Synthesis, Fastness and Spectral Properties of Some New Azo Pyrazole and Pyrazolotriazole Derivatives

Rizk, Hala F.,El-Badawi, Mahmoud A.,Ibrahim, Seham A.,El-Borai, Mohamed A. Korean Chemical Society 2010 대한화학회지 Vol.54 No.6

Coupling of 5-amino-1,3-diaryl-pyrazoles 1a-c with diazonium salts of different aryl amines gave a series of novel 1,3-diaryl-5-amino-4-arylazopyrazoles 3a-l. Such compounds could be also obtained by reaction of 5-amino-1,3-diaryl-4-nitroso- 1H-pyrazoles 2a-c with different aryl amines in alkaline medium. Oxidation of azo derivatives 3a-l with cupric acetate, in dimethyl formamide and stream of air, gave 2,4,6-triaryl-2,4-dihydropyrazolo [4,3-d]-1,2,3-triazoles 4a-l. and the fluorescence properties of the cyclic triazoles were studied. Diazotization of 5-amino-1,3-diaryl-1H-pyrazoles 1a-c by sodium nitrite in ortho-phosphoric acid followed by coupling with some aryl amines gave o-aminoazo compounds 5a-f. Cyclisation of compounds 5a-f in pyridine and cupric acetate gave the corresponding triazoles 6a-f. The coupling of compounds 6a-f with different aryl diazonium salts gave compounds 7a-j. The synthesized dyes were applied to polyesters as disperse dyes and the fastness properties were evaluated. 5-Amino-1,3-diaryl-pyrazoles 1a-c 와 다양한 aryl amine의diazonium salts를 반응시켜서 1,3-diaryl-5-amino-4-arylazopyrazoles 3a-l을 합성하였으며, 몇 가지 화합물은 5-amino-1,3-diaryl-4-nitroso-1H-pyrazoles 2a-c와 aryl amine의 diazonium salts를 반응시켜서 얻었다. 합성한 azo 유도체 화합물 3a-l을 DMF 용매 속에서 cupric acetate와 산화반응시켜서 2,4,6-triaryl-2,4-dihydropyrazolo [4,3-d]-1,2,3-triazoles 4a-l을 합성하였으며, 합성한 cyclic triazoles에 대한 형광 특성을 측정하였다. 한편, Diazotization of sodium nitrite/ortho-phosphoric acid 조건에서 5-amino-1,3-diaryl-1H-pyrazoles 1a-c를 diazotization화 반응시킨 다음에, aryl amines과 반응시켜서 o-aminoazo compounds 5a-f를 합성하였다. 합성한 화합물 5a-f를 pyridine/cupric acetate 반응 조건에서 반응시켜서 triazole 6a-f들을 합성하였으며, 얻어진 화합물 6a-f을 aryl diazonium salts과 반응시켜서 화합물 7a-j을 합성하였다. 합성한 염료 화합물을 polyesters에 분산염료와 정착성을 측정하였다.

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Ibrahim E. Helal,Hatim A. Al-Abbadi,Mohamed H. El-Daharawy,Mahmoud F. Ahmed 한국축산학회 2022 한국축산학회지 Vol.64 No.5

Delayed healing associated with distal limb wounds is highly challenging in equine clinicalpractice. This study aimed to evaluate healing rates between chronic non-granulatingwounds of horse distal limbs that were treated with maltodextrin/ascorbic acid gel alone orin combination with povidone-iodine 1% solution and those treated with povidone-iodine 1%only throughout the study period (35 days) in clinical settings. The study was conducted on18 adult horses (3–15 years old). Based on the treatment regimen utilized, the horses weredivided into three groups (n = 6), with each group having a similar mean wound area. Thepercentages of wound contraction, epithelialization, and overall wound healing were determinedweekly for each wound. By the end of the study, the total wound healing percentagewas significantly increased between the study groups (p < 0.05). The use of maltodextrin/ascorbic acid gel resulted in considerable wound contraction, rapid epithelialization, and complication-free wound healing. Based on the findings of this study, maltodextrin/ascorbic acidgel, independently or in combination with a 1% povidone-iodine solution, might be applied asa safe and effective wound healing promoting agent in horses with chronic non-granulatingwounds.

