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- 저자 : Junxia Su (검색결과 2 건)
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Junxia Su,Yu-Hui Wei,Minglong Liu,Tianxi Liu,Jianhua Li,Yuanchun Ji,Jianping Liang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Rhizoma Dioscoreae septemlobae (RDSE) hasbeen widely used for the treatment of hyperuricemia inChina. However, the therapeutic mechanism has beenunknown. This study investigated the antihyperuricemicmechanisms of the extracts obtained from RDSE and itsmain component dioscin (DIS) in hyperuricemic mice. Hyperuricemic mice were induced by potassium oxonate(250 mg/kg). RDSE or DIS was orally administered tohyperuricemic mice at dosages of 319.22, 638.43,1276.86 mg/kg/day for 10 days, respectively. Uric acid orcreatinine in serum and urine was determined by HPLC orHPLC–MS/MS, respectively. The xanthine oxidase (XO)activities in mice liver were examined in vitro. Proteinlevels of organic anion transporter 1 (mOAT1), uratetransporter 1 (mURAT1) and organic cation transporter 2(mOCT2) in the kidney were analyzed by western blotting. The results indicated that uric acid and creatinine in serumwere significantly increased by potassium oxonate, ascompared to that of control mice. Compared saline-treatedgroup, after RDSE treatment in the high and middle dose,the expression of mOAT1 increased 47.98 and 54.48 %,respectively, which accompanied with the decreasedexpression of mURAT1 (47.63 %) in high dose. After DIS treatment in high, middle and low dose, the expression ofmOAT1 increased 23.93, 32.80 and 25.28 % compared tosaline-treated group, respectively, which accompanied withthe decreased expression of mURAT1 (51.07, 51.42 and51.35 %). However, RDSE and DIS displayed a weak XOinhibition activity compared with allopurinol. Therefore,RDSE and DIS processed uricosuric and nephroprotectiveactions by regulation of mOAT1, mURAT1 and mOCT2.
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Chengfei Zhang,Junxia Zhang,Jianjiao Su,Shengjie Liu,Lu Zhang 아시아건강운동학회 2019 Journal of Asian Society for Health & Exercise Vol.1 No.2
In order to research and inquire the development of yoga intervention and health promotion deeply in China and to find out the differences between China and the United States. This research uses Citespace software to analyze the evolution vein, research hotspots, and module knowledge groups of yoga intervention and health promotion research in China and the United States from three aspects: basic information, keywords, and co-citation networks. On this basis, the research theme, formation and development trend of each module knowledge group is analyzed, and the comparative analysis of the research concept, research content and research trend of each module group is carried out. The results suggest that the United States is significantly better than China in terms of total number of publications, trends in publications, volume of journals, and authors" related publications. Plenty of differences do exist in research models, research hotspots, and research continuity between China and the United States. The comparison shows that the United States focuses on the medical value of yoga, while China focuses on the value of yoga exercise. The differences in research concepts between China and the United States have led to differences in research approach and development trends between China and the United States. This study has played a positive role in clarifying the development status of yoga intervention and health promotion in China which could accelerate future research.
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