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      • KCI등재

        Design of Self-Starting Hybrid Axial Flux Permanent Magnet Synchronous Motor Connected Directly to Line

        Mustafa Eker,Mehmet Akar,Cem Emeksiz,Zafer Dogan,Ahmet Fenercioglu 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.5

        In view of the current state of the reserves of electric energy generated resources and the share of electric motors in electricity consumption, many researches and studies related to efficiency in electric motors are being made. The presented work is related to the Axial Flux Permanent Magnet Synchronous Motor (AF-PMSM), which has recently undergone significant work based on the development of magnet and motor technology. In this study, a novel AF-PMSM was designed analytically through Finite Element Method (FEM) which can be started by connecting to a line such as an asynchronous motor in a transient state and can operate with high efficiency and power factor after synchronization in steady state without the need for an expensive motor drive. According to the obtained FEM results, a design with an efficiency class of IE4 of 5.5 kW shaft power, a 4 poles motor was obtained. As a result, economic calculations indicate that the extra cost of the designed Line start AF-PMSM with respect to the asynchronous motor is rapidly compensated by energy saving due to a more efficient operation, especially constant speed operations. As a result of the analysis obtained, the targeted values are reached. For induction motors and radial flux permanent magnet synchronous motors, a good alternative motor that can operate with high efficiency and power factor has been obtained.

      • KCI등재

        Absence and Resolution of Fragmented QRS Predict Reversible Myocardial Ischemia With Higher Probability of ST Segment Resolution in Patients With ST Segment Elevation Myocardial Infarction

        Mustafa Cetin,Sinan Altan Kocaman,Tuncay Kiris,Turan Erdogan,Aytun Canga,Murtaza Emre Durakoglugil,Yüksel Çiçek,Sitki Dogan,Omer Satiroglu 대한심장학회 2012 Korean Circulation Journal Vol.42 No.10

        Background and Objectives: Fragmented QRS complexes (fQRS) are associated with increased morbidity and mortality. The causative relationship between fQRS and cardiac fibrosis has been shown, but whether the presence and the number of fQRS on admission of elec-trocardiogram (ECG) predicts ST segment resolution in patients undergoing primary percutaneous coronary intervention (p-PCI) has not been investigated until now. Subjects and Methods: This study included one hundred and eighty-four consecutive patients with ST elevation myocardial infarction (STEMI) who underwent p-PCI. The presence or absence of fQRS on pre and post-PCI ECG and their relation with myocardial infarction and reperfusion parameters were investigated. Results: Patients with fQRS on admission of ECG or newly developed fQRS after p-PCI had increased inflammatory markers, higher cardiac enzyme levels, increased pain to balloon time, prolonged QRS time, more extended coronary involvement and more frequent Q waves on ECG in comparison to patients with absence or resolved fQRS. The presence and higher number of fQRS on admission or post-PCI ECGs were significantly related with low percent of ST resolution and myocardial reperfusion parameters. The area under the receiver operating characteristics curve values for the presence and number of fQRS to detect Thrombolysis in Myocardial Infarction Blush Grade 0 and 1,were 0.682 and 0.703. Conclusion: In our study, fQRS was significantly related to infarction and myocardial reperfusion parameters before and after p-PCI. Successful myocardial reperfusion by p-PCI caused the reduction in number of fQRS and QRS time with higher ST resolution. fQRS may be useful in identifying the patients at higher cardiac risk with increased ischemic jeopardized or infarcted myocardium, and persistent or newly developed fQRS may predict low percent of ST segment resolution in patients undergoing p-PCI. Background and Objectives: Fragmented QRS complexes (fQRS) are associated with increased morbidity and mortality. The causative relationship between fQRS and cardiac fibrosis has been shown, but whether the presence and the number of fQRS on admission of elec-trocardiogram (ECG) predicts ST segment resolution in patients undergoing primary percutaneous coronary intervention (p-PCI) has not been investigated until now. Subjects and Methods: This study included one hundred and eighty-four consecutive patients with ST elevation myocardial infarction (STEMI) who underwent p-PCI. The presence or absence of fQRS on pre and post-PCI ECG and their relation with myocardial infarction and reperfusion parameters were investigated. Results: Patients with fQRS on admission of ECG or newly developed fQRS after p-PCI had increased inflammatory markers, higher cardiac enzyme levels, increased pain to balloon time, prolonged QRS time, more extended coronary involvement and more frequent Q waves on ECG in comparison to patients with absence or resolved fQRS. The presence and higher number of fQRS on admission or post-PCI ECGs were significantly related with low percent of ST resolution and myocardial reperfusion parameters. The area under the receiver operating characteristics curve values for the presence and number of fQRS to detect Thrombolysis in Myocardial Infarction Blush Grade 0 and 1,were 0.682 and 0.703. Conclusion: In our study, fQRS was significantly related to infarction and myocardial reperfusion parameters before and after p-PCI. Successful myocardial reperfusion by p-PCI caused the reduction in number of fQRS and QRS time with higher ST resolution. fQRS may be useful in identifying the patients at higher cardiac risk with increased ischemic jeopardized or infarcted myocardium, and persistent or newly developed fQRS may predict low percent of ST segment resolution in patients undergoing p-PCI.

