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Atiye Seda Yar,Sevda Menevse,Irem Dogan,Ebru Alp,Volkan Ergin,Ahmet Cumaoglu,Aysel Aricioglu,Abdullah Ekmekci,Adnan Menevse 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Changes in vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), matrix metalloproteinase (MMP)-9, and endothelial nitric oxide synthase (eNOS) mRNA expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular neovascularization and permeability in proliferative diabetic retinopathy. The present study investigated the effects of resveratrol (RSV) treatment on the mRNA expression profile of VEGF, ACE, MMP-9, and eNOS, which are associated with vascular neovascularization, and glutathione, protein carbonyl,and nitrite–nitrate levels, which are markers of oxidative stress in eyes of diabetic rats. Twenty-four Wistar albino male rats were divided into four groups. After diabetes induction with streptozotocin (10 mg/kg/day) RSV was administered to the RSV and diabetes mellitus (DM) + RSV groups for 4 weeks. The mRNA levels were measured by quantitative real-time polymerase chain reaction assay, and biochemical estimations were determined with spectrophotometric assays in eye homogenates. The mRNA expression levels of VEGF, ACE, and MMP-9 were increased in the DM group compared with the control group, and RSV treatment decreased their mRNA levels. Expression of eNOS mRNA was increased in the RSV and DM groups and decreased in the DM+ RSV group. Nitrite–nitrate levels and protein carbonyl content were increased and glutathione levels were decreased in the DM group compared with controls. Consequently, these data suggest that RSV suppressed the expression of eNOS, which is actively involved in the inflammation and healing process in chronic diabetes. Although oxidative stress was increased in eye tissue from diabetic rats, mRNA levels of VEGF, MMP-9, and ACE genes associated with vascular remodeling did not change in diabetic eyes.
Karaogˇuz, Meral Yirmibes¸,O¨nen, I˙lke,Cos¸ar, Behc¸et,ArKan, Zehra,S¸ahin, Feride I˙ffet,Menevs¸e, Adnan 한국유전학회 2004 Genes & Genomics Vol.26 No.2
The D2 dopamine receptor (DRD2) gene is the first candidate gene that has shown promise of an association with alcoholism. A correlation between alcoholism and Al and A2 alleles of this gene has been under research. In this study, in order to determine the frequencies of allele polymorphisms in 52 unrelated type Ⅱ alcoholics and in 93 unrelated controls, extraction of DNA was performed and appropriate condition of polymerase chain reaction (PCR) was established before TaqI enzyme digestion. To determine the significant difference in genotypes and allelic frequencies between the two groups, Fisher's exact test and Yates' corrected chi-square test were performed, respectively. No significant differences were found between the alcoholics and the controls in the current study in genotypes (p = 0.1600) and in the frequency of the Al allele (p = 0.7513). As a result, the data from the study do not support the hypothesis that the Al allele of the DRD2 gene has an association with alcoholism but it could have put additive effect on the determination of the racial differences in the allele frequencies of the TaIA polymorphism.
Correlation between SERT polymorphisms and Venlafaxine response in major depression patients
Nevzat Yuksel,Ozlem Dogan,Mehmet Ali Ergun,Hatice Ersin Karslioglu,Aysegul Koc,Akin Yilmaz,Mustafa N. Ilhan,Adnan Menevse 한국유전학회 2010 Genes & Genomics Vol.32 No.3
Major depression (MD) has a complex multifactorial aetiology with genetic and environmental factors contributing to this disorder. As with all antidepressant treatments, there is variability in drug response because of heredity, and this leads us to focus on the genetic polymorphism of the drug's metabolising transporter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered an interesting candidate in the mechanism of antidepressant drugs. Here, we studied the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) to understand venlafaxine response. Venlafaxine was found to be effective in MD patients based on their HAM-D and CGI scores (p<0.05). Although the results did not yield a significant difference between the frequencies of the SS, LS,LL, 9/9, 10/10, 12/12 and 10/12 genotypes and venlafaxine response, venlafaxine dose was increased in patients with Stin2.12 and S alleles. These alleles might have a predisposition to mood disorders. Further studies with more patients are required to confirm this clinical association.