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Park, Kwang-Il,Kang, Sang-Rim,Park, Hyeon-Soo,Lee, Do Hoon,Nagappan, Arulkumar,Kim, Jin A,Shin, Sung Chul,Kim, Eun Hee,Lee, Won Sup,Chung, Hyon-Jong,An, Su Jin,Kim, Gon Sup Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P><I>Lonicera japonica THUNB.</I>, which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because of the anti-inflammation properties. This study aimed to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea <I>L. japonica T.</I> by nuclear factor-kappaB (NF-<I><I>κ</I></I>B) and mitogen-activated protein kinases (MAPKs) pathway. Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2, as well as mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1<I><I>β</I></I>, and IL-6. Moreover, polyphenols inhibited nuclear translocation of NF-<I><I>κ</I></I>B p65, phosphorylation/degradation of the inhibitor of <I><I>κ</I></I>B, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected. These results indicate that polyphenol components isolated from Korea <I>L. japonica T.</I> should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-<I><I>κ</I></I>B and p38 MAPK activity.</P>
Park, Kawngwoo,Jeong, Sang Soon,Kim, Jung Hoon,Chung, Hyun-Tai,Lee, Eun Jung,Moon, Hyo Eun,Park, Kwang Hyon,Kim, Jin Wook,Park, Hye Ran,Lee, Jae Meen,Lee, Hye Ja,Kim, Hye Rim,Cho, Yong Hwan,Paek, Sun The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.6
Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer. Methods : We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors. Results : NKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS. Conclusion : The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.
Park Kawngwoo,Park Kwang Hyon,Park Hye Ran,Lee Jae Meen,Kim Yong Hwy,Kim Dong-Young,Won Tae-Bin,Kong Sung Hye,Kim Jung Hee,Shin Chan Soo,Paek Sun Ha 대한의학회 2021 Journal of Korean medical science Vol.36 No.15
Background: Although long-term dopamine agonist (DA) therapy is recommended as a first-line treatment for prolactinoma, some patients may prefer surgical treatment because of the potential adverse effects of long-term medication, or the desire to become pregnant. This study aimed to determine whether surgical treatment of prolactinomas could be an alternative to DA therapy. Methods: In this retrospective study, 96 consecutive patients (74 female, 22 male) underwent primary pituitary surgery without long-term DA treatment for prolactinomas at a single institution from 1990 to 2010. All patients underwent primary surgical treatment in the microscopic transsphenoidal approach (TSA). Results: The median age and median follow-up period were 31 (16–73) years and 139.1 (12.2–319.6) months, respectively. An initial overall remission was accomplished in 47.9% (46 of 96 patients, 33 macroadenomas, and 13 microadenomas) of patients. DA dose reduction was achieved in all patients after TSA. A better remission rate was independently predicted by lower diagnostic prolactin levels and by a greater extent of surgical resection. Overall remission at the last follow-up was 33.3%, and the overall recurrence rate was 30.4%. The permanent complication rate was 3.1%, and there was no mortality. Conclusion: TSA can be considered a safe and potentially curative treatment for selective microprolactinomas as an alternative to treatment with a long-term DA.
