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Mohammad Ali Ebrahimzadeh,Mohammad Mohammad Taheri,Ehsan Ahmadpour,Mahbobeh Montazeri,Shahabeddin Sarvi,Mohammad Akbari,Ahmad Daryani 대한약침학회 2017 Journal of pharmacopuncture Vol.20 No.3
Objectives: The currently available agents for use against toxoplasmosis have serious limitations. Thus, the aim of the present study was to investigate the anti-Toxoplasma gondii (T. gondii) activities of methanol extracts of Feijoa sellowiana (F. sellowiana) (leaves and fruits), Quercus castaneifolia (Q. castaneifolia) (fruits), and Allium paradoxum (A. paradoxum) (leaves) in vitro and in vivo. Methods: Vero cells were treated with different concentrations (from 0 to 400 μg/mL) of the above extracts or with pyrimethamine at a dose of 50 mg/mL (positive control). Then, the viabilities of the T. gondii-infected cells were measured by using colorimetric MTT (3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide) assays. In addition, the survival rates of mice acutely infected with 2 × 104 RH strain tachyzoites of T. gondii were examined in vivo after intraperitoneal injection of the extracts at doses of 100 and 200 mg/kg/day for 5 days. Results: In the in vitro anti- T. gondii assay, the IC50 values were 12.77, 180.2, 74.73, 213.2 and 163.8 μg/mL, and the selectivity indices were 6.05, 1.31, 0.35, 0.69 and 1.30 for the F. sellowiana (leaves and fruits), Q. castaneifolia, and A. paradoxum extracts and pyrimethamine, respectively. Moreover, the mice treated with F. sellowiana (leaves and fruits) achieved better results in terms of survival than the others (P < 0.05). Conclusion: The results of the current study indicate that methanol extract of F. sellowiana has significant anti-Toxoplasma activity. Further study should be conducted to investigate the potential bioactivity of this extract through bioactivity-guided fractionation.
Ebrahimzadeh, Mohammad Ali,Taheri, Mohammad Mohammad,Ahmadpour, Ehsan,Montazeri, Mahbobeh,Sarvi, Shahabeddin,Akbari, Mohammad,Daryani, Ahmad KOREAN PHARMACOPUNCTURE INSTITUTE 2017 Journal of pharmacopuncture Vol.20 No.3
Objectives: The currently available agents for use against toxoplasmosis have serious limitations. Thus, the aim of the present study was to investigate the anti-Toxoplasma gondii (T. gondii) activities of methanol extracts of Feijoa sellowiana (F. sellowiana) (leaves and fruits), Quercus castaneifolia (Q. castaneifolia) (fruits), and Allium paradoxum (A. paradoxum) (leaves) in vitro and in vivo. Methods: Vero cells were treated with different concentrations (from 0 to $400{\mu}g/mL$) of the above extracts or with pyrimethamine at a dose of 50 mg/mL (positive control). Then, the viabilities of the T. gondii-infected cells were measured by using colorimetric MTT (3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide) assays. In addition, the survival rates of mice acutely infected with $2{\times}10^4$ RH strain tachyzoites of T. gondii were examined in vivo after intraperitoneal injection of the extracts at doses of 100 and 200 mg/kg/day for 5 days. Results: In the in vitro anti- T. gondii assay, the $IC_{50}$ values were 12.77, 180.2, 74.73, 213.2 and $163.8{\mu}g/mL$, and the selectivity indices were 6.05, 1.31, 0.35, 0.69 and 1.30 for the F. sellowiana (leaves and fruits), Q. castaneifolia, and A. paradoxum extracts and pyrimethamine, respectively. Moreover, the mice treated with F. sellowiana (leaves and fruits) achieved better results in terms of survival than the others (P < 0.05). Conclusion: The results of the current study indicate that methanol extract of F. sellowiana has significant anti-Toxoplasma activity. Further study should be conducted to investigate the potential bioactivity of this extract through bioactivity-guided fractionation.
