GIS를 이용한 산불발생위험지역 구분

이시영,안상현,원명수,이명보,임태규,신영철 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

산불로 인한 재해를 미연에 방지하고 피해를 저감하기 위해서는 산불발생위험지역을 사전에 파악하여 예방대책을 세울 필요가 있다. 따라서 본 연구에서는 산불발생인자에 따른 산불발생위험지역을 구분하고자 겸상북도 의성군에서 발생한 산불피해지역에 대하여 임상, 지형 등에 대하여 조사하였다. 조사된 요인들 간 독립성 유무를 상관분석을 이용하여 산불발생과 관련 있는 7개의 주제도를 선정하였으며, 선정된 주제도를 조건부확률과 지리정보시스템을 이용하여 산불발생확률을 계산하였다. 계산된 산불발생확률을 20개 등급으로 지수화하여 산불발생위험지역을 구분하였다. In order to decrease the area damaged by forest fires and to prevent the occurrence of forest fires, we are making an effort to improve prevention measures for forest fires. The objective of this study is to classify hazard regions where forest fires occur based on the factors that contribute to the occurrence of forest fires. Forest fire sites in the Uiseong-gun, Gyeongsangbuk-do were surveyed according to the factors of forest type and topographic characteristics where the forest fires occurred. We used a correlation analysis to determine the forest fire occurrence factors and a conditional probability analysis and GIS to determine a forest fire danger index. The resulting forest fire danger index was used in the classification of forest fire occurrence risk regions.

공구이동정책하에서의 공구할당 휴리스틱 알고리즘

최규탁,이정훈,오명진 慶南專門大學 1999 論文集 Vol.27 No.1

퍼지추론규칙을 이용한 적응형 평가시스템

엄명용,정순영,이원규 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.4

본 논문에서는 기존의 LCMS에서 사용되는 평가시스템에 퍼지 추론 규칙을 이용한 적응형 퍼지평가시스템(AFES : Adaptie Fuzzy Evaluation System)을 제안한다. AFES 는 학습자가 하나의 학습코스(learning course)에 들어가기 전에 퍼지진단평가(fuzzy diagnostic evealuation)를 통해 학습자에게 코스수준(course level)을 부여한다. 학습자는 코스수준에 따른 맞춤식 학습경로(learning path)로 학습을 종료한 후, 퍼지최종평가(fuzzy final evaluation)를 통해 최종성적(final grade)을 AFES 으로부터 부여 받는다. AFES, 의 가장 큰 특징은 최종성적의 점수 부여 규칙에 있는데, 만약 서로 다른 학습자가 동일한 문제 수에 대하여 같은 수의 정답을 냈더라도, AFES 는 125 가지 퍼지 추론 규칙(fuzzy reasoning rule)에 의거하여 탄력적으로 서로 다른 최종성적을 학습자에게 부여한다. We introduce an AFES(Adaptive Fuzzy Evaluation System) that applies an evaluation system used to existing LCMS(Learning Contents Management System) to a fuzzy reasoning rule. The AFES confers a course level on the learner through a fuzzy diagnostic evaluation before the learner enters a learning course. After the learner completes a learning course through the tailored learning path that is suitable for the learner’s level, the AFES confers a final grade on the learner by means of fuzzy final evaluation. The biggest characteristic of the AFES is a grade rule of the final grade. Although different learners get the same number of correct answers to the same number of questions, AFES flexibiv confers the different final grade on the learner by means of the number of 125’s fuzzy reasoning rules.

