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Reduction of matrix metalloproteinase-9 expression by culture filtrate of Paecilomyces farinosus J3
LEE, HYUN-JIN,PARK, CHUL-HONG,SON, HYUNG-U,HEO, JIN-CHUL,NAM, SUNG-HEE,LEE, KWANG-GIL,YEO, JOO-HONG,YOON, CHEOL-SIK,KIM, JONG-MYEUNG,SHIN, YONG-KYU,KIM, SI-OH,LEE, SANG-HAN Spandidos Publications 2011 Experimental and therapeutic medicine Vol.2 No.2
우제석(Jae Seok Woo),장선식(Sun Sik Jang),임석기(Seok Ki Im),이석동(Seok Dong Lee),이명식(Myeung Sik Lee),박정용(Jung Yong Park),홍성구(Seong Koo Hong),이성실(Sung Sill Lee),이상민(Sang Min Lee) 한국생명과학회 2011 생명과학회지 Vol.21 No.10
본 연구는 비지박을 이용한 섬유질발효사료(TMF) 급여가 육성기 한우 암소의 증체, 사료섭취량 및 체형변화에 미치는 영향을 구명하기 위하여 수행하였다. 6개월령 한우 암소 30두(평균체중125.9±12.0 kg)를 공시하여 3처리로 각각 10마리씩 완전 임의배치하여 6개월간 사양시험을 수행하였다. 처리구는 T1 (볏짚 자유급여와 배합사료(체중1.7%/일) 제한급여구), T2(TMF 자유 급여구) 및 T3 (TMF, 볏짚 자유급여와 배합사료(체중 1.0%/일) 제한급여구)로 수행하였다. 섬유질발효사료는 비지박 60%, 옥분 16.5%, 밀기울 10.4%, 볏짚 5%, 왕겨 7%, 요소 0.5%, 고토석회 0.5%, Lactic acid bacteria 0.1%를 첨가하여 제조하였다. 섬유질발효사료의 화학적 성분과 pH 값은 저장 0, 24, 48 및 72시간에 측정하였다. 비지박을 이용한 TMF의 저장기간에 따른 결과에서 건물, 조지방, 및 조섬유의 함량은 차이가 없었다. 저장 72시간에서 ADF 및 NDF함량은 0시간에서 보다 각각 9.52 및 3.15% 유의적으로 감소하였다(p<0.05). pH 또한 저장시간에 따라 점점 감소하였다. 체중, 사료섭취량 및 일당증체량은 TMF 급여구(T2, T3)에서 T1급여구 보다 높았다(p<0.05). 체형변화에 있어서도 T1처리구 보다 TMF 급여구가 높았다(p<0.05). 따라서 본 연구의 결과 비지박을 이용한 TMF 사료의 급여는 육성기 한우 암소의 발육을 향상시키는 것으로 나타났다. This study was conducted to determine the effects of total mixed fermentation (TMF) with bean curd dregs on body weight gain, feed intake and body size of growing Hanwoo heifers. Thirty Hanwoo heifers, 6 months of age and weighing 125.9±12.0 kg, were randomly allocated to 3 experimental groups of 10 animals each for a 6-month feeding trial. The groups were T1 (rice straw offered ad libitum with restricted (1.7% BW/day) concentrate), T2 (TMF only offered ad libitum) and T3 (TMF and rice straw offered ad libitum with restricted (1.0% BW/day) concentrate). TMF feeds were composed of 60% bean curd dregs, 16.5% corn meal, 10.4% wheat bran, 5% rice straw, 7% rice hulls, 0.5% urea matter, 0.5% magnesia lime and 0.1% lactic acid bacteria. The chemical composition and pH value of TMF feeds were measured at 0, 24, 48 and 72 hr after storage. In TMF with bean curd dregs, there were no differences in concentrations of DM, EE, and CF according to storage periouds. The ADF and NDF at 72 hr of storage time showed a significant decrease (9.52 and 3.15 %, respectively) compared to 0h of storage time (p<0.05). The value of pH was gradually decreased during the storage periods. Body weight gain, feed intake and average daily gain were higher in the TMF groups (T2, T3) compared to the T1 group (p<0.05). Changes in body size were also higher in the TMF groups compared to the T1 group (p<0.05). Thus, the present results indicate that TMF with bean curd dregs may help improve growth performance in growing Hanwoo heifers.
Seo Mi Ryoung,Kim Gunwoo,Moon Ki Won,Sung Yoon-Kyoung,Yoo Jong Jin,Yoon Chong-Hyeon,Lee Eun Bong,Lee Jisoo,Kang Eun Ha,Kim Hyungjin,Park Eun-Jung,Uhm Wan-Sik,Lee Myeung Su,Lee Seung-Won,Choi Byoong Yo 대한의학회 2021 Journal of Korean medical science Vol.36 No.17
Background: There is increasing interest in the quality of health care and considerable efforts are being made to improve it. Rheumatoid arthritis (RA) is a disease that can result in favorable outcomes when appropriate diagnosis and treatment are provided. However, several studies have shown that RA is often managed inappropriately. Therefore, the Korean College of Rheumatology aimed to develop quality indicators (QIs) to evaluate and improve the health care of patients with RA. Methods: Preliminary QIs were derived based on the existing guidelines and QIs for RA. The final QIs were determined through two separate consensus meetings of experts. The consensus was achieved through a panel of experts who voted using the modified Delphi method. Results: Fourteen final QIs were selected among 70 preliminary QIs. These included early referral to and regular follow-up with a rheumatologist, radiographs of the hands and feet, early initiation and maintenance of disease-modifying anti-rheumatic drug (DMARD) therapy, periodic assessment of disease activity, screening for drug safety and comorbidities, including viral hepatitis and tuberculosis before biologic DMARD therapy, periodic laboratory testing, supplementation with folic acid, assessment of the risk for cervical spine instability before general anesthesia, patient education, and specialized nurse. Conclusion: These QIs can be used to assess and improve the quality of health care for patients with RA.
