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자가면역 췌장염의 동반증상 없이 발생한 IgG4 연관 경화성 담관염
천송욱 ( Song Wook Chun ),최자성 ( Ja Sung Choi ),강버들 ( Beo Deul Kang ),김유진 ( Yu Jin Kim ),한기준 ( Ki Jun Han ),조현근 ( Hyeon Geun Cho ),오화은 ( Hwa Eun Oh1 ),조재희 ( Jae Hee Cho ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs and obliterative phlebitis. They usually involve various organs including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate. However, most of them are accompanied by autoimmune pancreatitis, and good response to steroid treatment is one of the hallmarks of this disease. We report a case of an 67-year-old man with IgG4 associated sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography and successfully treated with steroid therapy. (Korean J Gastroenterol 2013; 62:69-74)
정추자(Jeong, Chu-Ja),이선옥(Lee, Sun-Ock),강정희(Kang, Jung-Hee),김정아(Kim, Jeong Ah),김혜령(Kim, Hye-Ryoung),오경옥(Oh, Kyong-Ok),이숙자(Lee, Sook-Ja),전화연(Jun, Hoa-Yun),홍성경(Hong, Sung Kyung) 한국간호교육학회 2012 한국간호교육학회지 Vol.18 No.3
Purpose: The purpose of this study was to identify social support networks for each life-cycle stage of adults. Method: A total of 1,047 subjects included 454 young adults, 262 middle-aged adults and 331 senior adults. Data were collected using Oh’s Korean Version Norbeck’s Social Support Questionnaire (NSSQ), and analyzed using descriptive statistics, t-test, and ANOVA. Result: For the young adults, parents were the top and second priority as important social support resources, the third was siblings, and then friends. For the middle-aged, spouse was the first priority as an important social support resource, while the second and the third were children. For the senior adults, children ranked from the top to the seventh priority. The mean number of social support resources was 13.23 for the young adult, 12.93 for the middle-aged and 5.30 for the senior adults. Social support networks of the young adults significantly differed according to gender and marital status. That of the middle-aged significantly differed according to family size. In addition, that of the senior adults was significantly different according to marital status, economic status, religion and family size. Conclusion: It is essential to consider social support networks for each life-cycle stage of adults when making a social support intervention program.
만성 콩팥병 환자에서 추정 사구체 여과율에 따른 25-Hydroxyvitamin D의 특성
고정희 ( Jung Hee Koh ),곽임수 ( Ihm Soo Kwak ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),이하린 ( Harin Rhee ),성은영 ( Eun Young Seong ),박창준 ( Chang Jun Park ),김태균 ( Tae Kyun Kim ),오상보 ( Sang Bo Oh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Background/Aims: Accumulating data suggest that vitamin D deficiency is prevalent in patients with chronic kidney disease (CKD). However, comprehensive data are lacking for Koreans. The aim of this study was to survey vitamin D deficiency among patients with CKD in Korea and to identify the relationships among various factors. Methods: We conducted a retrospective cohort study of 444 patients who were divided into four subgroups by estimated glomerular filtration rate (eGFR) for comparisons of mean 25-hydroxyvitamin D [25(OH)D] level and other parameters. In addition, non-dialyzed patients were categorized into four groups based on 25(OH)D levels (<10, 10-19, 20-29, and ≥ 30 ng/mL), and risk factors for severe vitamin D deficiency (<10 ng/mL) were investigated. Results: Of patients with an eGFR ≥ 60 mL/min/1.73 m2, 43% (34/79) showed severe 25(OH)D deficiency, and the mean 25(OH)D level was 11.7±5.3 ng/mL. In CKD3 group, 53.2% (41/77) showed severe 25(OH)D deficiency, with a mean level of 11.3±7.2 ng/mL. In CKD4 group, 53.3% (49/92) had severe 25(OH)D deficiency, with a mean level of 11.0±6.2 ng/mL. Approximately 71% (139/196) of patients in CKD5 group showed severe deficiency, and the mean level was 9.2±5.9 ng/mL. Severe 25(OH)D deficiency was affected by winter season, renal function, diabetes, and low-density lipoprotein cholesterol. The serum parathyroid hormone level was inversely correlated with the 25(OH)D level, such that 25(OH)D < 20 ng/mL were associated with a steep increase in parathyroid hormone. Conclusions: Vitamin D deficiency is highly prevalent in the Korean population. Few patients met a sufficient 25(OH)D concentration, even in the early stages of CKD. Our data suggest that 25(OH)D level of 20 ng/mL is a threshold for a rapid increase in parathyroid hormone levels. (Korean J Med 2012;83:740-751)
Yeon Joo Lee,Il Hwan Oh,Hee Jun Baek,Chang Hwa Lee,Sang Sun Lee 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.2