정신분열병 증상을 동반한 진행성 핵상 마비 1례

박종익,조영래,홍진표,이민규,한오수,이명종 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

저자들은 환청과 망상을 주소로 정신과를 방문한 진행성 핵상 마비 환자를 진단하고 치료하였다. 진행성 핵상 마비는 보행 장해, 치매, 수직성 안구 운동의 장해가 특징적인 증상이며, 아직까지 특별한 치료법은 알려져 있지 않다. 정신과적 증상으로는 인지기능의 장해, 정동 및 행동의 변화, 수면 장해, 정신병적 증상 등이 있으며 정신분열병과 비슷한 증상을 보이는 경우는 극히 드물다고 한다. 본 증례에서는 파킨슨 증상과 정신병적 증상이 비슷한 시기에 발현된 진행성 핵상 마비의 예를 보고하면서 진단적 중요성을 강조하고자 한다. We have experienced a rare case of progressive supranuclear palsy with hallucination and delusion. The common manifestations of progressive supranuclear palsy are gait disturbance, mental change and sign of vertical ophthamoplegia but no efficacious therapy has been known. Neuropsychiatric symptom clusters include cognitive impairment, affective and behavioral changes, sleep disturbance, and psychotic symptoms. Though schizophrenia-like psychosis has been reported but this is certainly rare. Addressing a case of progressive supranuclear palsy, in whom parkisonian symptoms appeared with concurrent psychotic symptoms, we emphasize accurate diagnosis.

Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

Hierarchically three-dimensional (3D) nanotubular sea urchin-shaped iron oxide and its application in heavy metal removal and solar-induced photocatalytic degradation

Lee, Soon Chang,Jeong, Yesul,Kim, Youn Jung,Kim, Hyeran,Lee, Hyun Uk,Lee, Young-Chul,Lee, Sang Moon,Kim, Hae Jin,An, Ha-Rim,Ha, Myoung Gyu,Lee, Go-Woon,Lee, Young-Seak,Lee, Gaehang Elsevier 2018 Journal of hazardous materials Vol.354 No.-

<P><B>Abstract</B></P> <P>In this study, hierarchically three-dimensional (3D) nanotubular sea urchin-shaped iron oxide nanostructures (3D-Fe<SUB>2</SUB>O<SUB>3</SUB>) were synthesized by a facile and rapid ultrasound irradiation method. Additives, templates, inert gas atmosphere, pH regulation, and other complicated procedures were not required. Dense 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> with a relatively large Brunauer–Emmett–Teller (BET) surface area of 129.4 m<SUP>2</SUP>/g was synthesized within 23 min, and the BET surface area was further improved to 282.7 m<SUP>2</SUP>/g by a post heat-treatment process. In addition, this post processing led to phase changes from maghemite (γ phase) to hematite (α phase) Fe<SUB>2</SUB>O<SUB>3</SUB>. Subsequent characterization suggested that the growth mechanism of the 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> follows self-assembly and oriented attachment. The prepared 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> was applied to wastewater purification. Ultrasound-irradiated 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> can eliminate a As(V) and Cr(VI) from water with 25 times faster removal rate by using a one third smaller amount than commercial α-Fe<SUB>2</SUB>O<SUB>3</SUB>. This was attributed to the inter-particle pores and relatively positively charged surface of the nanostructure. In addition, post heat treatment on ultrasound-irradiated 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> significantly influenced the photocatalytic degradation of methylene blue and phenol, with a 25 times higher removal efficiency than that of commercial α-Fe<SUB>2</SUB>O<SUB>3</SUB>, because of both high BET surface area and good crystallization of the prepared samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The 3D- Fe<SUB>2</SUB>O<SUB>3</SUB> can be mass-produced by ultrasound irradiation method. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> possesses high BET surface area and interconvertible phase. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> exhibits rapid adsorption rates for heavy metals. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> exhibits excellent photocatalytic activities toward the dyes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice

Lee, Hyun Gyu,Cho, Nam-chul,Jeong, Ae Jin,Li, Yu-Chen,Rhie, Sung-Ja,Choi, Jung Sook,Lee, Kwang-Ho,Kim, Youngsoo,Kim, Yong-Nyun,Kim, Myoung-Hwan,Pae, Ae Nim,Ye, Sang-Kyu,Kim, Byung-Hak Elsevier 2016 The Journal of investigative dermatology Vol.136 No.1

