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RISS 인기검색어
- 검색키워드
- 저자 : Minglong Liu (검색결과 4 건)
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A new analytical ICCE and force prediction model for wide-row machining of free-form surface
Minglong Guo,Zhaocheng Wei,Jia Wang,Minjie Wang,Xiaoyu Wang,Shengxian Liu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.1
Cutting force is the most intuitive reflection of various influencing factors in the milling process, which is important for improving machining quality and efficiency. For the widerow milling with flat-end mill of free-form surface, an analytical in-cut cutting edge (ICCE) algorithm is studied in detail, and overall cutting force model is further constructed. The cutter location points along tool path are discretized into small oblique planes. Taking the oblique plane machining as the new object, the relative position of flat-end mill and workpiece in five-axis machining is defined parametrically. By constructing a semi-enclosed space in which the cutting edge participates in cutting, the ICCE is directly obtained. By analyzing the cutting force of oblique plane, the cutting force model of free-form surface can be established by spatial coordinate transformation. The simulation and experiment have demonstrated the correctness and effectiveness of the proposed ICCE algorithm and force prediction model.
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Rong Wu,Sen Zhou,Minglong Liu,Haiqian An,Zhe Wang,Tianxi Liu 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.3
Purpose: Vascular calcification (VC) is a common complication of end-stage renal disease (ESRD). This study aimed to examinechanges in the expression of miR-21-5p in ESRD patients with VC and to explore its clinical value in predicting the occurrenceand progression of uremic VC. Materials and Methods: 120 ESRD patients were divided into patients without VC group (n=38) and patients with VC group(n=82). All patients were followed up for 2 years to evaluate VC progression. qRT-PCR was used to detect serum miR-21-5p levels. Receiver operating characteristic curves were constructed to assess diagnostic value. Kaplan-Meier and log-rank methods wereutilized to calculate associations between VC progression and risk factors. Results: Serum miR-21-5p levels were significantly higher in ESRD patients with VC than in those without VC and increased progressivelywith increasing disease severity. Serum miR-21-5p levels were able to distinguish patients with VC from those withoutVC, with an area under the curve value of 0.883, a sensitivity of 81.7%, and a specificity of 84.2%. After 2 years of follow-up, miR-21-5p expression had increased in patients with worse VC severity, compared with those with stable VC severity. Patients withhigh miR-21-5p levels were more likely to develop more severe VC, indicating an association between miR-21-5p and VC progression(log-rank p=0.002). Multivariable Cox regression analysis suggested that serum miR-21-5p is an independent predictive factorof VC progression in ESRD patients (hazard ratio=2.064, 95% confidence interval=1.225–3.478, p=0.006). Conclusion: miR-21-5p is overexpressed in the serum of ESRD patients with VC. Our results suggest that overexpression of miR-21-5p is closely associated with VC progression.
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Qiushi Gu,Wanting Liu,Minglong Li 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Digital technology has been increasingly applied in the traditional tourism forms, including the heritage tourism. However, the role of technology and tradition for attracting tourists in industrial heritage tourism destinations has not been clearly identified. To narrow the research gaps, this study adopted a two stage study, based on grounded theory and factor analyses. In Study 1, through the data analysis of 60 in-depth interviews, 10 stimuli factors in 3 categories were identified. In Study 2, a questionnaire was developed based on the results of Study 1, through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), we established and tested a model of on-site stimulus factors. Findings can deepen the understanding of industrial heritage tourism from a tourist perspective and offer practical implications.
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Junxia Su,Yu-Hui Wei,Minglong Liu,Tianxi Liu,Jianhua Li,Yuanchun Ji,Jianping Liang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Rhizoma Dioscoreae septemlobae (RDSE) hasbeen widely used for the treatment of hyperuricemia inChina. However, the therapeutic mechanism has beenunknown. This study investigated the antihyperuricemicmechanisms of the extracts obtained from RDSE and itsmain component dioscin (DIS) in hyperuricemic mice. Hyperuricemic mice were induced by potassium oxonate(250 mg/kg). RDSE or DIS was orally administered tohyperuricemic mice at dosages of 319.22, 638.43,1276.86 mg/kg/day for 10 days, respectively. Uric acid orcreatinine in serum and urine was determined by HPLC orHPLC–MS/MS, respectively. The xanthine oxidase (XO)activities in mice liver were examined in vitro. Proteinlevels of organic anion transporter 1 (mOAT1), uratetransporter 1 (mURAT1) and organic cation transporter 2(mOCT2) in the kidney were analyzed by western blotting. The results indicated that uric acid and creatinine in serumwere significantly increased by potassium oxonate, ascompared to that of control mice. Compared saline-treatedgroup, after RDSE treatment in the high and middle dose,the expression of mOAT1 increased 47.98 and 54.48 %,respectively, which accompanied with the decreasedexpression of mURAT1 (47.63 %) in high dose. After DIS treatment in high, middle and low dose, the expression ofmOAT1 increased 23.93, 32.80 and 25.28 % compared tosaline-treated group, respectively, which accompanied withthe decreased expression of mURAT1 (51.07, 51.42 and51.35 %). However, RDSE and DIS displayed a weak XOinhibition activity compared with allopurinol. Therefore,RDSE and DIS processed uricosuric and nephroprotectiveactions by regulation of mOAT1, mURAT1 and mOCT2.
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