Finite-time Controller Design for Four-wheel-steering of Electric Vehicle Driven by Four In-wheel Motors

Qing-Hua Meng,Zong-Yao Sun,Yushan Li 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4

A smooth control method may do not obtain a desired convergence. On the other hand, a no-continuous method may cause a close-loop system to chatter. In order to avoid the aforementioned disadvantages, a non-smooth finite-time control method is proposed and applied on an active four-wheel-steering electric vehicle driven by four in-wheel motors to improve the safety and manoeuvrability in this paper. Based on an ideal electric vehicle steering tracking model, a non-smooth finite-time convergence controller is constructed for controlling the four wheels’ steering angles of an electric vehicle. The front wheel cornering stiffness, rear wheel cornering stiffness and external disturbance of a practical car are regarded as bounded uncertain parameters according to practical conditions. An A-class car model in the Carsim software is utilized to simulate the designed controller. The simulation results show that the controller based on finite-time convergence can track the ideal vehicle steering model better to obtain zero sideslip angle and expected yaw rate even when there exist perturbation of cornering stiffness and disturbance of lateral wind. It means the control system of the electric vehicle is robust with uncertainty. The simulation results also show that the non-smooth finite-time control method is better than the slide mode control method for the active four-wheel-steering system of the electric vehicle.

Output Tracking Control for Generalized High-Order Nonlinear System with Almost Disturbance Decoupling

Qing-Quan Tan,Zong-Yao Sun,Ting Li,Qing-Hua Meng 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6

In this paper, we introduce a new method to solve the problem of output tracking control for a class ofgeneralized high-order uncertain nonlinear systems with disturbance. A key contribution of this paper is a resultrelating its serious uncertainties including unknown high-order terms, unknown nonlinear functions and the signalto be tracked. The main result is that the tracking error belongs to a prescribed small neighborhood of the origin infinite time. Design procedure is presented by improved adding a power integrator method.

Fracture behavior of cylindrical sandstone specimens with two pre-existing flaws: experimental investigation and PFC3D simulation

Yan-Hua Huang,Sheng-Qi Yang,Guo-Qing Chen,Bo Meng 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.1

It is important to analyze the rock crack initiation, propagation and coalescence in fractured rock mass. At present, the 3D crack evolution process of pre-flawed rock has not been comprehensively studied during the deformation. In this study, uniaxial compression tests were carried out on cylindrical sandstone specimens with two pre-existing flaws with various ligament inclination angles. The crack evolution process at the front surface of the specimen was analyzed by photographic and AE monitoring. In addition, a 3D discrete element modelling was conducted to explore the spatial crack evolution behaviors during compressive loading. Both the numerical strength and final failure modes of specimens were consistent with those obtained in the laboratory experiment. The numerical simulation results revealed that the internal crack distribution was not always identical along the thickness direction. Two types of crack coalescence were identified. The experimental and numerical results enhance the understanding of 3D crack evolution mechanism of fractured rock under external loading.

Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China

Shan-Qing Wang,Guang-Ze Wang,Yu-Chun Li,Feng Meng,Shi-Gan Lin,Zhen-Hu Zhu,Ding-Wei Sun,Chang-Hua He,Xi-Min Hu,Jian-Wei Du 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.1

XPD Lys751Gln and Asp312Asn Polymorphisms and Gastric Cancer Susceptibility: A Meta-analysis of Case-control Studies