Gravimetric Measurements and Theoretical Calculations of 4-Aminoantipyrine Derivatives as Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution: Comparative Studies

A. A. Al-Amiery,Firas F. Sayyid,Ali M. Mustafa,Slafa I. Ibrahim,Mustafa K. Mohsin,Mahdi M. Hanoon,Mohammed H. H. Al-Kaabi,A. A. H. Kadhum,Wan Nor Roslam Wan Isahak 한국부식방식학회 2023 Corrosion Science and Technology Vol.22 No.2

Due to continuous promotion of green alternatives to toxic petrochemicals by government policies,research efforts towards the development of green corrosion inhibitors have intensified recently. The objectiveof the current work was to develop novel green and sustainable corrosion inhibitors derived from 4-aminoantipyrine to effectively prevent corrosion of mild steel in corrosive environments. Gravimetricmethods were used to investigate corrosion inhibition of 4-((furan-2-ylmethylene)amino)antipyrine (FAP)and 4-((pyridin-2-ylmethylene)amino)antipyrine (PAP) for mild steel in 1 M HCl. FAP and PAP were subjectedto quantum chemical calculations using density functional theory (DFT). DFT was used to determinethe mechanism of mild steel corrosion inhibition using inhibitors tested in HCl. Results demonstratedthat these tested inhibitors could effectively inhibit mild steel corrosion in 1.0 M HCl. At 0.0005 M, theseinhibitors’ efficiencies for FAP and PAP were 93.3% and 96.5%, respectively. The Langmuir adsorptionisotherm was obeyed by these inhibitors on the mild steel surface. Values of adsorption free energies,, revealed that FAP followed chemical and physical adsorptions.

Significance of endangered and threatened plant natural products in the control of human disease

Ibrahim, Mohamed Ali,Na, MinKyun,Oh, Joonseok,Schinazi, Raymond F.,McBrayer, Tami R.,Whitaker, Tony,Doerksen, Robert J.,Newman, David J.,Zachos, Louis G.,Hamann, Mark T. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.42

<P>One in five of the world’s plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50–100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) <I>Proc Natl Acad Sci USA</I> 98(10):5433–5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) <I>Proc Natl Acad Sci USA</I> 108(31):12943–12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant <I>Diplostephium rhododendroides</I> Hieron., as well as other potential drug-producing endangered species in this and other groups.</P>

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

Walid S. Ibrahim,Zeiad H. Eldaly,Mahmoud F. Rateb,Ahmed H. Aldoghaimy,Mohamed G. Saleh 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimalresponse to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods: A prospective interventional case series study recruited patients from a single center diagnosedwith DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of afliberceptwere performed. The primary outcome measure was mean change in visual acuity after switching toaflibercept. Results: Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution(logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ±0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57± 107.09 μm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03,328.24 ± 81.98, and 313.71 ± 85.79 μm, respectively). Both visual improvement and mean change in retinalthickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMARbut were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGFinjections provided acceptable short-term visual and retinal architectural improvement.

Dexmedetomidine during suprazygomatic maxillary nerve block for pediatric cleft palate repair, randomized double-blind controlled study

Mohamed F. Mostafa,Fatma A. Abdel Aal,Ibrahim Hassan Ali,Ahmed K. Ibrahim,Ragaa Herdan 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.1

Background: For children with cleft palates, surgeries at a young age are necessary to reduce feeding or phonation difficulties and reduce complications, especially respiratory tract infections and frequent sinusitis. We hypothesized that dexmedetomidine might prolong the postoperative analgesic duration when added to bupivacaine during nerve blocks. Methods: Eighty patients of 1-5 years old were arbitrarily assigned to two equal groups (forty patients each) to receive bilateral suprazygomatic maxillary nerve blocks. Group A received bilateral 0.2 mL/kg bupivacaine (0.125%; maximum volume 4 mL/side). Group B received bilateral 0.2 mL/kg bupivacaine (0.125%) + 0.5 µg/kg dexmedetomidine (maximum volume 4 mL/side). Results: The modified children’s hospital of Eastern Ontario pain scale score was significantly lower in group B children after 8 hours of follow-up postoperatively (P < 0.001). Mean values of heart rate and blood pressure were significantly different between the groups, with lower mean values in group B (P < 0.001). Median time to the first analgesic demand in group A children was 10 hours (range 8-12 hr), and no patients needed analgesia in group B. The sedation score assessment was higher in children given dexmedetomidine (P = 0.03) during the first postoperative 30 minutes. Better parent satisfaction scores (5-point Likert scale) were recorded in group B and without serious adverse effects. Conclusions: Addition of dexmedetomidine 0.5 μg/kg to bupivacaine 0.125% has accentuated the analgesic efficacy of bilateral suprazygomatic maxillary nerve block in children undergoing primary cleft palate repair with less postoperative supplemental analgesia or untoward effects.

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

Walid S,Ibrahim,Zeiad H,Eldaly,Mohamed G,Saleh,Mahmoud F,Rateb,Ahmed H,Aldoghaimy 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimal response to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods: A prospective interventional case series study recruited patients from a single center diagnosed with DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of aflibercept were performed. The primary outcome measure was mean change in visual acuity after switching to aflibercept. Results: Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution(logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ± 0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57± 107.09 μm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03, 328.24 ± 81.98, and 313.71 ± 85.79 μm, respectively). Both visual improvement and mean change in retinal thickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMAR but were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGF injections provided acceptable short-term visual and retinal architectural improvement.

