영유아예방접종시 보건소이용가정과 병의원 이용가정의 사회계층적 특성에 관한 분석연구

李恩珠,李明淑,車喆換 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

In order to develop an appropriate health care service program for a population. it is of utmost importance that the particular population's demograhic and socio-economic characteristics are taken into consideration. The purpose of this research was to determine which of the demographic and socio-economic factors gathered from basic family health records contribute to the decision by people to use either the hospitals and clinics. or health centers for their children's health care. The target area of this study was Guro 6 dong. Guro-Ku, Seoul. A sampling method of choosing families whose children(1-3 years old) had already received their third DPT vaccination resulted in 405 subject familes out of 3904 family health records which were on file at the Guro 6 dong health subcenter A general survey of the households under study revealed that 61.9% of the children received the vaccinations at a health center. and 38.1%. at a clinic or a hospital. The demographic. socio-economic. and maternal health behaviour characteristics were all analyzed for each of the 405 families. In addition. the likelihood of each family to use either the clinic and hospital or the health center was analyzed. Significant differences in the data were determined by the Chi-squared methcd. The factors affecting the utilization of medical facilities ware examined through a stepwise discriminant analysis. using the type of medical facility utilized as group variable, and the demographic characterlistics socio-economic characteristics. or maternal health behaviour as discriminant variable. 1. Of the demographic characteristics. father's education. the mother's age. mothor'education. and the mother's occupation had a hit ratio of 58.0% 2. Upon the analysis of socio-economic characteristics, type of housing, status of ownership of the house, household income, and whether the family had a telephone had a hit ratio of 69.9%. 3. Using maternal health behaviour. as the discriminating variable, and prenatal care, postpartum care had a hit ratio of 70.9%. 4. The stepwise discriminant analysis resulted in postpartum care, type of housing, ownership status of the house, mother's occupation, monthly income, and ownership of telephone having a hit ratio of 73.4%. The collection of basic health information of a population is essential for planning an appropriate health care service program. This research has shown that, as part of the basic information, demographic, and scoio-economic, as well as maternal health behavior characterisics are very important in determinizing an individual's preference for a particular type of medical facility from the available ones. Furthermore, these specific characteristics of a population may be used in planning a comprehensive health care service program to make certain appropriate facilities and programs are available. More need to be done in the future to discover the factors which influence the effective utilization of health service programs available to the population.

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.

Therapeutic outcomes of methotrexate injection in unruptured interstitial pregnancy

( Myung Joo Kim ),( Jae-ho Cha ),( Hyo Sook Bae ),( Mi Kyoung Kim ),( Mi-la Kim ),( Bo Sung Yun ),( You Shin Kim ),( Seok Ju Seong ),( Yong Wook Jung ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.6

Objective To examine the therapeutic outcomes of methotrexate (MTX) in the treatment of unruptured interstitial pregnancy. Methods We reviewed the medical records of patients who were diagnosed with interstitial pregnancy and received MTX as first-line treatment between January 2003 and July 2014 at CHA Gangnam Medical Center. The treatment success rates and subsequent pregnancy outcomes were examined. Results Ninety-seven patients were diagnosed with interstitial pregnancy between January 2003 and July 2014. Of them, 38 initially received MTX treatment. The diagnosis was made at a median of 6⁺³ weeks (5⁺⁰ to 11⁺³ weeks). Thirty patients received a systemic MTX injection, while the other 8 received a local MTX injection. Systemic treatment composed of an 8-day alternating MTX regimen, single-dose regimen, or high-dose regimen (100 mg/m² + 200 mg/m² intravenously over 12 hours). The local injection consisted of a direct MTX injection into the gestational sac with or without systemic MTX injection. Twenty-one patients (55.3%) were successfully treated with MTX. However, MTX therapy failed in 17 patients (44.7%), who required surgery. Mode of MTX treatment was the only predictive variable of MTX treatment success (P=0.039). Treatment success was seen in 7 of 8 patients (87.5%) in the local MTX group vs. 14 of 30 patients (46.7%) in the systemic MTX group. After treatment, 13 patients attempted a successive pregnancy; of them, 10 patients had a confirmed clinical pregnancy and healthy live birth. Conclusion Combined MTX treatment including a local injection might be an initial approach to the treatment of interstitial pregnancy.

