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Nguyen Ho Minh Duy,Tran Anh Tuan,Nguyen Hai Duong,Tran Anh Tuan,Nguyen Kim Dao,Atsuo Yoshitaka,Jin Young Kim,Seung Ho Choi,Pham The Bao 한국정보기술학회 2016 한국정보기술학회논문지 Vol.14 No.5
MRI and CT images are the most popular formats assisting a doctor in diagnosis and treatment, but highly accurate segmentation is a challenging problem due to intensity inhomogeneity and environmental noises. In this paper, we introduce an appropriate and effective automatic approach to facilitate this problem in two stages. In the first stage, skull region is removed from the brain by morphological active contour and level set process. Moreover, in level set process, some AI rules are defined on slice positions of brain to increase the accuracy. In the second stage, a modified EM method is performed on the resultant skull-stripping image to identify some candidate main regions of CSF (cerebro-spinal fluid), GM (gray matter), and WM (white matter). The candidate regions are then re-estimated into the proper CSF, GM, and WM through a Bayesian Estimation Process. The experimental results show that the proposed approach obtains a robust segmentation for IBSR, OASIS and Korean Hospital database. With the proposed AI-rules, the level set method gets good skull-stripping images regardless of MRI slice position in bran. Also, Bayesian postprocessing can improve the segmentation performance by 10~15% in CSF, GM and WM ratios compared the basic EM algorithm.
EXPERIMENTAL VALIDATION OF THE BACKSCATTERING GAMMA-RAY SPECTRA WITH THE MONTE CARLO CODE
Hoang, Sy Minh Tuan,Yoo, Sang-Ho,Sun, Gwang-Min Korean Nuclear Society 2011 Nuclear Engineering and Technology Vol.43 No.1
In this study, simulations were done of a 661.6 keV line from a point source of $^{137}Cs$ housed in a lead shield. When increasing the scattering angle from 60 to 120 degrees with a 6061 aluminum alloy target placed at angles of 30 and 45 degrees to the incident beam, the spectra showed that the single scattering component increases and that the multiple scattering component decreases. The investigation of the single and multiple scattering components was carried out using a MCNP5 simulation code. The component of the single Compton scattering photons is proportional to the target electron density at the point where the scattering occurs. The single scattering peak increases according to the thickness of the target and saturates at a certain thickness. The signal-to-noise ratio was found to decrease according to the target thickness. The simulation was experimentally validated by measurements. These results will be used to determine the best conditions under which this method can be applied to testing electron densities or to assess the thickness of samples to locate defects in them.
( Gyeoung Jin Kang ),( Jung Ho Park ),( Hyun Ji Kim ),( Eun Ji Kim ),( Boram Kim ),( Hyun Jung Byun ),( Lu Yu ),( Tuan Minh Nguyen ),( Thi Ha Nguyen ),( Kyung Sung Kim ),( Hiệu Phùng Huy ),( Mostafizu 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.4
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear. PRR16/Largen is a cell size regulator that is independent of mTOR and Hippo signalling pathways. However, little is known about the role PRR16 plays in the EMT process. We found that the expression of PRR16 was increased in mesenchymal breast cancer cell lines. PRR16 overexpression induced EMT in MCF7 breast cancer cells and enhances migration and invasion. To determine how PRR16 induces EMT, the binding proteins for PRR16 were screened, revealing that PRR16 binds to Abl interactor 2 (ABI2). We then investigated whether ABI2 is involved in EMT. Gene silencing of ABI2 induces EMT, leading to enhanced migration and invasion. ABI2 is a gene that codes for a protein that interacts with ABL proto-oncogene 1 (ABL1) kinase. Therefore, we investigated whether the change in ABI2 expression affected the activation of ABL1 kinase. The knockdown of ABI2 and PRR16 overexpression increased the phosphorylation of Y412 in ABL1 kinase. Our results suggest that PRR16 may be involved in EMT by binding to ABI2 and interfering with its inhibition of ABL1 kinase. This indicates that ABL1 kinase inhibitors may be potential therapeutic agents for the treatment of PRR16-related breast cancer.
Chemical Constituents of the Ficus elastica Leaves and Their Antioxidant Activities
Kiem, Phan Van,Minh, Chau Van,Nhiem, Nguyen Xuan,Tai, Bui Huu,Quang, Tran Hong,Anh, Hoang Le Tuan,Cuong, Nguyen Xuan,Hai, Truong Nam,Kim, Seung-Hyun,Kim, Jin-Kyoung,Jang, Hae-Dong,Kim, Young-Ho Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10
Lean mass and peak bone mineral density
Huy G. Nguyen,Minh TD. Pham,Lan T. Ho-Pham,Tuan V. Nguyen 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.4
Objectives: The association between body composition parameters and peak bone mineral density is not well documented. The aim of this study is to assess the relative contributions of lean mass and fat mass on peak bone mineral density (BMD). Methods: The study involved 416 women and 334 men aged between 20 and 30 years who were participants in the population-based Vietnam Osteoporosis Study. Whole body composition parameters (eg, fat mass and lean mass) and BMD at the lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. The association between lean mass and fat mass and BMD was analyzed by the linear regression model using the Least Absolute Shrinkage and Selection Operator (LASSO). Results: Peak BMD in men was higher than women, and the difference was more pronounced at the femoral neck (average difference: 0.123 g/cm2; 95% confidence interval [CI] 0.105–0.141 g/cm2) than at the lumbar spine (average difference 0.019 g/cm2; 95% CI, 0.005–0.036 g/cm2). Results of LASSO regression indicated that lean mass was the only predictor of BMD for either men or women. Each kilogram increase in lean mass was associated with ∼0.01 g/cm2 increase in BMD. Lean mass alone explained 16% and 36% of variation in lumbar spine and femoral neck BMD, respectively. Conclusions: Lean mass, not fat mass, is the main determinant of peak bone mineral density. This finding implies that good physical activity during adulthood can contribute to the maximization of peak bone mass during adulthood.
Spectral Change in Silver-Doped Sodium-Borate Glass by Using Femtosecond Laser Irradiation
이선균,Eunkyoung Kim,Ik-Bu Sohn,Jong-Ho Shin,Jongmin Lee,Kyung-Sik Jang,Minh-Tuan Trinh,임기수,Young-Chul Noh 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
Two-photon absorption by femtosecond laser irradiation changed the charge state of silver ions doped in sodium-borate glasses. We investigated the spectral characteristics of irradiated samples by using absorption, photoluminescence and excitation spectra. The sizes of the silver nanoparticles formed inside the glasses were estimated. We also fabricated a multilayer pattern of micro-spots to study the feasibility of three-dimensional optical memory by using femtosecond laser-induced photoluminescence change and we formed a grating to determine the change in the refractive index of the irradiated area.