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RISS 인기검색어
- 검색키워드
- 저자 : Deepak K Dash (검색결과 11 건)
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Deepak K Dash,Siva S Nayak,Soma Samanta,Tirtha Ghosh,Tarun Jha,Bhim C Maiti,Tapan K Maity 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
plant Ichnocarpus frutescens (Linn) R.Br. (Family-Apocynaceae) has been indicated for thethe possible antitumor activity and antioxidant role of Ichnocarpus frutescens in the mice transplanted withEhrlich ascites carcinoma (EAC). The chloroform and methanol extract of whole plant of Ichnocarpus frutescens(CEIF and MEIF) were administered intraperitoneally at the dose of 150 mg/kg and 300 mg/kg, body weight perday for 7 days after 24 h of tumor inoculation in mice. Treatment with CEIF at the dose of 150 mg/kg and300 mg/kg remarkably decreased the tumor volume, packed cell volume, viable cell count and increased thekg. Further the EAC mice treated with CEIF and MEIF showed significant decrease in the level of lipidperoxidation and significant increase in the level of antioxidant enzymes such as glutathione (GSH), superoxidedismutase (SOD) and catalase (CAT), however the decreasing and increasing capacity of CEIF was less in bothdoses as compared to MEIF. Based on these results, it can be concluded that the chloroform and methanol extactof Ichnocarpus frutescens exhibit significant antitumor and antioxidant activity in EAC bearing mice.Key wordsIchnocarpus frutescens, Ehrlich ascites carcinoma, antitumor activity, in vivo antioxidant activity.
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Deepak K Dash,Tirtha Ghosh,Veerendra C Yeligar,K Murugesh,Siva S Nayak,Bhim C Maiti,Tapan K Maity 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.3
The present study was carried out to investigate the antihyperglycemic, antihyperlipidemic and antioxidant effect of chloroform and methanol extract of whole plant of Ichnocarpus frutescens (CEIF and MEIF) in streptozotocin (STZ)-induced diabetic rats. Administration of CEIF and MEIF orally at the dose of 200 mg/kg and 400 mg/kg body weight resulted in significant (P < 0.01) reduction in blood glucose levels. The body weights were significantly (P < 0.001) reduced in STZ-induced diabetic rats when compared to normal rats while the extracts significantly (P < 0.01) prevented the decrease in body weight in the CEIF and MEIF treated rats. The study was further undertaken to evaluate the antioxidant and antihyperlipidemic potential of CEIF and MEIF in STZ-induced diabetic rats. The increased levels of lipid peroxidation in the liver tissues of diabetic rats were significantly reverted back to normal levels and a significant increase in the activity of antioxidant enzymes such as superoxide dismutase, catalase and the level of reduced glutathione in the liver of diabetic rats after the treatment with CEIF and MEIF was noticed. These results clearly indicate that CEIF and MEIF exhibit significant antihyperglycemic, antihyperlipidemic and in vivo antioxidant activity in STZ-induced diabetic rats and the results were found to be in a dose dependent manner
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Dash, Deepak K,Ghosh, Tirtha,Yeligar, Veerendra C,Murugesh, K,Nayak, Siva S,Maiti, Bhim C,Maity, Tapan K Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.3
The present study was carried out to investigate the antihyperglycemic, antihyperlipidemic and antioxidant effect of chloroform and methanol extract of whole plant of Ichnocarpus frutescens (CEIF and MEIF) in streptozotocin (STZ)-induced diabetic rats. Administration of CEIF and MEIF orally at the dose of 200 mg/kg and 400 mg/kg body weight resulted in significant (P<0.01) reduction in blood glucose levels. The body weights were significantly (P<0.001) reduced in STZ-induced diabetic rats when compared to normal rats while the extracts significantly (P<0.01) prevented the decrease in body weight in the CEIF and MEIF treated rats. The study was further undertaken to evaluate the antioxidant and antihyperlipidemic potential of CEIF and MEIF in STZ-induced diabetic rats. The increased levels of lipid peroxidation in the liver tissues of diabetic rats were significantly reverted back to normal levels and a significant increase in activity of antioxidant enzymes such as superoxide dismutase, catalase and the level of reduced glutathione in the liver of diabetic rats after the treatment with CEIF and MEIF was noticed. These results clearly indicate that CEIF and MEIF exhibit significant antihyperglycemic, antihyperlipidemic and in vivo antioxidant activity in STZ-induced diabetic rats and the results were found to be in a dose dependent manner.
