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Nam Su Youn,Nam Kwangwoo,Shim Ki-Nam,Yang Seoyon,Tae Chung Hyun,Jo Junwoo,Kim Nayoung,Park Seon Mi,Park Young Sook,Park Seun Ja,Jung Sung-Ae 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Background/Aims: This study aimed to develop a rehabilitation program for musculoskeletal pain experienced by gastrointestinal endoscopists and to investigate its usefulness. Methods: This was a multicenter cohort study. During the first 2 weeks, a questionnaire regarding daily workload and musculoskeletal symptoms was administered. Then, a rehabilitation program including equipment/posture correction and stretching was conducted during the remaining 6 weeks. Follow-up daily workload and musculoskeletal symptom surveys were distributed during the last 2 weeks. The program satisfaction survey was performed at the 6th and 8th weeks. Results: Among 118 participants (69 men), 94% (n=111) complained of musculoskeletal pain at baseline. Various hospital activities at baseline were associated with multisite musculoskeletal pain, whereas only a few workloads were correlated with musculoskeletal pain after the rehabilitation program. Follow-up musculoskeletal pain was negatively correlated with equipment/posture program performance; arm/elbow pain was negatively correlated with elbow (R=–0.307) and wrist (R=–0.205) posture; leg/foot pain was negatively correlated with monitor position, shoulder, elbow, wrist, leg, and foot posture. Higher performance in the scope position (86.8% in the improvement vs 71.3% in the aggravation group, p=0.054) and table height (94.1% vs 79.1%, p=0.054) were associated with pain improvement. An increased number of colonoscopy procedures (6.27 in the aggravation vs 0.02 in the improvement group, p=0.017) was associated with pain aggravation. Most participants reported being average (32%) or satisfied (67%) with the program at the end of the study. Conclusions: Our rehabilitation program is easily applicable, satisfactory, and helpful for improving the musculoskeletal pain experienced by gastrointestinal endoscopists.
Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection
( Kwangwoo Nam ),( Jeong Eun Shin ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.2
Background/Aims: Regular surveillance colonoscopy after colon cancer resection is recommended for detecting metachronous adenoma and cancer. However, risk factors for metachronous neoplasms have not been fully evaluated. We aimed to assess risk factors for advanced metachronous neoplasms during surveillance colonoscopy after colon cancer resection. Methods: Patients who underwent curative colectomy for nonmetastatic colon cancer between January 2002 and December 2012 were evaluated and followed up to December 2017. Results: A total of 293 patients were enrolled in this study. Among these, 179 (61.1%) were male, and the mean age was 63.2 ± 10.4 years. On perioperative clearing colonoscopy, synchronous high-risk adenomas (number ≥ 3, size ≥ 10 mm, high-grade dysplasia, villous histology, and serrated adenoma ≥ 10 mm) were detected in 95 patients (32.4%), and they were significantly associated with male sex, old age (≥ 65 years), current alcohol consumption, and current smoking (p < 0.05). During the follow-up period (mean 74.4 ± 36.4 months), advanced metachronous neoplasms were found in 45 patients (15.4%), including metachronous cancer in four (1.4%). In multivariate analysis, distal colon cancer (distal-to-splenic flexure; odds ratio [OR], 4.402; 95% confidence interval [CI], 1.658 to 11.689; p = 0.003), synchronous high-risk adenomas (OR, 3.225; 95% CI, 1.503 to 6.918; p = 0.003), and hypertension (OR, 2.270; 95% CI, 1.058 to 4.874; p = 0.035) were significant risk factors for advanced metachronous neoplasms. Conclusions: During surveillance after curative colon cancer resection, patients with distal colon cancer, synchronous high-risk adenomas, and hypertension may need meticulous follow-up to improve overall outcomes.
