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RISS 인기검색어
- 검색키워드
- 저자 : Penumetcha, Palla (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Modulation of Leptin Levels by Oxidized Linoleic Acid: A Connection to Atherosclerosis?
Meera Penumetcha,Nadya Merchant,Sampath Parthasarathy 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.4
The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r^(−/−)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r^(−/−) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat.
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Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil
Sampath Parthasarathy,Shylesh Bhaskaran,Nalini Santanam,Meera Penumetcha 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Diet has profound effects on the development of atherosclerosis. Fatty acid composition, antioxidants, andother components such as lignans have major effects on the atherosclerotic process. Sesame oil has both mono- and polyun-saturated fatty acid constituents in equal proportions. In addition, it also has high levels of numerous antioxidants and induc-ers of peroxisome proliferator-activated receptor. The objective of this study was to determine the anti-atherosclerotic effectsof sesame oil. In this study, male low-density lipoprotein (LDL) receptor (LDLR) . /. mice were fed atherogenic diet oratherogenic diet reformulated with the same level of sesame oil (sesame oil diet). Plasma lipids and atherosclerotic lesionswere quantified after 3 months of feeding. Sesame oil-containing diet significantly reduced the atherosclerotic lesion forma-tion and plasma cholesterol, triglyceride, and LDL cholesterol levels in LDLR . /. mice. These findings suggest that sesameoil could inhibit atherosclerosis lesion formation effectively, perhaps because of the synergistic actions of fatty acid and non-saponifiable components.
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Bacterial Hash Function Using DNA-Based XOR Logic Reveals Unexpected Behavior of the LuxR Promoter
Pearson, Brianna,Lau, Kin H.,Allen, Alicia,Barron, James,Cool, Robert,Davis, Kelly,DeLoache, Will,Feeney, Erin,Gordon, Andrew,Igo, John,Lewis, Aaron,Muscalino, Kristi,Parra, Madeline,Penumetcha, Palla Korean Society for Bioinformatics 2011 Interdisciplinary Bio Central (IBC) Vol.3 No.3
Introduction: Hash functions are computer algorithms that protect information and secure transactions. In response to the NIST's "International Call for Hash Function", we developed a biological hash function using the computing capabilities of bacteria. We designed a DNA-based XOR logic gate that allows bacterial colonies arranged in a series on an agar plate to perform hash function calculations. Results and Discussion: In order to provide each colony with adequate time to process inputs and perform XOR logic, we designed and successfully demonstrated a system for time-delayed bacterial growth. Our system is based on the diffusion of ${\ss}$-lactamase, resulting in destruction of ampicillin. Our DNA-based XOR logic gate design is based on the op-position of two promoters. Our results showed that $P_{lux}$ and $P_{OmpC}$ functioned as expected individually, but $P_{lux}$ did not behave as expected in the XOR construct. Our data showed that, contrary to literature reports, the $P_{lux}$ promoter is bidirectional. In the absence of the 3OC6 inducer, the LuxR activator can bind to the $P_{lux}$ promoter and induce backwards transcription. Conclusion and Prospects: Our system of time delayed bacterial growth allows for the successive processing of a bacterial hash function, and is expected to have utility in other synthetic biology applications. While testing our DNA-based XOR logic gate, we uncovered a novel function of $P_{lux}$. In the absence of autoinducer 3OC6, LuxR binds to $P_{lux}$ and activates backwards transcription. This result advances basic research and has important implications for the widespread use of the $P_{lux}$ promoter.
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