pressure (0.04 bar) was applied, the water flux at AL-FS orientation (i.e. active layer facing the feed solution) was observed to double. Reverse solute diffusion was also inhibited dramatically at both membrane orientations in PAFO. Filtration tests revealed that porous membranes with ultralow pressure in FO were more applicable than ultrafiltration (UF) because mild condition (i.e., 0.12 bar versus 1.25 bar) is conducive to preserving microalgae cell integrity.

Electrical signal characteristics of conductive asphalt concrete in the process of fatigue cracking

Yang, Qun,Li, Xu,Wang, Ping,Zhang, Hong-Wei Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.14 No.3

As a kind of intelligent materials, conductive asphalt concrete has a broad application prospect including melting ice and snow on the pavement, closing cracks in asphalt concrete, sensing pavement damage, and so on. Conductive pavement will be suffered from fatigue failure as conventional pavement in the process of service, and this fatigue damage of internal structure can be induced by electrical signal output. The characteristics of electrical signal variation of conductive asphalt concrete in the process of fatigue cracking were researched in this paper. The whole process was clearly divided into three stages according to resistance changes, and the development of fatigue damage wasn't obvious in stage I and stage II, while in stage III, the synchronicity between the resistance and damage began to appear. Thus, fatigue damage variable D and initial damage value $D_0$ represented by the functions of resistance were introduced in stage III. After calculating the initial damage value $D_0$ under different stress levels, it was concluded that the initial damage value $D_0$ had no noticeable change, just ranged between 0.24 and 0.25. This value represented a critical point which could be used to inform the repair time of early fatigue damage in the conductive asphalt pavement.

Combined water flux enhancement of PES-based TFC membranes in ultrasonic-assisted forward osmosis processes

Qun Wang,Xueli Gao,Zhun Ma,Jian Wang,Xiaojuan Wang,Yang Yang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-

For PES-based TFC FO membranes, a significant water flux surge occurred after a moderate ultrasonic irradiation. The Change in membrane transport parameters illustrated that internal concentration polarization (ICP) was weakened due to decreased structural parameter. Combined water flux enhancement via real-time ultrasonic irradiation was obtained and related to the CP effect and membrane orientation. Increasing irradiation intensity was more suitable in PRO mode than in FO mode. Low FS concentration in concentration combinations represented high ratio of ultrasonic-induced flux increment to energy input. Multiplying concentration difference was beneficial to obtain high conversion ratio of ultrasonic power to water flux.

Effects of traffic characteristics on pavement responses at the road intersection

Yang, Qun,Dai, Jingwang Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.4

Compared with pavement structures of ordinary road sections, pavement structures in the intersection are exposed to more complex traffic characteristics which may exacerbates pavement distresses such as fatigue-cracking, shoving, shear deformation and rutting. Based on a field survey about traffic characteristics in the intersection conducted in Shanghai China, a three dimensional dynamic finite-element model was developed for evaluating the mechanistic responses in the pavement structures under different traffic characteristics, namely uniform speed, acceleration and deceleration. The results from this study indicated that : (1) traffic characteristics have significant effects on the distributions of the maximum principal strain (MPS) and the maximum shear stress (MSS) at the pavement surface; (2) vehicle acceleration or deceleration substantially impact the MPS and MSS at pavement surface and could increase the magnitude of them by 20 percent to 260 percent; (3) in the vertical direction, with the increase of vehicle deceleration rate, the location of the MPS peak value and the MSS peak value changes from the sub-surface layer to the pavement surface.

Effects of traffic characteristics on pavement responses at the road intersection

Qun Yang,Jingwang Dai 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.4

Compared with pavement structures of ordinary road sections, pavement structures in the intersection are exposed to more complex traffic characteristics which may exacerbates pavement distresses such as fatigue-cracking, shoving, shear deformation and rutting. Based on a field survey about traffic characteristics in the intersection conducted in Shanghai China, a three dimensional dynamic finite-element model was developed for evaluating the mechanistic responses in the pavement structures under different traffic characteristics, namely uniform speed, acceleration and deceleration. The results from this study indicated that:(1) traffic characteristics have significant effects on the distributions of the maximum principal strain (MPS) and the maximum shear stress (MSS) at the pavement surface; (2) vehicle acceleration or deceleration substantially impact the MPS and MSS at pavement surface and could increase the magnitude of them by 20 percent to 260 percent; (3) in the vertical direction, with the increase of vehicle deceleration rate, the location of the MPS peak value and the MSS peak value changes from the sub-surface layer to the pavement surface.

Electrical signal characteristics of conductive asphalt concrete in the process of fatigue cracking

Qun Yang,Ping Wang,Xu Li,Hong-Wei Zhang 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.3

As a kind of intelligent materials, conductive asphalt concrete has a broad application prospect including melting ice and snow on the pavement, closing cracks in asphalt concrete, sensing pavement damage, and so on. Conductive pavement will be suffered from fatigue failure as conventional pavement in the process of service, and this fatigue damage of internal structure can be induced by electrical signal output. The characteristics of electrical signal variation of conductive asphalt concrete in the process of fatigue cracking were researched in this paper. The whole process was clearly divided into three stages according to resistance changes, and the development of fatigue damage wasn\'t obvious in stage I and stage II, while in stage III, the synchronicity between the resistance and damage began to appear. Thus, fatigue damage variable D and initial damage value D0 represented by the functions of resistance were introduced in stage III. After calculating the initial damage value D0 under different stress levels, it was concluded that the initial damage value D0 had no noticeable change, just ranged between 0.24 and 0.25. This value represented a critical point which could be used to inform the repair time of early fatigue damage in the conductive asphalt pavement.

