상행결장의 거대지방종으로 인한 대장중첩증 1예 : Case Report

백무준,김태윤,김성용,이문수,김창호,조무식 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Colonic lipoma is rare and mostly asymptomatic lesions; but as they become larger they may produce abdominal pain, constipation, diarrhea, hemorrhage, and intussusception. We report the case of a 61-year-old male who sufferd from nonspectific recurrent abdominal pain in the right upper and lower quadrants. Abdominal computed tomography (CT) revealed a constipating colonic tumor. The patient underwent an operative resection with primary anastomosis. His postoperative course was unremarkable, and he was discharged to home on postoperative day 11. Surgical pathologic examination comfirmed a large lipoma.

尖端科學技術을 應用한 反芻胃 醱酵調節

張文伯 中央大學校 遺傳工學硏究所 1990 遺傳工學硏究論集 Vol.3 No.1

At the year of 2000, GNP per capita year will exceed 5,000 dollar and a rapid increasas of animal product consumption will give rise to increase importation of feed grains which are heavily dependent upon from foreign supply. It is strongly suggested that maximum utilization of our own domestic feed resources and development of our own scientific technique on livestock management patterns are important. In this review paper, the various criteria for possible establishment of recombinant deoxyribonucleic acid systems in ruminal bacteria outlined and application for rumen additives to control to metabolism are discussed. Finally, application for Rusitec and/or computer modelling to manipulate feeding systems are suggested. Recombinant DNA technology offer a new approach to the study and eventual genetic manipulation of rumen becteria to modify the rate and extend of nutrient digestion within the rumen by controlled degradation of feedstuffs, regulation of specific fermentation products, control of specific bacterial species and stimulation of specific nutrient synthesis, but significant obstacles exist with this approach. Genetic systems of ruminal and of anaerobic bacteria of the mammalian gastrointestinal tract, in general, have not been studied and are largely unknown. Up to the present, the first and most successful antibiotic used as a feed additive for ruminant livestock belongs to a group of antibacterials termed ionophores. It is clear that there is a role for non-clinical antibiotics as feed additives for growth promotion and/or improvement in feed conversion efficiency in growing/fattening ruminants. Future research may yet show that antibiotics have a significant role to play in milk production. The most important features of Rusitec are the ability to maintain a steady fermentation pattern that is very similiar to the pattern observed in the rumen of the donor animals and expensive feed trials could be reduced. Quantitative or mathematical models for its data by computer simulation(modelling) are composed of equation representing the effcient feeding system of ruminants.

우리나라 일별 강수발생의 확률과 주기성의 특성

문승의,김백조,하창환 한국환경과학회 1997 한국환경과학회지 Vol.6 No.2

The characteristics on the transtion probabilities and periodicity for the daily precipitation occurrence in Korean peninsula are investigated by applying the Markov chain properties to daily precipitation occurrence. In order to examine the responses of Markov Chain properties to the applied period and their magnitudes, three cases (Case A: 1956∼1985 at 14 stations, Case B: 1965∼1994 at 14 stations, and Case C: 1985∼1994 at 63 stations) are considered in this study. The transition probabilities from wet day to wet day for all cases are about 0.50 and in summer, especially July, are higher. In addition, considering them in each station we can find that they are the highest at Ullung-do and lowest at Inchon for all cases. The annual equilibrium probabilities of a wet day appear 0.31 in Case A, 0.30 Case B, and 0.29 Case C, respectively. This may explain that as the data-period used becomes shorter, the higher the equilibrium probability is. The seasonal distributions of equilibrium probabilities are appeared the lowest(0.23∼0.28) in winter and the highest(more than 0.39) in spring and monthly in July and in October, repectively. The annual mean wet duration for all cases is 2.04 days in Case A, 1.99 Case B, and 1.89 Case C, repectively. The weather cycle obtained from the annual mean wet and dry duration is 6.54∼6.59 days, which are closely associated with the movement of synoptic systems. And the statistical tests show that the transitions of daily precipitation occurrence for all cases may have two-state first Markov chain property, being the stationarity in time and heterogeneity in space.

