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Intramammary sentinel lymph node with capsular extravasation in breast cancer
Paulo Roberto De Alcantara Fil,Carla Curi,Camila Souza Guatelli,Cynthia Aparecida B. de Toledo,Stephania Martins Bezerra,Fernando Augusto Soares,Fabiana Baroni Makdissi 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.5
Sentinel lymph node biopsy has been developed as the standard of treatment in breast cancer. Status of axillary sentinel lymph node is known to be a significant prognostic factor. Nevertheless, involvement of an intramammary lymph node with metastasis in breast cancer is a rare radiological and clinical presentation, and with extracapsular extravasation even more uncommon. Historically, reported series of patients with intramammary lymph node diagnosed by final histological examination are small in number and clinical significance of metastasis is still unclear. Here, we report a case of conservative breast cancer surgery with 3 intramammary sentinel lymph nodes containing metastasis and extracapsular extravasation. After multidisciplinary consensus, the patient was surgically reapproached with mastectomy. Even though the 3 intramammary sentinel lymph nodes were positive for metastases, pathology examination did not reveal any signs of malignancy in the mastectomy specimen.
Martins-Filho Paulo Ricardo,de Souza Araújo Adriano Antunes,Quintans-Júnior Lucindo José,Soares Bárbara dos Santos,Barboza Waneska de Souza,Cavalcante Taise Ferreira,Santos Victor Santana 한국역학회 2022 Epidemiology and Health Vol.44 No.-
This study investigated the dynamics of hospitalizations and in-hospital deaths from coronavirus disease 2019 (COVID-19) throughout the pandemic in northeast Brazil, the Brazilian region with the worst socioeconomic indicators. In total, 141,445 cases, 8,213 hospital admissions, and 1,644 in-hospital deaths from COVID-19 were registered from March 14, 2020 to February 5, 2022. The overall rates of hospitalization and in-hospital deaths were 5.8% and 20.0%, respectively. The hospitalization and death rates significantly decreased over time, which may have been related to progress in vaccination. During the spread of the Gamma variant (January to June 2021), most hospitalized individuals were young adults, and approximately 40% of deaths occurred in this age group. During the predominance of Delta (July to December 2021), over 75% of deaths occurred among the elderly and unvaccinated or partially vaccinated individuals. This rate decreased to 42.3% during the transmission of the Omicron variant (January to February 2022), during which 34.6% of deaths were recorded among fully vaccinated individuals (2 doses) and 23.1% among those who received full vaccination and a booster. The Omicron-driven third wave was associated with a rise in the proportion of deaths among vaccinated individuals, especially among those who had not received a booster dose.
Gabriel Dias Rodrigues,Ligia Soares Lima,Nicole Cristine Simões da Silva,Paula Gomes Lopes Telles,Teresa Mell da Mota Silva Rocha,Victor Quintella de Aragão Porto,Viviane Veloso Cardoso,Pedro Paulo da 대한고혈압학회 2022 Clinical Hypertension Vol.28 No.-
Sedentarism and chronic non-communicable diseases have been a worldwide health problem that is drastically exacerbated by the COVID-19 pandemic social impacts. Home-based exercises are widely encouraged during social isolation to counterbalance the physical inactive impacts. Although, in the context of hypertension, are home-based exercises effective in blood pressure controlling? Our objective is to conduct a systematic review of high-quality controlled trials comparing the possible effects of different types of home-based exercises in hypertensive patients. The literature search was carried out in three scientific databases: Medline, Europe PMC, and Lilacs. Articles were included following three criteria: analyzing the effect of home-based exercise programs on blood pressure in treated and untreated hypertensive patients; exercises must perform at home and on the frequency, intensity, time, and type (FITT) principle, and the articles were published in English. From the qualitative analysis of 27 original trials screened through 451 identified studies, the main results are the following: 1) both endurance, isometric strength, and respiratory home-based exercise programs were efficient to decrease blood pressure in hypertensive patients; 2) differences in methodological approaches regarding FITT components, distinct blood pressure values at baseline and specific underlying mechanisms must be considered as a potential bias of each home-based interventions. In conclusion, endurance, isometric strength, and breathing home-based programs seems to be effective to reduce blood pressure in hypertensive patients. However, further randomized controlled trials and mechanistic studies must be performing to guide evidence-based recommendations of home-based exercises as antihypertensive therapy.
