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Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
Nguyen Bich Thu,Trinh Nam Trung,Do Thi Ha,Nguyen Minh Khoi,Nguyen Viet Than,Thipthaviphone Soulinho,Nguyen Hai Nam,Tran Thi Phuong,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
The methanol extract of Zanthoxylum rhetsa (MZRR) were evaluated for its ability to suppress the formation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. MZRR presented an inhibition of LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that MZRR significantly inhibited the protein and mRNA expressions of iNOS and COX-2 in LPS-activated macrophages in a dose-dependent manner. LPS-induced COX-2, iNOS, and nuclear factor kappa beta (NF-kB) activity were also decreased in the presence of MZRR. The production of tumor necrosis factor-a (TNF-a), the mRNA expression levels of pro-inflammatory cytokines, including TNF-a and IL-1b, were reduced after MZRR administration in a dose dependent-manner. These results suggest that the MZRR extract involved in the inhibition of iNOS and COX-2 via the NF-kB pathway, revealing a partial molecular basis for anti-inflammatory properties of the MZRR extract.
Hien, Nguyen Khoa,Bao, Nguyen Chi,Ai Nhung, Nguyen Thi,Trung, Nguyen Tien,Nam, Pham Cam,Duong, Tran,Kim, Jong Seung,Quang, Duong Tuan Elsevier 2015 Dyes and pigments Vol.116 No.-
<P><B>Abstract</B></P> <P>A fluorescent chemosensor based on dimethylaminocinnamaldehyde-aminothiourea (DA) has been designed, synthesized, and applied with a combined theoretical and experimental study. The synthetic path, optimized molecular structure and characteristics of DA were carried out using the calculations at the B3LYP/LanL2DZ level of theory. The experimental investigations have a good agreement with the theoretical results. DA can be used as a chemosensor for simultaneous quantification of silver, copper, and mercury ions in aqueous solution at the ppb level. The stable geometric structures of the complexes between DA and Ag<SUP>+</SUP>, Hg<SUP>2+</SUP>, Cu<SUP>2+</SUP> with stoichiometry of 1:1, 2:1, and 2:1, have been found and investigated for electronic properties and fluorescence quenching phenomena by using Atoms in Molecules (AIM) and Natural Bond Orbitals (NBO) analyses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A chemosensor has been studied with a combined theoretical and experimental study. </LI> <LI> Suitable for detecting trace amounts of Ag(I), Hg(II), Cu(II) ions at the ppb concentration level. </LI> <LI> High water solubility, simplicity, rapid analysis time, wide range of pH. </LI> <LI> The stable geometric structures of the complexes have been found and investigated. </LI> <LI> The fluorescence quenching of complexes is studied by using AIM and NBO analyses. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Le Thu Trang,Dinh-Toi Chu,Nguyen Thi Hong Hanh,Nguyen Nam Trung 질병관리본부 2019 Osong Public Health and Research Persptectives Vol.10 No.2
Objectives: To identify trends in percentage body fat (PBF) in adolescents to determine gender-specific classification thresholds for being overweight and obese. Methods: A cross-sectional study of 899 adolescents (11 to 14.5 years) from Hanoi and Nam Dinh was conducted in Vietnam. PBF, subcutaneous fat and percentage of lean mass were measured directly using OMRON HBF 375 scales to measure bioelectrical impedance. Results: PBF decreased in boys with increasing age (p < 0.001). The difference in PBF between boys and girls, significantly increased with age after 12.5 years (p < 0.001). There was a stronger correlation between PBF and fat content (Pearson’s r = 0.860, p < 0.0001) than that between (BMI) and fat content (Pearson’s r = 0.521, p < 0.0001). The prevalence of being overweight or obese in girls was similar when determined by PBF or BMI. Hanoi had higher rates of adolescents being overweight or obese compared with Nam Dinh. Conclusion: PBF provides a more accurate body assessment for being overweight or obese in adolescents compared with BMI.
Screening of Vietnamese Medicinal Plants for Cytotoxic Activity
Nguyen Bich Thu,Trinh Nam Trung,Do Thi Ha,Nguyen Minh Khoi,Tran Viet Hung,Tran Thi Hien,Yim Namhui,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.1
Thirty-two methanol extracts of thirty-one Vietnamese medicinal plants were evaluated for the cytotoxic activity against five human cancer cell lines, including A549, MCF-7, HT 1080, Huh-7, and HepG2. Of these, the nine extracts of Acanthopanax trifoliatus (4), Acanthopanax gracilistylus (5), Siegesbeckia orientalis (10), Betula alnoides (11), Passiflora edulis (18), Zanthoxylum simulans (leaf, 23), Adenosma caeruleum (26), Solanum verbascifolium (29), and Alpinia malaccensis (31), exhibited high potent cytotoxic activity showing a certain degree of selectivity against the different cell types, with IC50 values ranging from 2.1 to 3.8 mg/mL.