Park Hye Ran,Jeong Sang Soon,Kim Jung Hoon,Myeong Ho Sung,Park Hyun Joo,Park Kwang Hyon,Park Kawngwoo,Yoon Byung Woo,Park Suyeon,Kim Jin Wook,Chung Hyun-Tai,Kim Dong Gyu,Paek Sun Ha 대한의학회 2023 Journal of Korean medical science Vol.38 No.40
Background: Since the long-term outcomes of 162 patients who underwent gamma knife radiosurgery (GKS) as an initial or adjuvant treatment for acoustic neuromas (ANs) with unilateral hearing loss were first reported in 1998, there has been no report of a comprehensive analysis of what has changed in GKS practice. Methods: We performed a retrospective study of the long-term outcomes of 106 patients with unilateral sporadic ANs who underwent GKS as an initial treatment. The mean patient age was 50 years, and the mean initial tumor volume was 3.68 cm3 (range, 0.10–23.30 cm3 ). The median marginal tumor dose was 12.5 Gy (range, 8.0–15.0 Gy) and the median follow-up duration was 153 months (range, 120–216 months). Results: The tumor volume increased in 11 patients (10.4%), remained stationary in 27 (25.5%), and decreased in 68 patients (64.2%). The actuarial 3, 5, 10, and 15-year tumor control rates were 95.3 ± 2.1%, 94.3 ± 2.2%, 87.7 ± 3.2%, and 86.6 ± 3.3%, respectively. The 10-year actuarial tumor control rate was significantly lower in the patients with tumor volumes of ≥ 8 cm3 (P = 0.010). The rate of maintaining the same Gardner-Robertson scale grade was 28.6%, and that of serviceable hearing was 46.4%. The rates of newly developed facial and trigeminal neuropathy were 2.8% and 4.7%, respectively. The patients who received marginal doses of less than 12 Gy revealed higher tumor control failure rates (P = 0.129) and newly occurred facial or trigeminal neuropathy rates (P = 0.040 and 0.313, respectively). Conclusion: GKS as an initial treatment for ANs could be helpful in terms of tumor control, the preservation of serviceable hearing, and the prevention of cranial neuropathy. It is recommended to perform GKS as soon as possible not only for tumor control in unilateral ANs with hearing loss but also for hearing preservation in those without hearing loss.
CASE REPORT : Inflamed Symptomatic Sellar Arachnoid Cyst; Case Report
( Kwang Hyon Park ),( Hoshin Gwak ),( Eun Kyung Hong ),( Sang Hyun Lee ) 대한뇌종양학회 대한신경종양학회 2013 Brain Tumor Research and Treatment Vol.1 No.1
Sellar arachnoid cysts are rare; an infected arachnoid cyst is extremely rare as only one case has been reported to date in the literature. Here, we report a patient with an infected or inflamed sellar arachnoid cyst that was successfully treated with transsphenoidal surgery (TSA). A 53-year-old female with a his-tory of chronic sinusitis developed a headache 5 months ago, and one month before admission poly-uria, polydipsia, and abnormal vaginal bleeding occurred. The magnetic resonance imaging (MRI) showed a sellar cystic mass with a thickened pituitary stalk. Preoperative hormonal study revealed nor-mal pituitary hormone levels except for a moderate elevation of prolactin. She was diagnosed with dia-betes insipidus of the central nervous system origin based on a water-deprivation test. TSA was per-formed under an impression of symptomatic Rathke`s cleft cyst according to the MRI findings. Intraoperative findings showed confirmation of turbid intracystic contents, but micro-organisms were unidentified on microbial culture. Pathology of the cyst wall revealed inflamed meningoepithelial lining cells compatible with an arachnoid cyst.
호흡기질병 감염 송아지에서 분리한 Pasteurella haemolytica의 생화학적 특성 및 약제 감수성
조광현 ( Kwang Hyon Cho ),박노찬 ( No Chan Park ),권헌일 ( Hun Ill Keun ),김이준 ( Lee Zun Kim ),박덕상 ( Duk Sang Park ) 한국가축위생학회 1991 韓國家畜衛生學會誌 Vol.14 No.2
The present study was conducted to investigate biochemical properties and antimicrobial drug susceptibilities of 36 strains of Pasleurella haemolytica(P haemolylica) isolated from pneumonic calves in Kyongbuk province during the period from January 1990 to December 1990. P haemolytica was isolated from 36 of 111(32.4%) pneumonic calves of 1 to 6 months of age. The majority of biochemical and cultural properties of P haemolylica isolated from calves were identical to those of the reference strains employed. All isolated were susceptible to baytril, gentamicin, and kanamycin, some of them were resistant to tetracycline, amikacin, streptomycin, and ampicillin.
