Study of the Effective Field Emitting Angle for an Individual Carbon Nanotube

Nannan Li,Zhe Wu,Jianlong Liu,Hai Zhang,Jing Guo,Baoqing Zeng 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.6

In this work, the effective field emitting angle θeff is introduced for a carbon nanotube (CNT)to relate the spatial variation of the current density along the tip’s surface to the emission current. The emission current can now be calculated by using I = 2π(1-cosθeff )r2J(0), where J(0) is theemission current density at the apex and r is the radius of curvature of the tips. Analytical resultsshow that θeff depends on the macroscopic field E0, the aspect ratio h/r and the normalized fielddistribution on the tip’s surface E(θ)/E(0). Simulation results show that E(θ)/E(0) converges withincreasing h/r and can be fitted by using a formula when h/r > 500. Finally, a fit function for θeff is obtained for h/r > 500 and E0 in the range of 1 - 25 V/µm.

Inhibition of mouse SP2/0 myeloma cell growth by the B7-H4 protein vaccine

( Nan Mu ),( Nannan Liu ),( Qiang Hao ),( Yujin Xu ),( Jialin Li ),( Weina Li ),( Shouzhen Wu ),( Cun Zhang ),( Haichuan Su ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.7

B7-H4 is a member of B7 family of co-inhibitory molecules and B7-H4 protein is found to be overexpressed in many human cancers and which is usually associated with poor survival. In this study, we developed a therapeutic vaccine made from a fusion protein composed of a tetanus toxoid (TT) T-helper cell epitope and human B7-H4IgV domain (TT-rhB7-H4IgV). We investigated the anti-tumor effect of the TT-rhB7-H4IgV vaccine in BALB/c mice and SP2/0 myeloma growth was significantly suppressed in mice. The TT-rhB7-H4IgV vaccine induced high-titer specific antibodies in mice. Further, the antibodies induced by TT-rhB7-H4IgV vaccine were capable of depleting SP2/0 cells through complement-dependent cytotoxicity (CDC) in vitro. On the other hand, the poor cellular immune response was irrelevant to the therapeutic efficacy. These results indicate that the recombinant TT-rhB7-H4IgV vaccine might be a useful candidate of immunotherapy for the treatment of some tumors associated with abnormal expression of B7-H4. [BMB Reports 2014; 47(7): 399-404]

Parameter Match of Powertrain and Economic Research for Electric City Bus

Meilan Zhou,Nannan Ding,Ruixue Liu,Xiaogang Wu,Shu Rong 보안공학연구지원센터(IJUNESST) 2013 International Journal of u- and e- Service, Scienc Vol.6 No.4

Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD

Zehong Yang,Yuanyuan Yu,Nannan Sun,Limian Zhou,Dong Zhang,HaiXin Chen,Wei Miao,Weihang Gao,Canyang Zhang,Changhui Liu,Xiaoying Yang,Xiaojie Wu,Yong Gao The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3

Background: Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, while its role in regulating lipid metabolism remain vacant. Thus, we investigated the function and mechanism of ginsenosides Rc in defending high fat diet (HFD)-induced NAFLD. Methods: Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects of ginsenosides Rc on intracellular lipid metabolism. RNAseq and molecular docking study were performed to explore potential targets of ginsenosides Rc in defending lipid deposition. Wild type and liver specific sirtuin 6 (SIRT6, 50721) deficient mice on HFD for 12 weeks were subjected to different dose of ginsenosides Rc to determine the function and detailed mechanism in vivo. Results: We identified ginsenosides Rc as a novel SIRT6 activator via increasing its expression and deacetylase activity. Ginsenosides Rc defends OA&PA-induced lipid deposition in MPHs and protects mice against HFD-induced metabolic disorder in dosage dependent manner. Ginsenosides Rc (20mg/kg) injection improved glucose intolerance, insulin resistance, oxidative stress and inflammation response in HFD mice. Ginsenosides Rc treatment accelerates peroxisome proliferator activated receptor alpha (PPAR-α, 19013)-mediated fatty acid oxidation in vivo and in vitro. Hepatic specific SIRT6 deletion abolished ginsenoside Rc-derived protective effects against HFD-induced NAFLD. Conclusion: Ginsenosides Rc protects mice against HFD-induced hepatosteatosis by improving PPAR-α-mediated fatty acid oxidation and antioxidant capacity in a SIRT6 dependent manner, and providing a promising strategy for NAFLD.

Adaptive Asymptotic Tracking Fault-tolerant Control of Uncertain Nonlinear Systems with Actuator Failures and Event-triggered Inputs

Yan Yan,Libing Wu,Nannan Zhao,Ruiyan Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.3

This paper is concerned with the problem of adaptive asymptotic tracking fault-tolerant control (FTC) for uncertain nonlinear systems with actuator faults and event-triggered inputs. Firstly, fault-tolerant controller is designed to effectively compensate the unknown actuator failures by constructing the proper parameter updated laws. Then, the event-triggered strategy based on the relative threshold method is applied to the proposed adaptive fault-tolerant controller. Furthermore, it is proved that all the closed-loop signals are uniformly bounded and the tracking error can asymptotically converge to zero. Finally, the simulation results are given to demonstrate the effectiveness of the presented control scheme.

