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Cansu Ozbayer,Hulyam Kurt,Suna Kalender,Hilmi Ozden,Hasan V. Gunes,Ayse Basaran,Ecir A. Cakmak,Kismet Civi,Yusuf Kalender,Irfan Degirmenci 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Diabetes is the leading cause of chronic renal failure. Our purpose was to determine the effects of N-nitro-l-arginine (l-NNA) and an extract of Stevia rebaudiana (Bertoni) (SrB) leaves on renal function in streptozotocin-nicotinamide (STZ-NA)–induced diabetic rats. Rats were divided into seven groups. Three of these groups were controls. Diabetes was induced by STZ-NA in the other four. Diabetic rats were treated with SrB (200 mg/kg), _L-NNA (100 mg/kg), or SrB + _L-NNA for 15 days after 5–8 weeks of diabetes. At the end of the experiments, urine and blood samples were collected from the rats, and kidney tissue samples were collected with the animals under ether anesthesia. Renal filtration changes were determined by measuring urine pH, urine volume, and serum and urine creatinine. Nitric oxide synthase (NOS) activity was measured in kidney homogenates. Alterations in kidney ultrastructure were determined by electron microscopy, and histological changes were examined by hematoxylin and eosin staining. No statistical differences were observed in urine creatinine or creatinine clearance. Even so, we observed higher NOS activity in SrB-treated diabetic rats. SrB-treated diabetic rats had less mitochondrial swelling and vacuolization in thin kidney sections than other diabetic groups. The control groups showed normal histological structure, whereas in the diabetic groups, membrane thickening, tubular epithelial cells, and cellular degeneration were observed. Thus, SrB has beneficial effects on diabetes compared with _L-NNA. Our results support the validity of SrB for the management of diabetes as well as diabetes-induced renal disorders.
Berat Yangi,Mehmet Cengiz Ustuner,Murat Dincer,Cansu Ozbayer,Neslihan Tekin,Derya Ustuner,Emine Colak,Umut Kerem Kolac,Emre Entok 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.11
Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced inflammation in rats. Forty-two, 3- to 4-month-old male Sprague Dawley rats were used in six groups. LPS (1 mg/kg) was administered intraperitoneally to rats in inflammation, inflammation + propolis30, and inflammation+propolis90 groups. Thirty milligram/kilogram and 90 mg/kg of propolis were given orally 24 h after LPS injection. After the determination of the inflammation in lung and liver tissues by 18F-fluoro-deoxy-d-glucose–positron emission tomography (18FDG-PET), samples were collected. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO), and DNA fragmentation were determined. The decrease of MDA levels in inflammation + propolis30 and inflammation + propolis90 groups was determined compared to the inflammation group in lung and liver tissues. The increase of SOD% inhibition in inflammation + propolis90 group was determined in liver, lung, and hemolysate compared to the inflammation group. Increased CAT activities in inflammation + propolis30 and inflammation + propolis90 groups were observed in liver tissue and hemolysate compared to inflammation group. In lung tissue, NO levels were lower in inflammation group compared to the control group, but DNA fragmentation levels were higher. 18F-FDG uptake of tissues in inflammation + propolis30 and inflammation + propolis90 groups was decreased compared to the inflammation group. In conclusion, the data of this study indicate that the propolis application may serve as a potential approach for treating inflammatory diseases through the effect of reducing inflammation and free oxygen radical production.
Kabay, Sahin,Ozden, Hilmi,Guven, Gul,Burukoglu, Dilek,Ustuner, Mehmet Cengiz,Topal, Fatma,Gunes, Hasan Veysi,Ustuner, Derya,Ozbayer, Cansu The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-${\kappa}B$) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degree extravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testicular torsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg, intravenous's) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA), superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performed after hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in the T/D groups compared with treatment group. Administration of PDTC prevented a further increase in MDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared with the control group. The rats in the treatment group had normal testicular architecture. The results suggest that PDTC can be a potential protective agent for preventing the biochemical and histological changes related to oxidative stress in testicular injury caused by testis torsion.
Sahin Kabay,Hilmi Ozden,Gul Guven,Dilek Burukoglu,Mehmet Cengiz Ustuner,Fatma Topal,Hasan Veysi Gunes,Derya Ustuner,Cansu Ozbayer 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidinedithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factorkappa B (NF-κB) activation. In this study, we aimed to investigate the effects of PDTC to testiculartorsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degreeextravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testiculartorsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg,intravenous’s) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA),superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performedafter hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in theT/D groups compared with treatment group. Administration of PDTC prevented a further increase inMDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared withthe control group. The rats in the treatment group had normal testicular architecture. The resultssuggest that PDTC can be a potential protective agent for preventing the biochemical and histologicalchanges related to oxidative stress in testicular injury caused by testis torsion.
