Rutabaga (Brassica napus L. var. napobrassica) Seeds, Roots, and Sprouts: A Novel Kind of Food with Antioxidant Properties and Proapoptotic Potential in Hep G2 Hepatoma Cell Line

Pawel Pasko,Karolina Bukowska-Strakova,Joanna Gdula-Argasinska,Malgorzata Tyszka-Czochara 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8

Although rutabaga (Brassica napus L. var. napobrassica) is a popular crop, especially in North Europe and North America, its sprouts are a new kind of vegetable. Rutabaga roots, and particularly sprouts, have not been investigated so far for antioxidant and anticancer effect on human tumor cells (Hep G2). Therefore, in vitro tests were conducted to find out whether rutabaga seeds, roots, and sprouts exert a cytotoxic effect on mammalian cells and combine them with other biological properties of particular parts of the plant. Rutabaga methanol extracts were measured for total phenolic, total flavonoid concentrations, and total antioxidant activity. Cytotoxicity of the investigated extracts was measured using 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide assay in Chinese hamster ovary cells (CHO-K1) and Hep G2 cells culture. Cell membrane integrity was assessed in CHO-K1 and Hep G2 cells by luminescence ToxiLight BioAssay. The results of the investigation have shown that sprouts have significantly higher antioxidant activity than seeds and roots, which may result from different contents of polyphenols. Rutabaga extracts (especially 8 day sprouts) inhibited the tumor cell line Hep G2 proliferation and had a slight effect on the normal mammalian CHO-K1 culture. An advanced analysis of previously observed morphological changes and cytotoxic properties demonstrated that the evaluated extracts exerted cell death via apoptosis. These findings strongly suggest that one of the biological activities of rutabaga is antiproliferative and proapoptotic potential specific to tumor cells. The obtained results demonstrate the antioxidant property of rutabaga and its potential as a nutritional supplement in cancer prevention. These findings also strongly advocate the application of rutabaga sprouts (especially harvested in conditions presented in this article) in functional food.

[Architects Storytelling] 유르코비치난방시설 국립문화기념물(NCM)재건축

마틴 파스코(Martin Pasko),DF 크리에이티브그룹(DF Creative Group) 현대건축사 2024 월간 CONCEPT Vol.- No.298

The Mechanism of Labor Motivation as a Determinant of Economic Security of Enterprises in Competitive Conditions

Lagodiienko, Volodymyr,Samoilenko, Viktoria,Pasko, Maryna,Ovod, Larysa,Matsulevych, Yevgeniy International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.2

In the study of the mechanism of labor motivation as a determinant of economic security of the enterprise in competitive conditions, it was found that motivation is determinant in creating the conditions for production and ensuring the active functioning of the enterprise. It is substantiated that the motivational mechanism is the presence of a system of levers, incentives, measures and other elements for economic and administrative incentives for employees, which are used for incentives to work, increase productivity and safety, and more. The motivational mechanism plays an important role in ensuring the economic security of the enterprise and at the same time is a lever to increase competitiveness in the market. The functions of the mechanism of labor motivation are singled out, among which: explanatory-substantiating, regulative, communicative, socialization, regulating. The stages of occurrence of the motive for the employee are classified. The interrelation of motives and incentives in the mechanism of labor motivation as determinants of economic security of the enterprise in competitive conditions is proved. It is proved that the mechanism of labor motivation as a determinant of economic security of the enterprise in competitive conditions should be aimed at: assistance in forming and achieving goals and objectives of the enterprise and achieving balance and equilibrium of economic goals and social responsibility of the enterprise; ensuring close cooperation between management and employees of the enterprise; focus on building a flexible mechanism; transition to a democratic style of governance and involvement of employees in decision-making.

