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A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Triterpenoids from aerial parts of Glochidion eriocarpum.
Thu, Vu Kim,Kiem, Phan Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Tung, Nguyen Huu,Cuong, Nguyen Xuan,Minh, Chau Van,Huong, Hoang Thanh,Lau, Trinh Van,Thuan, Ngo Thi,Kim, Young Ho Natural Product Communications 2010 Natural product communications Vol.5 No.3
<P>From the aerial parts of Glochidion eriocarpum, a new triterpene, glochieriol (1), three new triterpenoid saponins, glochieriosides C - E (2 - 4), together with four known triterpenes (glochidonol, glochidiol, lupeol, and 3-epi-lupeol) were isolated by using combined chromatographic separations. The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR.</P>
High-Resolution Simulations for Vietnam - Methodology and Evaluation of Current Climate
Jack Katzfey,Kim Nguyen,John McGregor,Peter Hoffmann,Suppiah Ramasamy,Hiep Van Nguyen,Mai Van Khiem,Thang Van Nguyen,Kien Ba Truong,Thang Van Vu,Hien Thuan Nguyen,Tran Thuc,Doan Ha Phong,Bang Thanh Ng 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.2
To assist the government of Vietnam in its efforts to better understand the impacts of climate change and prioritise its adaptation measures, dynamically downscaled climate change projections were produced across Vietnam. Two Regional Climate Models (RCMs) were used: CSIRO’s variable-resolution Conformal-Cubic Atmospheric Model (CCAM) and the limited-area model Regional Climate Model system version 4.2 (RegCM4.2). First, global CCAM simulations were completed using bias- and variance-corrected sea surface temperatures as well as sea ice concentrations from six Coupled Model Intercomparison Project Phase 5 (CMIP5) global climate models. This approach is different from other downscaling approaches as it does not use any atmospheric fields from the GCMs. The global CCAM simulations were then further downscaled to 10 km using CCAM and to 20 km using RegCM4.2. Evaluations of temperature and precipitation for the current climate (1980-2000) were completed using station data as well as various gridded observational datasets. The RCMs were able to reproduce reasonably well most of the important characteristics of observed spatial patterns and annual cycles of temperature. Average and minimum temperatures were well simulated (biases generally less than 1oC), while maximum temperatures had biases of around 1oC. For precipitation, although the RCMs captured the annual cycle, RegCM4.2 was too dry in Oct.-Nov. (−60% bias), while CCAM was too wet in Dec.- Mar. (130% bias). Both models were too dry in summer and too wet in winter (especially in northern Vietnam). The ability of the ensemble simulations to capture current climate increases confidence in the simulations of future climate.
Van Do Nguyen,Guinyun Kim,Duc Khue Pham,Duc Thiep Tran,Hee-Seock Lee,Hengsik Kang,In Soo Ko,Moo-Hyun Cho,Tien Thanh Kim,Van Duan Phung,남궁원,Young Seok Lee,Youngdo Oh 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.2
We measured isomeric cross-section ratios for the $^{45}$Sc($\gamma$,$n$)$^{44m,g}$Sc, $^{nat}$Ti($\gamma$,$x$)$^{44m,g}$Sc, $^{103}$Rh($\gamma$,4$n$)$^{99m,g}$Rh, and $^{nat}$Fe($\gamma$,$x$)$^{52m,g}$Mn reactions at the 65-MeV electron linac of the Pohang Accelerator Laborator by using the activation method. Samples of natural Sc, Ti, Rh, and Fe metallic foils were irradiated in an uncollimated bremsstrahlung beam. The isomeric cross-section ratios were determined from the activity measurement with a high-purity germanium detector. The measured isomeric ratios were 0.21 $\pm$ 0.03, 0.12 $\pm$ 0.03, 1.43 $\pm$ 0.20, and 0.28 $\pm$ 0.04 for the $^{45}$Sc($\gamma$,$n$)$^{44m,g}$Sc, $^{nat}$Ti($\gamma$,$x$)$^{44m,g}$Sc, $^{103}$Rh($\gamma$,4$n$)$^{99m,g}$Rh, and $^{nat}$Fe($\gamma$,$x$)$^{52m,g}$Mn reactions, respectively. The present results for the $^{45}$Sc($\gamma$,$n$)$^{44m,g}$Sc and $^{nat}$Fe($\gamma$,$x$)$^{52m,g}$Mn reactions are in good agreement with other measurements. The present results for $^{nat}$Ti($\gamma$,$x$)$^{44m,g}$Sc and $^{103}$Rh($\gamma$,4$n$)$^{99m,g}$Rh reactions are the first such measurements.
Chemical constituents and antioxidant activity of Ficus callosa.
Van Kiem, Phan,Cuong, Nguyen Xuan,Nhiem, Nguyen Xuan,Hang, Dan Thi Thuy,Nam, Nguyen Hoai,Ban, Ninh Khac,Minh, Chau Van,Bing, Zhou,Jang, Hae Dong,Kim, Young Ho Natural Product Communications 2011 Natural product communications Vol.6 No.2
<P>One new megastigmane glycoside, ficalloside (1), and eleven known compounds, were isolated from methanol extract of Ficus callosa leaves by repeated column chromatography. Their structures were established on the basis of spectral and chemical evidence. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity (ORAC) assay. Compound 8 exhibited potent antioxidant activity of 10.6 microM trolox equivalents at the concentration of 2 microM. At this concentration, compounds 4-7 and 9-12 showed significant antioxidant activity with ranging of 2.1-6.1 microM trolox equivalents.</P>
Nguyen, Van Minh,Nguyen, Tien Thua,Seo, Juwon,Yoon, Hyeon Kyu,Kim, Yeon Gyu Korean Society of Ocean Engineers 2018 Journal of advanced research in ocean engineering Vol.4 No.3
In the past, traditional methods of research on ship maneuvering performance were estimated in calm waters. However, the course-keeping ability and the maneuvering performance of a ship can be influenced by the presence of waves. Therefore, it is necessary to understand the maneuvering behavior of a ship in waves. In this study, the force acting on a moving ship and a rudder behind the model ship will be performed in regular waves in Changwon National University (CWNU). In addition, the prediction force acting on the rudder in calm waters was carried out and compared with those of Computational Fluid Dynamics (CFD). Model test in regular wave was performed to predict the force acting on the ship and the rudder behind the model ship in various wave directions. The effects of wavelength and wave direction on hydrodynamic forces acting on the ship hull versus rudder angle is discussed.
Robust Pole Assignment in a Specified Disk
Nguyen, Van-Giap,Nguyen, Tan-Tien,Lee, Gun-You,Kim, Sang-Bong Institute of Control 2000 Transaction on control, automation and systems eng Vol.2 No.2
This paper presents a method to assign robustly the closed loop system's poles in a specified disk by a state feedback for a linear time invariant system with structured or unstructured uncertainties. THe proposed robust design procedure includes two steps. Firstly, the perturbed closed loop matrix $A_{cl p}$ = $A_{cl}$ + Δ$A_{cl}$ is rearranged such that it is a function of the nominal closed loop matrix $A_{cl}$. Hence, we can control the positions of the perturbed closed loop poles by choosing $A_{cl}$ appropriately. Secondly, the feedback control law F that assigns the closed loop poles of the perturbed system in a specified disk is determined from the equation $A_{cl}$ = A + BF. A procedure for finding F is proposed based on partitioning every matrix of the equation $A_{cl}$ = A + BF in the horizontal direction.