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Murugesh, K,Yeligar, Veerendra C,Dash, Deepak Kumar,Maiti, BC,Maity, Tapan K Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.4
The present study was carried out to investigate the antidiabetic and antioxidant effect of methanolic extract of Berberis tinctoria leaves (MEBT), in streptozotocin induced diabetic rats. Oral administration of MEBT extract (150 mg/kg and 300 mg/kg) for a period of 14 days. Blood glucose levels, body weight food and liquid intake were measured on every $5^{th}$ day over a period of 14 days. In diabetic rats, MEBT at the dose of 150 mg/kg and 300 mg/kg body weight resulted in significant reduction in blood glucose levels. The study was further investigated to determine antioxidant and antihyperlipidemic potential of MEBT in streptozotocin (STZ) induced diabetic rats. These results suggest that the MEBT possess antidiabetic activity and is able to ameliorate biochemical damages in STZ induced diabetic rats and the results were found to be in a dose dependent manner.
RK-Butcher알고리듬의 사용에 의한 주기적 진동 문제의 수치적 시뮬레이션
박대철,Devarajan Gopal,V. Murugesh 한국융합신호처리학회 2008 융합신호처리학회 논문지 (JISPS) Vol.9 No.1
In this paper, Runge-Kutta (RK)-Butcher algorithm is proposed to study the periodic and oscillatory problems. Simulation results obtained using RK-Butcher algorithms and the classical fourth order Runge-Kutta (RK(4)) methods are compared with the exact solutions of a few periodic and oscillatory problems to confirm the performance of the proposed algorithm. The simulation results from RK-Butcher algorithms are always found to be very close to the exact solutions of these problems. Further, it is found that the RK-Butcher algorithm is superior when compared to RK(4) methods in terms of accuracy. The RK-Butcher algorithm can be easily implemented in a programming language and a more accurate solution may be obtained for any length of time. RK-Butcher algorithm is applicable as a good numerical algorithm for studying the problems of orbit and two body as it gives the nearly identical solutions. 본 논문은 주기적 진동 문제를 연구하기 위해 Runge-Kutta(RK)-Butcher 알고리듬이 소개되었다. RK-Butcher 알고리듬을 사용하여 얻어진 시뮬레이션 결과와 고전적인 4차 RK(4) 방법을 통해 얻은 결과들을 제안한 알고리듬의 성능을 확인하기 위하여 몇몇 주기적 진동 문제들의 정확한 해와 비교하였다. RK-Butcher 알고리듬의 시뮬레이션 결과는 항상 문제의 정확한 해 RK(4) 방법보다 더 근접한 결과를 줌이 확인되었다. 정확도 측면에서 RK-Butcher 알고리듬이 RK(4) 방법과 비교해볼 때 우수함을 알 수 있다. 제안한 RK-Butcher 알고리듬은 프로그램 언어로 쉽게 구현할 수 있으며 임의 시간에 종료해도 훌륭한 근사적인 해를 얻을 수 있다. RK-Butcher 알고리듬은 짧은 시간내에 이상적인 정확한 해에 근접한 결과를 주기 때문에 궤도 와 두 물체의 문제를 연구하는데 훌륭한 수치 알고리듬으로 적용가능하다.
Veerendra C. Yeligar,K. Murugesh,Deepak Kumar Dash,Siva Shankar Nayak,B. C. Maiti,Tapan K. Maity 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
unripe whole fruits of Luffa tuberosa (Roxb.) or Momordica tuberosa (Roxb) Cogn.(Cucurbitaceae) were evaluated for the antidiabetic and hyperlipidemic potential in streptozotocin (STZ) induceddiabetic rats. Diabetes was induced by administration of intra-peritoneal injection of streptozotocin at a dose of55 mg/kg body weight. After the induction of diabetes aqueous extract of L.tuberosa (AELT) was administeredorally at doses of 250 and 500 mg/kg. body weight/day for a period of 14 days. The Fasting blood glucose (FBG)levels, serum insulin levels, changes in body weight, food and liquid intake were measured. In diabetic rats, theAELT exhibited significant reduction in blood glucose levels. Biochemical assay of plasma total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc),after the extract supplementation was confirmed by significant reduction in the levels of above mentionedhyperlipidemic indicators. This study focus on the efficacy of L.tuberosa fruits for the management ofexperimental STZ induced diabetic rats and provides the scientific basis of ancient herbal therapy and use of thesefruits as vegetable.KeywordsLuffa tuberosa (Roxb.), streptozotocin, antihyperglycemic activity, antihyperlipidemic activity
Veerendra C. Yeligar,Murugesh K.,Deepak Dash,Siva S. Nayak,Bhim C. Maiti,Tapan K. Maity 한국생약학회 2006 Natural Product Sciences Vol.12 No.4
antitumor activity of crude saponin mixture obtained from Luffa tuberosa (Roxb.) (Fam;Cucurbitaceae) hairy roots (CSLT) in mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated.elevation in tumor-free survival and a highest number of survivors were observed after administration of CSLT(300 .g/kg), which was considered as an optimum dose for its antineoplastic action. The mean survival time(MST) for this dose was approximately 47.1± 0.74 d, when compared with 19.0± 0.36 d of untreated control.Administration of 30 .g/kg CSLT resulted in 130% long-term increased survival time. The measurement ofbody weight, tumor volume, packed cell volume, viable and non-viable count indicated the efficacy of CSLT intumor-bearing mice, there was a significant recovery in hematological profiles, and there was depletion in lipidnormal levels. The CSLT was found to be devoid of conspicuous short-term toxicity in the mice when animalswere intraperitoneally injected with 250, 500, 750 and 1000 .g/kg bodyweight. The treated mice showedconspicuous toxic symptoms only at a dose of 1500 .g/kg. Mortality of the animals was monitored up to 14 dpost drug treatment, 1/7th of the LD50 dose has been considered for the optimal antineoplastic activity.KeywordsLuffa tuberosa (Roxb.) Ehrlich ascites carcinoma, hematological profiles, antioxidant, antineoplasticactivity