Salvage of Failed Femoral Neck Fracture Fixation with Conversion Total Hip Arthroplasty Using the Direct Anterior Approach

Andrew Yun,Marilena Qutami,Kory B. Dylan Pasko 대한고관절학회 2020 Hip and Pelvis Vol.32 No.4

Purpose: Failed femoral neck fracture (FNF) fixation with in situ pinning presents a surgical challenge. Osteoporotic bone, retained hardware, and a typically elderly population magnify the risks of surgery. Here, outcomes of conversion total hip arthroplasty (THA) using two separate incisions in these high-risk patients were examined. Materials and Methods: Medical records for 42 patients with a prior history of FNF fixation who underwent conversion THA with hardware removal between 2009 and 2019 were retrospectively reviewed. Surgery was performed by a single surgeon at a single institution. All patients underwent hardware removal followed by direct anterior approach (DAA) THA using two separate incisions. Clinical outcomes, radiographic findings, and perioperative morbidity and mortality are reported. Results: Clinically, there were no postoperative dislocations, periprosthetic fractures, or infections at follow-up. After a mean follow-up of 4 years, the mean hip disability and osteoarthritis outcome score, junior (HOOS, Jr) was 91. Radiographically, the mean postoperative cup abduction was 44 degrees and the mean cup anteversion was 21 degrees with an improvement in preoperative leg length discrepancy. Perioperative complications included one case of immediate foot drop and two readmissions for medical issues. One patient died one month after conversion THA. Conclusion: Salvage of failed FNF treatment may be managed with conversion THA and DAA with a separate incision for hardware removal. Preservation of posterior soft tissues using a DAA and intraoperative fluoroscopy may mitigate well-known complications related to fracture and dislocation. While favorable clinical outcomes are possible, salvage surgery is still not without substantial surgical and medical risks.

Treatment of In-Stent Stenosis Following Flow Diversion of Intracranial Aneurysms with Cilostazol and Clopidogrel

Ehsan Dowlati,Kory B. Dylan Pasko,Jiaqi Liu,Charles A. Miller,Daniel R. Felbaum,Samir Sur,Jason J. Chang,Ai-Hsi Liu,Rocco A. Armonda,Jeffrey C. Mai 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.3

In-stent stenosis is a feared complication of flow diversion treatment for cerebral aneurysms. We present 2 cases of patients treated with pipeline flow diversion for unruptured cerebral aneurysms. Initial perioperative dual antiplatelet therapy (DAPT) consisted of standard aspirin plus clopidogrel. At 6-month follow-up cerebral angiography, the patients were noted to have developed significant in-stent stenosis (63% and 53%). The patients were treated with cilostazol and clopidogrel for at least 6 months. Subsequent angiography at 1-year post-treatment showed significant improvement of the in-stent stenosis from 63% to 34% and 53% to 21%. The role of cilostazol as treatment of intracranial in-stent stenosis has not been previously described. Cilostazol’s vasodilatory effect and suppression of vascular smooth muscle proliferation provides ideal benefits in this setting. Cilostazol plus clopidogrel may be a safe and effective alternative to standard DAPT for treatment of in-stent stenosis following flow diversion and warrants further consideration and investigation.

Management of failed UKA to TKA: conventional versus robotic-assisted conversion technique

Yun Andrew G.,Qutami Marilena,Chen Chang-Hwa Mary,Pasko Kory B. Dylan 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Background: Failure of unicompartmental knee arthroplasty (UKA) is a distressing and technically challenging complication. Conventional conversion techniques (CCT) with rods and jigs have produced varying results. A robotic-assisted conversion technique (RCT) is an unexplored, though possibly advantageous, alternative. We compare our reconstructive outcomes between conventional and robotic methods in the management of failed UKA. Methods: Thirty-four patients with a failed UKA were retrospectively reviewed. Patients underwent conversion total knee arthroplasty (TKA) with either a CCT or RCT. Seventeen patients were included in each group. All procedures were done by a single surgeon at a single institution, with a mean time to follow-up of 3.6 years (range, 1 to 12). The primary outcome measures were the need for augments and polyethylene thickness. Secondary outcome measures were complications, need for revision, estimated blood loss (EBL), length of stay, and operative time. Results: The mean polyethylene thickness was 12mm (range, 9 to 15) in the CCT group and 10mm (range, 9 to 14) in the RCT groups, with no statistical difference between the two groups (P = 0.07). A statistically significant difference, however, was present in the use of augments. In the CCT group, five out of 17 knees required augments, whereas none of the 17 knees in the RCT group required augments (P = 0.04). Procedurally, roboticassisted surgery progressed uneventfully, even with metal artifact noted on the preoperative computerized tomography (CT) scans. Computer mapping of the residual bone surface after implant removal was a helpful guide in minimizing resection depth. No further revisions or reoperations were performed in either group. Conclusions: Robotic-assisted conversion TKA is technically feasible and potentially advantageous. In the absence of normal anatomic landmarks to guide conventional methods, the preoperative CT scans were unexpectedly helpful in establishing mechanical alignment and resection depth. In this limited series, RCT does not seem to be inferior to CCT. Further investigation of outcomes is warranted.