<P>T-cell-mediated immune responses play an important role in body protection. However, aberrantly activated immune responses are responsible for inflammatory and autoimmune diseases. The regulation of pathologic immune responses may be a potential therapeutic strategy for the treatment of these diseases. Despite that multiple pharmacologic properties of benzoxathiole derivatives have been defined, the molecular mechanisms underlying these properties remain to be clarified. Here, we demonstrated the benzoxathiole derivative 2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one (BOT-4-one) regulated immune responses and ameliorated experimentally induced inflammatory skin diseases both in vitro and in vivo. BOT-4-one inhibited the differentiation of CD4(+) T-cell subsets by regulating the expression and production of T-cell lineage-specific master transcription factors and cytokines and activating the signal transducer and activator of transcription proteins. In addition, BOT-4-one inhibited TCR-mediated Akt and NF-kappa B signaling. Topical application of BOT-4-one ameliorated experimentally induced inflammatory skin diseases in mice models such as 2,4,6-trinitrochlorobenzene-induced contact and atopic dermatitis and IL-23-induced psoriasis-like skin inflammation. Our study demonstrated that BOT-4-one ameliorates inflammatory skin diseases by suppressing the pathogenic CD4(+) T cell differentiation and overall immune responses.</P>

Molecular Identification of Gyrodinium impudicum and Gymnodinium sanguineum by Comparing the Sequences of the Internal Transcribed Spacers 1,2 and 5.8S Ribosomal DNA

Lee, Tae Ho,LEE, SANG JUN,Lee, Jae Dong,Kim, Gi Young,Cho, Eun Seob,Ha, Myoung Gyu 한국수산학회 1999 Fisheries and Aquatic Sciences Vol.2 No.1

The sequences coding for the 5.8S rDNA and the internal transcribed spacers (ITS1 and ITS2) from the isolates of nine isolates of Gyrodinium impudicum and two isolates of Gymnodinium sanguineum species were amplified, sequenced and compared with the previously known Alexandrium species and Gymnodinium catenatum. The genetic distance analyses based on the sequence alignment indicated that Gymnodinium catenatum and Gyrodinium impudicum species were some related, Alexandrium species was distant. G. catenatum and G. sanguineum were quite separate, but these two species belonged to the same genus. G. impudicum and G. catenatum forming the closet cluster showed some variation in the alignment of ITS regions. The length of ITS1 varied more than that of ITS2 and the length of ITS1 and ITS2 was different for each G. impudicum, Gymnodinium and Alexandrium species. Also, the length of ITSl was shorter than that of ITS2. However, on the sequences of G. sanguineum, the length of ITS1 was longer about 23 nucleotides than that of ITS2. The phylogenetic analysis and rDNA similarity of G. impudicum and G. catenatum (59%) is higher than the that of G. catenatum and G. sanguineum (55%). It was thought that the phylogenetic analysis and the genetic distance revealed that G. impudicum and G. catenatum were clearly different species and G. impudicum may belong to the genus of Gymnodinium.

Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7

Lee Hyun,Yu Dong-Min,Bahn Myeong-Suk,Kwon Young-Jae,Um Min Jee,Yoon Seo Yeon,Kim Ki-Tae,Lee Myoung-Woo,Jo Sung-Je,Lee Sungsoo,Koo Seung-Hoi,Jung Ki Hoon,Lee Jae-Seon,Ko Young-Gyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is upregulated in the plasma membrane of fibrotic hepatocytes. Hepatocellular expression of PROM1 was also demonstrated in mice (Prom1CreER; R26TdTom) in which cells expressed TdTom under control of the Prom1 promoter. To understand the role of hepatocellular PROM1 in liver fibrosis, global and liver-specific Prom1-deficient mice were analyzed after bile duct ligation (BDL). BDL-induced liver fibrosis was aggravated with increased phosphorylation of SMAD2/3 and decreased levels of SMAD7 by global or liver-specific Prom1 deficiency but not by cholangiocyte-specific Prom1 deficiency. Indeed, PROM1 prevented SMURF2-induced SMAD7 ubiquitination and degradation by interfering with the molecular association of SMAD7 with SMURF2. We also demonstrated that hepatocyte-specific overexpression of SMAD7 ameliorated BDL-induced liver fibrosis in liver-specific Prom1-deficient mice. Thus, we conclude that PROM1 is necessary for the negative regulation of TGFβ signaling during liver fibrosis.

Evaluation of Failure Behavior of Sheet Metal Parts Using Continuum-based Ductile Fracture Model

Myoung-Gyu Lee,Wooram Noh,Chan-Yang Kim,Chung-An Lee,Heon-Young Kim 한국자동차공학회 2016 한국자동차공학회 학술대회 및 전시회 Vol.2016 No.11