다이오드 레이저를 이용한 연소진단기법

차학주(Hak-Joo Cha),김민수(Min-Soo Kim),신명철(Myung-Chul Shin),김세원(Se-Won Kim),김혁주(Hyuck-Joo Kim),한재원(Jae-Won Han) 한국연소학회 2003 KOSCOSYMPOSIUM논문집 Vol.- No.-

The Effects of Germanium Biotite Supplement as a Prophylactic Agent Against Respiratory Infection in Calves

Myung hwan Jung,Bock Gie Jung,Jae hyung Ko,Seung Bin Cha,Seung Won Shin,Won Jung Lee,Min Kyoung Shin,Yeon Kwon Jung,Bong Joo Lee,Han Sang Yoo 대한수의학회 2011 대한수의학회 학술대회발표집 Vol.2011 No.-

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

Cha, Yu-Jung,Lim, Kyoung Soo,Park, Min-Kyu,Schneider, Stephen,Bray, Brian,Kang, Myung-Chol,Chung, Jae-Yong,Yoon, Seo Hyun,Cho, Joo-Youn,Yu, Kyung-Sang Dove Medical Press 2014 Drug design, development and therapy Vol.8 No.-

<P><B>Background</B></P><P>KM-023 is a new second-generation nonnucleoside reverse-transcriptase inhibitor that is under development for the treatment of human immunodeficiency virus (HIV) type 1 infection.</P><P><B>Objective</B></P><P>This study determined KM-023 tolerability and pharmacokinetic characteristics in healthy subjects.</P><P><B>Materials and methods</B></P><P>A randomized, double-blinded, placebo-controlled, dose-escalation study was conducted in 80 healthy South Korean male volunteers. The subjects were allocated to single- or multiple-dose (once daily for 7 days) groups that received 75, 150, 300, or 600 mg drug or placebo in a 4:1 ratio. Safety and pharmacokinetic assessments were performed during the study. Plasma and urine concentrations were quantified using liquid chromatography–tandem mass spectrometry.</P><P><B>Results</B></P><P>The average maximum concentration (C<SUB>max</SUB>) and area under the concentration–time curve from time 0 to infinity (AUC<SUB>∞</SUB>) values of KM-023 for the 75–600 mg doses in the single-dose study ranged from 440.2 ng/mL to 1,245.4 ng/mL and 11,142.4 ng · h/mL to 33,705.6 ng · h/mL, respectively. Values of the mean C<SUB>max</SUB> at a steady state and AUC within the dosing interval ranged from 385.1 ng/mL to 1,096.7 ng/mL and 3,698.9 ng · h/mL to 10,232.6 ng · h/mL, respectively, following 75–600 mg doses in the multiple-dose study. Dose proportionality was not observed for KM-023. KM-023 showed a 0.6-fold accumulation after multiple doses in the 600 mg dose group. The mean half-life values ranged between 20.7 and 31.2 hours. KM-023 was generally well tolerated without serious adverse events.</P><P><B>Conclusion</B></P><P>KM-023 demonstrated dose- and time-dependent nonlinear pharmacokinetic characteristics after single or multiple doses over a dose range (75–600 mg) in healthy subjects. KM-023 showed favorable tolerability in this study. This Phase I clinical trial information can be used to design further clinical studies appropriately to evaluate KM-023 in patients with HIV-1 infection.</P>

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Joo, Myung-Jae,Cha, Jae-Kook,Lim, Hyun-Chang,Choi, Seong-Ho,Jung, Ui-Won Korean Academy of Periodontology 2017 Journal of Periodontal & Implant Science Vol.47 No.2

Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (${\varnothing}3{\times}6mm$) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group ($51.6mm^3$ and $46.6mm^3$, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.

Effect of Korean Red Ginseng on Superoxide Dismutase Inhibitor-Induced Pancreatitis in Rats: A Histopathologic and Immunohistochemical Study

Joo, Kwang Ro,Shin, Hyun Phil,Cha, Jae Myung,Nam, Sua,Huh, Youngbuhm Lippincott Williams Wilkins, Inc. 2009 PANCREAS Vol.38 No.6

OBJECTIVES:: Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS:: Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study. Pancreatitis was induced by intraperitoneal injection of diethyldithiocarbamate for 4 weeks. Korean red ginseng was fed orally to rats for the next 3 weeks. At week 7, all rats were killed, and pancreatic tissues were analyzed. RESULTS:: No histological alterations were detected in the pancreata of normal and KRG control groups. Tissues from the non-KRG-treated pancreatitis group exhibited marked pancreatic damage including changes in histological architecture, acinar cell necrosis and degeneration, and cytoplasmic vacuolization. However, tissues from the KRG-treated pancreatitis group exhibited no cellular damage and had normal histological pancreatic architecture. Immunohistochemical examination revealed that the expressions of nuclear factor &kgr;B, tumor necrosis factor α, inducible nitric oxide synthase, and the oxidant stress markers, malondialdehyde and 4-hydroxynonenal, were significantly decreased in the KRG-treated pancreatitis group as compared with the non-KRG-treated pancreatitis group. CONCLUSIONS:: Our results suggest that KRG has antioxidant therapeutic effects on superoxide dismutase inhibitor-induced pancreatitis by inhibition of nuclear factor &kgr;B.

영구형 심방 조율 유도 이식을 위한 전진 기법의 유용성

차광수,조정관,김주한,김준우,김성희,배열,안영근,박종철,서정평,박주형,정명호,박종춘,강정채 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.7

관상동맥 중재술후 재협착 병변 치료의 조기 성적

주신배,정명호,배열,안영근,박종철,차광수,서정평,박주형,조정관,박종춘,강정채,박옥규 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2