      • SCIESCOPUSKCI등재

        Design of Self-Starting Hybrid Axial Flux Permanent Magnet Synchronous Motor Connected Directly to Line

        Eker, Mustafa,Akar, Mehmet,Emeksiz, Cem,Dogan, Zafer,Fenercioglu, Ahmet The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.5

        In view of the current state of the reserves of electric energy generated resources and the share of electric motors in electricity consumption, many researches and studies related to efficiency in electric motors are being made. The presented work is related to the Axial Flux Permanent Magnet Synchronous Motor (AF-PMSM), which has recently undergone significant work based on the development of magnet and motor technology. In this study, a novel AF-PMSM was designed analytically through Finite Element Method (FEM) which can be started by connecting to a line such as an asynchronous motor in a transient state and can operate with high efficiency and power factor after synchronization in steady state without the need for an expensive motor drive. According to the obtained FEM results, a design with an efficiency class of IE4 of 5.5 kW shaft power, a 4 poles motor was obtained. As a result, economic calculations indicate that the extra cost of the designed Line start AF-PMSM with respect to the asynchronous motor is rapidly compensated by energy saving due to a more efficient operation, especially constant speed operations. As a result of the analysis obtained, the targeted values are reached. For induction motors and radial flux permanent magnet synchronous motors, a good alternative motor that can operate with high efficiency and power factor has been obtained.

      • Weekly Topotecan for Recurrent Small Cell Lung Cancer - a Retrospective Anatolian Medical Oncology Group Study

        Altinbas, Mustafa,Kalender, Mehmet Emin,Oven, Basak,Sevinc, Alper,Karaca, Halit,Kaplan, M. Ali,Alici, Suleyman,Arpaci, Erkan,Yildiz, Ramazan,Uncu, Dogan,Camci, Celalettin,Gumus, Mahmut Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

        Aim: To evaluate efficacy and tolerability of topotecan treatment for recurrent small cell lung carcinoma. Patients and Methods: A total of 62 patients were evaluated retrospectively. Statistical analysis was performed using GraphPad Instat (version 3.05). Results: DFifty five of patients (89%) were male and 7 (11%) were female. Median age was $56.7{\pm}9.3$ (34-75). Forty eight of patients (80%) were extensive stage (ES) at the time of diagnosis. Fifty of the patients (80.6 Medical Oncology Clinic) were given median 5.36 cycles of cisplatin-etoposide (2-8 cycles). Time to recurrence was $15.6{\pm}6.13$ weeks in patients with limited stage (LS) and $6.3{\pm}3.82$ weeks in extensive stage (ES) (p<0.0001). Overall survival was $14.0{\pm}6.08$ months in ES and $17.9{\pm}6.88$ months in LS. The difference between two groups was statistically meaningful (p=0.0447). The overall survival of the patients was $14.8{\pm}6.43$ months (4.5-40 months). In terms of survival, there was no difference between males and females (p=0.1171). In 17 (27%) patients who were refractory to topotecan or in whom progression occurred other chemotherapies were used. Conclusion: Small cell lung cancer is chemosensitive, but recurrences occur in short time. Other chemotherapy regimens are used in progression. Topotecan is one of them. Patients who were young and in whom recurrences occur late had given better response to topotecan. Because of the retrospective nature of the study, we couldn't reach the records exactly and consequently, rate and duration of response couldn't be calculated. In recurrent SCLC topotecan is one of the treatment choices. But both hematological and non hematological side effects should be taken into consideration.