Mohammad Yaseen Ahmad,차현실,오인택,Tirusew Tegafaw,XUMIAO,Son Long Ho,Shanti Marasini,Adibehalsadat Ghazanfari,Huan Yue,채권석,장용민,이강호 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.4
We prepared gadolinium oxide (Gd2O3) nanoparticles (GNPs) coated with a trans‐activator of transcription (TAT) peptide with cell‐penetrating ability (i.e., TAT‐GNPs) through one‐pot process. We characterized the particle diameter, surface‐coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT‐GNPs. We measured in vivo T1 magnetic resonance images (MRI) in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2/s/mM (r2/r1 = 1.6, r2 = transverse water proton relaxivity), which is four to five times higher than those of commercial Gd‐chelates. The in vivo T1 MRI exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT‐GNPs acted as an enhanced cancer‐imaging agent similar to the cancer‐targeting agent in T1 MRI.
Mohammad Fraiwan AL-Saleh,Ahmad Mohammad Al-Ananbeh 한국통계학회 2005 Journal of the Korean Statistical Society Vol.34 No.2
In this paper, we consider the estimation of the correlation coefficient in the bivariate normal distribution, based on a sample obtained using a modi- fication of the moving extreme ranked set sampling technique (MERSS) that was introduced by Al-Saleh and Al-Hadhrami (2003a). The modification involves using a concomitant random variable. Nonparametric-type methods as well as the maximum likelihood estimation are considered under different settings. The obtained estimators are compared to their counterparts that are obtained based simple random sampling (SRS). It appears that the suggested estimators are more efficient
Ahmad, Khurshid,Baig, Mohammad Hassan,Mushtaq, Gohar,Kamal, Mohammad Amjad,Greig, Nigel H.,Choi, Inho Bentham Science 2017 Current Alzheimer research Vol.14 No.11
<P>Conclusion: The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases.</P>
A novel desulfurization practice based on diesel acidification prior to activated carbon adsorption
Mohammad Ahmad Al-Ghouti,Yahya Salem Al-Degs 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.4
Commercial diesel is often rich with organosulfur compounds and a value of 7,100 mgS/kg was recentlyreported. As confirmed by chromatographic analysis, about 36% of sulfur compounds are originated from dibenzothiophene. Following uncommon desulfurization method, organosulfur compounds were efficiently removed upon dieselacidification by organic acids prior to activated carbon adsorption. Protonation of S-containing compounds has enhancedtheir uptake by activated carbon. Competitive adsorption of di/tri/tetra-aromatics and dibenzothiophene fromsynthetic fuel proved that the later solute was preferentially removed against other aromatics upon fuel acidification. Results showed that 48% of organosulfur compounds were eliminated upon adding acetic acid to a final content of 3%by vol.. Principal component analysis indicated that acid content and carbon mass are the most significant factors onorganosulfur compounds removal: %Removal=5.8 (Acid Content)+6.3 (Mass)−0.02 (PD)−0.90 (Temp). The practicalefficiency of the proposed method was demonstrated by removing organosulfur compounds from commercial diesel.
Free vibration analysis of concrete arch dams by quadratic ideal-coupled method
Mohammad Rezaiee-Pajand,Ahmad Aftabi Sani,Mohammad Sadegh Kazemiyan 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.65 No.1
This paper is devoted to two new techniques for free vibration analysis of concrete arch dam-reservoir systems. The proposed schemes are quadratic ideal-coupled eigen-problems, which can solve the originally non-symmetric eigen-problem of the system. To find the natural frequencies and mode shapes, a new special-purpose eigen-value solution routine is developed. Moreover, the accuracy of the proposed approach is thoroughly assessed, and it is confirmed that the new scheme is very accurate under all practical conditions. It is also concluded that both decoupled and ideal-coupled strategy proposed in the previous works can be considered as special cases of the current more general procedure.
