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- 저자 : Qi Bian (검색결과 13 건)
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Qi Zhang,Li-qun Hu,Hong-qi Li,Jun Wu,Na-na-Bian,Guang Yan 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ± dP/dt and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of CD3+ and CD14+ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.
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Qi Bian,Ke Zeng,Kai Qiu,Jiaojian Liu,Yancun Niu,Yancui Liu,Jianghuai Hu,Gang Yang 한국고분자학회 2015 Macromolecular Research Vol.23 No.7
Solid vinyl monomer with functional group “phthalonitrile” was successfully introduced into microspheres to make poly{styene-co-4-(4-vinylphenoxy) phthalonitrile} microspheres (PSPMs) with uniform (UPSPMs) and core-shell (core-shell PSPMs) structure using soap-free emulsion polymerization by the new approach of “codissolution”. The core-shell PSPMs then were used as the design platform to make metallophthalocyanine-containing microspheres. EA, FTIR, SEM, TEM, UV-vis, TGA, XPS, solid 1H NMR and XRD techniques were employed to analyze the formation and morphology of PSPMs and metallophthalocyanine-containing microspheres. The results showed that UPSPMs and core-shell PSPMs were both realized and they were regular sphericities with diameters of around 370 nm. The percentages of reacting weight of 4-(4-vinylphenoxy) phthalonitrile were close to 50%. Based on the design platform of core-shell PSPMs, metallophthalocyanine-containing microspheres could be obtained and the content of metallophthalocyanine was close to 19%.
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Zhang, Qi,Hu, Li-qun,Li, Hong-qi,Wu, Jun,Bian, Na-na,Yan, Guang The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ${\pm}dP/dt$ and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of $CD3^+$ and $CD14^+$ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.
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Kernel Reference Set and Its Computation Algorithm
Ding-Yuan Bian,Qi-Wei Ge,Qian Zhu,Qian-Ming Shao 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
This paper proposes a new concept of graphs: kernel reference set. A kernel reference set is a fraction of vertices in a graph such that if their positions are known, positions of all other vertices can be derived from information of the distance matrix. We present an algorithm to find kernel reference set of graphs. Because the problem of kernel reference set is firstly proposed in this paper, and the theoretical limit of computation complexity is unknown currently. So we implement our algorithm with C to do the simulation. From simulation results, we verified the validity of our algorithm and evaluate its performance. Inspired by anchor nodes in wireless sensor networks, kernel reference set could be used to analyze anchorbased localization schemes of WSNs applications such as coalmine security monitoring, etc.
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Non-interest Income, Profit, and Risk Efficiencies: Evidence from Commercial Banks in China
Wen-Long Bian,Xiang-Nan Wang,Qi-Xiang Sun 한국증권학회 2015 Asia-Pacific Journal of Financial Studies Vol.44 No.5
Chinese commercial banks are transforming their activities into more non-interest income businesses under a highly regulated financial system. This paper investigates the effects of this transformation on profit and risk efficiencies. We find that commission and fee income sig- nificantly reduce risk efficiency due to the circumvention of the regulation on deposit interest rate and the assumption of risk that should have been borne by customers. In terms of trad- ing income, it significantly reduces profit efficiency due to the upper limit of the loan-deposit ratio, the lack of investment channels and low returns of bond markets. The regulatory authorities are supposed to further liberalize the banking industry and grant banks more rights.
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Xiao Cui,Jing Guo,Qi‑dong Zhang,Xiao‑jun Meng,Bing‑chuan Bian,Ren‑gao Zhao,Yu‑bai Ma,Fang‑qiu Zu 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.10
The slow β relaxation which occurring at temperatures far below glass transition temperature, typically playing importantroles in the plastic deformation behavior of metallic glasses. Compared with polymer glasses, most of the metallic glasses donot exhibit obvious β relaxation based on dynamic mechanical analysis. In the current work, prominent β relaxation behaviorsof a series (LaxCe100−x) Al10Co25(x = 50, 60, 70, 80) bulk metallic glasses (BMGs) at low temperature are observed usingdynamic mechanical analysis. Compared with other BMGs, the LaCe based BMGs show a pronounced β relaxation peak andrelative low peak temperature, the activation energy of the β relaxation based on Arrhenius equation are calculated around79.3 kJ/mol to 86.4 kJ/mol, which obey an empirical rule that Eβ ≈ (26 ± 4) RTg, with the coefficient of 23. Experimentalresults from room temperature compression tests for the LaCe based BMGs indicate that low temperature activated β relaxationbehaviors facilitate the good plasticity of the LaCe based BMGs.