이정식,조광명,변종각 한국물환경학회 1994 한국물환경학회지 Vol.10 No.1
An adequate treatment is required for leachates from municipal solid waste landfills because they contain a high concentration of organics. This research was performed to investigate the effects of ozonation on removal of organics, especially refractory, in leachates. Ozonation of a raw leachate showed that both COD and BOD decreased during the first 2 hr contact period, then increased, and finally decreased again after 4 hr contact. Ozonation of an effluent, containing almost nonbiodegradable organics, from a batch activated sludge treatment resulted in increase in COD and BOD during a 4 hr contact period, and then the concentrations decreased. In addition, treatments of raw and ozonated leachates by an activated sludge process with a F /M ratio of approximately 0.1㎏ BOD/㎏ MLSS-day showed only a difference of 2∼3% in COD or BOD removal efficiencies. Most of the biodegradable organics formed from refractory organics during ozonation could he biologically removed. Therefore, it could be concluded that part of the refractory organics in leachates could be biologically removed after ozonation and that it would be more effective to ozonate leachate after an biological process.
VapB as a regulator of osteoclastogenesis via modulation of PLCγ2-Ca<sup>2+</sup>-NFAT signaling
Choi, Sik-Won,Yeon, Jeong-Tae,Park, Kie-In,Lee, Chang Hoon,Youn, Byung Soo,Oh, Jaemin,Lee, Myeung Su Elsevier 2012 FEBS letters Vol.586 No.3
<P><B>Highlights</B></P><P>► We investigate the role of VapB in RANKL-induced osteoclast differentiation. ► Knock-down of VapB suppressed osteoclastogenesis. ► Over-expression of VapB accelerated RANKL-mediated osteoclast differentiation by induction of NFATc1. ► VapB regulates RANKL-mediated osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling.</P> <P><B>Abstract</B></P><P>VapB has been shown to regulate calcium homeostasis in amyotrophic lateral sclerosis. Calcium signaling is also important in metabolic bone diseases, but the role of VapB in the generation of osteoclasts for bone resorption during osteoclastogenesis is not known. Therefore, we investigated the role of VapB in RANKL-induced osteoclast differentiation. Interestingly, VapB is induced during osteoclastogenesis, and regulates osteoclast differentiation by modulating NFATc1. The results also suggest that VapB regulates osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling. The involvement of PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling in VapB-regulated osteoclastogenesis was confirmed by a pharmacological study. Taken together, the results indicate that VapB positively regulates RANKL-mediated osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling.</P>
Ye Bora,정보라,Lee Myeung-jin,Kim Tae Hyeong,Park Sam-Sik,Jung Jaeil,이승현,Kim Hong-Dae 나노기술연구협의회 2022 Nano Convergence Vol.9 No.51
Vanadium-based catalysts have been used for several decades in ammonia-based selective catalytic reduction (NH3-SCR) processes for reducing NOx emissions from various stationary sources (power plants, chemical plants, incinerators, steel mills, etc.) and mobile sources (large ships, automobiles, etc.). Vanadium-based catalysts containing various vanadium species have a high NOx reduction efficiency at temperatures of 350–400 °C, even if the vanadium species are added in small amounts. However, the strengthening of NOx emission regulations has necessitated the development of catalysts with higher NOx reduction efficiencies. Furthermore, there are several different requirements for the catalysts depending on the target industry and application. In general, the composition of SCR catalyst is determined by the components of the fuel and flue gas for a particular application. It is necessary to optimize the catalyst with regard to the reaction temperature, thermal and chemical durability, shape, and other relevant factors. This review comprehensively analyzes the properties that are required for SCR catalysts in different industries and the development strategies of high-performance and low-temperature vanadium-based catalysts. To analyze the recent research trends, the catalysts employed in power plants, incinerators, as well as cement and steel industries, that emit the highest amount of nitrogen oxides, are presented in detail along with their limitations. The recent developments in catalyst composition, structure, dispersion, and side reaction suppression technology to develop a high-efficiency catalyst are also summarized. As the composition of the vanadium-based catalyst depends mostly on the usage in stationary sources, various promoters and supports that improve the catalyst activity and suppress side reactions, along with the studies on the oxidation state of vanadium, are presented. Furthermore, the research trends related to the nano-dispersion of catalytically active materials using various supports, and controlling the side reactions using the structure of shaped catalysts are summarized. The review concludes with a discussion of the development direction and future prospects for high-efficiency SCR catalysts in different industrial fields.