COMPLETELY GENERALIZED MILDLY NONLINEAR COMPLEMENTARITY PROBLEMS FOR FUZZY MAPPINGS

Huang, Nan-Jing,Zhang, Wen-Bin 한국전산응용수학회 1997 Journal of applied mathematics & informatics Vol.4 No.2

In this paper we introduce and study a new class of completely generalized mildly nonlinear complementarity problems for fuzzy mappings and construct some new iterative algorithms. We also show the existence of solution and the convergence of iterative sequences generated by the algorithm. Our results extend some recent results of Noor, Chang and huang.

Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells

Huang Nan,Wei Yaxun,Cheng Yi,Wang Xiaolong,Wang Qi,Chen Dong,Li Wenjing 한국유전학회 2022 Genes & Genomics Vol.44 No.6

Background: Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. Objective: To decipher the underlying molecular functions of TfR1 based on its influence on transcriptome profile in cancer cells. Methods: In this study, we first identified the expression pattern and prognostic influence of TFRC in cervical cancer patients from TCGA database. To explore the regulatory outcomes of TfR1 from the view of whole transcriptome profile, we generated TFRC knockdown (TFRC-KD) HeLa cells and negative control (NC) cells using short hairpin RNA (shRNA) method. Unbiased transcriptome sequencing (RNA-seq) experiment was used to analyze the global expression level and alternative splicing (AS) changes between TFRC-KD and NC cells. Results: We found TFRC was consistently elevated in cervical cancer samples and tightly associated with prognosis of patients. Differential expression analysis revealed that 629 differentially expressed genes (DEGs) were identified between TFRC-KD and NC. Functional enrichment analysis of these DEGs revealed that TFRC-KD extensively disturbed cell physiology related pathways, including immunity, cell metabolism and gene expression. Moreover, dysregulated AS profile also indicated that TfR1 has important roles in the AS regulation. Hundreds of TfR1-regulated AS genes were involved in DNA repair, cell death, transcription and viral reproduction pathways, which were tightly associated with cancer cell progression. Conclusions: In summary, we for the first time explored the molecular functions of TfR1 at transcriptional and post-transcriptional levels. These results demonstrate TfR1 participates in the progression of cervical cancer by affecting the expression and AS levels of genes in cancer associated pathways, which greatly extends our understanding of TfR1 functions besides iron homeostasis and provide novel options in cancer treatment by targeting TfR1.

FIXED POINT THEOREMS FOR COMPATIBLE MAPPINGS WITH APPLICATIONS TO THE SOLUTIONS OF FUNCTIONAL EQUATIONS ARISING IN DYNAMIC PROGRAMMINGS

HUANG, NAN-JING,LEE, BYUNG SOO,KANG, MEE KWANG 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

Some common fixed point theorems for compatible mappings are shown. As an application, the existence and uniqueness of common solutions for a class of functional equations arising in dynamic programmings are discussed.

GENERALIZED NONLINEAR QUASIVARIATIONAL INCLUSIONS FOR FUZZY MAPPINGS

Huang, Nan-Jing,Cho, Yeol-Je The Youngnam Mathematical Society Korea 1997 East Asian mathematical journal Vol.13 No.2

Application of a Q Method Study to Understanding Nurses’ Perspective of Adopting Evidence-Based Nursing

Ruo-Nan Jueng,Shu-He Huang,Tsui-Ping Li,Hui-Yu Liang,Chiu-Mieh Huang 한국간호과학회 2017 Asian Nursing Research Vol.11 No.4

Purpose: This study applied the Q method to identify and describe the various types of nurse perceptions that are crucially associated with their engagement in evidence-based nursing (EBN). Methods: The study participants were nurses at a medical center and a regional teaching hospital. A series of Q sorts was performed by nurses to subjectively rank the Q statements. Q statements were constructed based on the literature related to EBN adoption by nurses and face-to-face interviews. Results: A total of 60 participants were invited to rank 44 Q statements related to EBN. Factor analysis was conducted on the rankings of the Q statements. The following are the five prominent shared perspectives: (1) emphasized the obstacles to evidence searching and reading ability; (2) emphasized the organizational promotive strategies; (3) emphasized the available supportive resources; (4) emphasized the significance of EBN; and (5) emphasized the evidence-searching ability and external incentives. The five identified groups of perspectives can enhance hospital administrators to acknowledge the barriers and incentives associated with EBN practices. Conclusion: The exploration of clustering nurses' perceptions may facilitate the development of customized strategies to enable more appropriate training.

