http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Olga Barbarash,Olga Gruzdeva,Evgenya Uchasova,Yulia Dyleva,Ekaterina Belik,Olga Akbasheva,Victoria Karetnikova,Aleksandr Shilov 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.4
Background: Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications. Methods: We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA. Results: On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004). Conclusions: The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia
Gervas, Polina,Ivanova, Anna,Vasiliev, Nikolay,Ananina, Olga,Zharkova, Olga,Rogovieva, Olga,Verzhbitskaya, Natalia,Didichuk, Ivan,Cheremisina, Olga,Popova, Natalia,Goldberg, Victor,Cherdyntsev, Evgeny Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Incorporation of molecular analysis of the epidermal growth factor receptor (EGFR) gene into routine clinical practice has shown great promise to provide personalized therapy of the non-small cell lung cancer (NSCLC) in the developed world. However, the genetic testing of EGFR mutations has not yet become routine clinical practice in territories remote from the central regions of Russia. Therefore, we aimed to study the frequency of major types of activating mutations of the EGFR gene in NSCLC patients residing in West Siberia. Materials and Methods: We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding squamous cell lung carcinomas) by real time polymerase chain reaction. Results: EGFR mutations were detected in 28 of the 147 (19%) patients. There were 19 (13%) cases with mutations in exon 19 and 9 cases (6%) in exon 21. Mutations were more frequently observed in women (42%, p=0.000) than in men (1%). A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28%, p=0.019) and in adenocarcinomas (21%, p=0.024) than in large cell carcinomas, mixed adenocarcinomas, and NOS (4%). The EGFR mutation rate was much higher in never-smokers than in smokers: 38% vs. 3% (p=0.000). The frequency of EGFR mutations in the Kemerovo and Tomsk regions was 19%. Conclusions: The incorporation of molecular analysis of the EGFR gene into routine clinical practice will allow clinicians to provide personalised therapy, resulting in a significant increase in survival rates and improvement in life quality of advanced NSCLC patients.
Novel antigen panel for modern broad-spectrum recombinant rotavirus A vaccine
Olga A. Kondakova,Peter A. Ivanov,Oleg A. Baranov,Ekaterina M. Ryabchevskaya,Marina V. Arkhipenko,Eugene V. Skurat,Ekaterina A. Evtushenko,Nikolai A. Nikitin,Olga V. Karpova 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.2
Purpose: Recombinant rotavirus A vaccines are being developed as an alternative to existing live oral attenuated vaccines. One of the main problems in the production of such vaccines is the genetic diversity of the strains that are in circulation. The goal of this study was to create an antigen panel for modern broad-spectrum recombinant rotavirus A vaccine. Materials and Methods: The antigens of rotavirus were cloned and expressed in Escherichia coli. Antigenic specificity was investigated by Western blot analysis, which was performed using commercial polyclonal antisera to several RVA strains. Phylogenetic analysis was based on the amino acid sequences of the VP8* protein fragment of human RVA isolates representing genotypes P[4], P[6], and P[8]. Results: A universal panel of antigens was established, including consensus and conserved sequences of structural proteins VP8*, VP5*, and VP7, which are the main targets of neutralizing antibodies. For the first time, a consensus approach was used in the design of extended antigens based on VP8* (genotypes P[4], P[6], and P[8]) and VP5* (genotype P[8]) proteins’ fragments. In addition, a gene coding the protein (ep-875) containing several copies of conserved short neutralizing epitopes of VP8*, VP7, and VP5* was created. Western blot analysis demonstrated that three synthetic VP8*-based antigens were not recognized by commercial antiserum against rotavirus strains isolated more than 35 years ago, but the specific activity of the VP5* and ep-875 antigens was confirmed. The problems of serological mismatch of vaccine strains and antigens with currently circulating strains are discussed. Conclusion: Five antigens representing sequences of structural proteins belonging to different genotypes can be used in various combinations (from mono- to pentavalent mixtures) for the development of an effective broad-spectrum rotavirus vaccine.
Olga D. Baydik,Armen Yuri Gasparyan 대한의학회 2016 Journal of Korean medical science Vol.31 No.10
The detection of plagiarism in scholarly articles is a complex process. It requires not just quantitative analysis with the similarity recording by anti-plagiarism software but also assessment of the readers’ opinion, pointing to the theft of ideas, methodologies, and graphics. In this article we describe a blatant case of plagiarism by Chinese authors, who copied a Russian article from a non-indexed and not widely visible Russian journal, and published their own report in English in an open-access journal indexed by Scopus and Web of Science and archived in PubMed Central. The details of copying in the translated English article were presented by the Russian author to the chief editor of the index journal, consultants from Scopus, anti-plagiarism experts, and the administrator of the Committee on Publication Ethics (COPE). The correspondents from Scopus and COPE pointed to the decisive role of the editors’ of the English journal who may consider further actions if plagiarism is confirmed. After all, the chief editor of the English journal retracted the article on grounds of plagiarism and published a retraction note, although no details of the complexity of the case were reported. The case points to the need for combining antiplagiarism efforts and actively seeking opinion of non-native English-speaking authors and readers who may spot intellectual theft which is not always detected by software.
The Problems that Interfere the Development of Trade And Economic Relations in Fish Industry
Olga Yu. Vorojbit 한국로고스경영학회 2009 한국로고스경영학회 학술발표대회논문집 Vol.2009 No.7월
In the recent years the problem of competitiveness in fishing industry of Russian Far East is of the highest importance. There is a number of tasks that require urgent solution. The solution of any problem is impossible without diagnosing the causes and identifying the main factors. It is important to realize the main peculiarities and problems of entrepreneurship development in the fishing industry of the Russian Far East, which provides more than 60% of the fishery production in the country. This article identifies key obstacles for sustainable development of fisheries in Russian Far East.
( Olga Pysmenna ) 한국정책학회 2020 International Journal of Policy Studies Vol.11 No.2
Purpose. This case study aims to examine a developing country’s COVID-19 response system. In particular, the study focuses on exploring Ukraine’s COVID-19 response system using collaborative governance literature. Design approach. This study utilizes a case study approach. By applying a content analysis method to textual data that were collected from multiple sources, the article presents how the Ukrainian government, private sector, nonprofit organizations, and citizens responded to the pandemic early on and how these responses have coproduced early control of the spread of COVID-19 in Ukraine. Findings. The findings demonstrate that the Ukrainian response to the COVID-19 crisis is based on collaboration among various stakeholders, including government agencies, the for-profit sector, nonprofit organizations, and individual citizens.
Sustainable Economic Development and Resource-Saving: Interrelation and Mutual Influence
Olga V. Antipova,Oleg M. Suprun,Vera A. Gnevasheva,Sergeys Ignatyevs,Nazygul Batyrova 대한산업공학회 2020 Industrial Engineeering & Management Systems Vol.19 No.1
The issues of resource-saving are the central problem in the national economy in general and in the economy of the enterprise. The assessment of production efficiency and resource-saving programs is one of the most important conditions that determine the validity of management decisions. This study focuses on the complexities of the transition from a consumption economy to the development based on a reasonable balance between consumption and environmental conservation. The main purpose is to illustrate the relationship between the factors of resource-saving and sustainable development of the economy. The methods of communication modeling based on reducing the dimension of the factor space through Hotelling transformations are used. Displaying such a logical connection determines the need for a stimulating effect on the joint activities of production units of enterprises and scientific institutions. As a result, the economy obtains the following benefits: a new understanding of efficiency based on the consideration of the cost of natural goods and the damage from anti-environmental decisions; the benefits of improving technologies of lean production, recovery, the organization of production and labor.