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- 저자 : Shen Xuefang (검색결과 2 건)
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Shen Xuefang,Chen Xiangyuan,Wang Jing,Liu Jing,Wang Zhiyao,Hua Qing,Wu Qichao,Su Yanguang,He Huanzhong,Hu Yuqin,Meng Zhipeng,Xiong Wanxia,Zhu Minmin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 participate in high glucose-mediated endothelial inflammation. In this study, we hypothesize that SET8 regulates PTEN expression, thus contributing to high glucose-mediated vascular endothelial inflammation. Our data indicated that plasma soluble intercellular adhesion molecule-1 (sICAM-1) and endothelial selectin (e-selectin) were increased in patients with diabetes and diabetic rats. PTEN expression was augmented in the peripheral blood mononuclear cells of patients with diabetes and in the aortic tissues of diabetic rats. Our in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose led to endothelial inflammation via upregulation of PTEN. Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8. SET8 overexpression reversed the effects of high-glucose treatment. shSET8-mediated endothelial inflammation was counteracted by siPTEN. Furthermore, SET8 was found to interact with FOXO1. siFOXO1 attenuated high glucose-mediated endothelial inflammation. FOXO1 overexpression-mediated endothelial inflammation was counteracted by siPTEN. H4K20me1 and FOXO1 were enriched in the PTEN promoter region. shSET8 increased PTEN promoter activity and augmented the positive effect of FOXO1 overexpression on PTEN promoter activity. Our in vivo study indicated that SET8 was downregulated and FOXO1 was upregulated in the peripheral blood mononuclear cells of patients with diabetes and the aortic tissues of diabetic rats. In conclusion, SET8 interacted with FOXO1 to modulate PTEN expression in vascular endothelial cells, thus contributing to hyperglycemia-mediated endothelial inflammation.
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Current progress on gold recovery from refractory ore and waste electrical and electronic equipment
Ji Xuran,Shen Zhijie,Xu Wenping,Yao Shimiao,Zhang Hairong,Xiong Lian,Li Hailong,Guo Haijun,Chen Xuefang,Chen Xinde 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.9
The physical and chemical properties of gold promote its application, such as in the high-tech, electronic products, and aerospace industries. The easily leachable ore is gradually depleted. Thus, it becomes necessary to extract gold from other resources such as refractory ore and electrical and electronic equipment. The normal method of leaching for gold is cyanide leaching, but it is very dangerous for both environment and operator. Non-cyanide leaching methods, including thiourea leaching, halide leaching, and sulfate leaching have been developed to substitute cyanide leaching. A variety of methods to enrich gold from leaching solutions are described in this paper, including solvent extraction, electrowinning, activated carbon adsorption, and ion exchange resins. Among those methods, ion exchange resins can adsorb gold with high adsorption efficiency and regenerate easily as well. This paper focuses on the research progress of the recovery of gold from non-cyanide leachates by ion exchange resins, summarizes the existing resin types and elution processes, points out the limitations in the application of current ion exchange resins, and discusses possible solutions.
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