      • KCI등재

        Simultaneous Sulfide and Nitrite Removal from Industrial Wastewaters under Denitrifying Conditions

        Esra Can Dogan,Mustafa Türker,Levent Dagasan,Ayla Arslan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.3

        Bio-oxidation of sulfide under denitrifying conditions is a key process in the treatment of gas and liquids that are contaminated with sulfide and nitrite. A lab-scale continuous flow stirred tank reactor (CFSTR)was operated with nitrite as the electron acceptor for the evaluation of the effects of loading rates, hydraulic retention time (HRT) and substrate concentrations on the performance of the autotrophic denitrification process. The influent sulfide concentration was maintained at 0.16 kg/m3and the HRT was decreased from 8.4 to 2 h and for the entire study period, the sulfide removal efficiency was above 80% for the loading rates that ranged from 0.47 to 2.16 kg S-2/m3day. However, lower influent loading of NO2--N that correspond to the stoichiometric ratios was used and the nitrite removal efficiency was close to 100%. The stoichiometry of sulfide oxidation was calculated by assuming the different end-products based on thermodynamic approach. We compared the calculated values with experimental yield values. Bio-oxidation of sulfide under denitrifying conditions is a key process in the treatment of gas and liquids that are contaminated with sulfide and nitrite. A lab-scale continuous flow stirred tank reactor (CFSTR)was operated with nitrite as the electron acceptor for the evaluation of the effects of loading rates, hydraulic retention time (HRT) and substrate concentrations on the performance of the autotrophic denitrification process. The influent sulfide concentration was maintained at 0.16 kg/m3and the HRT was decreased from 8.4 to 2 h and for the entire study period, the sulfide removal efficiency was above 80% for the loading rates that ranged from 0.47 to 2.16 kg S-2/m3day. However, lower influent loading of NO2--N that correspond to the stoichiometric ratios was used and the nitrite removal efficiency was close to 100%. The stoichiometry of sulfide oxidation was calculated by assuming the different end-products based on thermodynamic approach. We compared the calculated values with experimental yield values.

      • KCI등재
      • KCI등재

        Correlation between SERT polymorphisms and Venlafaxine response in major depression patients

        Nevzat Yuksel,Ozlem Dogan,Mehmet Ali Ergun,Hatice Ersin Karslioglu,Aysegul Koc,Akin Yilmaz,Mustafa N. Ilhan,Adnan Menevse 한국유전학회 2010 Genes & Genomics Vol.32 No.3

        Major depression (MD) has a complex multifactorial aetiology with genetic and environmental factors contributing to this disorder. As with all antidepressant treatments, there is variability in drug response because of heredity, and this leads us to focus on the genetic polymorphism of the drug's metabolising transporter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered an interesting candidate in the mechanism of antidepressant drugs. Here, we studied the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) to understand venlafaxine response. Venlafaxine was found to be effective in MD patients based on their HAM-D and CGI scores (p<0.05). Although the results did not yield a significant difference between the frequencies of the SS, LS,LL, 9/9, 10/10, 12/12 and 10/12 genotypes and venlafaxine response, venlafaxine dose was increased in patients with Stin2.12 and S alleles. These alleles might have a predisposition to mood disorders. Further studies with more patients are required to confirm this clinical association.

