Retrofitting of RC Piles using GFRP Composites

Purushotham Reddy,P. Alagusundaramoorthy,R. Sundaravadivelu 대한토목학회 2009 KSCE JOURNAL OF CIVIL ENGINEERING Vol.13 No.1

Extensive research has been carried out in recent years on the use of Fibre-Reinforced Polymer (FRP) composites in the strengthening of Reinforced Concrete (RC) structures. The piles in berthing structures need to be retrofitted to accommodate berthing of higher Dead Weight Tonnage (DWT) vessels. This paper presents the Finite element analysis, to study the behavior of retrofitted RC Pile specimens strengthened with Glass Fiber Reinforced Polymer (GFRP) composites using commercial software ANSYS. Experiments were also conducted to justify the finite element analysis results. Eight RC pile specimens were cast with same reinforcement details to study the behavior under different loading conditions. Four specimens were used as control and remaining four were retrofitted with GFRP fabric. The effect of retrofitting on RC pile specimens was studied. The load deflection and load strain plots obtained from numerical study is compared with the experimental plots. The crack patterns in the pile specimens are also presented. A parametric study is carried out to investigate the effect of various parameters on the strength of RC piles. The parameters include unconfined concrete strength, the steel ratio and the thickness of FRP.

Histomorphology and Immunohistochemistry of Gastrointestinal Stromal Tumors in a Malaysian Population

Kkrishnappa, Purushotham,Loh, Eu Jhin,Mohamad, Ibtisam Binti,Tata, Mahadevan Deva,Akhilesh, Meenakshi,Palayan, Kandasami Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6

Purpose: To study histomorphological and immunohistochemical patterns of gastro-intestinal stromal tumours (GISTs) in Malaysia. Materials and Methods: A total of 29 GIST cases from Hospital Tuanku Ja'afar, Seremban, were studied retrospectively over a period of 10 years from January 2002 to December 2011. Patient demographic data like age, sex and etnicity were collected. Tumour characteristics like site, maximum dimension and specimen type were analysed. Evaluation was according to established criteria into very low, low, intermediate and high-risk categories. Immunohistochemical characteristics were also analysed. Results: The mean age of patients was 59.7 years. Males (59%) were found to be more commonly affected than females (41%). The Chinese (45%) were commonly affected than Malays (41%), and Indians (10%). The most common symptom was pain in the abdomen (13.8%). More than half of the cases were seen in stomach (53%). The tumour size ranged from 1.5 cm to 17 cm with a mean of 6.94cm. Microscopic findings revealed that the spindle cell type was the most common (76%). It was observed that the majority of the cases (48%) were categorised in the intermediate risk group. Immunohistochemical staining showed positivity for CD117 (78.6%), CD34 (71.4%), vimentin (86.2%), S-100 (27.6%), SMA (35.7%), PKC THETA (46.4%) and PDGRFA (67.9%).

Investigation of Electrical Tree Growth of XLPE Nano Composites using Time–Frequency Map and Clustering Analysis of PD Signals

S. Purushotham,S.Chandrasekar,Gian Carlo Montanari 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.6

Failure of underground cables due to electrical treeing phenomena, i.e. formation of electrical discharges in the imperfections of cable insulation, is a major problem faced by electrical utilities. Many research works on nanocomposites are being carried out to improve the electrical treeing resistance of the XLPE cable insulation material. Technological advancements in communication and data analytic systems have shown the way for implementing online continuous partial discharge (PD) monitoring systems for high voltage apparatus. Hence collection of PD database of XLPE nanocomposites in the laboratory during entire electrical tree growth process is important for implementing effi cient condition monitoring systems and relatively little work has been published in this area. In this work, PD characteristics of XLPE nanocomposites with 1, 3, 5 and 10 wt% silica were investigated. Electrical tree growth and corresponding phase resolved PD (PRPD) pattern were analysed with respect to time. Cluster analysis of equivalent time–frequency mapping of PD signals was carried out with respect to tree growth time period. Statistical analysis was performed for the entire set of PD data. Results show that cluster analysis of T–F map of PD data is useful in estimating early failure of insulating material due to treeing. Addition of silica nano fi llers in the range of 3–5 wt% concentration signifi cantly improves the PD resistance and breakdown time of XLPE material.

In vivo imaging of tumor apoptosis using histone H1-targeting peptide

Wang, K.,Purushotham, S.,Lee, J.Y.,Na, M.H.,Park, H.,Oh, S.J.,Park, R.W.,Park, J.Y.,Lee, E.,Cho, B.C.,Song, M.N.,Baek, M.C.,Kwak, W.,Yoo, J.,Hoffman, A.S.,Oh, Y.K.,Kim, I.S.,Lee, B.H. Elsevier Science Publishers 2010 Journal of controlled release Vol.148 No.3

In vivo imaging of apoptosis could allow monitoring of tumor response to cancer treatments such as chemotherapy. Using phage display, we identified the CQRPPR peptide, named ApoPep-1(Apoptosis-targeting Peptide-1), that was able to home to apoptotic and necrotic cells in tumor tissue. ApoPep-1 also bound to apoptotic and necrotic cells in culture, while only little binding to live cells was observed. Its binding to apoptotic cells was not dependent on calcium ion and not competed by annexin V. The receptor for ApoPep-1 was identified to be histone H1 that was exposed on the surface of apoptotic cells. In necrotic cells, ApoPep-1 entered the cells and bound to histone H1 in the nucleus. The imaging signals produced during monitoring of tumor apoptosis in response to chemotherapy was enhanced by the homing of a fluorescent dye- or radioisotope-labeled ApoPep-1 to tumor treated with anti-cancer drugs, whereas its uptake of the liver and lung was minimal. These results suggest that ApoPep-1 holds great promise as a probe for in vivo imaging of apoptosis, while histone H1 is a unique molecular signature for this purpose.