Ahmad M. Abu-Jrai,Ala’a H. Al-Muhtaseb,Jehad A. Yamin,Khalid A. Ibrahim,Omar A. Al-Khashman,Mouath A. Al-Shaweesh,Muhannad A. Hararah,Umer Rashid,Mohammad Ahmad,Gavin M. Walker 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
The performance of a highly cross-linked polyethylene catalyst supported on alumina for low temperature selective catalytic reduction of NOx by unburned hydrocarbons (HCs) existing in an exhaust gas was examined at different engine conditions with the addition of exhaust-gas recirculation. The HXPE catalyst was shown to exhibit good NOx reduction activity at low temperatures (100–250℃) where the only reductant was the unburned HC, which was already present in the exhaust flow. The maximum NOx reduction of approximately 52% was achieved at a temperature of 150℃. HXPE demonstrated very good selectivity toward N2 in the majority of tested conditions ( 80%).
Mohammad Mohammadianpanah,Shapour Omidvari,Shadi Zohourinia,Mansour Ansari,Leila Ghahramani,Mohammad Zare-Bandamiri,Ahmad Mosalaei,Niloofar Ahmadloo,Saeedeh Pourahmad,Hamid Nasrolahi,Sayed Hasan Hamed 대한대장항문학회 2015 Annals of Coloproctolgy Vol.31 No.4
Purpose: Despite advances in rectal cancer treatment over the last decade, local control and risk of late side effects due to external beam radiation therapy (EBRT) remain as concerns. The present study aimed to investigate the efficacy and the safety of low-dose-rate endorectal brachytherapy (LDRBT) as a boost to neoadjuvant chemoradiation for use in treating locally advanced distal rectal adenocarcinomas. Methods: This phase-II clinical trial included 34 patients (as the study arm) with newly diagnosed, locally advanced (clinical T3–T4 and/or N1/N2, M0) lower rectal cancer. For comparative analysis, 102 matched patients (as the historical control arm) with rectal cancer were also selected. All the patients were treated with LDRBT (15 Gy in 3 fractions) and concurrent chemoradiation (45–50.4 Gy). Concurrent chemotherapy consisted of oxaliplatin 130 mg/m2 intravenously on day 1 plus oral capecitabine 825 mg/m2 twice daily during LDRBT and EBRT. Results: The study results revealed a significant differences between the study arm and the control arm in terms in the pathologic tumor size (2.1 cm vs. 3.6 cm, P = 0.001), the pathologic tumor stage (35% T3–4 vs. 65% T3–4, P = 0.003), and the pathologic complete response (29.4% vs. 11.7%, P < 0.028). Moreover, a significantly higher dose of EBRT (P = 0.041) was found in the control arm, and a longer time to surgery was observed in the study arm (P < 0.001). The higher rate of treatment-related toxicities, such as mild proctitis and anemia, in the study arm was tolerable and easily manageable. Conclusion: A boost of LDRBT can optimize the pathologic complete response, with acceptable toxicities, in patients with distal rectal cancer.
Integrating approach to size and site at a sanitary landfill in Selangor state, Malaysia
Mohammad Khairi Younes,Noor Ezlin Ahmad Basri,Zulkifli Mohammad Nopiaha,Hassan Basri,Mohammed F. M. Abushammala,Khairul Nizam Abdul Maulud 대한환경공학회 2015 Environmental Engineering Research Vol.20 No.3
Solid waste production increases due to population and consumption increments. Landfill is the ultimate destination for all kinds of municipal solid waste; and is the most convenient waste disposal method in developing countries. To minimize investment and operational costs and society’s opposition towards locating landfills nearby, proper landfill sizing and siting are essential. In this study, solid waste forecasting using Autoregressive Integrating Moving Average (ARIMA) was integrated with government future plans and waste composition to estimate the required landfill area for the state of Selangor, Malaysia. Landfill siting criteria were then prioritized based on expert’s preferences. To minimize ambiguity and the uncertainty of the criteria prioritizing process, the expert’s preferences were treated using integrated Median Ranked Sample Set (MRSS) and Analytic Hierarchy Process (AHP) models. The results show that the required landfill area is 342 hectares and the environmental criteria are the most important; with a priority equal to 48%.