      • Morphine: Patient Knowledge and Attitudes in the Central Anatolia Part of Turkey

        Colak, Dilsen,Oguz, Arzu,Yazilitas, Dogan,Imamoglu, Inanc Goksen,Altinbas, Mustafa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

        Background: In Muslim majority countries (MMC) opioid use for pain management is extremely low. The underlying factors contributing to this are not well defined. Aim: The aim of this study was to survey the attitudes of cancer patients towards morphine use for pain management in a MMC and identify the factors that influence patient decisions to accept or refuse morphine as treatment for cancer pain. Settings/participants: Patients were questioned whether they had pain or not, the severity and the medications for pain management. Questions included what type of medication they thought morphine was, whether or not they would be willing to take morphine if recommended for pain management and the basis for their decision if they were against morphine use. Results: Four hundred and eighty-eight patients participated in the study. Some 50% of the patients who refused morphine use and 36.8% of the patients who would prefer another drug, if possible, identified fear of addiction as the basis for their decision. Reservation of morphine for later in their disease was the case for 22.4% of the patients who refused morphine use. Only 13.7 % of the patients refusing morphine and 9.7% of the patients who preferred another drug, if possible, cited religious reasons as the basis for this decision. Conclusions: Identifying the underlying factors contributing to low opioid use for pain management in MMC is important. Once the underlying factors were identified, all efforts should be taken to overcome them as they are barriers to improving patient pain management.

      • KCI등재

        Use of UVP to Investigate the Evolution of Bed Configuration

        M. Sukru Guney,Gokcen Bombar,Aysegul O. Aksoy,Mustafa Dogan 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.5

        Ultrasonic Velocity Profiler (UVP) is a widely used instrument which allows the determination of the complete velocity profile. UVP can also measure the echo amplitude in the mean time. In this study, it is intended to use the UVP transducers in an indirect way to detect the bottom surface by orienting them vertically downward. Preliminary experiments were conducted with immobile bed by using uniform, non-uniform sediment as well as wooden and plastic surface. It was appeared that the first remarkable peak corresponds to the bottom surface. The time variations of local bed elevations were registered by applying this technique in order to determine the erosion and deposition around a bridge pier and local scour around a horizontal submerged pipe. It was revealed that the so registered scour depths were in good agreement with those observed during the experiments. Consequently, it is demonstrated that time varied bed elevations can be measured via the first peak value of echo amplitudes by placing UVP transducers vertically.

      • KCI등재

        Relationship between Pulmonary Artery Stiffness and Functional Capacity in Patients with Heart Failure with Reduced Ejection Fraction

        Erkan Yildirim,Murat Celik,Uygar Cagdas Yuksel,Mutlu Gungor,Baris Bugan,Deniz Dogan,Yalcin Gokoglan,Hasan Kutsi Kabul,Suat Gormel,Salim Yasar,Mustafa Koklu,Cem Barcin 대한심장학회 2017 Korean Circulation Journal Vol.47 No.6

        Background and Objectives: Functional capacity varies significantly among patients with heart failure with reduced ejection fraction (HFrEF), and it remains unclear why functional capacity is severely compromised in some patients with HFrEF while it is preserved in others. In this study, we aimed to evaluate the role of pulmonary artery stiffness (PAS) in the functional status of patients with HFrEF. Methods: A total of 46 heart failure (HF) patients without overt pulmonary hypertension or right HF and 52 controls were enrolled in the study. PAS was assessed on parasternal short-axis view using pulsed-wave Doppler recording of pulmonary flow one centimeter distal to the pulmonic valve annulus at a speed of 100 mm/sec. PAS was calculated according to the following formula: the ratio of maximum flow velocity shift of pulmonary flow to pulmonary acceleration time. Results: PAS was significantly increased in the HFrEF group compared to the control group (10.53±2.40 vs. 7.41±1.32, p<0.001). In sub-group analysis of patients with HFrEF, PAS was significantly associated with the functional class of the patients. HFrEF patients with poor New York Heart Association (NYHA) functional capacity had higher PAS compared those with good functional capacity. In multivariate regression analysis, NYHA class was independently correlated with PAS. Conclusion: PAS is associated with functional status and should be taken into consideration as an underlying pathophysiological mechanism of dyspnea in patients with HFrEF.

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