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Mediation effect of herpes zoster derived by statin use on cardiovascular disease risk
Sung-Han Kim,Sung-Cheol Yun,Young-Ho Khang,Min-Chul Kim,Sun Uck Kwon,Gyung-Min Park,Young-Rak Cho,Kwang Min Lee,Moo Hyun Kim 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.5
Background/Aims: Although statins are widely used to reduce the risk of cardiovascular disease (CVD) including stroke and myocardial infarction (MI), it is reported that statin use increases the incidence of herpes zoster (HZ) that is associated with increased risk of CVD. So, we evaluated the mediation effect of HZ caused by statin use on CVD. Methods: We analyzed a prospective cohort from the National Health Insurance Service-database of South Korea. All individuals received a medical check-up and were followed-up from 2002 to 2013. Results: A total of 275,382 individuals > 40 years old were followed up for 11 years from 2003. Of these, 11,415 people (4%) were classified as statin users and 263,967 (96%) as non-statin users. Those who used statins had significantly lower risks of cardiovascular events, stroke, and MI compared with non-statin users; the adjusted hazard ratios in the multivariate analysis were 0.90 (95% confidence interval [CI], 0.82 to 0.98), 0.88 (95% CI, 0.80 to 0.98), and 0.91 (95% CI, 0.79 to 1.07), respectively. When we calculated the mediating effect of cardiovascular events by statin use through HZ, 11.6% of the total beneficial effect of cardiovascular events by statin use was mitigated through the occurrence of HZ caused by statin use. This mediating effect was higher in the younger age group (< 60 years). Conclusions: This study showed that statin use reduced CVD by 10%, but the protective effect of statin use against CVD was mitigated by approximately 10% through the development of HZ caused by statin use.
Human Basophils Express CD22 without Expression of CD19
Han, Kyung-ja,Kim, Yong-Goo,Lee, Je-Hoon,Lim, Ji-Hyang,Lee, Kyo-Young,Kang, Chang-Suk,Kim, Won-Il,Kim, Byung-Kee,Shim, Sang-In,Kim, Sun-Moo 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Background : Even modern automatic cell counters can not count basophils precisely. Therefore, we need a rapid, accurate, precise and easy method to count basophils. Method : Using flow cytometry, basophils(CD22+/CD19-) and B cells(CD22+/CD19+) were counted. Within a large lymphocyte light scatter gate, %basophils(G%baso) and %B cells(G%B) were determined from the total count. Another method of analysis was to make two regions(R1 for basophils and R2 for B cells) and to determine in those %basophils(R1%baso) and %B cells(R2%B) without gating. The flow cytometric basophil counts of the blood of 21 normal controls and 43 CML patients were compared with manual basophil count(Ma%baso) and basophil count by Coulter STKS(Auto%baso). CD22+/CD19- cells were sorted by a FACSCalibur. Results : The G%baso of all sample was 4.66˚æ5.35% and R1%baso was 4.23˚æ4.88%, and they were well correlated(r=0.996, P<0.001). The G%B of all samples was 1.55˚æ1.68% and R2%B was 1.59˚æ1.67%, and they were well correlated too(r=0.993, P<0.001). Their correlation was better in normal control than in CML. G%baso was well correlated to Ma%baso(r=0.827) and Auto%baso(r=0.806), and R1%baso was well correlated to Ma%baso(r=0.831) but showed poor correlation to Auto%baso(r=0.734). Auto%baso revealed poorest correlation to Ma%baso(r=0.692). The sorted CD22+/CD19- cells were all basophils(99.480.30%) and they revealed CD13, CD33, dim CD45 expression, whereas CD3, CD14, CD16, HLA-DR were not detected on them. Conclusions : We discovered a specific marker combination to identify basophils(CD22+/CD19-) and suggest that flow cytometric analysis using these markers is an easy, reliable and accurate method of basophil counting. (Cytometry 37:178-183, 1999)
