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Oh, Se-Yeol,Kim, Jongsoon,Kwon, Soon-Hong,Chung, Sung-Won,Kwon, Soon-Goo,Park, Jong-Min,Choi, Won-Sik Korean Society for Agricultural Machinery 2014 바이오시스템공학 Vol.39 No.3
Purpose: Phytosanitary irradiation treatment can effectively control regulated pests while maintaining produce quality. The objective of this study was to establish the best irradiation treatment for mangosteen, a popular tropical fruit, using a Monte Carlo simulation. Methods: Magnetic resonance image (MRI) data were used to generate a 3-D geometry to simulate dose distributions in a mangosteen using a radiation transport code (MCNP5). Microsoft Excel with visual basic application (VBA) was used to divide the image data into seed, flesh, and rind. Radiation energies used for the simulation were 10 MeV (high-energy) and 1.35 MeV (low-energy) for the electron beam, 5 MeV for X-rays, and 1.25 MeV for gamma rays from Co-60. Results: At 5 MeV X-rays and 1.25 MeV gamma rays, all areas (seeds, flesh, and rind) were irradiated ranging from 0.3 ~ 0.7 kGy. The average doses decreased as the number of fruit increased. For a 10 MeV electron beam, the dose distribution was biased: the dose for the rind where the electrons entered was $0.45{\pm}0.03$ kGy and the other side was $0.24 {\pm}0.10$ kGy. Use of an electron kinetic energy absorber improved the dose distribution in mangosteens. For the 1.35 MeV electron beam, the dose was shown only in the rind on the irradiated side; no significant dose was found in the flesh or seeds. One rotation of the fruit while in front of the beam improved the dose distribution around the entire rind. Conclusion: These results are invaluable for determining the ideal irradiation conditions for phytosanitary irradiation treatment of tropical fruit.
Efficient Classification of Birds and Drones Considering Real Observation Scenarios Using FMCW Radar
Se-Won Yoon,Soo-Bum Kim,Joo-Ho Jung,Sang-Bin Cha,Young-Seok Baek,Bon-Tae Koo,In-Oh Choi,Sang-Hong Park 한국전자파학회JEES 2021 Journal of Electromagnetic Engineering and Science Vol.21 No.4
In this study, we consider real observation scenarios and propose an efficient method to accurately distinguish drones from birds using features obtained from their micro-Doppler (MD) signatures. In the simulations conducted using a rotating-blade model and a flapping-wing model, the classification result degraded significantly due to the diversity of both drones and birds, but a combination of features obtained for longer observation times significantly improved the accuracy. MD bandwidth was found to be the most efficient feature, but sufficient observation time was required to exploit the period of time-varying MD as a useful feature.
The Diagnostic Efficacy of M2BPGi for Liver Fibrosis in HCC and NAFLD Patients
( Se Young Jang ),( Won Young Tak ),( Soo Young Park ),( Young-oh Kweon ),( Yu Rim Lee ),( Bina Jeong ),( Sangkyung Seo ),( Gyoun-eun Kang ),( Gyeonghwa Kim ),( Keun Hur ),( Heon Tak Ha ),( Jae Min Ch 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Mac-2 binding protein glycan isomer (M2BPGi) is recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis. This study aimed to evaluate the diagnostic efficacy of serum M2BPGi for liver fibrosis in hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD) patients. Methods: M2BPGi levels were analyzed in serum samples collected from biopsy-proven HCC (n=135) and NAFLD (n=113) patients. Fibrosis was graded histopathologically in non-tumorous portion of HCC and NAFLD. Serum M2BPGi levels were determined with an automated immunoassay analyzer. Spearman’s correlation and Kruskal-Wallis test were used to evaluate the correlation and comparison among groups. Diagnostic efficacy for fibrosis was evaluated by the area under the receiver operating characteristic curve (AUC). Results: Median levels (range) of M2BPGi in HCC and NAFLD patients were 1.21 (0.12-14.33) cut-off index (COI) and 0.59 (0.13-5.90) COI, respectively. In HCC patients, fibrosis stages were 0 (n=22), 1 (n=10), 2 (n=11), 3 (n=16), and 4 (n=76). The M2BPGi levels showed a significant positive correlation (r= 0.436, P<0.001) with fibrosis grade in HCC patients and yielded the lower AUC value, 0.787 (P< 0.001) than transient elastography (TE), AUC value, 0.806 (P=0.030) to predict advanced fibrosis (F >2). In NAFLD patients, fibrosis stages were 0 (n=22), 1 (n=34), 2 (n=28), 3 (n=19), and 4 (n=10). The M2BPGi levels showed a significant positive correlation (r=0.578, P<0.001) with fibrosis grade in NAFLD patients and yielded the higher AUC value, 0.824(P< 0.001) than TE, AUC value, 0.637(P=0.035) to predict advanced fibrosis (F >2). Conclusions: Serum M2BPGi can be a useful non-invasive biomarker for predicting fibrosis in HCC and especially in NAFLD patients.