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Veerendra C. Yeligar,Murugesh K.,Deepak Dash,Siva S. Nayak,Bhim C. Maiti,Tapan K. Maity 한국생약학회 2006 Natural Product Sciences Vol.12 No.4
antitumor activity of crude saponin mixture obtained from Luffa tuberosa (Roxb.) (Fam;Cucurbitaceae) hairy roots (CSLT) in mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated.elevation in tumor-free survival and a highest number of survivors were observed after administration of CSLT(300 .g/kg), which was considered as an optimum dose for its antineoplastic action. The mean survival time(MST) for this dose was approximately 47.1± 0.74 d, when compared with 19.0± 0.36 d of untreated control.Administration of 30 .g/kg CSLT resulted in 130% long-term increased survival time. The measurement ofbody weight, tumor volume, packed cell volume, viable and non-viable count indicated the efficacy of CSLT intumor-bearing mice, there was a significant recovery in hematological profiles, and there was depletion in lipidnormal levels. The CSLT was found to be devoid of conspicuous short-term toxicity in the mice when animalswere intraperitoneally injected with 250, 500, 750 and 1000 .g/kg bodyweight. The treated mice showedconspicuous toxic symptoms only at a dose of 1500 .g/kg. Mortality of the animals was monitored up to 14 dpost drug treatment, 1/7th of the LD50 dose has been considered for the optimal antineoplastic activity.KeywordsLuffa tuberosa (Roxb.) Ehrlich ascites carcinoma, hematological profiles, antioxidant, antineoplasticactivity
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A study on wound healing activity of Bacopa monnieri Linn. aerial parts
Tirtha Ghosh,Tapan Kumar Maity,Deepak Kumar Dash,Anindya Bose 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.2
Bacopa monnieri is being used in the traditional system of medicine for a variety of ailments. In the present study, the ethanolic extract of Bacopa monnieri aerial parts has been studied for its wound healing activity using various models in rats. Significant increase in wound contraction and skin breaking strength were observed in the excision and incision wound models respectively. There was also significant increase in hydroxyproline content, DNA content, superoxide dismutase activity, catalase activity, glutathione level and decrease in the level of thiobarbituric acid reactive substances in the 12th day post wounding tissue of experimental rats in the ethanol extract treated groups with respect to the control group. The effect of the extract was found to be comparable with the standard drug nitrofurazone. From the results it may be concluded that the plant Bacopa monnieri is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine. Saponins may be responsible for the observed wound healing activity.
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A study on wound healing activity of Bacopa monnieri Linn. aerial parts
Ghosh, Tirtha,Maity, Tapan Kumar,Dash, Deepak Kumar,Boss, Anindya Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.2
Bacopa monnieri is being used in the traditional system of medicine for a variety of ailments. In the present study, the ethanolic extract of Bacopa monnieri aerial parts has been studied for its wound healing activity using various models in rats. Significant increase in wound contraction and skin breaking strength were observed in the excision and incision wound models respectively. There was also significant increase in hydroxyproline content, DNA content, superoxide dismutase activity, catalase activity, glutathione level and decrease in the level of thiobarbituric acid reactive substances in the $12^{th}$ day post wounding tissue of experimental rats in the ethanol extract treated groups with respect to the control group. The effect of the extract was found to be comparable with the standard drug nitrofurazone. From the results it may be concluded that the plant Bacopa monnieri is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine. Saponins may be responsible for the observed wound healing activity.