BACKGROUND/OBJECTIVES: Vitamin D deficiency is common in hemodialysis patients. The aim of this study was to identify whether or not sun exposure and dietary vitamin D intake have effects on serum 25-hydroxyvitamin D (25(OH)D) status in hemodialysis (HD) patients. The objective was to identify the main determinants of serum vitamin D status in the study subjects. SUBJECTS/METHODS: A cross-sectional study of 47 HD patients (19 males and 28 females) was performed. We assessed serum 25(OH)D and 1,25(OH)2D levels between August and September 2012 and analyzed the prevalence of vitamin D deficiency in HD patients. To evaluate the determinants of serum 25(OH)D levels, we surveyed dietary vitamin D intake, degree of sun exposure, and outdoor activities. To compare biological variables, serum 25(OH)D was stratified as below 15 ng/ml or above 15 ng/ml. RESULTS: Mean 25(OH)D and 1,25(OH)2D levels were 13.5 ± 5.8 ng/ml and 20.6 ± 11.8 pg/ml, respectively. The proportions of serum 25(OH)D deficiency (< 15 ng/ml), insufficiency (15-< 30 ng/ml), and sufficiency (≥ 30 ng/ml) in subjects were 72.4%, 23.4%, and 4.3%, respectively. Prevalence of vitamin D deficiency in female patients was 78.6%, whereas that in males was 63.2% (P = 0.046). Vitamin D intake and sun exposure time were not significantly different between the two stratified serum 25(OH)D levels. Dietary intake of vitamin D did not contribute to increased serum 25(OH)D levels in HD patients. The main effective factors affecting serum 25(OH)D status were found to be the sun exposure and active outdoor exercise. CONCLUSIONS: Hypovitaminosis D is common in HD patients and is higher in females than in males. Sun exposure is the most important determinant of serum 25(OH)D status in HD patients.
Sung, Ji-Hee,Kim, Soo Hyun,Kim, Yoo-Min,Kim, Ji-Hye,Kim, Mi-Na,Lee, Hye Ran,Lee, Hye-Jung,Lee, Eun-Jung,Choi, Suk-Joo,Oh, Soo-young,Roh, Cheong-Rae,Kim, Jong-Hwa De Gruyter 2016 Journal of perinatal medicine Vol.44 No.8
<P><B>Abstract</B></P>Objective: To investigate the neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery.Study Design: This is a retrospective cohort study of women with twin pregnancies delivered at ≥34 weeks of gestation from 1995 to 2014. Subjects were categorized into two groups according to gestational age at delivery: late-preterm group (34–36 weeks) and term group (≥37 weeks). Neonatal outcome measures including neonatal intensive care unit (NICU) admission, mechanical ventilator support, and respiratory distress syndrome (RDS) were compared between the late-preterm and term group based on chorionicity (monochorionic or dichorionic) and delivery indication (elective or non-elective).Results: A total of 1198 twin pregnancies were included in the study: 679 in the late-preterm group and 519 in the term group. Late-preterm twin infants had higher rates of NICU admission, mechanical ventilator support, and RDS than did term twin infants, regardless of the chorionicity and indication for delivery. In the multivariable analysis, late-preterm birth, monochorionicity, and non-elective delivery were independently associated with a significantly higher risk of NICU admission and mechanical ventilator support.Conclusion: The late-preterm birth was associated with a higher risk of adverse neonatal outcome regardless of chorionicity and indication for delivery, and showed significantly increased risk by monochorionicity and non-elective delivery.
Clinical characteristics and prognostic factors of invasive intracranial aspergillosis (초)
( Sung Joon Jin ),( Se Na Hwang ),( Su Jin Jeong ),( Hee Kyung Choi ),( Han Sung Lee ),( Bum Sik Chin ),( Sang Hoon Han ),( Chang Oh Kim ),( Hyo Youl Kim ),( Young Goo Song ),( Jun Yong Choi ),( June 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-
Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
Oh Jong Min,Gao Qian,Shin Woong-Hee,Lee Eun-Young,Chung Dawoon,Choi Grace,Nam Sang-Jip,Kim Hoon 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-
Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration ( IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant ( Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases.
Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats
( Sang Hun Kim ),( Hwa Song Jong ),( Myung Ha Yoon ),( Seon Hee Oh ),( Ki Tae Jung ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.2
Background: The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, sec-O-glucosylhamaudol (SOG) showed an analgesic effect. This study was performed to examine the antinociceptive effect of intrathecal SOG in the formalin test.Methods: Male Sprague-Dawley rats were implanted with an intrathecal catheter. Rats were randomly treated with a vehicle and SOG (10 g, 30 g, 60 g, and 100 g) before formalin injection. Five percent formalin was injected into the hind-paw, and a biphasic reaction followed, consisting of flinching and licking behaviors (phase 1, 0-10 min; phase 2, 10-60 min). Naloxone was injected 10 min before administration of SOG 100 g to evaluate the involvement of SOG with an opioid receptor. Dose-responsiveness and ED50 values were calculated.Results: Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 g and maximum effects were achieved at a dose of 100 g in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 (25.8-35.5) g during phase 1, and 48.0 (41.4-55.7) during phase 2. The antinociceptive effects of SOG (100 g) were significantly reverted at both phases of the formalin test by naloxone.Conclusions: These results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor. (Korean J Pain 2017; 30: 98-103)