In-transit development of color abnormalities in turkey breast meat during winter season
( Rafael H. Carvalho ),( Danielle C. B. Honorato ),( Paulo D. Guarnieri ),( Adriana L. Soares ),( Mayka R. Pedrao ),( Alexandre Oba ),( Fernanda G. Paiao ),( Elza I. Ida ),( Massami Shimokomaki ) 한국축산학회(구 한국동물자원과학회) 2018 한국축산학회지 Vol.60 No.1
Background: The poultry industry suffers losses from problems as pale, soft and exudative (PSE), and dark, firm and dry (DFD) meat can develop in meat as a result of short- and long-term stress, respectively. These abnormalities are impacted by pre-slaughter animal welfare. Methods: This work evaluated the effects of open vehicle container microclimate, throughout the 38 ± 10 km journey from the farm to the slaughterhouse, on commercially turkey transported during the Brazilian winter season. The journey was initiated immediately after water bath in truck fitted with portable Kestrel anemometers to measure air ventilation, relative humidity, temperature and ventilation. Results: The inferior compartments of the middle and rear truck regions showed highest temperature and relative humidity, and lower air ventilation. In addition, the superior compartments of the front truck regions presented lower temperature and wind chill, and highest air ventilation. The breast meat samples from animals located at the inferior compartments of the middle and rear truck regions and subjected to with water bath (WiB) treatment presented highest DFD-like and had lowest PSE-like meat incidence than those from animals located at other compartments within the container. Lower incidence of PSE-like meat was observed in birds without water bath (WoB). Conclusions: Assessment on turkeys transported under Brazilian southern winter conditions revealed that breast meat quality can be affected by relative humidity, air ventilation, temperature, and transport under subtropical conditions promoting color abnormalities and the formation of simultaneously PSE-like and DFD-like meat.
Nutritional and productive parameters of Holstein/Zebu cows fed diets containing cactus pear
Lucas Daniel Alcantara Borges,Vicente Ribeiro Rocha Junior,Flavio Pinto Moncao,Camila Soares,Jose Reinaldo Mendes Ruas,Fredson Vieira e Silva,Joao Paulo Sampaio Rigueira,Natanael Mendes Costa,Laura Lu 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.9
Objective: This study ascertained effects of cactus pear in association with different roughage in the diet of F1 Holstein/Zebu cows on intake, nutrient digestibility, nitrogen balance, ingestive behavior and performance. Methods: Eight cows with 72±11 days of lactation were used. The experimental design was simultaneous in two 4×4 Latin squares. Four experimental diets were used: Diet 1, sorghum silage as exclusive roughage; Diet 2, sorghum silage associated with cactus pear in a proportion of 50% of the roughage (dry matter basis); Diet 3, elephant grass (Pennisetum purpureum cv. Roxo) as exclusive roughage; Diet 4, elephant grass associated with cactus pear in a proportion of 50% of the roughage. The roughage:concentrate ratio was 75:25. Results: Dry matter intake (p = 0.01) was higher with sorghum silage. There were differences in dry matter intake (p = 0.01), crude protein (p<0.01), ether extract (p = 0.01), non-fibrous carbohydrates (p<0.01) and total digestible nutrients (p = 0.01) among the diets. Cactus pear in the diet reduced water intake by 44.52% (p<0.01). The nitrogen balance was 59.71% and 27.49% lower in animals treated with exclusive sorghum silage and sorghum silage associated with cactus pear in relation to diets with elephant grass and elephant grass associated with cactus pear, respectively (p<0.01). The diets did not influence the milk production (p = 0.70), 3.5% fat corrected milk production (p = 0.72) or feed efficiency (p = 0.61). Conclusion: The association of cactus pear with sorghum or elephant grass silage does not alter milk production, reduces the intake of dry matter and water and improves the digestibility of nutrients.
Felipe Marin,Adriano Fagali de Souza,Alexandre Mikowski,Luís Henrique Guarnieri Fontanella,Paulo Soares,Luis Norberto López de Lacalle 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.4
The hybrid manufacturing procedure of combining an initial machining process and a posterior laser powder bed fusion (LPBF) process opens a new range of possibilities for manufacturing complex parts, promising to reduce both costs and printing time. Hence, the first portion of the part might be manufactured by machining, which is used as the substrate for the LPBF. Different manufacturing processes produce a melting interface zone (MIZ) that can affect the mechanical properties of hybrid parts. This work investigates the properties of the MIZ in hybrid parts. The influence of the energy density of the LPBF process on the interface zone and the mechanical properties of the final hybrid part were assessed. The different tests showed high-quality interphase even with low energy density, with a melting depth of up to 0.3 mm. Tomography analysis showed no pores in the MIZ and the increase in pore number with the scanning speed, reducing the UTS of the hybrid samples from 8 to 42% in relation to machined Corrax®. Additionally, a test piece for injection molding was produced by this new hybrid manufacturing process. The results showed that the costs and manufacturing time were reduced by about 50%, showing a potential application of hybrid manufacturing in such applications. Besides, this work identifies a limitation of the hybrid manufacturing approach using LPBF machines which are not equipped with a system to identify the substrate coordinate system. The present study develops an operational method to identify the coordinate system in order to ease the referencing of the pre-machined substrate within the machine platform.
