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- 저자 : Felipe Marin (검색결과 2 건)
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Felipe Marin,Adriano Fagali de Souza,Alexandre Mikowski,Luís Henrique Guarnieri Fontanella,Paulo Soares,Luis Norberto López de Lacalle 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.4
The hybrid manufacturing procedure of combining an initial machining process and a posterior laser powder bed fusion (LPBF) process opens a new range of possibilities for manufacturing complex parts, promising to reduce both costs and printing time. Hence, the first portion of the part might be manufactured by machining, which is used as the substrate for the LPBF. Different manufacturing processes produce a melting interface zone (MIZ) that can affect the mechanical properties of hybrid parts. This work investigates the properties of the MIZ in hybrid parts. The influence of the energy density of the LPBF process on the interface zone and the mechanical properties of the final hybrid part were assessed. The different tests showed high-quality interphase even with low energy density, with a melting depth of up to 0.3 mm. Tomography analysis showed no pores in the MIZ and the increase in pore number with the scanning speed, reducing the UTS of the hybrid samples from 8 to 42% in relation to machined Corrax®. Additionally, a test piece for injection molding was produced by this new hybrid manufacturing process. The results showed that the costs and manufacturing time were reduced by about 50%, showing a potential application of hybrid manufacturing in such applications. Besides, this work identifies a limitation of the hybrid manufacturing approach using LPBF machines which are not equipped with a system to identify the substrate coordinate system. The present study develops an operational method to identify the coordinate system in order to ease the referencing of the pre-machined substrate within the machine platform.
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Lima, Felipe Teixeira,Seba, Viviane,Silva, Gabriel,Torrezan, Guilherme Silva,Polaquini, Carlos Roberto,Pinhanelli, Vitor Caressato,Baek, Seung J.,Fachin, Ana Lú,cia,Regasini, Luis Octavio,Marins MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.7
<P>Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent in human osteosarcoma cell lines U2OS, MG-63, and Saos-2. CH-5 inhibited cell viability at lower concentrations than curcumin, leading to the induction of apoptosis. The cellular levels of the transcription factors p53 and Sp1 affect the expression of cellular pathways that lead to apoptosis. CH-5 increased p53 protein levels in U2OS cells and reduced Sp1 levels, with a consequent effect on the expression of their target genes DNA methyltransferase 1 (<I>DNMT1)</I> and growth arrest and DNA damage-inducible 45 alpha gene (<I>Gadd45a)</I>. CH-5 repressed <I>DNMT1</I> and increased <I>Gadd45a</I> mRNA expression, which was dependent on p53, as this effect was only observed in the colorectal cancer cell line HCT116 with active p53, but not in the isogenic p53-deficient HCT116 cells. CH-5 also reduced the protein levels of DNMT1, which led to the upregulation of <I>Gadd45a</I>. These results suggest that CH-5 has potentially higher anticancer activity than curcumin, which is associated with the expression of apoptosis-associated genes regulated by the transcription factors Sp1 and p53. Future work on CH-5 will define the therapeutic potential of this compound in vivo.</P>
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