플라비아닌산을 이용한 클로르프마진의 용매추출 분광광도법

정문모,남수자,이미나,이지연,허문회,안문규 慶星大學校 1998 論文集 Vol.19 No.2

‘말(語)-류’ 성조형의 방언 간 대응 양상과 의의

이문규(Lee, Moon-kyu) 한국어문학회 2015 語文學 Vol.0 No.128

This study examines the correspondence aspects of ‘mal(語)-pattern’ and direction of change of tonal system in the Korean tone dialects. The correspondence aspects of the surface tonal patterns of ‘mal(語)-class’ in middle Korean and several modern tone dialects are may be summarized as follows. [표참조] After considering the aspects, we can realize the fact that there is a tendency for ‘mal(語)-pattern’ to be integrated into ‘mal(斗)-pattern’ or ‘mal(馬)-pattern’ in Korean tonology. The ‘mal(語)-pattern’ [HLLL] of Yukjin dialects is the result of the change ‘[RLLL] >[HLLL]’. And ‘mal(語)- pattern’ [HHLL] of the young generation of Daegu dialect is the the result of the change ‘[RHLL] > [HHLL]’. Both [HLLL] and [HHLL] are ‘mal(斗)- pattern’ in those dialects. On the other hand, [LHLL] of Jinju dialect is ‘mal (馬)-pattern’. At the pitch system level, this integrating phenomenon of ‘mal(語)-class’ is the process in which ‘rising’ or ‘lowest’ pitch extinct because of their articulatory difficulties. And at complexity class of tonal system, this phenomenon implicate that three-tonal patterns system of Korean tonal dialects changes to two-tonal patterns systems, and ultimately these dialects are changing to non-tone language.

국어 성조 체계의 ‘말(馬)’-형 선호 경향과 그 의의

이문규(Lee, Moon-Kyu) 한국어문학회 2018 語文學 Vol.0 No.141

Among several tone patterns in the Korean tone system, there is a tendency for the ‘mal(馬)’-pattern to have the strongest preference. This is based on the following several tonal phenomena: 1) All three replacements of tonal patterns that are common in the middle Korean and the modern Korean tone dialects aim the ‘mal(馬)’-pattern. And these replacements have been expanded with time. 2) The ‘mal(馬)’-pattern is the common tonal pattern of all the symbolic words in both the middle Korean and the modern Korean tone dialects. 3) The ‘mal(馬)’-pattern shows a significantly higher share in the tonal patterns of Sino-Korean family names than in the sound of Chinese characters used for other words. 4) The ratio of the ‘mal(馬)’-pattern has diachronically increased in the tonal patterns of Sino-Korean words. It is reasonable to assume that the preference for the ‘mal(馬)’-pattern should go back to the period when the pattern was with the initial-low-tone since it is phonetically the most unmarked tonal pattern. Furthermore, it can also be assumed that the tone systems of the middle Korean and the Hamgyeong-dialect group with the ‘mal(馬)’-pattern in the initial-low-tone, are the closest to the proto-Korean tone system.

성조형 실현 규칙의 임의화와 16세기 말엽의 성조 체계

이문규(Lee, Moon-Kyu) 한국어문학회 2017 語文學 Vol.0 No.137

The Incapacitation of the actualization rules of the tonal pattern (TP) reveals the remarkable changes since the “side-dot” began to be used in the documents in the history of Korean tonal system. It is noted that no other significant changes occurred in the level of morphemic TP or combination of TP in the same period. The actualization rules of TP consists of the “pitch-assignment rules” and the “pitch-adjustment rules.” These actualization rules in Korean were gradually incapacitated toward the end of the sixteenth century. During the mid-fifteenth century, the surface TP of a phonological word was aligned with the actualization rules of TP. However, it brought the changes at the end of sixteenth century, affected by the incapacitation of the pitch-assignment rules and the pitch-adjustment rules. The incapacitation of the actualization rules of TP has blurred the distinction between tonal patterns and pitches. Additionally, this phenomenon is interpreted to cause the dephonologizing of Korean tones. In conclusion, the incapacitation of the actualization rules of TP shows that the second stage of tonological changes of Korean language had already appeared in the end of the sixteenth century. It seems reasonable to argue that the tonal system in the sixteenth century should be distinct from that of the mid-fifteenth century. Until the sixteenth century the incapacitation of the actualization has been complete, as the source materials maintain the morphemic TP system and the first stage of tonological pattern in the fifteenth century.