Systematic Review of Single Large and/or Multinodular Hepatocellular Carcinoma: Surgical Resection Improves Survival

Yang, Xiang-Di,Pan, Ling-Hui,Wang, Lin,Ke, Yang,Cao, Ji,Yang, Chun,Zhong, Jian-Hong,Luo, Wang,Guo, Jiao,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: The role of surgical resection for patients with single large (${\geq}5cm$) and/or multinodular (${\geq}2$) hepatocellular carcinoma (HCC) is still controversial. This systematic review was performed to evaluate the safety and efficacy of resection for patients with single large and/or multinodular HCC. Materials and Methods: Databases (the PubMed, Web of Science, Embase, and Cochrane databases) were systematically searched to identify relevant studies exploring the safety and efficacy of resection for single large and/or multinodular HCC, published between January 2000 and December 2014. Perioperative morbidity and mortality, overall survival, and disease-free survival of the resection group were calculated. In addition, these outcome variables were also calculated for the control group in the included studies. Results: One randomized controlled trial and 42 nonrandomized studies involving 9,580 patients were eligible for analysis. Eight (1,594 patients) of the 43 studies also reported the outcomes of transarterial chemoembolization (TACE). Although 51.4% of patients featured cirrhosis, 90.7% of them demonstrated Child-Pugh A liver function in the resection group. The median rates of morbidity (24.5%) and mortality (2.5%) after resection were significantly higher than that of TACE (11.0%, P<0.001; 1.9%, P<0.001). However, patients who underwent resection had significantly higher median one-, three-, and five-year overall survival (76.1%, 51.7%, and 37.4%) than those who underwent TACE (68.3%, 31.5%, and 17.5%, all P<0.001). The median 1-, 3-, and 5-year DFS rates after resection were 58.3%, 34.6%, and 24.0%, respectively. Conclusions: Although tumor recurrence after resection for patients with single large and/ or multinodular HCC continues to be a major problem, resection should be considered as a strategy to achieve long-term survival.

Mechanical and Thermal Properties Enhancement and Swelling Behavior of Bacterial Cellulose/Collagen/Polyvinyl Alcohol Nanofiber Hydrogel Film

Qun Yang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.2

Composite hydrogel films of bacterial cellulose/collagen/polyvinyl alcohol were prepared by soaking methodusing bacterial cellulose hydrogel (BC) was as the base material, collagen (COL) and polyvinyl alcohol (PVA) wereintroduced as the reinforcement material to further improve the tensile strength especially elongation at break. Morphology,mechanical property, and thermal stability of composite hydrogel films were also investigated. The swelling behavior wasstudied using Schott’s second-order swelling model in detail. Research results show that BC/PVA/COL composite showed181.9 % improvement in elongation at break to that of BC. It further improved the tensile strength of the obtained BC/PVA/COL composite film by 12.9 % after crosslinking treatment. Importantly, further investigation demonstrated that thestructural stability and thermal stability of the composite hydrogel films were remarkably enhanced. Swelling behavior of BCand the composite nanofiber hydrogel films in DI water followed the Schott’s second-order swelling model, the swelling ofcomposites significantly reduced after crosslinking treatment.

Composite Design of Disturbance Observer and Reentry Attitude Controller: An Enhanced Finite-time Technique for Aeroservoelastic Reusable Launch Vehicles

Zhenshu Yang,Jianzhong Yang,Qi Mao,Liqian Dou,Qun Zong 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8

In this paper, we concern the reentry attitude control (RAC) scheme design for aeroservoelastic reusable launch vehicles (RLVs). The basic problem is to derive a RAC technique such that the aeroservoelastic RLV can achieve a robust tracking of the desired attitudes in a rapid way despite the existence of parameter uncertainties as well as external disturbances. Following from the elastic equations and attitude dynamics of the RLV, we formulate a control-oriented model in matched structure. Our main contribution is threefold. First, using the fast terminal sliding mode algorithm, the disturbance observers are designed to generate the estimation of uncertainties and disturbances, while can ensure the estimation errors converge to the origin within a timely fashion. Second, the finite-time super-twisting sliding mode control method and cascade-loop design are developed to incorporate into the new RAC strategy; hence it leads to a guaranteed tracking ability of the reentry attitude in a timely way. Third, a finite-time integral sliding mode filter is proposed in the control scheme such that the virtual input signal can be tackled well. Additionally, numerical simulations of a dynamic model for the RLV are implemented to demonstrate the effectiveness and performance of the developed RAC strategy and furthermore its aeroservoelastic properties.