蛋白質 分解率과 에너지 水準이 反芻胃微生物 成長과 암모니아 態窒泰및 pH변화에 미치는 영향

張文伯 건국대학교 1988 論文集 Vol.26 No.1

This experiments were conducted to measure the rumen microbial growth, ammonia-N concentration and pH changes in the incubation media added with casein having different degradabilities(90.0, 76.5, 63.0, 49.5 and 36.0% )and different energy levels (low, medium and high). Casein treated with heat to reduce degradability and soluble carbohydrate was used as an energy source. The results obtained were as follows ; 1. Ammonia-N concentrations in the incubation media were average value of 1.98, 2.38 and 0.82mg/100ml, respectively in l7w, medium and high energy levels and the lowest value in the high energy level. 2. pH of the incubation media were average value of 6.27, 6.05 and 5.60 in the low, medium and high energy levels, respectively and the lowest pH were obtained in the highest energy level In the incubation mediums. However, casein degradability was not affected pH value. 3. Microbial cell density in the incubation media increased as increasing energy level and as increasing casein degradability.

사람 혈청 Vitronectin의 정제 및 항 Vitronectin 다클론 항체의 생산

장윤혜,김백남,이성순,문경,김승후,이재담 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

Background: Vitronectin is one of major cell- adhesive glycoprotein in mammalian serum and plasma ; the other is fibronectin. It is a mixture of 65 and 75kDa protein in plasma which promotes spreading of a variety of cultured cells ,inhibits the cytotoxicity of membrane attacks complex C5b-7 and modulates thrombin-antithrombin III activity. Human plasma and serum contain 10-40mg of vitronectin per 100ml,but only a few mg or less of vitronectin can be isolated with a 0.5-20% recovery efficiency through very long processes or with expensive,commercially available monoclonal antibody. In this study, we purified the vitronectin from human plasma and produced anti-vitronectin polyclonal antibody using purified vitronectin. Methods: Vitronectin was purified from the human plasma by heparin-sepharose column and its efficacy was measured by cell spreading assay. Anti-vitronectin polyclonal antibody produced and confirmed by ELISA and immunoblotting. Results: This procedures produced about 0.8mg vitronectin from 100ml human plasma within 2 days. 1) Purified vitronectin promoted spreading of HepG2 hepatoma cells on substrates with a half maximal activity at 0.lug/ml. 2) In SDS-PAGE analysis of purified protein, 2 bands were found and their molecular weights were 75kDa and 65kDa,respectively. 3) The immunoblotting assay showed that the bands of molecular were same site as SDSPAGE analysis. Conclusion: Simple,rapid purified vitronectin by heparin-sepharose column and anti-vitronectin antibody may facilitate the elucidation of vitronectin function and action mechanism in human body.

국내 Epstein-Barr 바이러스 일차감염의 임상적 특성

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2007 감염과 화학요법 Vol.39 No.6

In this study, the clinical features of 264 patients of primary Epstein-Barr virus (EBV) infection between the years of 2002-2006 were evaluated retrospectively. The median age of the patients was 6 years old (0-69), and the hospitalization rate was 78.0%. Fever (83.3%) and sore throat (50.4%) were the most common symptoms. Cervical lymphadenopathy (71.2%), tonsillitis (51.1%), splenomegaly (26.1 %), hepatomegaly (25.8%), rash (10.2%) and jaundice (1.5%) were observed. Cervical lymphadenopathy was less frequent in older age groups. The annual number of primary EBV infections according to the age group during the study period did not change significantly in this study.

조기위암 천공 1예

이문수,김태윤,김성용,백무준,김창호,조무식 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

An exceedingly rare case of perforated early gastric cancer is reported. A 68-year-old man developed a peritonitis due to perforation of early gastric cancer. Emergency radical operation was performed and followed by uneventful recovery. The histologic examination of the surgical specimen showed early gastric cancer of typeⅢ, composed signet ring cell carcinoma. 5 years of surgery, the patients survived with no evidence of tumor recurrence. The rarity of this complication in early gastric cancer is discussed and the literature reviewed.

총 경정맥 영양 요법(TPN)중에 발생한 Wernicke-Korsakoff syndrome 1 예

이문수,김태윤,김성용,백무준,김창호,조무식 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Total parenteral nutrition is commonly known as a safe and convenient method of nutritional supplemantation for malnourished patients. Several metabolic complications have been adquately studied and reported their diagnosis and management. There was, however, no precisional data and studies of vitamin B1 deficiecy induced Wernicke's encephalopathy. And Wernicke's encephalopathy may be difficult to recognize, expecially if it is in the early stage and if all manifestation s are not yet present, and because a patients with Wernicke's encephalopathy may become comatose and die if the disorder is not diagnosed and vitamin B1 not given promptly. Therefore Wernicke's encephalopathy is emergent. We report a case of Wernicke-Korsakoff encephalopathy that was caused by vitamin B1 deficiency