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Abundant Manganese Complex-Anchored BiOI Hybrid Photocatalyst for Visible Light-Driven CO2 Reduction
Xin Xin,Ning Ma,Changying Hu,Qi Liang,Zhaoyong Bian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.2
An abundant manganese complex-anchored BiOI hybrid system for CO2 photocatalytic conversion was constructed. Layered BiOI and tricarbonyl Mn bipyridyl complex with carboxyl acid groups were connected with covalent bonds and used as visible light antenna and CO2 reduction reaction centers, respectively. The covalent connection of this hybrid system benefits the transfer of electrons from the semiconductor to the Mn complex. The anchoring group (carboxyl) is the key to CO2 reduction for the direct coupling of the two units, facilitating the transfer of electrons from BiOI to the manganese complexes. The photocatalytic properties and stability of the tri-carbonyl Mn–bipyridyl complex were significantly enhanced with the aid of anchored BiOI. A high turnover number (TON = 74) of HCOO- formation from CO2 could be achieved using this hybrid system under visible light irradiation.
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Li, Bai-Rong,Zhou, Guo-Wu,Bian, Qi,Song, Bin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer. Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carried out to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk. Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominant model: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR = 1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph = 0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and never smoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results. Conclusions: This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism and gastric cancer risk. However, larger scale studies are needed for confirmation.
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Dawei Gao,Min Zhao,Ximing Qi,Yanping Liu,Nan Li,Zhiwei Liu,Yanhong Bian 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.2
Gynostemma pentaphyllum (GP) is a natural plant resources for diabetes therapy, however, there is little research on the mechanisms of GP. The present study was undertaken to characterize if G. pentaphyllum saponins (GPs) is the principal active compound of GP responsible for anti-diabetes, and to examine the relativity between blood glucose modulate and antioxidation. The GPs-treated streptozotocin diabetic rats had a more effective hypoglycemic status than those of diabetic control rats, which also ameliorate dyslipidemia. GPs has increased SOD and GSH-px activities, and the spleen and thymus indexes in diabetic rats. The insulin levels in the GPs-treated groups were significantly higher than diabetic control group. Our finding provides a new insight into the application of GPs for the treatment of oxidative stress related diseases.
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( Ru Zhang ),( Xue-mei Huang ),( Hui-juan Yan ),( Xin-yi Liu ),( Qi Zhou ),( Zhi-yong Luo ),( Xiao-ning Tan ),( Bian-ling Zhang ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.3
To investigate a novel β-glucosidase from Bifidobacterium breve ATCC 15700 (BbBgl) to produce compound K (CK) via ginsenoside F2 by highly selective and efficient hydrolysis of the C-3 glycoside from ginsenoside Rd, the BbBgl gene was cloned and expressed in E. coli BL21. The recombinant BbBgl was purified by Ni-NTA magnetic beads to obtain an enzyme with specific activity of 37 U/mg protein using pNP-Glc as substrate. The enzyme activity was optimized at pH 5.0, 35°C, 2 or 6 U/ml, and its activity was enhanced by Mn<sup>2+</sup> significantly. Under the optimal conditions, the half-life of the BbBgl is 180 h, much longer than the characterized β-glycosidases, and the Km and V<sub>max</sub> values are 2.7 mM and 39.8 μmol/mg/min for ginsenoside Rd. Moreover, the enzyme exhibits strong tolerance against high substrate concentration (up to 40 g/l ginsenoside Rd) with a molar biotransformation rate of 96% within 12 h. The good enzymatic properties and gram-scale conversion capacity of BbBgl provide an attractive method for large-scale production of rare ginsenoside CK using a single enzyme or a combination of enzymes.
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