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RISS 인기검색어
- 검색키워드
- 저자 : Navindra P. Seeram (검색결과 4 건)
- 무료
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Strawberry Consumption Is Associated with Increased Antioxidant Capacity in Serum
Susanne M. Henning,Navindra P. Seeram,Yanjun Zhang,,Kun Gao,Ru-Po Lee,David C. Wang,Alona Zerlin,Hannah Karp,Gail Thames,Jenny Kotlerman,Zhaoping Li,David Heber 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Strawberries are known to contain antioxidants, but the significance of ingesting antioxidant-rich fruits remains to be established. In order to determine whether the consumption of strawberries impacted measures of in vivo antioxidant capacity, frozen strawberries (250g) were administered daily for 3 weeks to 21 healthy female volunteers. Compliance was confirmed by quantitating pelargonidin-glucuronide, urolithin A-glucuronide, and 2,5-dimethyl-4-hydroxy-3-[2H]furanone-glucuronide in plasma and urine by liquid chromatography–mass spectrometry and antioxidant capacity in serum measured by the increase in lag phase of low-density lipoprotein after copper sulfate exposure, DNA strand breaks in lymphocytes, and activity of phase II enzymes. Among these measures lipid peroxidation lag time increased by 20% (P<.01), whereas other measures did not change significantly. The potent antioxidant defenses in humans make determination of changes due to dietary ingestion in healthy individuals difficult. In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population.
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Navindra P. Seeram,Yanjun Zhang,Rodney McKeever,Susanne M. Henning,Ru-po Lee,Marc A. Suchard,Zhaoping Li,Steve Chen,Gail Thames,Alona Zerlin,Martha Nguyen,David Wang,Mark Dreher,David Heber 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention dueto its reported health benefits. This has resulted in the consumption of liquid and powder pomegranate extracts as alternativesto PJ. Therefore establishing the bioavailability of polyphenols from these extract preparations is necessary. Sixteen healthyvolunteers sequentially consumed, with a 1-week washout period between treatments, PJ (8 ounces, Wonderful fruit variety),a pomegranate polyphenol liquid extract (POMxl, 8 ounces), and a pomegranate polyphenol powder extract (POMxp, 1,000mg). The three interventions provided 857, 776, and 755 mg of polyphenols as gallic acid equivalents, respectively. Plasmabioavailability, judged based on ellagic acid levels over a 6-hour period, did not show statistical differences in area under thecurve for the three interventions: 0.14. 0.05, 0.11. 0.03, and 0.11. 0.04 .mol.hour/L for PJ, POMxl, and POMxp, re-spectively. The time of maximum concentration was delayed for POMxp (2.58. 0.42 hours) compared to PJ (0.65. 0.23hours) and POMxl (0.94. 0.06 hours). Urolithin-A glucuronide, a urinary metabolite of ellagic acid, was not significantlydifferent with the three interventions, reaching levels of approximately 1,000 ng/mL. This study demonstrates that ellagitan-nin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in timeof maximum concentration of POMxp compared to PJ and POMxl.
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Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations
Pragati P. Nahar,Angela L. Slitt,Navindra P. Seeram 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.7
Inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, Alzheimer’s disease, and cancer. An overwhelming amount of data indicates that curcumin, a polyphenol obtained from the Indian spice turmeric, Curcuma longa, is a potential chemopreventive agent for treating certain cancers and other chronic inflammatory diseases. However, the low bioavailability of curcumin, partly due to its low solubility and stability in the digestive tract, limits its therapeutic applications. Recent studies have demonstrated increased bioavailability and health-promoting effects of a novel solid lipid particle formulation of curcumin (Curcumin SLCP, Longvida®). The goal of this study was to evaluate the aqueous solubility and in vitro anti-inflammatory effects of solid lipid curcumin particle (SLCP) formulations using lipopolysaccharide (LPS)-stimulated RAW 264.7 cultured murine macrophages. SLCPs treatment significantly decreased nitric oxide (NO) and prostaglandin-E2 (PGE2) levels at concentrations ranging from 10 to 50 μg/mL, and reduced interleukin-6 (IL-6) levels in a concentration-dependent manner. Transient transfection experiments using a nuclear factor-kappa B (NF-κB) reporter construct indicate that SLCPs significantly inhibit the transcriptional activity of NF-κB in macrophages. Taken together, these results show that in RAW 264.7 murine macrophages, SLCPs have improved solubility over unformulated curcumin, and significantly decrease the LPSinduced pro-inflammatory mediators NO, PGE2, and IL-6 by inhibiting the activation of NF-κB.
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Mee Young Hong,Navindra P. Seeram,Yanjun Zhang,David Heber 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4
Chinese red yeast rice (RYR), a food herb made by fermenting Monascus purpureus Went yeast on white rice, contains a mixture of eight different monacolins that inhibit cholesterogenesis and also red pigments with antioxidant properties. Monacolin K (MK) is identical to lovastatin (LV). Both LV and RYR contain statins, which could inhibit de novo cholesterogenesis, which is critical to the growth of tumor cells. Dysregulation of the cholesterol biosynthetic pathway has been demonstrated during progression to androgen independence in xenograft models, and it has been proposed that cholesterogenesis and androgen receptor (AR) up-regulation are essential to androgen-independent cell survival. This study was designed to examine the differences between the effects of RYR and LV on androgen-dependent LNCaP cells and androgen-independent cells overexpressing AR (LNCaP-AR). RYR showed more potent inhibition effect on prostate cancer cell growth compared to LV. Both the pigment and monacolin-enriched fractions purified from RYR inhibited proliferation (P < .001) to a lesser extent than intact RYR. While mevalonate, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), restored proliferation in LV-treated cells, it failed to do so in RYR-treated cells. Expression of the HMGCR gene was up-regulated by LV (P < .001) but not RYR in both LNCaP and LNCaP-AR cells. These results suggest that the RYR matrix beyond MK alone may be bioactive in inhibiting androgen-dependent and -independent prostate cancer growth. In vivo studies are needed to further establish the potential advantages of RYR over LV in prostate cancer chemoprevention and in the prevention of the emergence of androgen independence.
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