Trung Hau Nguyen,YongGyeong Kim,Jin-Sung Kim,Yulah Jeong,Hye Min Park,Jin Woo Kim,Ji-Eun Kim,Hyemin Kim,Nam-Soo Paek,강창호 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
To expect the positive physiological functions from probiotic consumption, the lactic acid bacteria should survive, partially, in the gastrointestinal (GI) tract. This study aimed to evaluate the viable stability of probiotic bacterial cells (Lactobacillus plantarum MG989, L. fermentum MG901, Streptococcus thermophilus MG5140, Lactococcus lactis MG5125, and Enterococcus faecium MG89-2) that were coated with sodium alginate and pumpkin powder (SP) by comparing their resistance in simulated intestinal fluid (with pancreatin) and simulated gastric fluid (with pepsin) in vitro with that of the non-coated free cells. The viable stability was determined by counting cells with colony forming unit (CFU) from agar plate culture of SP coated and non-coated free cells in simulated GI conditions. Survival rate enhanced up to 28.7% and 14.0% in the condition of simulated gastric fluid and simulated intestinal fluid, respectively. The results showed that the SP coated cells exhibited considerably greater resistance to the simulated gastric fluid than the activated cells (p < 0.001), showing that the SP coating may enhance the survival of probiotic bacteria after consumption during their transit through the GI tract after freeze-drying process.
Nguyen, Trung-Kien,Oh, Nam-Jin,Le, Viet-Hoang,Lee, Sang-Gug IEEE 2006 IEEE transactions on microwave theory and techniqu Vol.54 No.2
A low-power low flicker-noise receiver front-end for 915-MHz-band IEEE 802.15.4 standard in 0.18-μm CMOS technology is implemented. A power-constrained simultaneous noise and input matching low-noise amplifier (LNA) can be achieved by using a conventional inductive degeneration cascode amplifier with an extra gate-source capacitor. In combination with the LNA, a passive mixer showing low 1/f noise performance is adopted to convert the RF signal directly to the baseband signal. The measured results show a conversion gain of 30 dB and a noise figure of 3 dB with 1/f noise corner frequency of 30 kHz. Two-tone test measurements indicate -5-dBm input third-order intercept point and +45-dBm input second-order intercept point. The RF receiver front-end dissipates 2 mA from a 1.8-V supply.
Trung, Tran Nam,Seo, Dong-Bum,Quang, Nguyen Duc,Kim, Dojin,Kim, Eui-Tae Elsevier 2018 ELECTROCHIMICA ACTA Vol.260 No.-
<P><B>Abstract</B></P> <P>Vertically aligned MoS<SUB>2</SUB> flakes were grown on indium tin oxide (ITO) and ITO/ZnO substrates using metalorganic chemical vapor deposition. The thickness of MoS<SUB>2</SUB> flakes was manipulated at the few-layer level (5–10), which is desirable for energy-storage and energy-conversion applications. For photoelectrochemical (PEC) cells, a few-layer flake photoelectrode yielded a considerably higher photocurrent density (930 μA/cm<SUP>2</SUP> at 0.2 V) than a MoS<SUB>2</SUB> thin-film photoelectrode (360 μA/cm<SUP>2</SUP> at 0.2 V) due to the former's high density of active sites, slow intraband relaxation rate from excitonic states, and low defect density. Furthermore, the heterostructure of ZnO/MoS<SUB>2</SUB> flakes exhibited a remarkably high photocurrent density of 1.6 mA/cm<SUP>2</SUP> at 0.2 V and a long-term stability under the PEC operating conditions because of its enhanced photogenerated carrier separation and transfer. Thus, such a heterostructure is promising as an efficient, nontoxic, inexpensive, and earth-abundant PEC electrode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Vertically aligned growth of few-layer MoS<SUB>2</SUB> flakes using MOCVD. </LI> <LI> Manipulating MoS<SUB>2</SUB> morphology from thin films to few-layer flakes. </LI> <LI> Efficient and long-term stable photoelectrochemical activity of ZnO/MoS<SUB>2</SUB> flakes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Nguyen, Van-Dinh,Tran, Le-Nam,Duong, Trung Q.,Shin, Oh-Soon,Farrell, Ronan IEEE 2017 IEEE Transactions on Vehicular Technology VT Vol.66 No.5
<P>We consider a linear precoder design for an underlay cognitive radio multiple-input multiple-output (MIMO) broadcast channel, where the secondary system consisting of a secondary base station (BS) and a group of secondary users is allowed to share the same spectrum with the primary system. All the transceivers are equipped with multiple antennas, each of which has its own maximum power constraint. Assuming zero-forcing (ZF) method to eliminate the multiuser interference, we study the sum rate maximization problem for the secondary system subject to both per-antenna power constraints at the secondary BS and the interference power constraints at the primary users. The problem of interest differs from the ones studied previously that often assumed a sum power constraint and/or single antenna employed at either both the primary and secondary receivers or the primary receivers. To develop an efficient numerical algorithm, we first invoke the rank relaxation method to transform the considered problem into a convex–concave problem based on a downlink-uplink result. We then propose a barrier interior-point method to solve the resulting saddle point problem. In particular, in each iteration of the proposed method we find the Newton step by solving a system of discrete-time Sylvester equations, which help reduce the complexity significantly, compared to the conventional method. Simulation results are provided to demonstrate fast convergence and effectiveness of the proposed algorithm.</P>