Perspective of red imported fire ant (Solenopsis invicta) management in Taiwan

Rong-Nan Huang 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

The red imported fire ant (RIFA, Solenopsis invicta), an exotic species, detected in Taiwan in 2003 was originally from USA. A program was launched immediately under Bureau of Animal and Plant Health Inspection and Quarantine Council of Agriculture (BAPHIQ) in 2004 for RIFA management. The National Red Imported Fire Ant Control Center (NRIFACC) helps the BAPHIQ to integrate/coordinate the RIFA eradication program which involves every governmental department, however the actual implementation of prevention and control work is the local government. It has made a significant progress in public education, since our general public can recognize RIFA accurately now and succeed to localize RIFA in Northern Taiwan. However, nationwide RIFA eradication is still far from success, the major constraints of the eradication program in Taiwan include (1) RIFA had likely been in Taiwan longer than reported, (2) difficulty to detect incipient infestation, (3) mass reproductive queens that can spread over 10-20 km after nuptial flight, (4) movement control is not easy to perform, (5) man power or company for chemical treatment is not enough, (6) funding is insufficient to allow success, (7) meteorological condition disfavors the control practice. Fortunately, we have developed humidity resistant baits that could enhance the control efficiency of RIFA in humid or wet conditions and resolve the weather constraints of RIFA and other invasive ants control in wet tropical and subtropical habitats. For the success of NRIFACC eradication efforts, participation of all stakeholders would remain a very important strategy in the future. In particular, a centralized team would further facilitate the management of RIFA. Moreover, due to the increasing in international trades and the recent detection of RIFA in Japan and Korea, an international efforts and cooperation on RIFA management is a key issue to control global movements of RIFA.

Efficacy and Safety of 12 Weeks of Daclatasvir, Asunaprevir Plus Ribavirin for the Treatment of HCV Genotype 1b Infection without Baseline NS5A Resistance-Associated Variants (DARING)-Interim Report

( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.

Combined Cutinase and Keratinolytic Enzyme to Endow Improved Shrink-resistance to Wool Fabric

Nan Zhang,Panghui Huang,Ping Wang,Yuanyuan Yu,Man Zhou,Qiang Wang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4

The overlapping cuticle scales on the wool surface cause severe felting shrinkage during laundering. However, theconventional wool anti-felting processing mostly adopts dichloroisocyanurate (DCCA), which produces absorbable organichalogen (AOX) with high toxicity in the effluents and cause severe environmental problems. Herein, an environmentalfriendlyenzymatic method was proposed and investigated to endow satisfactory shrink-proofing property for wool fabricswithout severe damages. The cutinase from Thermobifida fusca and the keratinolytic enzyme from Bacillus subtilis wereconsecutively used to treat wool fabrics for 4 h and 24 h, respectively. The area shrinkage of the resultant wool fabricsdecreased from 12.4 % to 5.86 % for to the cuticle was partly broken, which met the machine-washable requirement with anacceptable strength loss of 7.46 %. Moreover, the dyeability and wettability of the resultant fabric were improved after thecombined enzymatic treatments, due to the destruction of the lipid layer and breakdown of keratin by combined cutinase andkeratinolytic enzyme according to the analyses such as scanning electron microscope (SEM) and X-ray photoelectronspectroscopy (XPS) and contact angle. Overall, our result revealed that the synergistic actions of cutinase and keratinolyticenzyme treatments could effectively disintegrate cuticles and remove scales.

