http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정상 면역 환자에서 천공과 출혈을 동반한 거대세포바이러스 대장염
김선욱,차윤진,김민환,진무년,이중희,박혜정,장수연,이혁 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2
Cytomegalovirus (CMV) infection in immunocompromised patients is associated with significant morbidity, mortality, and adverse clinical outcome. However, CMV infection in immunocompetent patients has been considered to have subclinical and self-limited course, and does not require treatment. We reports a case of CMV colitis, presented with colon perforation and lower gastrointestinal bleeding in a immunocompetent 31-year-old young male. After conservative treatment, colonoscopy revealed multiple ulcers in transverse colon. CMV colitis was confirmed by microscopic findings and immunohistochemistry. After successful treatment with ganciclovir, the patient improved without invasive procedure.
EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예
김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.
Jin, Moo-Nyun,Kim, Sun Wook,Kim, Young Ju,Kim, Hyun Ju,Lee, Jung-Hee,Hong, Myeong-Ki,Chang, Byung-Chul Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
With the aging population, more patients who have undergone previous coronary artery bypass grafting (CABG) are surviving long enough to require subsequent aortic valve replacement (AVR). Conventional redo AVR after prior CABG involves resternotomy, dissection and clamping of the patent bypass graft vessel. Favorable results have been reported for AVR following previous CABG; however, the problems of this procedure includes that injury to the patent bypass grafts can result in catastrophic complications. Increasing patient age and comorbidities may increase operative mortality, less invasive percutaneous aortic valve intervention has advanced. However, because there are no sufficient data comparing transcatheter aortic valve intervention with surgical AVR, currently, the surgical approach should still be consider as the standard of treatment for AVR following previous CABG. We report a patient in whom successful conventional AVR was underwent after previous CABG with patent left internal mammary artery.
( Moo Nyun Jin ),( Jae Sun Uhm ),( Hui Nam Pak ),( Moon Hyoung Lee ),( Bo Young Joung ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Subsequent development of atrial fibrillation (AF) is common after radiofrequency catheter ablation of typical atrial flutter (AFL); however, the risk factors of AF after successful AFL ablation have yet to be clearly established. This study investigates the prevalence of and risk factors for AF after successful AFL ablation. Methods: A total of 293 consecutive patients (236 men, mean age 56±14 years) without valvular heart disease who underwent radiofrequency catheter ablation of typical AFL were enrolled in the study. Results: AF was observed in 136 (46%) before ablation. During a follow-up of 40±37 months (1-199 months) 103 (35%) patients had AF after ablation including 37 (13%) newly diagnosed with AF. The patients with postablation AF had higher proportion of male sex (87% vs. 77%, p=0.003), had a larger LA diameter (43±6 vs. 41±6, p=0.03), and had AF before AFL ablation (65% vs. 36%, p<0.001) more frequently than those without postablation AF. In multivariate logistic regression analysis, male sex (OR 2.45, 95% CI 1.02-5.89, p=0.045) and AF before AFL ablation (OR 3.62, 95% CI 2.03-6.46, p<0.001) were significantly associated with the development of AF after AFL ablation. Conclusions: Patients with typical AFL undergoing successful ablation remain at an elevated risk for AF occurrence. Hypertrophic cardiomyopathy, AF before AFL ablation and male sex were independent risk factors of AF development after AFL ablation.
( Moo Nyun Jin ),( Myeong Ki Hong ),( Sang Hoon Shin ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
As the population ages, the number of patients who have undergone previous coronary artery bypass grafting (CABG) requiring subsequent aortic valve replacement (AVR) will be increased. However, redo AVR after prior CABG is associated with a higher mortality than AVR as a primary procedure. Redo AVR in patients with patent internal mammary artery (IMA) graft remains a challenge in terms of the critical IMA dissection and myocardial protection. Conventional strategy involves resternotomy, dissection and temporary occlusion of the IMA with subsequent aortic cross clamping to prevent cardioplegia wash out. The problems with this procedure include injury to the IMA graft can result in catastrophic complications. We describe the case of a patient in whom successful conventional AVR was underwent 34 months after previous CABG with patent left internal mammary artery (LIMA) on left anterior descending artery (LAD).
졸겔 법으로 제조한 압전 센서용 PZT 박막의 결정 배향 및 전기적 특성 연구
변진무 ( Jin Moo Byun ),이호년 ( Ho Nyun Lee ),이홍기 ( Hong Kee Lee ),이성의 ( Seong Eui Lee ),이희철 ( Hee Chul Lee ) 한국센서학회 2010 센서학회지 Vol.19 No.3
This study examined the dependency of crystalline orientation and electric properties of sol-gel PZT film on hydrolysis, a PbTiO3 seed layer and a concentration of sol-gel solution. The PZT thin films were prepared by using 2-Methoxyethanol-based sol-gel method and spin-coating on Pt/Ti/SiO2/Si substrates. The 1-μm-thick PZT films were coated and then fired in a furnace by direct insert method. The highly (111) oriented PZT film of pure perovskite structure could be obtained. We could control the degree of orientation by various parameters such as hydrolysis, a PbTiO3 seed layer and a concentration of sol-gel solution. The highest measured remanent polarization, dielectric constant and piezoelectric coefficient are 24.16μC/cm2, 2808, and 159 pC/N, respectively.