방사선 측정 및 해석 연구 : Assessment of Defected Feul by Analysis of Reactor Coolant Activities 원자로 냉각수중의 방사능해석에 의한 결합핵연료봉의 평가

이호연,오헌진,전재식,오희필,양재춘,정문규,박해용 대한방사선 방어학회 1986 방사선방어학회지 Vol.11 No.2

중성자와 우라늄의 핵반응에 의해 생성된 핵분열생성물의 물리적 특성을 이용하여 원자로 내의 핵연료 상태를 해석하는 모델을 개선하였다. 이 모델에서는 고체 핵연료 내에서 특정핵종의 핵분열 생성물의 생성과 이것이 원자로 냉각재까지 방출되는 과정을 계산하고 추적하며 방사능농도와 결합핵연료봉의 수를 관계짓는 방정식의 계수들을 결정한다. 핵분열생성물의 거동은 이탈(knock out)과 이동(migration) 두 부분으로 나누어 해석하였으며 트램프 우라늄의 영향을 분리할 수 있도록 하였다. 실측자료로는 가압 경수형 원자로인 고리 원자력발전소 1호기의 1차 냉각제를 분석해서 얻은 I-131과 I-133의 방사능 강도를 이용하였다. 이 실험자료와 위 방정식에서 구한 방사능 강도로부터 구한 결함 핵연료의 수는 제3주기에서 9.34±1.13개 제6주기에서 0.294±0.092개로 나타났다. An improved method of assessing fuel status by analysis of the fission product in the reactor coolant system is proposed. The release mechanism of specific fission products is established for determination of the coefficients in the equations which relate the radioactivities with the amount of defected fuel. Knock-out and migration models are employed in the formulation of the release mechanism. The influence of the tramp uranium is quantified. Sample calculations were made for KNU 1 reactor system using the I-131 and I-133 concentrations in the primary coolant. The estimated number of defected fuel pins in the third and sixth cycles appeared to be 9.34±1.13 and 0.294±0.092, respectively.

自動倉庫 시스템에서의 物品拂出을 위한 알고리즘

李文圭,白源章 啓明大學校 産業技術硏究所 1986 産業技術硏究所 論文報告集 Vol.8 No.-

This paper deals with an order picking problem in automated warehousing systems wher given orders are grouped to be picked such that the total distance travelled by the order picking vehicle is minimized. For the problem, several algorithms based on cluster analysis are presented, and computer programs are developed to illustrate the efficiency and validity of the algorithms. Through simulations, the algorithms are compared with those of other studies. The results of our experiments are shown to be substantially better than those of the previous studies in terms of the distance travelled.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

밀도순위지수에 의한 할당규칙의 성능평가에 관한 연구

李文圭 啓明大學校 産業技術硏究所 1990 産業技術硏究所 論文報告集 Vol.13 No.1

물품의 입출고가 수작업으로 이루어지는 종래의 자동창고에 있어서 물품의 밀도순위지수(DOI)는 저장장소할당을 위한 하나의 기준이 된다. 그러나 그러한 밀도순위지수에 의한 할당규칙은 물품의 입고와 출고가 동시에 이루어지는 dual-command의 경우에는 최적해를 제공하지 못한다. 본 연구에서는 이 규칙의 성능을 평가하기 위하여 컴퓨터 시뮬레이션을 이용하여 기존의 할당규칙들과의 성능 차이를 비교하였다. 또한, 물품에게 할당될 저장공간의 순서를 나타내는 곡선이 저장성과에 미치는 영향을 분석하였다. The density-order index is one criterion for assigning inventory items to storage locations within a manually-operated warehouse. However, the optimality of the storage assignment rule based on the density-order index is not garanteed in cases where storages and retrievals of items are to be carried out under dual command. Though computer simulation this paper examines the performance of the rule by comparing it with those of other rules such as that based on either cube-per-order index, item space requirement, or popularity. The effects of space filling curves on storage assignment are also addressed.

안면부 종창을 동반한 Henoch-Scho¨nlein 자반증 1례

이재휘,서무규,임문환,박성기,김태우,이창연 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

We experienced a case of Henoch-Scho‥nlein purpura with are manifestation of facial swelling in a 7-year-old boy.