쯔쯔가무시병에서 가피의 위치와 복장과의 관계

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 쯔쯔가무시병의 예방을 위하여 위험지역에서 긴소매 윗옷을 입고 바지 끝을 양말 속에 넣는 것이 권장되고 있다. 이러한 예방조치의 효용성을 알아보기 위하여 우리는 쯔쯔가무시병에서 가피의 위치와 신발과 복장과의 관계를 살펴보았다. 재료 및 방법 : 2005년 10-12월 사이 6개 병원에서 전형적인 임상양상, 가피의 존재, 혈청검사 결과로 쯔쯔가무시병이 의심되거나 확진된 159명의 성인을 대상으로 가피의 위치, 추정 감염일, 야외활동, 당시 착용한 신발과 복장 등 을 조사하였다. 결과 : 혈청검사는 5명에서 시행되지 않았고 99명이 양성이었으며, 가피는 142명에서 발견되었다. 몸의 두 군데에서 발견된 6명을 제외한 136명 중 82명(60.3%)에서 가피는 하반신(아랫배, 엉덩이, 서혜부, 생식기, 넓적다리, 종아리)에 있었다. 감염일이 추정가능하고 가피가 1개만 있는 44명을 대상으로 하였을 때, 가피가 하반신에서 발견된 17명에서 슬리퍼를 신거나 맨발인 경우는 5명이었으나 상반신에 있는 27명 중에는 아무도 없었다(P=0.006). 바지아랫단을 양말 속에 집어 넣은 4명 중 1명은 하반신에서 3명은 상반신에서 가피가 발견되었다. 42명이 긴 소매 윗옷을 입었는데, 이중 16명은 하반신에서 26명은 상반신에서 가피가 발견되었다(P=1.00). 결론 : 쯔쯔가무시병 환자에서 신발을 신지 않거나 발이 잘 보호되지 않았을 때 가피는 하반신에 더 잘 생겼다. 바지 아랫단의 처리방법이나 긴 소매 윗옷의 착용은 가피의 위치와 통계적으로 유의한 연관관계는 발견되지는 않았다. 그러나 표본수가 적고 유충의 침범경로에 영향을 줄수 있는 다른 요인이 있기 때문에 가피의 위치와 연관관계가 없다고 이 연구에서 단정할 수는 없다. 따라서 쯔쯔가무시병의 예방을 위한 실용적인 권고를 위해서는 더 많은 연구가 필요하다. Background:Wearing a long-sleeved shirt and tucking the pants legs into the socks is recommended to prevent scrub typhus. This study investigated associations between the location of eschar and the type of clothes and shoes to evaluate the efficacy of these protective measures. Materials and Methods:One-hundred and fifty nine patients in whom scrub typhus was confirmed or suspected based on the typical clinical manifestations, presence of eschar, or positive results of serologic tests at 6 Korean hospitals from October to December 2005 were included in this study. We collected the information on the location of eschar, presumed exposure date to chiggers, and the clothes and shoes which they had worn. Results:Serologic tests were positive in 99 patients. Eschars were observed in 142 patients and 6 of them exhibited more than 2 eschars. Eighty-two (60.3%) of 136 patients with a single eschar had an eschar on the lower half of the body. Of the 44 patients whose exposure date could be estimated, and who had only a single eschar, 5 of the 17 patients with eschars in the lower half of their bodies, and none of the 27 patients with eschars in the upper half of their bodies went barefoot or wore open footware (P=0.006). Only 4 patients tucked the pants into their socks, and an eschar was found in the lower half in one patient, and in the upper half of the body in the other 3 patients. Of 42 patients who wore long-sleeved shirts, eschars were found in their lower bodies in 16, and on their upper bodies in 26 (P=1.00). Conclusion:When the feet were not protected properly with shoes, eschars were found more frequently on the lower half of the body than on the upper half. Wearing a long-sleeved shirt or tucking the pants legs into the socks was not found to be significantly correlated to the location of eschars. Further studies involving larger samples are necessary for the development of practical guidelines of protective measures to prevent scrub typhus.

위암으로 오인된 악성 흑색종 수술 1 예 : A case report

이문수,김태윤,김성용,백무준,김창호,조무식 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The malignant melanoma matastatic to the stomach is a rare tumor. Its treatment is controversial and median survival after diagnosis is usually <1year. Here a case of malignant melanoma metastatic to the stomach is reported in a 77 years old woman who presented with epigastric discomfort for three months, and was diagnosed as ademocarcinoma at preoperation. The patient was performed subtotal gastrectomy, gastroduodenostomy, omentectomy, and was discharged with no complication on the twenty-one posoperation day. We report a case of malignant melanoma metastatic to the stomach with a review of the literature.