Rabelo, Katharina Alves,Cavalcanti, Yuri Wanderley,de Oliveira Pinto, Martina Gerlane,Melo, Saulo Leonardo Sousa,Campos, Paulo Sergio Flores,de Andrade Freitas Oliveira, Luciana Soares,de Melo, Daniel Korean Academy of Oral and Maxillofacial Radiology 2017 Imaging Science in Dentistry Vol.47 No.3
Purpose: To quantify artifacts from different root filling materials in cone-beam computed tomography (CBCT) images acquired using different exposure parameters. Materials and Methods: Fifteen single-rooted teeth were scanned using 8 different exposure protocols with 3 different filling materials and once without filling material as a control group. Artifact quantification was performed by a trained observer who made measurements in the central axial slice of all acquired images in a fixed region of interest using ImageJ. Hyperdense artifacts, hypodense artifacts, and the remaining tooth area were identified, and the percentages of hyperdense and hypodense artifacts, remaining tooth area, and tooth area affected by the artifacts were calculated. Artifacts were analyzed qualitatively by 2 observers using the following scores: absence (0), moderate presence (1), and high presence (2) for hypodense halos, hypodense lines, and hyperdense lines. Two-way ANOVA and the post-hoc Tukey test were used for quantitative and qualitative artifact analysis. The Dunnet test was also used for qualitative analysis. The significance level was set at P<.05. Results: There were no significant interactions among the exposure parameters in the quantitative or qualitative analysis. Significant differences were observed among the studied filling materials in all quantitative analyses. In the qualitative analyses, all materials differed from the control group in terms of hypodense and hyperdense lines (P<.05). Fiberglass posts did not differ statistically from the control group in terms of hypodense halos(P>.05). Conclusion: Different exposure parameters did not affect the objective or subjective observations of artifacts in CBCT images; however, the filling materials used in endodontic restorations did affect both types of assessments.
Katharina Alves Rabelo,Yuri Wanderley Cavalcanti,Martina Gerlane de Oliveira Pinto,Saulo Leonardo Sousa Melo,Paulo Sérgio Flores Campos,Luciana Soares de Andrade Freitas Oliveira,Daniela Pita de Melo 대한영상치의학회 2017 Imaging Science in Dentistry Vol.47 No.3
Purpose: To quantify artifacts from different root filling materials in cone-beam computed tomography (CBCT) images acquired using different exposure parameters. Materials and Methods: Fifteen single-rooted teeth were scanned using 8 different exposure protocols with 3 different filling materials and once without filling material as a control group. Artifact quantification was performed by a trained observer who made measurements in the central axial slice of all acquired images in a fixed region of interest using ImageJ. Hyperdense artifacts, hypodense artifacts, and the remaining tooth area were identified, and the percentages of hyperdense and hypodense artifacts, remaining tooth area, and tooth area affected by the artifacts were calculated. Artifacts were analyzed qualitatively by 2 observers using the following scores: absence (0), moderate presence (1), and high presence (2) for hypodense halos, hypodense lines, and hyperdense lines. Two-way ANOVA and the post-hoc Tukey test were used for quantitative and qualitative artifact analysis. The Dunnet test was also used for qualitative analysis. The significance level was set at P<.05. Results: There were no significant interactions among the exposure parameters in the quantitative or qualitative analysis. Significant differences were observed among the studied filling materials in all quantitative analyses. In the qualitative analyses, all materials differed from the control group in terms of hypodense and hyperdense lines (P<.05). Fiberglass posts did not differ statistically from the control group in terms of hypodense halos (P>.05). Conclusion: Different exposure parameters did not affect the objective or subjective observations of artifacts in CBCT images; however, the filling materials used in endodontic restorations did affect both types of assessments.
Rahul Davis,Abhishek Singh,Robson Bruno Dutra Pereira,Roberta Maia Sabino,Ketul Popat,Paulo Soares,Lincoln Cardoso Brandão 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.6
Shape memory alloys are mainly used in medical devices and surgical implants due to their biocompatibility. Machining these alloys into intricate patterns can be challenging due to their poor thermal conductivity which could lead to a poor surface finish. The poor surface finish causes a release of toxic elements such as Nickel, leading to contact allergies and thus deteriorating its biocompatibility. Using the right cooling technology can help improve their machinability and overcome issues related to surface integrity. The current study investigates the effect of milling parameters (cutting-speed, feed rate, and depth of cut) and different cooling strategies (flood coolant, cryogenic liquid nitrogen, and a hybrid approach) on the surface integrity of F2063 Ni55.6Ti44.4 shape memory alloy. In addition, the effect of cryogenically treating the cutting tool for further enhancement of surface finish was investigated. A considerable modification on the milled surfaces was observed when using the hybrid cooling/milling approach and cryo-treated tools in terms of morphological, chemical compositional, crystallographic, and microhardness. In addition, this modified surface had a noticeably improved bioactivity due to enhanced hydrophobicity (with contact angle 92°) and surface topography (Ra: 341.69 nm), which favoured cell adhesion and proliferation. The results indicate that the modified Ni55.6Ti44.4 alloy surface might be adequate for use in medical applications.