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Jeong Hoon Yang,Joo Myung Lee,Taek Kyu Park,Young Bin Song,Joo-Yong Hahn,Jin-Ho Choi,Seung-Hyuk Choi,Cheol Woong Yu,Woo Jung Chun,Ju Hyeon Oh,Bon-Kwon Koo,Jin-Ok Jeong,Hyo-Soo Kim,Hyeon-Cheol Gwon 대한심장학회 2019 Korean Circulation Journal Vol.49 No.6
Background and ObjectivesThere are limited data regarding the clinical efficacy of the proximal optimization technique (POT) in the treatment of coronary bifurcation lesions. We investigated the influence of POT on the clinical outcomes of patients with coronary bifurcation lesions. MethodsWe enrolled a total of 1,191 patients with a bifurcation lesion with a side branch (SB) diameter ≥2.5 mm treated with a drug-eluting stent from 18 centers between January 2003 and December 2009. The primary outcome was major adverse cardiac events (MACEs: cardiac death, myocardial infarction or target lesion revascularization [TLR]). We performed one-to-many (1:N) propensity score matching with non-fixed matching ratio. ResultsPOT was performed in 252 patients. During follow-up (median 37 months), the incidence of MACE was lower in the POT group than it was in the non-POT group (adjusted hazard ratio, 0.43; 95% confidence interval [CI], 0.24–0.79; p=0.006). After propensity score matching, these were 0.34; 95% CI, 0.17–0.69; p=0.003 for MACE and 0.37; 95% CI, 0.17–0.78; p=0.01 for TLR. The use of POT was associated with significantly lower TLR in patients treated without kissing ballooning, but was not in those who underwent kissing ballooning (p for interaction=0.03). ConclusionsIn coronary bifurcation lesions with a large SB, POT may be beneficial to improve long-term clinical outcome, particularly in patients treated without kissing ballooning during the procedure. Trial RegistrationClinicalTrials.gov Identifier: NCT01642992
Jeong, Gil-Saeng,Kwon, Ok-Kyoung,Park, Bo-Young,Oh, Sei-Ryang,Ahn, Kyung-Seop,Chang, Min-Jung,Oh, Won Keun,Kim, Jin-Cheol,Min, Byung-Sun,Kim, Youn-Chul,Lee, Hyeong-Kyu Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.7
<P>A new lignan, sylvestrin (1), was isolated from the MeOH-soluble fraction of the roots of <I>Anthriscus sylvestris</I> H<SMALL>OFFM.</SMALL> (Umbelliferae), along with six lignans (2—7), three coumarins (8—10), and a polyacetylene (11). The structure of sylvestrin was determined to be 2-(3′,4′,5′-trimethoxybenzylidene)-3-(3″,4″-methylendioxybenzyl)-γ-butyrolactone (1) by spectroscopic means, including 2D-NMR. The eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of (−)-deoxypodophyllotoxin (3), angeloyl podophyllotoxin (5), deoxypicropodophyllin (6), picropodophyllotoxin (7), and falcarindiol (11) increased approximately 4.6, 3.6, 3.7, 3.9, and 3.9-fold, at 0.001, 1, 1, 1, and 20 μ<SMALL>M</SMALL>, respectively, over that of the untreated control. In addition, compounds 3, 5, 6, and 7 showed apoptosis-inducing activities that were measured by DNA fragmentation in HL-60 cells.</P>
Jeong, Jin-Woo,Choi, Sung Hyun,Han, Min Ho,Kim, Gi-Young,Park, Cheol,Hong, Su Hyun,Lee, Bae-Jin,Park, Eui Kyun,Kim, Sung Ok,Leem, Sun-Hee,Jeon, You-Jin,Choi, Yung Hyun MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.6
<P>Excessive bone resorption by osteoclasts causes bone loss-related diseases and reactive oxygen species (ROS) act as second messengers in intercellular signaling pathways during osteoclast differentiation. In this study, we explored the protective effects of fermented oyster extract (FO) against receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclast differentiation in murine monocyte/macrophage RAW 264.7 cells. Our results showed that FO markedly inhibited RANKL-induced activation of tartrate-resistant acid phosphatase and formation of F-actin ring structure. Mechanistically, FO has been shown to down-regulate RANKL-induced expression of osteoclast-specific markers by blocking the nuclear translocation of NF-κB and the transcriptional activation of nuclear factor of activated T cells c1 (NFATc1) and c-Fos. Furthermore, FO markedly diminished ROS production by RANKL stimulation, which was associated with blocking the expression of nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) and its regulatory subunit Rac-1. However, a small interfering RNA (siRNA) targeting <I>NOX1</I> suppressed RANKL-induced expression of osteoclast-specific markers and production of ROS and attenuated osteoclast differentiation as in the FO treatment group. Collectively, our findings suggest that FO has anti-osteoclastogenic potential by inactivating the NF-κB-mediated NFATc1 and c-Fos signaling pathways and inhibiting ROS generation, followed by suppression of osteoclast-specific genes. Although further studies are needed to demonstrate efficacy in in vivo animal models, FO may be used as an effective alternative agent for the prevention and treatment of osteoclastogenic bone diseases.</P>
Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
Jeong-Hyeon Kim,Hyeong-Min Byun,Eui-Cheol Chung,Han-Young Chung,Ok-Nam Bae 한국독성학회 2013 Toxicological Research Vol.29 No.3
Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.