남광우 ( Kwangwoo Nam ),송태준 ( Tae Jun Song ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5
Endoscopic ultrasound (EUS) has recently become widely used for the diagnosis and treatment of gastrointestinal disease. With applications of linear EUS and EUS-guided fine needle aspiration, many EUS-guided interventions are now emerging as feasible treatment options for patients with pancreatobiliary disease. EUS-guided drainage from pseudocyst, bile duct, pancreatic duct, and the gallbladder are becoming routine procedure. EUS-guided celiac plexus neurolysis and block can relieve intractable pancreatic pain. Moreover, EUS-guided local tumor therapy (ethanol ablation and radiofrequency ablation) may be feasible in selected patients. Safe EUS-guided intervention requires a good deal of experience but is becoming widely used to treat pancreatobiliary disease. (Korean J Med 2015,89:507-514)
( Yohan Nam ),( Seokmin Yoon ),( Jihye Baek ),( Jong-hwa Kim ),( Miri Park ),( Kwangwoo Hwang ),( Wonyong Kim ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3
The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of Lactobacillus, a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed Lactiplantibacillus plantarum LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model. HK-LRCC5314 markedly decreased body weight gain, adipose tissue (neck, subcutaneous, and epididymal) weight, and fasting glucose levels. In the adipose tissue, mRNA expression levels of stress-T2D associated factors (NPY, Y2R, GLUT4, adiponectin, and leptin) and pro-inflammatory factors (TNF-α, IL-6, and CCL-2) were also altered. Furthermore, HK-LRCC5314 increased the abundance of Barnesiella, Alistipes, and butyrate-producing bacteria, including Akkermansia, in feces and decreased the abundance of Ruminococcus, Dorea, and Clostridium. Thus, these findings suggest that HK-LRCC5314 exerts protective effects against stress-T2D via gut microbiome modulation, suggesting its potential as a supplement for managing stress-T2D.
안전한 소프트웨어 설계를 위한 위협 모델링 및 안전도 측정에 관한 연구
남희재 ( Heejae Nam ),이윤영 ( Yunyoung Lee ),이진주 ( Jinju Lee ),신동휘 ( Donghwi Shin ),이광우 ( Kwangwoo Lee ),김승주 ( Seungjoo Kim ),원동호 ( Dongho Won ) 한국정보처리학회 2006 한국정보처리학회 학술대회논문집 Vol.13 No.2
네트워크와 인터넷의 이용률이 높아지면서 그와 관련된 많은 소프트웨어들이 개발되고 있다. 하지만 네트워크를 통해 소프트웨어에 쉽게 접근할 수 있게 되면서 공격자의 접근 또한 쉬워졌다. 그럼에도 불구하고 많은 소프트웨어들이 설계 시, 위협에 대한 보안문제를 체계적인 방법으로 다루지 않고 있다. 본 논문에서는 소프트웨어 설계에 있어서 위협을 파악하고 대응할 수 있는 방법을 제시하는 위협 모델링(Threat Modeling)과 이를 보완하여 위협과 대응책 간의 관계를 통해 소프트웨어의 안전도를 측정할 수 있는 방법과 절차를 제시한다.
남현우(Hyunwoo Nam),박능수(Neungsoo Park),이강우(Kwangwoo Lee),안인석(Ihn-Seok Ahn) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1
가상화 시스템은 하드웨어 위에 가상머신을 관리하는 VMVM이 존재하고 VMM은 커널 보다 높은 권한 계층으로 Guest OS의 관리 제어할 수가 있다. 본 논문은 이러한 VMM의 높은 권한 수준을 이용하여 Guest OS의 각종 메모리 및 이벤트 정보를 모니터링 할 수 있는 라이브러리를 설계하고 그 구현을 설명하였다. 본 연구의 실험은 리눅스 커널 모듈 형태로 구현된 KVM(Kernel-based)을 사용하여 가상머신들의 상태정보를 읽거나 수정할 수 있는 모니터링 라이브러리를 제작하였다. 구현된 모니터링 라이브러리는 동작중인 가상머신의 메모리나 CPU 레지스터를 읽거나 쓸 수 있게 만들며 GDT, IDT, 시스템 콜 테이블과 같은 커널 객체를 접근할 수 있는 API를 제공하고 있다. 이러한 가상화 모니터링 기술은 기존의 커널 기반 모니터링 시스템에서 발생하던 커널 레벨의 공격 위험이나 한계점을 극복하고 보다 안정적인 모니터링을 할 수 있을 것으로 기대된다.