OH, MI-HWA,PAEK, SE-HEE,SHIN, GI WON,KIM, HAE-YEONG,JUNG, GYOO YEOL,OH, SANGSUK International Association for Food Protection 2009 Journal of food protection Vol.72 No.6
<P>The objective of this study was to develop a novel technique for parallel analysis of eight important foodborne microbes using capillary electrophoresis-based single-strand conformation polymorphism (CE-SSCP) coupled with multiplex PCR. Specific primers for multiplex PCR amplification of the 16S rRNA gene were designed, corresponding to eight species of bacteria, including Escherichia coli, Clostridium perfringens, Campylobacter jejuni, Salmonella enterica, Listeria monocytogenes, Vibrio parahaemolyticus, Staphylococcus aureus, and Bacillus cereus, for the species-specific identification and optimal separation of their PCR products in subsequent analysis by CE-SSCP. Multiplex PCR conditions including annealing temperature, extension time, the number of PCR cycles, and primer concentrations were then optimized for simultaneous detection of all target foodborne bacteria. The diagnostic system using CE-SSCP combined with multiplex PCR developed here can be used for rapid investigation of causative agents of foodborne illness. The simplicity and high sensitivity of the method may lead to improved management of safety and illness related to food.</P>
Se Hui Oh(오세휘),Nak Jun Choi(최낙준),Sang Hyuk Seo(서상혁),Min Sung An(안민성),Kwang Hee Kim(김광희),Ki Beom Bae(배기범),Jin Won Hwang(황진원),Sang Heon Lee(이상헌),Ji Hyun Kim(김지현),Sam Ryong Jee(지삼룡),Mi Seon Kang(강미선),Kwa 대한종양외과학회 2016 Korean Journal of Clinical Oncology Vol.12 No.1
Purpose: Colorectal obstruction develops most frequently by carcinoma, and 7%–30% of these colorectal carcinomas are acute cases. The oncologic safety of self-expanding metal stent (SEMS) insertion as a bridge to surgery has not yet been established. Thus, we investigated the oncologic safety of SEMS insertion as a bridge to surgery in patients with obstructive colorectal cancer. Methods: This retrospective had 56 patients enrolled requiring emergency management for obstructive colorectal cancer at stage II or III, who had undergone curative surgery between July 2008 and June 2011. These subjects were divided into two groups: patients who had undergone emergency surgery without SEMS insertion (non-stent group) and those who had undergone elective surgery after preoperative decompression with SEMS insertion (stent group). The two groups were compared for clinicopathologic characteristics, postoperative complications, and survival rate. Results: Enterostomy was performed in 25 patients (100.0%) in the non-stent group and 1 patient (3.2%) in the stent group; laparoscopic surgery was carried out in 7 patients (28.0%) in the non-stent group and 19 patients (61.29%) in the stent group, each showing statistically significant differences. There was no statistically significant difference in postoperative complications and 5-year disease-free survival rate (72% vs. 74.19%, P=0.87, respectively). Conclusion: In treatment of malignant colorectal obstruction, elective operation after stent insertion had similar oncologic outcomes compared with emergency operation. Preoperative stent insertion not only lowers the incidence of enterostomy but also makes laparoscopic surgery possible, thereby enhancing patients’ quality of life. Therefore, preoperative stent insertion is a useful method that may replace emergency surgery in treatment of malignant colorectal obstruction.
Gut microbial modulation attenuates COPD development via suppression of inflammation and apoptosis
( Se Hee Lee ),( Yoon Ok Jang ),( Jong Jin Choi ),( Jae Seung Lee ),( Yeon-mok Oh ),( Sang-do Lee ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Chronic obstructive pulmonary disease (COPD) is the treatable, but hardly curable disease associated with significant morbidity. The association of microbial dysbiosis between the lung and gut in respiratory diseases has been recently suggested. However, the therapeutic implication of the gut microbiome for COPD has not been elucidated. In this study, we demonstrated the gut microbiome modulation could attenuate the development of emphysema. Methods: To modulate gut microbiome, fecal microbiota transplantation (FMT), diet modification, or both were adopted to mice exposed to smoking and poly I:C for emphysema model. We analyzed the severity of emphysema by mean linear intercept (MLI) and apoptosis by fluorescent TUNEL assay. Microbiome analysis were also performed in feces and fecal extracellular vesicle. Results: With smoking exposure, MLI was significantly increased, but this increase was attenuated with FMT or high fiber diet. Weight loss, combined with smoking exposure, was not noted in mice with FMT. The high fiber diet significantly reduced the number of macrophages and lymphocytes in bronchoalveolar lavage fluid (BALF) with a reduced concentration of IL-6 and IFN-r in the BALF and serum. The TUNEL score was significantly lower in mice with FMT or high fiber diet, suggesting reduced cell apoptosis. In microbiome analysis, Bacteroidacae and Lachnospiracae, which alleged to metabolize fiber into short chain fatty acids (SCFAs), increased at family level in FMT and high fiber diet. The fecal concentration of SCFAs was also notably higher with FMT and high fiber diet. Conclusions: FMT and high fiber diet attenuated emphysema development via local and systemic inflammation and the change of gut microbiota composition. Gut microbiota modulation showed therapeutic potential in emphysema, which would provide a new paradigm in the treatment of COPD.