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Ghosh, Tirtha,Maity, Tapan Kumar,Dash, Deepak Kumar,Bose, Anindya Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.3
The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieri aerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanol-induced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both the fractions were endowed with significant hepatoprotective activity. EAF and NBF were investigated for hepatoprotective activity in albino rats at 300 mg/kg, p.o. dose and compared with standard drug Silymarin (25 mg/kg, p.o.). Results show that both the fractions were effective in blunting ethanol-induced enhanced activities of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, level of serum bilirubin (both total and direct), liver weight loss and was also effective in reducing ethanol-induced lipid peroxidation both in vitro and in vivo. Furthermore, the fractions could also enhance ethanol-induced suppressed activities of superoxide dismutase, catalase and decreased level of reduced glutathione. Results of hepatocellular damage caused by ethanol and its recovery by EAF and NBF, suggest that they might be considered as a potential source of natural hepatoprotective agents, which could be related to the free radical scavenging properties of saponins present in high concentration in the fractions.
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Murugesh, K,Yeligar, Veerendra C,Dash, Deepak Kumar,Maiti, BC,Maity, Tapan K Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.4
The present study was carried out to investigate the antidiabetic and antioxidant effect of methanolic extract of Berberis tinctoria leaves (MEBT), in streptozotocin induced diabetic rats. Oral administration of MEBT extract (150 mg/kg and 300 mg/kg) for a period of 14 days. Blood glucose levels, body weight food and liquid intake were measured on every $5^{th}$ day over a period of 14 days. In diabetic rats, MEBT at the dose of 150 mg/kg and 300 mg/kg body weight resulted in significant reduction in blood glucose levels. The study was further investigated to determine antioxidant and antihyperlipidemic potential of MEBT in streptozotocin (STZ) induced diabetic rats. These results suggest that the MEBT possess antidiabetic activity and is able to ameliorate biochemical damages in STZ induced diabetic rats and the results were found to be in a dose dependent manner.
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Tirtha Ghosh,Tapan Kumar Maity,Deepak Kumar Dash,Anindya Bose 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.3
The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieri aerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanolinduced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both the fractions were endowed with significant hepatoprotective activity. EAF and NBF were investigated for hepatoprotective activity in albino rats at 300 mg/kg, p.o. dose and compared with standard drug Silymarin (25 mg/kg, p.o.). Results show that both the fractions were effective in blunting ethanolinduced enhanced activities of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, level of serum bilirubin (both total and direct), liver weight loss and was also effective in reducing ethanol–induced lipid peroxidation both in vitro and in vivo. Furthermore, the fractions could also enhance ethanol-induced suppressed activities of superoxide dismutase, catalase and decreased level of reduced glutathione. Results of hepatocellular damage caused by ethanol and its recovery by EAF and NBF, suggest that they might be considered as a potential source of natural hepatoprotective agents, which could be related to the free radical scavenging properties of saponins present in high concentration in the fractions.
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Veerendra C. Yeligar,K. Murugesh,Deepak Kumar Dash,Siva Shankar Nayak,B. C. Maiti,Tapan K. Maity 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
unripe whole fruits of Luffa tuberosa (Roxb.) or Momordica tuberosa (Roxb) Cogn.(Cucurbitaceae) were evaluated for the antidiabetic and hyperlipidemic potential in streptozotocin (STZ) induceddiabetic rats. Diabetes was induced by administration of intra-peritoneal injection of streptozotocin at a dose of55 mg/kg body weight. After the induction of diabetes aqueous extract of L.tuberosa (AELT) was administeredorally at doses of 250 and 500 mg/kg. body weight/day for a period of 14 days. The Fasting blood glucose (FBG)levels, serum insulin levels, changes in body weight, food and liquid intake were measured. In diabetic rats, theAELT exhibited significant reduction in blood glucose levels. Biochemical assay of plasma total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc),after the extract supplementation was confirmed by significant reduction in the levels of above mentionedhyperlipidemic indicators. This study focus on the efficacy of L.tuberosa fruits for the management ofexperimental STZ induced diabetic rats and provides the scientific basis of ancient herbal therapy and use of thesefruits as vegetable.KeywordsLuffa tuberosa (Roxb.), streptozotocin, antihyperglycemic activity, antihyperlipidemic activity
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