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Park Kyongok,Lee Seonhye 한국생활환경학회 2019 한국생활환경학회지 Vol.26 No.4
Dementia is the 9th most burden some illness globally. It has increased the demand for the care of the elderly. To decrease the care demand and burden for person with dementia (PWD), technology such as the development of robots is gaining interest. The objective to this study was to perform a meta-analysis to identify the effect of interventions with socially assistive robots on negative mood of PWD. A meta-analysis was conducted to estimate the overall effect size of intervention for negative mood. Of the 234 articles identified, 6 randomized controlled trials were included in this review. Meta analysis’ results was showed a small effect size and was significantly different between the robot intervention group and the control group. Therefore, robot intervention was found to be effective in decreasing negative mood for PWD. This study will contribute to the practical usage of socially assistive robots to reduce negative mood of PWD.
Kim, Seon Young,Im, Kyongok,Park, Si Nae,Kwon, Jiseok,Kim, Jung-Ah,Choi, Qute,Hwang, Sang Mee,Han, Sung-Hee,Kwon, Sunghoon,Oh, Il-Hoan,Lee, Dong Soon Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.1
<P>Cytogenetic testing is important to ensure patient safety before therapeutic application of mesenchymal stromal cells (MSCs). However, the standardized methods and criteria for the screening of chromosomal abnormalities of MSCs have not yet been determined. We investigated the frequency of cytogenetic aberrations in MSCs using G-banding and fluorescence in situ hybridization (FISH) and suggest reference values for aneuploidy in MSCs. Cytogenetic analysis was performed on 103 consecutive cultures from 68 MSCs (25 adipose-origin, 20 bone marrow-origin, 18 cord blood-origin, and 5 neural stem cells; 8 from adipose tissue of patients with breast cancer and 60 from healthy donors). We compared the MSC aneuploidy patterns with those of hematological malignancies and benign hematological diseases. Interphase FISH showed variable aneuploid clone proportions (1%-20%) in 68 MSCs. The aneuploidy patterns were asymmetric, and aneuploidy of chromosomes 16, 17, 18, and X occurred most frequently. Clones with polysomy were significantly more abundant than those with monosomy. The cutoff value of maximum polysomy rates (upper 95th percentile value) was 13.0%. By G-banding, 5 of the 61 MSCs presented clonal chromosomal aberrations. Aneuploidy was asymmetric in the malignant hematological diseases, while it was symmetric in the benign hematological diseases. We suggest an aneuploidy cutoff value of 13%, and FISH for aneuploidy of chromosomes 16, 17, 18, and X would be informative to evaluate the genetic stability of MSCs. Although it is unclear whether the aneuploid clones might represent the senescent cell population or transformed cells, more attention should be focused on the safety of MSCs, and G-banding combined with FISH should be performed.</P>
교대근무를 하는 일반병동 간호사의 간호업무 수행실태, 수행주체와 직무만족에 대한 융복합적 조사연구
박경옥,이여진,안지원,Park, Kyongok,Yi, Yeojin,An, Jiwon 한국융합학회 2021 한국융합학회논문지 Vol.12 No.7
This study is a secondary data analysis to investigate the nursing tasks performance, appropriate performer, and job satisfaction in the general wards with sift work. We found that nurses performed direct (45%) and indirect nursing (55%). The workload per shift was 37.2% in the day, 35.6% in the evening, and 27.2% at night. The tasks performed after handover were 'direct nursing (34.5%)' and 'documentation and notification (25.8%)'. Nurses responded that there were some tasks that could be delegated to nursing assistants or had ambiguous boundaries with other medical personnel. There was a significant correlation between compliance to the job description of the night shift and job satisfaction (rs=.43, p=.01). These results imply that it is necessary to establish strategies that will enhance work efficiency based on job analysis by shift work, reduce handover time using EMR system, stmart devices, and clarify appropriate performers. 본 연구는 일반병동에 근무하는 교대근무 간호사의 간호업무 수행실태와 직무만족도를 확인하기 위한 2차 자료 분석 연구이다. 연구 결과, 전체 간호 업무 중 대상자가 수행한 직접간호는 45%, 간접간호는 55%를 차지하였다. 교대 근무별로 주간에 수행한 업무량은 전체 업무량의 37.2%였고 인계 후 수행한 업무는 '직접간호(34.5%)'와 '기록과 보고(25.8%)'였다. 대상자들은 본인이 수행한 업무 중 일부분에 대해 간호보조 인력에게 위임 가능하거나, 타 의료인과 경계가 모호한 업무가 있다고 응답하였다. 야간근무의 직무이행도와 직무만족도 간의 유의한 상관관계(rs=.43, p=.01)가있었다. 이러한 결과는 교대근무별 직무분석에 근거한 업무효율성 제고 및 EMR적용, 스마트 기기 등을 활용한 인계시간 감소 전략, 업무 수행주체를 명확히 하는 방안이 필요함을 시사한다.
