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- 저자 : Tianxi Liu (검색결과 3 건)
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Shu Huang,Tianxi Liu,Zhe Yang,Hong Zhu,Lulu Ren,Weng Weei Tjiu 한국고분자학회 2012 Macromolecular Research Vol.20 No.6
In this paper, nano-sized MgAl-layered double hydroxides (LDH) were synthesized via a very fast nucleation and slow aging method that can be suspended in water. Poly(vinyl alcohol) (PVA)/LDH nanocomposite hydrogels were then prepared using a cyclic freezing/thawing method. The mechanical properties of PVA hydrogels were significantly enhanced by incorporation of LDH nanoplatelets. After 7, 9, and 11 freezing/thawing cycles, the tensile strength of PVA nanocomposite hydrogels containing 0.5 wt% LDH was remarkably increased by 100%, 100%, and 300%, respectively, while the Young’s modulus was increased by 25%, 22%, and 149%, respectively. More interestingly,the nanocomposite hydrogels exhibited larger elongation at the break than neat PVA hydrogels. However,after addition of the LDH nanoplatelets, the water-swelling ability of PVA hydrogels decreased. The microstructures and morphologies of PVA/LDH nanocomposite hydrogels were further investigated by scanning electron microscopy,transmission electron microscopy, and differential scanning calorimetry. The results showed that well-dispersed LDH nanoplatelets played an important role in increasing physical cross-linking density by inducing PVA crystallization and the formation of more uniform polymer networks. As a result, the mechanical properties of PVA hydrogels were greatly improved, even at very low LDH loading levels.
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Rong Wu,Sen Zhou,Minglong Liu,Haiqian An,Zhe Wang,Tianxi Liu 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.3
Purpose: Vascular calcification (VC) is a common complication of end-stage renal disease (ESRD). This study aimed to examinechanges in the expression of miR-21-5p in ESRD patients with VC and to explore its clinical value in predicting the occurrenceand progression of uremic VC. Materials and Methods: 120 ESRD patients were divided into patients without VC group (n=38) and patients with VC group(n=82). All patients were followed up for 2 years to evaluate VC progression. qRT-PCR was used to detect serum miR-21-5p levels. Receiver operating characteristic curves were constructed to assess diagnostic value. Kaplan-Meier and log-rank methods wereutilized to calculate associations between VC progression and risk factors. Results: Serum miR-21-5p levels were significantly higher in ESRD patients with VC than in those without VC and increased progressivelywith increasing disease severity. Serum miR-21-5p levels were able to distinguish patients with VC from those withoutVC, with an area under the curve value of 0.883, a sensitivity of 81.7%, and a specificity of 84.2%. After 2 years of follow-up, miR-21-5p expression had increased in patients with worse VC severity, compared with those with stable VC severity. Patients withhigh miR-21-5p levels were more likely to develop more severe VC, indicating an association between miR-21-5p and VC progression(log-rank p=0.002). Multivariable Cox regression analysis suggested that serum miR-21-5p is an independent predictive factorof VC progression in ESRD patients (hazard ratio=2.064, 95% confidence interval=1.225–3.478, p=0.006). Conclusion: miR-21-5p is overexpressed in the serum of ESRD patients with VC. Our results suggest that overexpression of miR-21-5p is closely associated with VC progression.
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Junxia Su,Yu-Hui Wei,Minglong Liu,Tianxi Liu,Jianhua Li,Yuanchun Ji,Jianping Liang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Rhizoma Dioscoreae septemlobae (RDSE) hasbeen widely used for the treatment of hyperuricemia inChina. However, the therapeutic mechanism has beenunknown. This study investigated the antihyperuricemicmechanisms of the extracts obtained from RDSE and itsmain component dioscin (DIS) in hyperuricemic mice. Hyperuricemic mice were induced by potassium oxonate(250 mg/kg). RDSE or DIS was orally administered tohyperuricemic mice at dosages of 319.22, 638.43,1276.86 mg/kg/day for 10 days, respectively. Uric acid orcreatinine in serum and urine was determined by HPLC orHPLC–MS/MS, respectively. The xanthine oxidase (XO)activities in mice liver were examined in vitro. Proteinlevels of organic anion transporter 1 (mOAT1), uratetransporter 1 (mURAT1) and organic cation transporter 2(mOCT2) in the kidney were analyzed by western blotting. The results indicated that uric acid and creatinine in serumwere significantly increased by potassium oxonate, ascompared to that of control mice. Compared saline-treatedgroup, after RDSE treatment in the high and middle dose,the expression of mOAT1 increased 47.98 and 54.48 %,respectively, which accompanied with the decreasedexpression of mURAT1 (47.63 %) in high dose. After DIS treatment in high, middle and low dose, the expression ofmOAT1 increased 23.93, 32.80 and 25.28 % compared tosaline-treated group, respectively, which accompanied withthe decreased expression of mURAT1 (51.07, 51.42 and51.35 %). However, RDSE and DIS displayed a weak XOinhibition activity compared with allopurinol. Therefore,RDSE and DIS processed uricosuric and nephroprotectiveactions by regulation of mOAT1, mURAT1 and mOCT2.
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