Pathological Fracture of Femoral Neck Leading to a Diagnosis of Wilson’s Disease: A Case Report and Review of Literature

Nishit Bhatnagar,Purushotham Lingaiah,Jeetendra Singh Lodhi,Yugal Karkhur 대한골대사학회 2017 대한골대사학회지 Vol.24 No.2

Wilson’s disease (WD) is a rare inherited disorder of copper metabolism. It chiefly has hepatic, neurological and ophthalmic manifestations. Although osteoporosis, rickets and early arthritis are common features of WD, they are under-recognized. Musculoskeletal manifestations very rarely lead to diagnosis of the disease. Here we present a case of a 12-years-old girl who presented with a 3-months-old pathological fracture of neck of femur. WD was diagnosed on investigating the cause of the pathological fracture, which was managed by performing a conventional McMurray’s intertrochanteric osteotomy. At 6 months follow up, fracture had united and patient was able to ambulate with support. WD can be a rare cause of pathological fracture. A high index of suspicion must be maintained in patients of pathological fracture presenting with associated neuropsychiatric or hepatic manifestations.

An in vivo electromyographic evaluation of pain relief using different therapies in masticatory myalgia patients

Parvathi K,Balakrishnan,Sowmya M,Kumar,Purushotham Chippala,Chethan Hegde 대한구강악안면외과학회 2020 대한구강악안면외과학회지 Vol.46 No.5

Objectives: This study is aimed to evaluate and compare the effect of moist heat fomentation therapy with ultrasound therapy in patients with the masticatory myalgia. Materials and Methods: The study was conducted on 42 patients with masticatory myalgia, dividing them into two groups; Group A (21 patients), received moist heat therapy and Group B (21 patients), received ultrasound therapy for seven effective days. Prior and after the treatment the numeric rating scale (NRS) and the electromyography (EMG) scores were recorded and compared. The observations were analyzed clinically and statistical support was taken to assess the NRS and EMG data. Results: Irrespective of the groups, patients testified a significant reduction in pain after the treatment. From the EMG readings; even though the standard deviation for each group was varied considerably, EMG recorded an improved muscle activity. Statistical analysis was used to assess and identify the best treatment methodology between the two modalities. Conclusion: From the statistical analysis, it is concluded that, though both the therapies had significantly reduced the symptomatic response, it is moist heat fomentation that improved muscle activity both statistically and clinically in comparison to ultrasound.

Internet of Things-Based Command Center to Improve Emergency Response in Underground Mines

Jha, Ankit,Verburg, Alex,Tukkaraja, Purushotham Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.1

Background: Underground mines have several hazards that could lead to serious consequences if they come into effect. Acquiring, evaluating, and using the real-time data from the atmospheric monitoring system and miner's positional information is crucial in deciding the best course of action. Methods: A graphical user interface-based software is developed that uses an AutoCAD-based mine map, real-time atmospheric monitoring system, and miners' positional information to guide on the shortest route to mine exit and other locations within the mine, including the refuge chamber. Several algorithms are implemented to enhance the visualization of the program and guide the miners through the shortest routes. The information relayed by the sensors and communicated by other personnel are collected, evaluated, and used by the program in proposing the best course of action. Results: The program was evaluated using two case studies involving rescue relating to elevated carbon monoxide levels and increased temperature simulating fire scenarios. The program proposed the shortest path from the miner's current location to the exit of the mine, nearest refuge chamber, and the phone location. The real-time sensor information relayed by all the sensors was collected in a comma-separated value file. Conclusion: This program presents an important tool that aggregates information relayed by sensors to propose the best rescue strategy. The visualization capability of the program allows the operator to observe all the information on a screen and monitor the rescue in real time. This program permits the incorporation of additional sensors and algorithms to further customize the tool.

Structural studies of Mn doped ZnO nanoparticles

B.N. Dole,V.D. Mote,V.R. Huse,Y. Purushotham,M.K. Lande,K. M. Jadhav,S.S. Shah 한국물리학회 2011 Current Applied Physics Vol.11 No.3

Mn substituted ZnO nanoparticles with compositional formula Zn_(1-x)Mn_xO where x = 0.00, 0.04 and 0.08were synthesized by sol-gel route. All the samples sintered at 650 ℃ for 12 h in a furnace followed by furnace cooling up to room temperature. X-ray diffraction (XRD) studies shows the presence of hexagonal crystal structure as same as parent compound (ZnO) in all samples. The lattice parameters ‘a’ and ‘c’were determined from XRD data and found that they increase linearly with the Mn content, which suggests that doped Mn ions go to Zn sites. Grain size, X-ray density and Atomic packing fraction (APF)were evaluated using XRD data and found that grain size increases while X-ray density and Atomic packing fraction (APF) decreases with dopant concentration increases. The functional groups and chemical interactions of Mn substituted Zinc oxide samples were also determined at various peaks using FTIR data and observed the presence of function groups in the samples. Results of such an investigation presented in this paper.