Yin, Qing-Hua,Liu, Chuan,Hu, Jian-Bing,Meng, Rong-Rong,Li, Lian,Wang, Ya-Jie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Published data regarding the association between xeroderma pigmentosum group D (XPD) Lys751Gln and Asp312Asn polymorphisms and gastric cancer susceptibility havew been inconclusive. This meta-analysis was therefore performed toobtain a more precise estimation of any relationship. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of Lys751Gln and Asp312Asn polymorphisms and susceptibility to gastric cancer. Summary odds ratios (ORs) and its 95% confidence intervals (95% CIs) were calculated using a random-effects model with the software STATA (version10.0). Results: A total of 12 case-control studies including 3,147 cases and 4,736 controls were included. Overall, no significant associations were found in some models (for Lys751Gln: Lys/Gln vs Lys/Lys: OR=1.144, 95% CI=0.851-1.541, Gln/Gln vs Lys/Lys: OR=1.215, 95% CI = 0.740-1.955, dominant model: OR=1.137, 95% CI=0.818-1.582; recessive model: OR=1.123, 95% CI=0.765-1.650; for Asp312Asn: Asp/Asn vs Asp/Asp: OR=1.180, 95% CI=0.646-2.154, dominant model: OR=1.380, 95% CI = 0.812-2.346), but significantly elevated susceptibility was found for Asp312Asn polymorphism in some models (Asn/Asn vs Asp/Asp: OR=2.045, 95% CI=1.254-3.335, recessive model: OR=1.805, 95% CI =1.219-2.672), for the additive model, the XPD Lys751Gln and Asp312Asn polymorphisms were not significantly associated with gastric cancer susceptibility. In stratified analyses, significantly elevated susceptibility was found for some models in the Chinese population. Conclusion: This meta-analysis suggested the XPD Asp312Asn polymorphism might be a potential biomarker of gastric cancer susceptibility in overall population, while both XPD Lys751Gln and Asp312Asn polymorphisms might be risk factors of gastric cancer susceptibility in Chinese.

Down-regulation of miRNA-452 is Associated with Adriamycin-resistance in Breast Cancer Cells

Hu, Qing,Gong, Jian-Ping,Li, Jian,Zhong, Shan-Liang,Chen, Wei-Xian,Zhang, Jun-Ying,Ma, Teng-Fei,Ji, Hao,Lv, Meng-Meng,Zhao, Jian-Hua,Tang, Jin-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Adriamycin (ADR) is an important chemotherapeutic agent frequently used in treatment of breast cancer. However, resistance to ADR results in treatment failure in many patients. Recent studies have indicated that microRNAs (miRNAs) may play an important role in such drug-resistance. In the present study, microRNA-452 (miR-452) was found to be significantly down-regulated in adriamycin-resistant MCF-7 cells (MCF-7/ADR) compared with the parental MCF-7 cells by miRNA microarray and real-time quantitative PCR (RT-qPCR). MiR-452 mimics and inhibitors partially changed the adriamycin-resistance of breast cancer cells, as also confirmed by apoptosis assay. In exploring the potential mechanisms of miR-452 in the adriamycin-resistance of breast cancer cells, bioinformatics analysis, RT-qPCR and Western blotting showed that dysregulation of miR-452 played an important role in the acquired adriamycin-resistance of breast cancer, maybe at least in part via targeting insulin-like growth factor-1 receptor (IGF-1R).

Bond-slip Constitutive Relation between BFRP Bar and Basalt Fiber Recycled-aggregate Concrete

Wen-jing Meng,Hua-xin Liu,Gen-jin Liu,Xiang-qing Kong,Xue-zhi Wang 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.5

In order to investigate the bond stress-slip constitutive relation between BFRP bar and basalt fiber recycled-aggregate concrete, 81 central pullout specimens were tested. Basalt fiber volume percent, fiber length and concrete strength grade were considered to be experimental variables to obtain the bond stress-slip curves. The results showed that adding basalt fiber into recycled-aggregate concrete will reduce the bond stress between BFRP bar and recycled-aggregate concrete but enhance the ductility of bond property; the bond stress increases with the increasing of fiber length and concrete strength grade. The bond stress-slip constitutive model was proposed and the results showed that the model is good in effect of fitting. The constitutive model can reflect the bonding mechanism between BFRP bar and basalt fiber concrete well, it also can provide reference for theoretical analysis and engineering applications of the bond and anchor property between BFRP bars strengthened recycled concrete.