Han Moo-Jae,Yang Seung-Woo,Shin Yo-Han,Bae Sang-Il,Moon Young-Min,Jeon Wan,Yu To-Sol,Kang Jin-Kyu,Kim Jin-Young,Heo Seung-Uk,박성광,나정은,Chung Jin Beom 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.11
During radiotherapy, some patients owing to the variability in skin sensitivities, may experience adverse skin reactions for doses at which other patients are asymptomatic. Hence, when abnormal symptoms appear on a patient's skin, the etiology should be verified. Accordingly, a surface dosimeter on the skin can help ascertain whether accurate doses are irradiated. Furthermore, surface doses are measured in the field junction gaps during craniospinal irradiation or during large-area radiotherapy to avoid adverse reactions due to cumulative skin doses from multiple beams. However, the point dose measurement errors of surface dosimeters exceed approximately 10% and have low-positional accuracies because the attachment sites are approximated with the help of the naked eye. Moreover, accurate information on field junction gaps cannot be obtained. Therefore, in clinical practice, a flexible array dosimeter is required as it can measure the dose distribution on the body surface by adapting its shape to the body curvatures. In this study, we implemented a flexible array dosimeter and, based on its constituent materials, evaluated the attenuation rate associated with its use. A polyester (PET) film was used as the underlying substrate. HgI2 and PbI2 photoconductors were used for their good performances in films. Furthermore, the measurement accuracy was verified through comparisons with Monte Carlo simulation outcomes. The resulting PET film had an attenuation rate of 2.22% at a 50-μm thickness. At the minimum material thickness of 25 μm, the attenuation rates for HgI2 and PbI2 were 4.69% and 5.72%, respectively. Further research is needed to fabricate HgI2-based digital skin dosimeters with a thickness under 25 μm. Radiation detection and pixel resolution should be evaluated to accurately confirm the field junction gap.
CORTICOSPINAL TRACT PROJECTION TO THE LUMBAR SPINAL CORD THROUGH VENTRAL FUNICULI IN THE RAT
Han, Hong-Jun,Cha, Sang-Hoon,Kim, Jong-Hwan,Shim, Dae-Moo,kim, Sang-Soo,Kwon, Soon-Koo 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1
쥐의 요추에서 피질 척수로의 투사와 척수내에서의 분포를 Kidney Bean lectin-Phaseolus vulgbaris leucoagglutinin (PHA-L) 의 전행성 운반을 이용하여 연구 하였다. 이 연구를 통하여 발견한 새로운 사실은 적은 수의 피질척수로가 양측의 배측 방삭을 통하여 요척수까지 투사되며, 또한 얼마간의 피질척수로는 동측의 복삭을통하여 요척수에 도달하며 전측회색질의 대형 신경세포에 종착하는 것으로 본다. 또한 배측의 회색질에서는 피질척수로의 신경사가 주로 Rexed laminaeⅢ에서 Ⅵ사이에 분포하고 있음 발견하였다. 대부분의 피질척수로는 반대측의 후주를 통하여 하강하여 Rexed laminae Ⅲ-Ⅵ에 투사하는 것으로 알려져 있으나, 이 연구를 통하여 요척수까지 투사되며, 또한 일부는 동측의 복삭을 통해 요척수에 도달하여, 전측 회색질의 대형 신경세포에 종착하는것을 알수 있었다. 일부의 신경사는 척수회색질의 Eexed lamina Ⅰ, Ⅱ, Ⅹ과 중간내에도 분포함을 보였다. In the rat lumbar spinal cord, the pathways and distribution of CST(corticospinal tract) axons were investigated using anterograde transport of PHA-L(kidney bean lectin-Phaseolus vulgaris leucoagglutinin). New findings of this study are: (1) that a small number of CST axons projected to lumbosacral spinal cord bilaterally in the dorsolateral funiculi, and (2) that a few labeled axons traveled through the ipsilateral ventral funiculus of the lumbar spinal cord and appeared to terminate on the large ventral horn neurons. In the gray matter, axons of CSTs were mainly distributed in Rexed laminae Ⅲ through Ⅵ of the dorsal horn. Some of the CST axons are also found in laminae Ⅰ, Ⅱ, Ⅹ, and the intermediate zone.
