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Oh, Minhwa,Huh, Eugene,Oh, Myung Sook,Jeong, Ji-Seon,Hong, Seon-Pyo Elsevier 2018 Journal of Pharmaceutical and Biomedical Analysis Vol.153 No.-
<P><B>Abstract</B></P> <P>We developed a diagnostic method for Parkinson's disease by simultaneously analyzing biogenic amines and their metabolites using reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection (RP-HPLC-IPAD) method. Dopamine (DA), 3, 4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), and homovanillic acid (HVA) were used as biomarkers to diagnose Parkinson's disease. All target components were detected with good sensitivity using sodium hydroxide (as a post-column eluent). The limit of detection (S<B>/</B>N <B>=</B> 3) and limit of quantification (S<B>/</B>N <B>=</B> 10) of the target components ranged from 0.020 to 2.400 ng and from 0.080 to 8.000 ng, respectively. The coefficients of linear regression ranged from 0.9996 to 1.0000, all inter-day and intra-day precision values were <3.43%, and the average recovery and RSD ranged from 97.55 to 103.60% and 0.22 to 4.79% for mice striatum samples. This method exhibited good selectivity, sensitivity, and reproducibility and can be used directly without any pretreatment steps. Our method will be useful as a tool to diagnose Parkinson’s disease.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We developed a diagnostic method for PD by simultaneously analyzing biogenic amines and their metabolites using RP-HPLC-IPAD method. </LI> <LI> This novel RP-HPLC-IPAD method for detecting biogenic amines and their metabolites is reported here for the first time. </LI> <LI> Dopamine (DA), 3, 4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and homovanillic acid (HVA) were used as biomarkers to diagnose PD. </LI> <LI> The striatum tissues of mice brains were analyzed within 20 minutes with good accuracy, precision, and sensitivity for all biomarkers. </LI> <LI> This method is a novel approach to analyzing biogenic amines and their metabolites, and will be useful as a tool to diagnose PD. </LI> </UL> </P>
최영희(Younghee Choi),정민화(Minhwa Jung),정영순(Youngsuen Jung),정상수(Sangsoo Jeong),유광석(Kwangseok Ryoo),서창덕(Changduck Suh),임인철(In-Chil Lim) 한국정보과학회 1996 한국정보과학회 학술발표논문집 Vol.23 No.1A
자동색인(Automatic Indexing)의 색인어 추출 방법으로는 어휘 사전을 이용한 방법과 조사의 배열순위 정보를 이용한 방법이 주로 사용된다. 전자의 경우 어휘 사전의 구축과 신조어와 같은 미등록어의 처리에 어려움이 있으며, 후자의 경우는 불용어 사전의 구축이라는 불편함이 있다. 본 논문에서는 전자의 미등록어 처리에도 적용 가능하도록, 조사의 배열순위 정보를 확장하여 전 품사에 대한 배열순위 정보를 구성, 어휘 사전이 없을 경우에도 형태소 분석을 수행하여 명사를 자동으로 추출하도록 하는 방안을 제시한다.
Experiment and simulation of tearing mode evolution with electron cyclotron current drive in KSTAR
Kim, Kyungjin,Na, Yong-Su,Kim, Minhwa,Jeon, Y.M.,Lee, K.D.,Bak, J.G.,Choi, M.J.,Yun, G.S.,Lee, S.G.,Park, S.,Jeong, J.H.,Terzolo, L.,Na, D.H.,Yoo, M.G. Elsevier 2015 CURRENT APPLIED PHYSICS Vol.15 No.4
<P><B>Abstract</B></P> <P>The tearing mode (TM) plasma instability was observed in low confinement (L-mode) plasmas when non-axisymmetric magnetic perturbation (MP) was applied using external coils during 2011 campaign of KSTAR. Based on the collected information of the magnetic island location in a plasma, a discharge was designed for suppression of a (2,1) TM mode by adjusting electron cyclotron (EC) launcher angles to the estimated island position. Here, the (m,n) notation describes the poloidal mode number and the toroidal mode number of the TM, respectively. The discharge is analysed with experimental observations and numerical simulations. Mirnov coil (MC) arrays and electron cyclotron emission (ECE) are used for analysis of the island width and the location as well as the mode number. The EC deposition and its alignment with the island are estimated by X-ray imaging crystal spectroscopy (XICS) and ECE measurements. An integrated numerical system is employed for modelling of this discharge to analyse a temporal evolution of the mode activity by integrating plasma equilibrium, transport, heating and current drive, and the magnetic island evolution, in a self-consistent way. The effect of EC current drive is discussed by comparing with another TM discharge but without ECCD. Some possibilities for classifying this mode to neoclassical tearing mode (NTM) and stabilisation effect of ECCD are suggested based on the experimental observation and the simulation results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Suppression of (2,1) TM/NTM by applying ECH/CD for the first time in KSTAR. </LI> <LI> Suppression of the mode examined by experimental observations and simulations. </LI> <LI> Simulation of a mode without ECCD to compare with/without the applied control. </LI> </UL> </P>