Visible light photocatalytic reduction of nitrobenzene using Ag/Bi2MoO6 nanocomposite

R.M. Mohamed,F.M. Ibrahim 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.22 No.-

Hydrothermal method was used to prepare Bi2MoO6 nanoparticles, and photo-assisted depositionmethod (PAD)was used to doped silver into Bi2MoO6 surface. Different characterization techniques wereused to characterize the produced Bi2MoO6 and Ag/Bi2MoO6 nanoparticles, such as for the surface areameasurement, X-ray diffraction, photoluminescence emission spectra, transmission electron microscopy,ultraviolet and visible spectroscopy, and X-ray photoelectron spectroscopy. Photocatalytic reductionof nitrobenzene under visible light irradiation was used to measure the photocatalytic performance ofBi2MoO6 and Ag/Bi2MoO6 nanoparticles. The results reveal that doping of silver led to a shift of theabsorption edge of Bi2MoO6 to high wavelength. 0.15 wt% Ag/Bi2MoO6 has the highest photocatalyticactivity. The highest photocatalytic activity 0.15 wt% Ag/Bi2MoO6 nanoparticle remains unchanged afterreuse five times.

Erythrocyte-mediated Delivery of Pravastatin: In Vitro Study of Effect of Hypotonic Lysis on Biochemical Parameters and Loading Efficiency

Gamaleldin I. Harisa,Mohamed F. Ibrahim,Fars K. Alanazi 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

Exposure of erythrocytes to hypotonic lysis creates pores in the cell membrane, through which pravastatin can enter and become trapped, after resealing them with a suitable buffer. We investigated the effects of tonicity, incubation time and drug concentration on drug loading into erythrocytes. Furthermore, we investigate the effects of pravastatin on erythrocyte oxidative stress markers and osmotic fragility behavior. Encapsulation was achieved using buffer solutions of different tonicities (0.5, 0.6 and 0.7% NaCl) and different drug concentrations (2, 4, 8 and 10 mg/mL) for a range of incubation times (15, 30, 60 and 120 min). The results demonstrated that controlled hypotonic lysis could entrap pravastatin in human erythrocytes, with acceptable loading parameters. The highest loading (34%) was achieved at 0.6% NaCl and 10 mg/mL pravastatin for 60 min incubation. At this pravastatin concentration, oxidative stress markers were similar to those seen in controls, and fragility and hematological parameters were unaffected in drug-loaded erythrocytes. These results indicate that the loading process and pravastatin concentration had no deleterious effects on the structure of pravastatinloaded erythrocytes, suggesting that they may therefore have a similar life span to normal cells. Pravastatin-loaded erythrocytes may thus provide an effective extended-release-delivery system for pravastatin.

In Vitro Pharmacodynamic Profile of Loranthus ferrugineus: Evidence for Noncompetitive Antagonism of Norepinephrine-induced Vascular Contraction

Omar Z. Ameer,Ibrahim M. Salman,Hafsa S. Najim,Ghassan Z. Abdullah,Muthanna F. Abdulkarim,Mun Fei Yam,Amirin Sadikun,Mohamed Z. Asmawi 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.4

The mode by which Loranthus ferrugineus methanol extract antagonizes and/or modulates norepinephrine-induced vasoconstriction was investigated in rat aortic rings. The vascular effects of three different concentrations of this extract were challenged against cumulative additions of norepinephrine. Phentolamine,a nonselective α-adrenoceptor antagonist, verapamil, an L-type calcium channel blocker, and papaverine, a phosphodiesterase inhibitor, were used in three different concentrations as positive controls. Log concentration-response curves and double-reciprocal plots were constructed for the extract and each vasorelaxant. To characterize antagonism reversibility, the norepinephrine maximum contractile effect was examined before extract addition to the aortic ring chamber and after its removal. Phentolamine shifted the norepinephrine log concentration-response curve to the right with no significant depression in the maximum response. Similar to verapamil and papaverine, the extract produced a rightward shift in norepinephrine log concentration-response curve and a significant drop in maximum response. The double-reciprocal plots showed comparable y-intercept values for all phentolamine concentrations, a characteristic of competitive antagonism. In contrast, different y-intercept values on double-reciprocal plots were obtained for each concentration of extract, verapamil, and papaverine, typical of noncompetitive antagonism. The norepinephrine maximum contractile response was approximately similar before the addition of extract and after its removal. The data collectively showed that L. ferrugineus methanol extract exerted its vascular effect by reversible noncompetitive antagonism of norepinephrine-induced vasoconstriction. These findings add to the understanding of the cardiovascular mechanisms by which L. ferrugineus, a plant traditionally used for the management of hypertension, elicits its action.