Applicability and Safety of in Vitro Skin Expansion Using a Skin Bioreactor: A Clinical Trial
Jeong, Cheol,Chung, Ho Yun,Lim, Hyun Ju,Lee, Jeong Woo,Choi, Kang Young,Yang, Jung Dug,Cho, Byung Chae,Lim, Jeong Ok,Yoo, James J.,Lee, Sang Jin,Atala, Anthony J. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6
Background Tissue expansion is an effective and valuable technique for the reconstruction of large skin lesions and scars. This study aimed to evaluate the applicability and safety of a newly designed skin expanding bioreactor system for maximizing the graft area and minimizing the donor site area. Methods A computer-controlled biaxial skin bioreactor system was used to expand skin in two directions while the culture media was changed daily. The aim was to achieve an expansion speed that enabled the skin to reach twice its original area in two weeks or less. Skin expansion and subsequent grafting were performed for 10 patients, and each patient was followed for 6 months postoperatively for clinical evaluation. Scar evaluation was performed through visual assessment and by using photos. Results The average skin expansion rate was $10.54%{\pm}6.25%$; take rate, $88.89%{\pm}11.39%$; and contraction rate, $4.2%{\pm}2.28%$ after 6 months. Evaluation of the donor and recipient sites by medical specialists resulted in an average score of 3.5 (out of a potential maximum of 5) at 3 months, and 3.9 at 6 months. The average score for patient satisfaction of the donor site was 6.2 (out of a potential maximum of 10), and an average score of 5.2 was noted for the recipient site. Histological examination performed before and after the skin expansion revealed an increase in porosity of the dermal layer. Conclusions This study confirmed the safety and applicability of the in vitro skin bioreactor, and further studies are needed to develop methods for increasing the skin expansion rate.
Ok Hwan Cha,Cheol-Hoi Kim,Jun Seok Lee,Jong Pil Jeong,Joong Seo Park,Jandi Kim,정현,Eun-Kyung Suh 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1
The temperature dependence of the electroluminescence spectra of InGaN/GaN multi-quantumwell light-emitting diodes (LEDs) has been investigated over a range of temperatures and currents. The presence of localization effects in the active InGaN layers can be deduced from the observed considerable blue shifts of the electroluminescence emission peak with increasing temperature in the low-temperature region. Exciton-phonon couplings in the active layer are also observed at low temperatures. The electroluminescence intensity was measured to determine the internal quantum efficiency of the LEDs as a function of temperature. When the temperature decreases from room temperature to 170~200 K, the electroluminescence intensity increases due to a reduction in the nonradiative recombination, and the internal quantum efficiency is improved. At T < 170 K, the electroluminescence intensity is reduced significantly. This reduction of the electroluminescence intensity mainly results from the low carrier capture efficiency in the active layer due to the high Mg activation energy, the electron-hole separation in multi quantum wells, and the high internal piezoelectric field. However, in the case of LEDs using a narrow barrier, the electroluminescence intensity is reduced slightly at low temperatures. Therefore, in order to measure the internal quantum efficiency by using the temperature dependence of the electroluminescence spectra in LEDs, one must carefully consider the effects of carrier injection at low temperature.
Cheol Park,Eun Ok Choi,Hyun Hwangbo,Hyesook Lee,Jin-Woo Jeong,Min Ho Han,Sung-Kwon Moon,Seok Joong Yun,Wun-Jae Kim,Gi-Young Kim,Hye-Jin Hwang,Yung Hyun Choi 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.3
BACKGROUND/OBJECTIVES: Zanthoxylum schinifolium is traditionally used as a spice for cooking in East Asian countries. This study was undertaken to evaluate the anti-proliferative potential of ethanol extracts of Z. schinifolium leaves (EEZS) against human bladder cancer T24 cells. MATERIALS/METHODS: Subsequent to measuring the cytotoxicity of EEZS, the anti-cancer activity was measured by assessing apoptosis induction, reactive oxygen species (ROS) generation, and mitochondrial membrane potential (MMP). In addition, we determined the underlying mechanism of EEZS-induced apoptosis through various assays, including Western blot analysis. RESULTS: EEZS treatment concentration-dependently inhibited T24 cell survival, which is associated with apoptosis induction. Exposure to EEZS induced the expression of Fas and Fas-ligand, activated caspases, and subsequently resulted to cleavage of poly (ADP-ribose) polymerase. EEZS also enhanced the expression of cytochrome c in the cytoplasm by suppressing MMP, following increase in the ratio of Bax:Bcl-2 expression and truncation of Bid. However, EEZS-mediated growth inhibition and apoptosis were significantly diminished by a pan-caspase inhibitor. Moreover, EEZS inhibited activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway, and the apoptosis-inducing potential of EEZS was promoted in the presence of PI3K/Akt inhibitor. In addition, EEZS enhanced the production of ROS, whereas N-acetyl cysteine (NAC), a ROS scavenger, markedly suppressed growth inhibition and inactivation of the PI3K/Akt signaling pathway induced by EEZS. Furthermore, NAC significantly attenuated the EEZS-induced apoptosis and reduction of cell viability. CONCLUSIONS: Taken together, our results indicate that exposure to EEZS exhibits anticancer activity in T24 bladder cancer cells through ROS-dependent induction of apoptosis and inactivation of the PI3K/Akt signaling pathway.