스포츠에서 발생한 적탈행동에 관한 조사 연구

임경섭 한국교원대학교 학교체육연구소 1995 학교체육연구소지 Vol.2 No.1

Histopathological Comparison among Biolimus, Zotarolimus and Everolimus-Eluting Stents in Porcine Coronary Restenosis Model

임경섭,배인호,정명호,박대성,김종민,김정하,조동련,심두선,박근호,홍영준,안영근 대한심장학회 2013 Korean Circulation Journal Vol.43 No.11

Background and Objectives: The aim of this study was to examine the histolopathogical effects among the biolimus, zotarolimus, and everolimus eluting stent (EES) in the porcine coronary restenosis model. Subjects and Methods: Pigs were randomized into three groups in which the coronary arteries (15 pigs, 10 coronaries in each group)had either a biolimus A9 eluting stent (BES, n=10), zotarolimus eluting stent (ZES, n=10) or an EES (n=10). Histopathologic analysis was performed at 28 days after stenting. Results: There were no significant differences in the injury score among the three groups. There was a significant difference in the internal elastic lamina, lumen area, neointima area, percent area stenosis, and the fibrin and inflammation score among the three groups (4.3±0.53 mm2, 2.5±0.93 mm2, 1.8±1.03 mm2, 40.7±20.80%, 1.7±0.41, 1.4±0.72 in the BES group vs. 5.1±0.55 mm2, 2.3±1.14 mm2, 2.8±1.00mm2, 55.4±21.23%, 2.0±0.39, 1.6±0.76 in the ZES group vs. 4.4±0.53 mm2, 1.7±1.22 mm2, 2.8±1.23 mm2, 64.0±26.00%, 1.8±0.76, 2.1±0.90 in the EES group, respectively). BES is more effective in inhibiting neointimal hyperplasia compared to ZES and EES (p<0.0001). According to the fibrin and inflammation score, BES and EES are more effective in decreasing the fibrin deposition compared to ZES (p<0.001). Moreover, BES and ZES are more effective in reducing the inflammatory reaction compared to EES (p<0.001). Conclusion: The result demonstrates that BES shows better histopathological characteristics than ZES and EES at one month after stenting in the porcine coronary restenosis model.

담배 흡연으로 인한 한국인의 방사선 피폭선량 계산에 관한 연구

임경섭,유연재,김광표 대한방사선방어학회 2010 대한방사선방어학회 학술발표회 논문요약집 Vol.2010 No.04

삼각섬유 연골 복합체 척골 기시부 손상에 대한 관혈적 봉합술의 임상 결과

임경섭,류인혁,김경철,이지호,안기백,문성철 대한수부외과학회 2014 대한수부외과학회지 Vol.19 No.4

목적: 삼각섬유 연골 복합체 기시부 손상의 관혈적 봉합술의 임상 결과를 분석하고, 관혈적 봉합술의 유용성을 알아보고자 하였다방법: 삼각섬유연골 복합체 기시부 손상으로 관혈적 봉합술을 시행하였던 8예를 대상으로 하였다. 평균나이는 34세 였으며, 남자는 5명, 여자는 3명이었다. 결과 분석은 modified Mayo wrist score (MMWS)와 disabilities of the arm, shoulder and hand (DASH), 통증-visual analogue scale (VAS)를 사용하였으며, 이학적 검진을 통해 원위 요척관절불안정성 유무를 분석하였다. 결과: 평균 추시 기간은 36.5개월(범위, 12?64개월)이었다. MMWS는 평균 52.5 (범위, 25-85)에서 82.5 (범위, 75- 100)으로 향상되었으며(p=0.02), DASH 점수는 평균 39.6 (범위, 65-13.5)에서 13.4 (범위, 2.5-33.3)으로 향상되었다(p=0.012). 동통은 통증-VAS 4.6 (범위, 6-3)에서 2 (범위, 0-3)로 감소하였다(p=0.016). 4예에서 수술 전 원위 요척관절 불안정성이 관찰되었으며, 수술 후 불안정성이 남아있는 경우는 없었다. 결론: 삼각섬유연골 복합체 기시부 손상에 대한 관혈적 봉합술의 임상결과는 만족스러우며, 삼각섬유연골 복합체 된 4 예에서도 추가 술식 없이 불안정성이 호전되는 것을 확인하였다. Purpose: To investigate short term clinical outcomes of the open surgical repair for triangular fibrocartilage complex (TFCC) foveal detachment. Methods: We retrospectively reviewed 8 patients (5 men, 3 women) who had been treated with open surgical repair of the TFCC type 1B injury, from 2005 to 2013 and who were followed up for more than one year after surgery. Mean age at time of surgery was 34 years. The right side was involved in 3 patients, and the left in 5. The clinical results of surgery were assessed with modified Mayo wrist score (MMWS), disabilities of the arm, shoulder and hand (DASH) score and pain-visual analogue scale (VAS). Physical examination was performed to evalu- ate the prescence of distal radioulnar instability, preoperatively and at the latest follow-up. Results: The mean follow up period were 36.5 months (range, 12-64 months). The mean MMWS improved from 52.5 (range, 25-85) preoperatively to 82.5 (range, 75-100) postoperatively (p=0.02). The mean DASH score improved from 39.6 (range, 65-13.5) preoperatively to 13.4 (range, 2.5-33.3) postoperatively (p=0.012). The preoperative mean pain-VAS was 4.6 (range, 6-3); these value was reduced to mean 2 (range, 0-3) at the latest follow-up (p=0.016). There were no patients remaining instability after the surgery, although four patients showed distal radioulnar joint (DRUJ) instability before surgery. Conclusion: The surgical outcomes of open repair for TFCC foveal detachment (type 1B) was contentable. Also, in cases of type 1B injury associated with DRUJ instability were managed sucessfully without additional procedure.