Videogames in Cybersecurity: Philosophical and Psychological Review of Possible Impact

Bogdan, Levyk,Maletska, Mariia,Khrypko, Svitlana,Leonid, Kryvyzyuk,Olga, Dobrodum,Pasko, Katerina International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.7

An issue of security and threat is urgent as well as it concerns everyone: a person, community, state, etc. Today, the question of cybersecurity has become especially relevant due to general digitalization and the spread of the cyberculture. In terms of it, the growing popularity of videogames can be observed. Their impact on society differs significantly, therefore, it needs thorough consideration. The purpose of the article is to disclose the role of videogames in cybersecurity. To achieve the stated purpose, such methods as analysis, synthesis, systematization and practical involvement of videogames have been used. As a result, three levels of possible threat of videogames has been distinguished: videogames as a possibly dangerous software, as a tool of propaganda and spread of stereotypes, as a space for the creation of virtual communities. In conclusion, it is stated that videogames can be not only a threat, but also a tool for strengthening the cybersecurity.

Cybercrime as a Discourse of Interpretations: the Semantics of Speech Silence vs Psychological Motivation for Actual Trouble

Matveev, Vitaliy,Eduardivna, Nykytchenko Olena,Stefanova, Nataliia,Khrypko, Svitlana,Ishchuk, Alla,PASKO, Katerina International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.8

The article studies the discourse and a legal uncertainty of the popular and generally understandable concept of cybercrime. The authors reveal the doctrinal approaches to the definition of cybercrime, cyberspace, computer crime. The analysis of international legal acts and legislation of Ukraine in fighting cybercrime is carried out. The conclusion is made about the need to improve national legislation and establish international cooperation to develop the tools for countering cybercrime and minimizing its negative outcomes. The phenomenon of nicknames is studied as a semantic source, which potentially generates a number of threats and troubles - the crisis of traditional anthroponymic culture, identity crisis, hidden sociality, and indefinite institutionalization, incognito style, a range of manifestations of loneliness - from voluntary solitude to traumatic isolation and forced detachment. The core idea is that it is the phenomenon of incognito and hidden name (nickname and other alternatives) that is the motivational stimulus for the fact of information trouble or crime.

Use of Visual Digital Media to Develop Creativity: The Example of Video Games

V., Zabolotnyuk,S., Khrypko,I., Ostashchuk,D., Chornomordenko,A., Timchenko,T., Motruk,K., Pasko,O., Lobanchuk International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.12

In the post-information era, most of technologies have a visual part, or at least some functions related to visualization. It is also one of the popular means of presenting materials in education area. However, despite its popularity, the impact of visualization on the effectiveness of learning still remains controversial. Even more controversial is its usefulness in developing creativity, which is one of the most important skills for today's employee. The authors considered the use of visualization as a tool for the development of children's creativity on the example of learning video games, in particular, ClassCraft to distinguish features that, from the point of view of psychology, may lead to developing creativity even being not useful for educational purposes. It is concluded that video games useful for learning may have features, that are inappropriate in formal educational context, but important to develop creative thinking.