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( Hae Lim Lee ),( Si Hyun Bae ),( Bohyun Jang ),( Seawon Hwang ),( Hyun Yang ),( Hee Chul Nam ),( Pil Soo Sung ),( Sung Won Lee ),( Jeong Won Jang ),( Jong Young Choi ),( Nam Ik Han ),( Byung Joo Song 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: According to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus reactivation. The aim of this study was to evaluate the effect of pharmacological immunosuppression on HCV reactivation. Methods: The medical records of patients who underwent systemic chemotherapy, corticosteroid therapy, or other immunosuppressive therapies between January 2008 and March 2015 were reviewed. Subsequently, 202 patients who were seropositive for the anti-HCV antibody were enrolled. Exclusion criteria were: unavailability of data on HCV RNA levels, a history of treatment for chronic hepatitis C, and the presence of liver diseases other than a chronic HCV infection. Results: Among the 120 patients enrolled in this study, hepatitis was present in 46 patients (38%). None of the patients were diagnosed with severe hepatitis. Enhanced replication of HCV was noted in nine (27%) of the 33 patients who had data available on both basal and follow-up HCV RNA loads. Reappearance of the HCV RNA from an undetectable state did not occur after treatment. The cumulative rate of enhanced HCV replication was 23% at 1 year and 30% at 2 years. Conclusions: Although enhanced HCV replication is relatively common in HCV-infected patients treated with chemotherapy or immunosuppressive therapy, it does not lead to serious sequelae. (Gut Liver 2017;11:870-877)
Effects of the Fermented Milk Intake on Human Antioxidant Activity and Blood Alclhol Concentration
Hae-Seon Nam,Kyong-Ae Lee,Yong-Jin Lee,Yong-Bae Kim,Sung-Ho Kim,Sang-Han Lee,Sun-Hwa Lee,Yoon-Jin Lee,Ho-Young Kim,Young-Tae Ahn,Kwang-Sei Lim,Chul-Sung Huh 한국식품과학회 2006 Food Science and Biotechnology Vol.15 No.1
Erlotinib Induced Trichomegaly of the Eyelashes
Sang Hoon Jeon,Jeong Seon Ryu,Gwang Seong Choi,Jung Soo Kim,Hea Yoon Kwon,Min Su Kim,Hae Seong Nam,Jae Hwa Cho,Seung Min Kwak,Hong Lyeol Lee,Hyun Jung Kim,Geun Jeong Hong 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.74 No.1
Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used for non-small-cell lung cancer patients. Its untoward cutaneous effects are largely well known and developed in many patients treated with EGFR TKIs. However trichomegaly of eyelash is rarely reported. Although trichomegaly is not a drug-limiting side effect, it could be troublesome of continuing the treatment because of cosmetic issue or eyeball irritation by long eyelashes. Therefore clinicians are needed to pay attention to this uncommon effect. We herein describe erlotinib induced trichomegaly of eyelashes in a woman with adenocarcinoma of the lung.
Integration of a Passive-Type UHF RFID Tag Using Ferroelectric Memory Technology
Hae-Chan Park,Suk-Kyoung Hong,Ae-Kyoung Lee,Baek-Hee Lee,Hee-Bok Kang,Heon-Yong Chang,Ji-Hye Choi,Nam-Kyun Park,Sanghyun Park,Sung Joo Hong,Sung-Sil Cho,Sung-Yeon Hwang,Yoon-Jung Kim,Young-Jin Son 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.2I
We investigated a passive-type rewritable radio-frequency identification (RFID) tag operating at the UHF (860 . 960 MHz) band and using ferroelectric memory (FeRAM) technology. The transponder integrated circuit(IC) for the UHF RFID tag was implemented with 0.25-μm one-poly four-metal standard logic CMOS technology with the addition of a FeRAM and Schottky diodes. The Pb(Zr,Ti)O3(PZT) capacitor array with a unit area of 1.4 × 1.4 μm2 for the FeRAM-embedded RFID tag showed a remnant polarization of 30 μC/cm2 and a leakage current of 1 × 10.5 A/cm2 at 3 V after full process integration. The novel ferroelectric technology utilizing a stacked capacitor structure and a high capacitance PZT capacitor allowed a highly competitive transponder chip size (550 × 550 μm2) by reducing the area of the analogue circuit without adding any complexity to the process integration. The PZT capacitor-based analogue circuitry showed almost the same performance as that of conventional capacitor type circuitry. Thus, the ferroelectric memory technology is very promising for the realization of a cost-effective, passive-type, rewritable UHF RFID tag.
Antioxidant Activity of Theaflavin and Thearubigin Separated from Korean Microbially Fermented Tea
Sang-Hae Nam,Mi-Yae Shon,?Seok-Kyu Park 한국식품영양과학회 2007 Preventive Nutrition and Food Science Vol.12 No.1
Theaflavins (TF) and thearubigins (TR) were separated from Korean microbially fermented tea leaves. Contents of TF (74.4 μM/g) and TR (37.2%) were higher than reported for black tea fermented by oxidase. Antioxidant activities of TF, TR and EGCG were analyzed and protective effects of COS7 cells against copper and cadmiuminduced toxicity were investigated. TF and TR exhibited good inhibition rates of about 85~90% for antioxidant and scavenging activities of free radicals and protected COS7 cells against apoptosis or damage caused by stress, such as cadmium and copper-oxidative injury, free radicals etc. These results indicate that TF, TR and EGCG have antioxidant and scavenging activities against free radicals and protect COS7 cells from Cu, Cd induced injury.
Sung Soo Kim,Hyun Kuk Kim,Hyung Wook Park,Myung Ho Jeong,임경섭,Hae Jin Kee,Yu Hee Ryu,Han Byul Kim,Joo-Young Na,Young-Jae Ki,Keun-Ho Park,Dong-Hyun Choi,Ki Hong Lee,Nam Sik Yoon,Jeong Gwan Cho 대한심장학회 2020 Korean Circulation Journal Vol.50 No.1
Background and Objectives: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular arrhythmia (VA) after AMI in a porcine model. Methods: Twenty pigs were randomly divided into 2 groups based on RDN (RDN, n=10; Sham, n=10). After implanting a loop recorder, AMI was induced by occlusion of the middle left anterior descending coronary artery. Catheter-based RDN was performed for each renal artery immediately after creating AMI. Sham procedure used the same method, but a radiofrequency current was not delivered. Electrocardiography was monitored for 1 hour to observe VA. One week later, the animals were euthanized and the loop recorder data were analyzed. Results: Ventricular fibrillation event rate and the interval from AMI creation to first VA in acute phase were not different between the 2 groups. However, the incidence of premature ventricular complex (PVC) was lower in the RDN than in the Sham. Additionally, RDN inhibited prolongation of the corrected QT (QTc) interval after AMI. The frequency of non-sustained or sustained ventricular tachycardia, arrhythmic death was lower in the RDN group in the early period. Conclusions: RDN reduced the incidence of PVC, inhibited prolongation of the QTc interval, and reduced VA in the early period following an AMI. These results suggest that RDN might be a therapeutic option in patients with electrical instability after AMI.