Effects of aflatoxin B1 combined with ochratoxin A and/or zearalenone on metabolism, immune function, and antioxidant status in lactating dairy goats

Huang, Shuai,Zheng, Nan,Fan, Caiyun,Cheng, Ming,Wang, Shang,Jabar, Adil,Wang, Jiaqi,Cheng, Jianbo Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.4

Objective: This experiment investigated the effects of aflatoxin B1 (AFB1) alone or mixed with ochratoxin A (OTA) and/or zearalenone (ZEA) on the metabolism, immune function, and antioxidant status of dairy goats. Methods: Fifty lactating Laoshan dairy goats were randomly assigned to one of five treatment groups (n = 10) for 14 days. Goats were fed no additive (control) or administered with $50{\mu}g\;AFB1/kg$ dry matter (DM) (AFB1), $50{\mu}g\;AFB1/kg$ $DM+100{\mu}g\;OTA/kg$ DM (AFB1+OTA), $50{\mu}g\;AFB1/kg$ $DM+500{\mu}g\;ZEA/kg$ DM (AFB1+ZEA), or $50{\mu}g\;AFB1/kg$ $DM+100{\mu}g\;OTA/kg$ $DM+500{\mu}g\;ZEA/kg$ DM (AFB1+OTA+ZEA). Results: Dry matter intake and milk production were lower in goats fed AFB1+OTA+ZEA than in controls. Supplementation with AFB1, OTA, and ZEA significantly decreased red blood cell count, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean platelet volume, and significantly increased white blood cell count, when compared with the control group. Compared with control, the combination of AFB1, OTA, and ZEA significantly increased alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities, total bilirubin (TBIL), interleukin-6, and malondialdehyde (MDA), but significantly reduced immunoglobulin A concentration, the activities of superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), and total antioxidant capacity (T-AOC) in serum. Administration of AFB1 combined with OTA led to higher ALP, ALT, TBIL, and MDA, as well as lower milk production, SOD and GSH-Px activities, and T-AOC, than administration of AFB1 combined with ZEA. Conclusion: The mixture of AFB1, OTA, and ZEA exerted the greatest adverse effects on dairy goats, meanwhile the deleterious damage of the other mycotoxin combinations were in varying degrees. The findings of this study could provide guidance for the prevention and treatment of the consequences of contamination of animal feeds with combinations of mycotoxin.

Synthesis, Crystal Structure and Theoretical Calculation of a Novel Nickel(II) Complex with Dibromotyrosine and 1,10-Phenanthroline

Huang, Guimei,Zhang, Xia,Fan, Yuhua,Bi, Caifeng,Yan, Xingchen,Zhang, Zhongyu,Zhang, Nan Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10

A new complex [$Ni(phen)(C_9H_8Br_2NO_3)_2{\cdot}2CH_3OH{\cdot}2H_2O$] [phen: 1,10-phenanthroline $C_9H_8Br_2NO_3$: 3,5-dibromo-L-tyrosine] was synthesized and characterized by IR, elemental analysis and single crystal X-ray diffraction. X-ray crystallography shows that Ni(II) ion is six-coordinated. The Ni(II) ion coordinates with four nitrogen atoms and two oxygen atoms from three ligands, forming a mononuclear Ni(II) complex. The crystal crystallizes in the Orthorhombic system, space group $P2_12_12$ with a = 12.9546 ${\AA}$, b = 14.9822 ${\AA}$, c = 9.9705 ${\AA}$, V = 1935.2 ${\AA}$, Z = 1, F(000) = 1008, S = 0.969, ${\rho}_{calcd}=1.742g{\cdot}cm^{-3}$, ${\mu}=4.688mm^{-1}$, $R_1$ = 0.0529 and $wR_2$ = 0.0738 for 3424 observed reflections (I > $2{\sigma}(I)$). Theoretical study of the title complex was carried out by density functional theory (DFT) method and the B3LYP method employing the $6-3l+G^*$ basis set. The energy gap between HOMO and LUMO indicates that this complex is prone to interact with DNA. CCDC: 908041.