설사자돈(泄瀉子豚) 유래(由來) 대장균(大腸菌)의 항생물질(抗生物質) 내성(耐性)에 관(關)하여
조광현 ( Kwang Hyon Cho ),박노찬 ( No Chan Park ),권헌일 ( Hun Ill Keun ),김이준 ( Lee Zun Kim ),박덕상 ( Duk Sang Park ) 한국가축위생학회 1992 韓國家畜衛生學會誌 Vol.15 No.2
The present study was conducted to investigate the biochemical characteristics and antibiotic resistance of pathogenic Escherichia coli(E. coli) isolated from piglets with diarrhea in Kyongbuk province during the period from February to November 1991. 368 E. coli strains were isolated from 382 piglets with diarrhea and the biochemical and cultural reaction were compared with the classification criteria of Edwards and Ewing. Tetracycline and sulfadimethoxine were found to be highly ineffective at in vitro inhibition of the E. coli of piglets origin. The majority of E. coli were susceptible to amikacin, chloramphenicol and gentamicine. 89(89.0%) of 100 strains of E. coil were resistant to one or more drugs. The organisms resistant to 20 or 3 drugs were 54(60.6%) of 89 strains, whereas 16(17.9%) strains were found to be resistant to one drug. 55(61.8%) out of 89 drug resistance strains carried R factors(R+) which were transferable to the recipients by conjugation.
각성상태하에서 굴곡성내시경을 이용한 경비 및 경구 기관내 삽관시 혈압, 맥박, 심박축량의 변화
박진규,임영진,이국현,염광원,박재현 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.3
To evaluate the clinical usefulness of fiberoptic intubation, we recorded the changes of arterial pressure, heart rate and cardiac output during fiberoptic nasotracheal and orotracheal intubation, while measuring the time taken for the intubation procedure. Anesthesia of pharynx was achieved by oral gargling of 10 ml of 4% lidocaine, and for nasotracheal intubation, nasal mucosa was anesthetized by application of 4% cocaine usirig cotton-tipped swabs. Anesthesia of the larynx and trachea was done by superior laryngeal nerve block with 6 ml of 2% lidocaine, and translaryngeal injection with 4% lidocaine by cricothyroid membrane puncture. After sedation with intravenous diazepam and fentanyl, awake fiberoptic (n=32) or orotracheal intubation (n=18) was performed on the patients (ASA class 1 or 2) in whom difficult intubation was expected. Mean arterial pressure, heart rate and cardiac output did not change significantly during intubation procedure, nor were these values significantly different between nasotracheal and orotracheal intubation group. The time taken by intubation procedure were compared, and there was no significant difference between two groups. In postoperative interviews, a few (3/28) patients complained discom-forts. It could be concluded that under approapriate anesthesia and sedation, awake fiberoptic nasotracheal or orotracheal intubation is a safe and useful approach producing minimal cardiovascular changes and discomforts.
Clinical Study on Toothbrushing Forces
Kwang-Ho Lee,Yun-Jeong Jee,이천희,Yun-Hwa Choi,Ji-Hyon Park,Ha-Na Choi 대한예방치과학회 2007 International Journal of Clinical Preventive Denti Vol.3 No.2
Objectives: The purpose of this study was to evaluate tooth brushing force. Methods: The authors have performed the clinical study on toothbrushing forces with the Tooth-Brushing Force Guider (Lion, Co., Japan)and dental plaque removals for 50 adults and 40 children were jouned the experiment on toothbrushing with rolling method, in order to find the average forces for toothbrushing and estimate the optimal forces to decrease the PHP index more than 2 points. Co-relation coefficiency was estimated between the toothbrushing forces and the plaque removals after measured them individually. Results: The average of maximum forces on toothbrushing were estimated as 265.4±62.9g in adults and 161.2±98.5g in children. Toothbrushing forces were more at posterior teeth portions than at anterior portions both in adults and in children, except at the labial side of anterior portion for adult. 3. It revealed that the more toothbrushing forces were taken, the more decrease of PHP index in adults and it was so much relationship between the tooth brushing forces and plaque removals in children. Conclusion: Optimum force for toothbrushing in order to decrease more than 2 points of plaque index was estimated as about 280g to 290g for Korean adults and more than 150g to 160g for children.