Family with Sequence Similarity 83 Member H Promotes the Viability and Metastasis of Cervical Cancer Cells and Indicates a Poor Prognosis

Chao Chen,Hua-Feng Li,Yu-Jie Hu,Meng-Jie Jiang,Qing-Sheng Liu,Jia Zhou 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.7

Purpose: Family with sequence similarity 83 member H (FAM83H) plays key roles in tumorigenesis. However, the specific rolesof FAM83H in cervical cancer (CC) have not been well studied. Materials and Methods: The RNA-seq data of 306 CC tissues and three normal samples downloaded from The Cancer GenomeAtlas were used to analyze the expression of FAM83H. The Kaplan-Meier method was used to draw survival curves. Associationsbetween FAM83H expression and clinicopathological factors were analyzed by chi-square test. Cox proportional hazards modelwas used to analyze prognostic factors. Loss-of-function assays were conducted to discover the biological functions of FAM83Hin cell proliferation, colony formation, invasion, and migration. Real-time Quantitative Reverse Transcription PCR (qRT-PCR)and Western blotting were used to measure the expression levels of FAM83H in CC cell lines. Results: Our results demonstrated that FAM83H is overexpressed in CC tissues and that high FAM83H expression is associatedwith worse overall survival (OS). High FAM83H expression in CC was associated with clinical stage, pathologic tumor, and pathologicnode. Univariate analysis suggested that FAM83H expression was significantly related to the OS of CC patients. Althoughmultivariate analysis showed that FAM83H expression was not an independent prognostic factor for the OS of CC patients, the effectsof FAM83H on CC cell growth and motility was significant. Loss-of-function experiments demonstrated that knockdown ofFAM83H inhibited proliferation, colony formation, migration, and invasion of CC cells by inactivating PI3K/AKT pathway. Conclusion: FAM83H might play a crucial role in CC progression and could act as a novel therapeutic target in CC.

A facile macroporous resin-based method for separation of yellow and orange Monascus pigments

Suo Chen,Dong-Xiao Su,Meng-Xiang Gao,Jia-Lan Zhang,Ying-Bao Liu,Qing-Hua Wu,Hua-Lin Yang,Li Li 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.4

The yellow Monascus pigments (YMPs) namedmonascin and ankaflavin and the orange Monascus pigments(OMPs) named rubropunctatin and monascorubrinare two groups of bioactive components in a mixture statein the Monascus fermented products. In order to separatethese two groups of bioactive pigments, a facile macroporousresin-based method was developed. The weak-polarresin CAD-40 was selected from the seven tested macroporousresins as it revealed better properties for theadsorption and desorption of the YMPs and OMPs. Then,CAD-40 resin was used for column-chromatographicseparation. After eluted by 4 bed volumes of ethanol, theyellow group (monascin and ankaflavin) and the orangegroup (rubropunctatin and monascorubrin) were successfullyseparated and purified, with an increased content from49.3% and 44.2% in the crude pigment extract to 85.2%and 83.0% in the final products, respectively. This methodwould be helpful for the large-scale separation and purificationof Monascus pigment products with specificbioactivity.

SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN

Shen Xuefang,Chen Xiangyuan,Wang Jing,Liu Jing,Wang Zhiyao,Hua Qing,Wu Qichao,Su Yanguang,He Huanzhong,Hu Yuqin,Meng Zhipeng,Xiong Wanxia,Zhu Minmin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 participate in high glucose-mediated endothelial inflammation. In this study, we hypothesize that SET8 regulates PTEN expression, thus contributing to high glucose-mediated vascular endothelial inflammation. Our data indicated that plasma soluble intercellular adhesion molecule-1 (sICAM-1) and endothelial selectin (e-selectin) were increased in patients with diabetes and diabetic rats. PTEN expression was augmented in the peripheral blood mononuclear cells of patients with diabetes and in the aortic tissues of diabetic rats. Our in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose led to endothelial inflammation via upregulation of PTEN. Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8. SET8 overexpression reversed the effects of high-glucose treatment. shSET8-mediated endothelial inflammation was counteracted by siPTEN. Furthermore, SET8 was found to interact with FOXO1. siFOXO1 attenuated high glucose-mediated endothelial inflammation. FOXO1 overexpression-mediated endothelial inflammation was counteracted by siPTEN. H4K20me1 and FOXO1 were enriched in the PTEN promoter region. shSET8 increased PTEN promoter activity and augmented the positive effect of FOXO1 overexpression on PTEN promoter activity. Our in vivo study indicated that SET8 was downregulated and FOXO1 was upregulated in the peripheral blood mononuclear cells of patients with diabetes and the aortic tissues of diabetic rats. In conclusion, SET8 interacted with FOXO1 to modulate PTEN expression in vascular endothelial cells, thus contributing to hyperglycemia-mediated endothelial inflammation.