Esophageal Involvement of Pemphigus Vulgaris Associated with Upper Gastrointestinal Bleeding
Sooyun Chang,박수정,Sun Wook Kim,Moo-Nyun Jin,Jung-Hee Lee,Hyun Ju Kim,홍성필,김태일 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.5
Esophageal involvement of pemphigus vulgaris is rare, and when present, the most common presenting symptoms reported in the medical literature are odynophagia and dysphagia. Here, we present two cases of pemphigus vulgaris presenting with upper gastrointestinal hemorrhage because of esophageal involvement of the disease. In case 1, a 41-year-old female patient with a prior diagnosis of pemphigus vulgaris presented with hematemesis. Esophagogastroduodenoscopy showed diffuse mucosal exfoliation and oozing bleeding of the oropharynx and esophagus. The patient recovered after the administration of high-dose corticosteroids and immunosuppressants. In case 2, a 30-year-old female patient with known pemphigus vulgaris also presented with hematemesis, showing similar endoscopic findings to the first case. She also responded to the same treatment. Esophageal involvement of pemphigus vulgaris responds to high-dose corticosteroids and immunosuppressants. Thus, in patients with pemphigus vulgaris with signs or symptoms of upper gastrointestinal bleeding, an early endoscopy for the evaluation of esophageal involvement is beneficial.
Gastric Adenocarcinoma:Hypotonic CT Staging and Pathologic Correlation
Oh,Do Yoon,Goo,Young Moo,Park,Hee Ju,Kim,Pyo Nyun,Kim,Il Young,Kim,Chang Jin 순천향대학교 1993 논문집 Vol.16 No.4
위암의 수술전 병기 결정을 위해 CT(Computed Tomography)가 시행된다. 그러나 위암의 병기 결정에 있어서 CT의 정확도에 대해서는 논란이 많다. 저자들은 CT의 정확성을 알아보기 위해 저긴장성 복부(Hypotonic abdominal)CT를 시도하였다. 위 내시경 검사에 의한 조직 생검에서 위암이 확진된 101명의 환자에서 수술전 병기 결정을 위해 저긴장성 복부 CT를 시행하였다. CT 검사벙법은 5mm 두께의 절편과 5mm 간격으로 시행하였다. 검사 시행 20분전에 환자의 장운동을 이완시키기 위해 10mg의 브스코판(Scoplamine bultylbromide)을 정맥 수사하였다. 상기 환자중 30명이 수술을 시행하였다. 위암의 병기 결정을 위해 상기 환자의 CT 소견을 AJCC(American Joint Committe on Cancer)의 TNM 분류에 의해 병기를 정하였다. 암의 위벽 침윤 정도를 평가한 경우, CT 소견과 병리 조직 소견과는 14명중 30명이 일치하여 47%(P=.0001, R=0.678)의 일치율을 보였다. 국소 임파절 전이의 경우 CT와 병리조직과는 50%(P=.201, R=0.422)의 일치율을 보였다. 병기결정에 대한 저긴장성 복부 CT와 병리조직과는 57%(P=0.0001, R=0.694)의 일치율을 나타냈다. 본 연구에서 저긴장성 복부 CT는 그 정확도를 높이기 위해 좀더 많은 노력이 필요할 것으로 사료된다.
Park, Hye Jung,Lee, Jae-Hyun,Park, Kyung Hee,Ann, Hea Won,Jin, Moo-Nyun,Choi, Soo-Young,Lee, Yong-Won,Hong, Chein-Soo,Park, Jung-Won The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.3
<P><B>Purpose</B></P><P>The higher prevalence of respiratory allergic disease may be due to increased exposure to inhalation allergens. We conducted a survey of allergic diseases in autumn and winter with detection of major indoor allergens in major cities in Korea.</P><P><B>Methods</B></P><P>We enrolled 110 subjects from the fourth Korea National Health and Nutrition Examination Survey with stratified, cluster, and systematic sampling procedures. All participants answered a health questionnaire as well as underwent a skin prick test (SPT) and ImmunoCAP for 11 indoor major allergens. We also measured the levels of 5 major allergens (Der f 1, Der p 1, Can f 1, Bla g 1, and Asp f 1) in fine indoor dust from the houses of 60 subjects with a 2-site ELISA.</P><P><B>Results</B></P><P>The prevalence of allergic rhinitis and asthma were 25.5% and 7.3%, respectively. The most common sensitized allergens identified by SPT and ImmunoCAP were <I>Dermatophagoides farinae</I> (40.9%, 36.8%), followed by cockroach (23.6%, 19.5%), mugwort (13.6%, 22.9%), oak (9.1%, 22.9%), Japanese hop (9.1%, 8.6%), and dog dander (8.2%, 6.9%). There was a modest discrepancy between SPT and ImmunoCAP. Der f 1 and Der p 1 were detected in 91.7% and 45.0% of the enrolled houses, respectively. Der f 1 indicated high concentrations in all specific provinces in Korea; however, Der p 1 measured high only in the south. Dog dander allergens were present in 71.7% of houses; however, Bla g 1 was present in only 11.7% of houses and Asp f 1 was not detected in any houses.</P><P><B>Conclusions</B></P><P>The most important inhalant allergens in Korea are house dust mites followed by cockroach, mugwort, oak, Japanese hop, and dog dander in indoor environment, in which The dominant species of house dust mites were different according to region.</P>