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Do, Misol,Han, Dohyun,Wang, Joseph Injae,Kim, Hyunsoo,Kwon, Wooil,Han, Youngmin,Jang, Jin-Young,Kim, Youngsoo BioMed Central 2018 Clinical proteomics Vol.15 No.1
<P><B>Background</B></P><P> The application of advanced imaging technologies for identifying pancreatic cysts has become widespread. However, accurately differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and invasive intraductal papillary mucinous neoplasms (IPMNs) remains a diagnostic challenge with current biomarkers, necessitating the development of novel biomarkers that can distinguish IPMN malignancy. </P><P><B>Methods</B></P><P>Cyst fluid samples were collected from nine IPMN patients (3 LGD, 3 HGD, and 3 invasive IPMN) during their pancreatectomies. An integrated proteomics approach that combines filter-aided sample preparation, stage tip-based high-pH fractionation, and high-resolution MS was applied to acquire in-depth proteomic data of pancreatic cyst fluid and discover marker candidates for IPMN malignancy. Biological processes of differentially expressed proteins that are related to pancreatic cysts and aggressive malignancy were analyzed using bioinformatics tools such as gene ontology analysis and Ingenuity pathway analysis. In order to confirm the validity of the marker candidates, 19 cyst fluid samples were analyzed by western blot. </P><P><B>Results</B></P><P>A dataset of 2992 proteins was constructed from pancreatic cyst fluid samples. A subsequent analysis found 2963 identified proteins in individual samples, 2837 of which were quantifiable. Differentially expressed proteins between histological grades of IPMN were associated with pancreatic diseases and malignancy according to ingenuity pathway analysis. Eighteen biomarker candidates that were differentially expressed across IPMN histological grades were discovered—7 DEPs that were upregulated and 11 that were downregulated in more malignant grades. HOOK1 and PTPN6 were validated by western blot in an independent cohort, the results of which were consistent with our proteomic data.</P><P><B>Conclusions</B></P><P>This study demonstrates that novel biomarker candidates for IPMN malignancy can be discovered through proteomic analysis of pancreatic cyst fluid.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12014-018-9193-1) contains supplementary material, which is available to authorized users.</P>
OAI PMIPv6를 이용한 FPMIPv6 테스트베드의 구현 및 분석
도미솔 ( Misol Do ),( Khuong Quoc Anh ),박창용 ( Changyong Park ),손민한 ( Minhan Shon ),추현승 ( Hyunseung Choo ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.2
PMIPv6 (Proxy Mobile IPv6)는 네트워크 기반 이동성 지원 프로토콜로 MN (Mobile Node)의 이동성 프로토콜 스택 유무와 관계없이 MN의 이동성을 지원한다. 하지만 핸드오버 과정에서 이동성 관련 시그널링을 완료할 때까지 지연이 발생하고 핸드오버 동안 MN으로 향하는 패킷이 손실된다는 단점을 갖고 있다. 이러한 단점을 보완하기 위한 기법으로 FPMIPv6 (Fast Handover for PMIPv6)가 제안되었다. 본 논문에서는 PMIPv6의 오픈소스인 OAI PMIPv6 (OpenAirInterface PMIPv6)를 기반으로 FPMIPv6 테스트베드를 구축하고 MN의 핸드오버를 실험하여 실제 FPMIPv6 환경에서의 핸드오버 지연 및 패킷손실 정도를 측정한다.
Lee, Jungwoon,Xia, Yan,Son, Mi‐,Young,Jin, Guanghai,Seol, Binna,Kim, Min‐,Jeong,Son, Myung Jin,Do, Misol,Lee, Minho,Kim, Dongsup,Lee, Kyeong,Cho, Yee Sook WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.50
<P><B>Pluripotenz‐Booster</B>: RSC133, ein neues synthetisches Derivat von Indolacrylsäure/Indolpropionsäure, zeigt zweifache Aktivität, indem es Histondeacetylase und DNA‐Methyltransferase inhibiert. Außerdem verbessert es wirksam die Reprogrammierung von menschlichen somatischen Zellen in einen pluripotenten Zustand und unterstützt Wachstum und Erhaltung von humanen pluripotenten Stammzellen (hPSCs).</P>