Ozbay, Pelin Ozun,Ekinci, Tekin,Caltekin, Melike Demir,Yilmaz, Hasan Taylan,Temur, Muzaffer,Yilmaz, Ozgur,Uysal, Selda,Demirel, Emine,Kelekci, Sefa Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: To determine the cut-off values of the preoperative risk of malignancy index (RMI) used in differentiating benign or malignant adnexal masses and to determine their significance in differential diagnosis by comparison of different systems. Materials and Methods: 191 operated women were assessed retrospectively. RMI of 1, 2, 3 and 4; cut-off values for an effective benign or malignant differentiation together with sensitivity, specificity, negative and positive predictive values were calculated. Results: Cut-off value for RMI 1 was found to be 250; there was significant (p<0.001) compatibility at this level with sensitivity of 60%, positive predictive value (PPV) of 75%, specificity of 93%, negative predictive value (NPV) of 88% and an overall compliance rate of 85%. When RMI 2 and 3 was obtained with a cut-off value of 200, there was significant (p<0.001) compatibility at this level for RMI 2 with sensitivity of 67%, PPV of 67%, specificity of 89%, NPV of 89%, histopathologic correlation of 84% while RMI 3 had significant (p<0.001) compatibility at the same level with sensitivity of 63%, PPV of 69%, specificity of 91%, NPV of 88% and a histopathologic correlation of 84%. Significant (p<0.001) compatibility for RMI 4 with a sensitivity of 67%, PPV of 73%, specificity of 92%, NPV of 89% and a histopathologic correlation of 86% was obtained at the cut-off level 400. Conclusions: RMI have a significant predictability in differentiating benign and malignant adnexal masses, thus can effectively be used in clinical practice.
Nurgul Ozbay,Adife Seyda Yargic 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
Toxic metal bearing effluents can cause severe environmental contamination; thus metal removal by adsorption is a vital situation. In this study, apple pulp carbon was tested as low-cost adsorbent for the copper(II) and cobalt(II) adsorption studies. 25 full factorial experimental design was utilized to optimize the effects of pH, adsorbent dosage, initial metal ion concentration, contact time and temperature. ANOVA, F-test and Student’s t-test showed that Cu(II) and Co(II) adsorption is slightly temperature and contact time dependent but markedly increases with solution pH and adsorbent dosage. Although the initial Cu(II) concentration had a negative effect on removal efficiency, the initial Co(II) concentration had a positive effect. The suggested optimum conditions for 90.49% Cu(II) and 65.11% Co(II) removal were: pH 5, the adsorbent dosage = 0.4 g/50 mL, the initial metal ion concentration = 10 and 20 mg/L, temperature = 40 and 20 °C, contact time = 60 and 120 min, respectively. pH was found as significant within a 95% confidence level for both Cu(II) and Co(II) removal. Additionally, main effects of adsorbent dosage and initial concentration, the interaction effect of pH × initial concentration were also found as significant for Cu(II) removal. In conclusion, apple pulp carbon could be successfully applied for the removal of heavy metals because of its low-cost and abundance.
Cost optimization of high strength concretes by soft computing techniques
Erdogan Ozbay,Ahmet Oztas,Adil Baykasoglu 사단법인 한국계산역학회 2010 Computers and Concrete, An International Journal Vol.7 No.3
In this study 72 different high strength concrete (HSC) mixes were produced according to the Taguchi design of experiment method. The specimens were divided into four groups based on the range of their compressive strengths 40-60, 60-80, 80-100 and 100-125 MPa. Each group included 18 different concrete mixes. The slump and air-content values of each mix were measured at the production time. The compressive strength, splitting tensile strength and water absorption properties were obtained at 28 days. Using this data the Genetic Programming technique was used to construct models to predict mechanical properties of HSC based on its constituients. These models, together with the cost data, were then used with a Genetic Algorithm to obtain an HSC mix that has minimum cost and at the same time meets all the strength and workability requirements. The paper describes details of the experimental results, model development, and optimization results.
Bulent Arasa,Fatih Ozbay 한국국방연구원 2008 The Korean Journal of Defense Analysis Vol.20 No.1
The Russian and Iranian governments define their relations as ""very close"" and ""strategic"" in many areas. The frontiers of this cooperation, in geopolitical terms, include the south Caucasus, central Asia, Afghanistan, and the oil- and natural gas-rich Caspian basin, while, at the issue level, the cooperation includes the nuclear issue, disarmament, the struggle against terrorism, the Iraqi quagmire, the Palestinian problem, and the U.S. military expansion into Eurasia. The signs of cooperation in these areas are, among others, regular political dialogue and similar attitudes in refusing to include the Lebanese Hizballah on terrorist lists, pursuing political relations with Hamas, maintaining a pro-Arab position on the Arab-Israeli question, objecting to foreign military engagement in Eurasia, and having a common voice during the Israeli-Lebanese conflict in 2006. However, we need to discover the nature of these relations in order to decide whether the close Russian-Iranian relations can be described as a strategic alliance. What is the strategic depth of Russian-Iranian relations? Do the relations consist merely of the conjectural necessities of the post-Cold War period? What are the ""red lines"" in Russian-Iranian relations? This article analyzes the relations between these two countries from a broader perspective, to examine the meaning of the relations in bilateral, regional and international contexts.