Shin, Dong-Yeop,Park, Jin Kyun,Li, Chih Chiao,Park, Hee Sue,Moon, Soo Young,Kim, Sung-Min,Im, Kyongok,Chang, Yoon Hwan,Yoon, Sung-Soo,Lee, Dong-Soon Elsevier 2019 Leukemia research Vol.79 No.-
<P><B>Abstract</B></P> <P>We hypothesized that a subset of idiopathic cytopenia of undetermined significance (ICUS) is associated with an increased autonomous proliferation with exhaustion of hematopoiesis. The aim of this study was to investigate the cell turnover rate and replicative history of the bone marrow cells of ICUS patients. To this end, we examined telomere length (TL), proliferation, and apoptosis of the bone marrow cells of ICUS patients and healthy controls (HCs) using telomere quantitative fluorescence <I>in situ</I> hybridization and immunohistochemical staining for Ki-67 and cleaved caspase-3. We also performed targeted sequencing of 88 myeloid-associated genes. A total of 37 patients with ICUS were enrolled in this study, with a median age of 66 years (range: 31–83). TLs were significantly shorter in patients with ICUS than in the HCs (8.8, interquartile range [IQR] 6.8–12.1 vs 18.4, IQR 14.4–22.0, p < 0.0001). Proliferation (Ki-67-positive) and apoptosis (cleaved caspase-3-positive) were significantly increased in patients with ICUS compared to HCs (median = 20.0% vs 5.0%, <I>p</I> = 0.0003; 45.0% vs 22.5%, <I>p</I> = 0.0005, respectively). The shortening of TL and the increased proliferation and apoptotic activity was also prominent in patients with ICUS without mutation and dysplasia than in HCs (p < 0.0001, p < 0.0001, and p = 0.0093, respectively). TL was not associated with mutational profile and clinical characteristics as well in patients with ICUS. To our knowledge, this is the first study to show that ICUS is associated with premature replicative senescence with increased proliferation and apoptosis of bone marrow cells. Further study is needed to address the cause of replicative exhaustion in ICUS patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Telomere is shortened in idiopathic cytopenia of undetermined significance (ICUS). </LI> <LI> Proliferation (Ki-67) and apoptosis activity (caspase-9) are increased in ICUS. </LI> <LI> Telomere shortening and increased Ki-67/caspase-9 is consistent in non-mutated ICUS. </LI> <LI> ICUS can be associated with premature replicative senescence. </LI> </UL> </P>
Gang, Moonhee,Jung, Mi Sook,Park, Sunyoung,Park, Younghee,Oh, Kyongok Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2017 Cancer nursing Vol.40 No.6
<P>Background: Attitudes toward menopause vary across cultures and influence women's experiences of menopausal symptoms, possibly leading to reduced posttreatment quality of life in breast cancer survivors. Objective: The aim of this study is to examine the effects of menopausal symptoms and attitudes on health-related quality of life in breast cancer survivors who were premenopausal at the time of diagnosis. Methods: A total of 139 women receiving chemotherapy with/without endocrine therapy were assessed with self-report questionnaires of established reliability and validity. Hierarchical regression was conducted to assess the impact of menopausal symptoms and attitudes on quality of life, while controlling for demographic characteristics. Results: Overall, participants endorsed more than half of 46 symptoms, most at the level of mild symptoms, and most reported a less positive attitude toward menopause. Lower quality of life was significantly predicted by more menopausal symptoms endorsed and more negative attitudes when controlling for demographic factors associated with quality of life (R-2= 26.1%). Most participants experienced change from premenopause to postmenopause after the completion of adjuvant chemotherapy with or without tamoxifen. Conclusions: The results suggest that more menopausal symptoms and negative attitudes toward menopause may affect health-related quality of life considerably in chemotherapy-treated Asian breast cancer survivors. Implications for Practice: Healthcare professionals should develop a better understanding of the effects of menopausal symptoms and attitudes on quality of life by using a culturally relevant perspective based on patients' sociocultural backgrounds. Furthermore, these findings help healthcare professionals communicate with their Asian clients in a more informed way and provide culturally appropriate and individualized care.</P>
( Yoon-jeong Oh ),( Dong-yeop Shin ),( Sang Mee Hwang ),( Sung-min Kim ),( Kyongok Im ),( Hee Sue Park ),( Jung-ah Kim ),( Yeong Wook Song ),( Ana Marquez ),( Javier Martin ),( Dong-soon Lee ),( Jin K 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated with AID in patients with MDS. Methods: Eighty-eight genetic mutations associated with myeloid malignancy were sequenced in 73 MDS patients. The association between these mutations and AID was then analyzed. Results: The median age of the 73 MDS patients was 70 years (interquartile range, 56 to 75), and 49 (67.1%) were male. AID was observed in 16 of 73 patients (21.9%). Mutations were detected in 57 (78.1%) patients. The percentage (68.8% vs. 80.7%, p = 0.32) and the mean number of mutations (1.8 ± 1.6 vs. 2.2 ± 1.8, p = 0.34) in MDSpatients with or without AID were similar. However, the ten-eleven translocation-2 (TET2) mutation rate was significantly higher in patients with AID than in those without (31.3% vs. 5.3%, respectively; p = 0.001). All TET2 mutations were variants of strong clinical significance. Conclusions: Mutation of TET2 in patients with MDS may be associated with increased risk of developing AID.