Antibacterial activity of florfenicol composite nanogels against Staphylococcus aureus small colony variants

Liu, Jinhuan,Ju, Mujie,Wu, Yifei,Leng, Nannan,Algharib, Samah Attia,Luo, Wanhe The Korean Society of Veterinary Science 2022 Journal of Veterinary Science Vol.23 No.5

Background: Florfenicol might be ineffective for treating Staphylococcus aureus small colony variants (SCVs) mastitis. Objectives: In this study, florfenicol-loaded chitosan (CS)-sodium tripolyphosphate (TPP) composite nanogels were prepared to allow targeted delivery to SCV infected sites. Methods: The formulation screening, the characteristics, in vitro release, antibacterial activity, therapeutic efficacy, and biosafety of the florfenicol composite nanogels were studied. Results: The optimized formulation was obtained when the CS and TPP were 10 and 5 mg/mL, respectively. The encapsulation efficiency, loading capacity, size, polydispersity index, and zeta potential of the optimized florfenicol composite nanogels were 87.3% ± 2.7%, 5.8% ± 1.4%, 280.3 ± 1.5 nm, 0.15 ± 0.03, and 36.3 ± 1.4 mv, respectively. Optical and scanning electron microscopy showed that spherical particles with a relatively uniform distribution and drugs might be incorporated in cross-linked polymeric networks. The in vitro release study showed that the florfenicol composite nanogels exhibited a biphasic pattern with the sustained release of 72.2% ± 1.8% at 48 h in pH 5.5 phosphate-buffered saline. The minimal inhibitory concentrations of commercial florfenicol solution and florfenicol composite nanogels against SCVs were 1 and 0.25 ㎍/mL, respectively. The time-killing curves and live-dead bacterial staining showed that the florfenicol composite nanogels were concentration-dependent. Furthermore, the florfenicol composite nanogels displayed good therapeutic efficacy against SCVs mastitis. Biological safety studies showed that the florfenicol composite nanogels might be a biocompatible preparation because of their non-toxic effects on the renal tissue and liver. Conclusions: Florfenicol composite nanogels might improve the treatment of SCV infections.

Antibacterial activity of a novel florfenicol-loaded chitosan-sodium tripolyphosphate composite nanogels in vitro and in mice against Staphylococcus aureus small colony variants

Jinhuan Liu,Mujie Ju,Yifei Wu,Nannan Leng,Samah Attia Algharib,Wanhe Luo 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.5

Background: Florfenicol might be ineffective for treating Staphylococcus aureus small colony variants (SCVs) mastitis. Objectives: In this study, florfenicol-loaded chitosan (CS)-sodium tripolyphosphate (TPP) composite nanogels were prepared to allow targeted delivery to SCV infected sites. Methods: The formulation screening, the characteristics, in vitro release, antibacterial activity, therapeutic efficacy, and biosafety of the florfenicol composite nanogels were studied. Results: The optimized formulation was obtained when the CS and TPP were 10 and 5 mg/mL, respectively. The encapsulation efficiency, loading capacity, size, polydispersity index, and zeta potential of the optimized florfenicol composite nanogels were 87.3% ± 2.7%, 5.8% ± 1.4%, 280.3 ± 1.5 nm, 0.15 ± 0.03, and 36.3 ± 1.4 mv, respectively. Optical and scanning electron microscopy showed that spherical particles with a relatively uniform distribution and drugs might be incorporated in cross-linked polymeric networks. The in vitro release study showed that the florfenicol composite nanogels exhibited a biphasic pattern with the sustained release of 72.2% ± 1.8% at 48 h in pH 5.5 phosphate-buffered saline. The minimal inhibitory concentrations of commercial florfenicol solution and florfenicol composite nanogels against SCVs were 1 and 0.25 μg/mL, respectively. The time-killing curves and live–dead bacterial staining showed that the florfenicol composite nanogels were concentration-dependent. Furthermore, the florfenicol composite nanogels displayed good therapeutic efficacy against SCVs mastitis. Biological safety studies showed that the florfenicol composite nanogels might be a biocompatible preparation because of their non-toxic effects on the renal tissue and liver. Conclusions: Florfenicol composite nanogels might improve the treatment of SCV infections.

Migration pattern and crystallization characteristics of CeO2 in tailing glass-ceramics under microwave irradiation

Wence Xu,Zhao Cao,Rui Ma,Nannan Wu,Shunli Ouyang 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.3

Slag glass-ceramics doped with different proportions of CeO2 were prepared by fusion casting method using iron tailings andfly ash as raw materials. The effect of CeO2 on the activation energy and crystallization pattern of glass-ceramics under theeffect of ohmic thermal radiation and microwave radiation was investigated. The experimental results show that thecrystallization activation energy of glass-ceramics gradually increases with the addition of CeO2, and the diopside crystallizationis suppressed. Compared with conventional heat-treated samples, microwave irradiation effectively reduces the glass transitiontemperature, mainly depending on the enhanced crystallization kinetics by microwave non-thermal effects. Further analyzedby Raman spectroscopy, the microwave effect promoted the combination of Ce4+ with [SiO4] to generate fully depolymerizedQ0, inhibited the generation of Q2 and Q3, and increased the glass stability.