Numerical Simulation of Periodic and Oscillatory Problems by Using RK-Butcher Algorithms
Park, Dae-Chul,Gopal, Devarajan,Murugesh, V. The Korea Institute of Convergence Signal Processi 2008 융합신호처리학회 논문지 (JISPS) Vol.9 No.1
본 논문은 주기적 진동 문제를 연구하기 위해 Runge-Kutta(RK)-Butcher 알고리듬이 소개되었다. RK-Butcher 알고리듬을 사용하여 얻어진 시뮬레이션 결과와 고전적인 4차 RK(4) 방법을 통해 얻은 결과들을 제안한 알고리듬의 성능을 확인하기 위하여 몇몇 주기적 진동 문제들의 정확한 해와 비교하였다. RK-Butcher 알고리듬의 시뮬레이션 결과는 항상 문제의 정확한 해 RK(4) 방법보다 더 근접한 결과를 줌이 확인되었다. 정확도 측면에서 RK-Butcher 알고리듬이 RK(4) 방법과 비교해볼 때 우수함을 알 수 있다. 제안한 RK-Butcher 알고리듬은 프로그램 언어로 쉽게 구현할 수 있으며 임의 시간에 종료해도 훌륭한 근사적인 해를 얻을 수 있다. RK-Butcher 알고리듬은 짧은 시간내에 이상적인 정확한 해에 근접한 결과를 주기 때문에 궤도 와 두 물체의 문제를 연구하는데 훌륭한 수치 알고리듬으로 적용 가능하다. In this paper, Runge-Kutta (RK)-Butcher algorithm is proposed to study the periodic and oscillatory problems. Simulation results obtained using RK-Butcher algorithms and the classical fourth order Runge-Kutta (RK(4)) methods are compared with the exact solutions of a few periodic and oscillatory problems to confirm the performance of the proposed algorithm. The simulation results from RK-Butcher algorithms are always found to be very close to the exact solutions of these problems. Further, it is found that the RK-Butcher algorithm is superior when compared to RK(4) methods in terms of accuracy. The RK-Butcher algorithm can be easily implemented in a programming language and a more accurate solution may be obtained for any length of time. RK-Butcher algorithm is applicable as a good numerical algorithm for studying the problems of orbit and two body as it gives the nearly identical solutions.
Deepa Bhat,Haricharan Chittoor,Pushpalatha Murugesh,Pushpa Nagavalli Basavanna,Sunilkumar Doddaiah 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.4
The formaldehyde (FA) is a universally used chemical for preservation of cadavers in dissection halls. The adverse effects of formalin exposure are health concern to faculty, workers, and students. The benefits of using formalin, its cost effectiveness, and its proper fixation and efficient preservation of tissue, have to outweigh its adverse effects on the health of those working with it. The best way to ensure the benefits outweigh the risks are providing adequate ventilation, using personal protective equipment, and developing awareness of FA’s adverse effects. This study observed that both government and private colleges had better ventilation when more windows and doors were present, but active ventilation strategies like powerful exhaust, along with monitoring of FA level (personal or dissection hall), were needed. Students exposed to FA suffered eye and nose mucosal irritation. But faculty and workers with prolonged exposure to FA had more severe respiratory symptoms and suffered migraines. Hence personal FA monitoring and personal protective equipment must be made mandatory for those with prolonged exposure to FA. In addition, proper ventilation should be in place to reduce formalin vapours levels in workspaces.
Deepak K Dash,Tirtha Ghosh,Veerendra C Yeligar,K Murugesh,Siva S Nayak,Bhim C Maiti,Tapan K Maity 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.3
The present study was carried out to investigate the antihyperglycemic, antihyperlipidemic and antioxidant effect of chloroform and methanol extract of whole plant of Ichnocarpus frutescens (CEIF and MEIF) in streptozotocin (STZ)-induced diabetic rats. Administration of CEIF and MEIF orally at the dose of 200 mg/kg and 400 mg/kg body weight resulted in significant (P < 0.01) reduction in blood glucose levels. The body weights were significantly (P < 0.001) reduced in STZ-induced diabetic rats when compared to normal rats while the extracts significantly (P < 0.01) prevented the decrease in body weight in the CEIF and MEIF treated rats. The study was further undertaken to evaluate the antioxidant and antihyperlipidemic potential of CEIF and MEIF in STZ-induced diabetic rats. The increased levels of lipid peroxidation in the liver tissues of diabetic rats were significantly reverted back to normal levels and a significant increase in the activity of antioxidant enzymes such as superoxide dismutase, catalase and the level of reduced glutathione in the liver of diabetic rats after the treatment with CEIF and MEIF was noticed. These results clearly indicate that CEIF and MEIF exhibit significant antihyperglycemic, antihyperlipidemic and in vivo antioxidant activity in STZ-induced diabetic rats and the results were found to be in a dose dependent manner