안녕, 퀵서비스맨 외 1편

임경섭 고요아침 2008 열린시학 Vol.13 No.4

Comparison of Sirolimus Loaded PLGA-PEG Co-Polymer Coronary Stent and Bare Metal Stent in a Porcine Coronary Restenosis Model

임경섭,나재운,박준규,정명호,김동곤,배인호,박대성,김종민,김정하,조동련,심두선,박근호,홍영준,안영근 한국고분자학회 2014 Macromolecular Research Vol.22 No.6

The aim of this study was to compare the effect of the sirolimus loaded PLGA-PEG co-polymer coronarystent with that of the bare metal stent in a porcine coronary restenosis model. Pigs were randomized into two groups(10 pigs, 10 coronary arteries in each group), in which either the sirolimus loaded PLGA-PEG copolymer stent(SPPS, n=10) or the bare metal stent (BMS, n=10) was implanted in the coronary arteries. Histopathologic analysiswas performed at 28 days after stenting. There were no significant differences in the injury score, internal elasticlamina (IEL) area, and inflammation score between the two groups. There were significant differences in the lumenarea (3.6±0.42 mm2 in the SPPS group vs. 2.5±0.89 mm2 in the BMS group, p<0.001), in the neointimal area (1.2±0.34 mm2in the SPPS group vs. 2.5±0.99 mm2 in the BMS group, p<0.001), in the percent area stenosis (26.0±6.58% in theSPPS group vs. 48.6±16.95% in the BMS group, p<0.001) and in the fibrin score (1.2±0.41 in the SPPS group vs. 0.5±0.26 in the BMS group, p<0.001). These results demonstrate that SPPS had a superior effect on suppression ofneointimal hyperplasia than BMS at one month after stenting in a porcine coronary restenosis model.

Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model

임경섭,정명호,배인호,박준규,박대성,김종민,김정하,조동련,심두선,박근호,홍영준,안영근 전남대학교 의과학연구소 2013 전남의대학술지 Vol.49 No.3

Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia,the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm2 in the AES group vs. 0.4±0.25 mm2 in the PES group,p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80%in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.

조지는 리피 강을 등지고서 외 1편

임경섭 천년의시작 2015 (계간)시작 Vol.14 No.3

Treatment of an 8-mm Myxoma Using Acellular Corneal Tissue

임경섭,위성욱,김재찬 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.1

A myxoma is a benign tumor found in the heart and in various soft tissues; however, a corneal myxoma israre. A mucinous mass of unknown etiology was observed on the left cornea of a 32-year-old male patient. We performed deep anterior lamellar keratoplasty using acellular corneal tissue and concurrent amnioticmembrane transplantation. Hematoxylin and eosin staining revealed vacuolation of the parenchyma andmyxoid change in the corneal tissue that occurred in the anterior half of the corneal parenchyma. We identifieda myxoid stroma by Alcian blue staining and observed collagen fibers with denatured stroma by Massontrichrome staining. The patient’s visual acuity improved from light perception to 20 / 200, and the intraocularpressure remained within the normal range for one year after surgery. The transplanted cornea survivedsuccessfully with well-maintained transparency, and recurrence was not observed one year after surgery.

과두과증식을 동반한 안면비대칭 환자에서 과두절제술의 적용과 효과

임경섭,차정열,황충주 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

과두과증식은 하악의 3차원적인 골격적인 비대가 일어나는 병적인 상태이다. 이러한 과두과증식의 원인은 호르몬의 작용, 외상, 감염, 유전, 태아기 때의 요인, hypervascularity 등의 요인으로 알려져 있다. 과두과증식의 진단 시 가장 중요한 것은 과두과증식 상태가 아직도 활성화 상태인지 판단하는 것이다. 이러한 과두과증식의 상태에 따라서 안면비대칭 환자의 치료는 이환측 과두의 성장 부위를 제거하는 과두절제술을 시행하는 방법, 성장이 완료될 때까지 기다렸다가 통상적인 악교정 수술만을 시행하거나 과두절제술을 병행하는 시술방법이 있다. 과두과증식의 활성화 상태를 판단하는 것은 치료 안정성에 매우 중요한 요인이며, bone scan이나 주기적인 3차원 컴퓨터 단층촬영이나 정모두부방사선사진 등을 통하여 확인할 수 있다. 본 보고에서는 과두과증식을 동반한 안면비대칭 환자를 과두절제술을 이용하여 개선한 증례를 소개하고자 한다. Condylar hyperplasia is a pathologic condition showing 3-dimensional skeletal hyperplasia of the mandible. The reason for condylar hyperplasia is not yet known, but the effects of hormone, trauma, infection, genetics, fetal condition, and hypervascularity are known as possible reasons. When we diagnose a patient as having condylar hyperplasia, it is important to decide if it is in progress or not. Treatment for facial asymmetry due to condylar hyperplasia are decided accordingly, including condylectomy, that is removal of growth site of the affected condyle, and conventional orthognathic surgery only or condylectomy with orthognathic surgery after the completion of growth. Therefore, it is important to determine the growth state of condylar hyperplasia in treatment stability. This is verified through bone scan and regular check-ups with 3D CT or PA cephalogram. This case report introduces an improved case of facial asymmetry with condylectomy together with orthognathic surgery.