Implementation of a Reactive Semantics for an Industrial Manipulator using OPRoS
Sang-Hoon Ji,Jae-Sung Han,Eun-Cheol Shin,Sang-Moo Lee,Byung-Wook Choi 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
A Robot in factories has to execute its mission robustly in coarse environments and handle many types of events in dynamic real world. The former is related to dependability or real-time characteristics and the latter is related to reactivity or feasibility. But it is very difficult to prepare robot SW with reactivity and dependability at the same time for the industrial manipulators because general SW with feasibility fails to meet real-time requirements. Therefore, we suggest a method how to make industrial robot software have reactive semantics. For this aim, we use OPRoS (Open software Platform for Robotic Services) and application centric language interpreter. In this framework, state machine component connected abstracted sensor model components invoke signal to an interpreter component in order handle various external operation conditions. And the interpreter determines which robot behaviors will executed for the signals and make suitable robot behavior components work. Finally, we implement our robot software on mulit-core system in order to meet real-time needs including low-latency and strict period time.
Han Sang Park,Jeong-Moo Lee,Kwangpyo Hong,Eui Soo Han,Suk Kyun Hong,YoungRok Choi,Nam-Joon Yi,Kwang-Woong Lee,Kyung-Suk Suh 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.3
Backgrounds/Aims: From June of 2016, the Model for End-Stage Liver Disease (MELD)-based allocation system replaced the Child- Turcotte-Pugh (CTP) score-based system for organ allocation liver in Korea. The aim of this study was to analyze changes in outcomes and arising issues before and after the implementation of the MELD system. Methods: From June 2014 to June 2018, 129 patients were selected from recipients who underwent deceased donor liver transplantation (DDLT) in Seoul National University Hospital. Pediatric cases were excluded. According to the allocation system, patients were divided into two groups (52 in the MELD group and 77 in the CTP group). Results: MELD scores of the two groups differed significantly (37.8 ± 2.0 in the MELD group vs. 31.0 ± 8.2 in the CTP group; p = 0.001). The etiology of patients was changed for liver transplantation. The proportion of alcoholic liver cirrhosis increased in the era of the MELD allocation system. However, proportions of hepatitis B related liver cirrhosis and hepatocellular carcinoma were decreased. Six-month mortality rate of the MELD group was 25.0%, which was higher than that (11.7%) of the CTP group (p = 0.022). The 90-day complication rate was significantly higher in the MELD group than in the CTP group (11.5% vs. 2.6%; p = 0.040). Conclusions: When the MELD allocation system was used to distribute livers to severely ill patients, it resulted in poorer outcomes after surgery and higher proportion of alcoholic cirrhosis. Thus, it is necessary to adjust the MELD allocation system so that outcomes after DDLT could be improved.
Han, Ho Jae,Park, Soo Hyun,Park, Kwon Moo,Yoon, Byung Cheol,Kim, Tae Sung,Lee, Jang Hern 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
The protective effective of caffeic acid (CA) against oxidative stress-induced inhibition of proximal tubule apical transporter was investigated. In the present study, 10^-4 M H_2O_2 did not affect cell viability regardless of incubation time. However, it decreased apical transporters' activity such as Na^+/H^+ antiporter in the proximal tubule cells. CA(>10^-6 M) prevented H_2O_2-induced inhibition of apical transporters. Thus, we investigated its action mechanism. CA also prevented H_2O_2-induced lipid peroxides formation, arachidonic acid (AA) release, and Ca^2+ uptake. In conclusion, CA, in part, prevented H_2O_2-induced inhibition of apical transporter activity via decrease of AA release and Ca^2+ uptake in primary cultured renal proximal tubule cells.