Freedom of Expression

Mingliang Li 한국콘텐츠학회 2013 ICCC International Digital Design Invitation Exhib Vol.2013 No.-

Using Visual Knowledge Graph to Explore the Research Trend of Resistance Training in China

( Mingliang Zhang ),( Bin Li ) 아시아스포츠융합과학회 2020 Asia Pacific Journal of Applied Sport Sciences Vol.1 No.1

PURPOSE The purpose of this study was to explore the development and research trends of resistance training and to study the knowledge structure of resistance training. METHOD Using the bibliometric Citespace visualization software, we analyzed the 416 articles on resistance training that include word frequency and centrality, time zone view, and keyword clustering studies in the CNKI database in the last 20 years. RESULT Over the past two decades, the number of publications on resistance training in China has shown an increasing trend. The research evolution process has gone through three stages: initial exploration, transitional development, and deepening and expansion. Research hotspots mainly focus on resistance exercise, strength training in sports and aerobic exercise, exercise Therapy, exercise prescription, skeletal muscle and muscle strength and the objects involved are concentrated on patients, diabetes and special populations. It was also found that the topics studied in the last 5 years were focused on diabetes, obesity, rehabilitation and special populations; the knowledge construction consists of 9 sub-field of resistance training, resistance Exercise, aerobic exercise, muscle strength, muscle mass, strength training, sports, athletic performance and bone density. CONCLUSION The field of resistance training research has changed dramatically over the past 20 years. It is expected that research journals will increase year by year over the next 5 years, and the focus of research will be around diabetes, obesity, and special populations. Resistance training research will slowly be integrated into medicine.

A Social Network Analysis of Ski Research Topics in China

( Mingliang Zhang ),( Weiqi Chai ),( Wangda Guo ),( Bin Li ) 아시아스포츠융합과학회 2020 Asia Pacific Journal of Applied Sport Sciences Vol.1 No.3

PURPOSE The purposes of this paper were to: (1) study the development process of skiing knowledge network and to understand the research focus and development trend of skiing in different periods, and (2) to analyze the sub areas of ski cohesion research. METHOD Using CiteSpace visualization software of bibliometrics, a social network analysis was conducted on a total of 325 papers on 14 sports professional core journals in China Knowledge Network (CNKI) from 1990 to 2019. RESULT The research results showed that the amount of articles on skiing topics has been increased rapidly and the ski research themes change over time. In last 10 years, the main focuses of the research were Winter Olympics, ski tourism, ski industry, freestyle skiing aerials and competitive sports. The Winter Olympics, ice and snow sports and ski industry are the current and future hot research topics and frontiers. The knowledge structure consists of eight theme fields, including Winter Olympics, ski resorts, ice and snow sports, ice and snow industry, ski tourism, sports management, freestyle skiing aerials and snowboarding u-track skiing. CONCLUSION First of all, in the past 30 years, keywords in the field of ski research have undergone great changes. The Winter Olympics and ski industry topics are the current and future key research trends. In-depth research on these two topics will be an important challenge for scholars. Secondly, keyword network analysis provides new ideas and research methods for exploring the structure and development trend of the skiing field.

Study on Stable Estimation Method for Lead-acid Battery SOC by Extended Kalman Filter

Changhao Piao,Mingliang Liu,Ling Su,Zuncheng Li,Chongdu Cho,Sheng Lu 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.4

Synthesis and Characterization of CdSe/CdS/N-Acetyl-L-Cysteine/Quercetin Nano-Composites and Their Antibacterial Performance

Wang, Kunjie,Li, Mingliang,Li, Hongxia,Guan, Feng,Zhang, Deyi,Feng, Huixia,Fan, Haiyan Korean Chemical Society 2015 대한화학회지 Vol.59 No.2

We have discovered that quercetin, once coated on the CdSe and CdSe-CdS quantum dots (QDs), becoming highly water soluble. In the present work, we have successfully synthesized CdSe/CdS/N-Acetyl-L-Cysteine(NAC)/Quercetin nano-composites in the aqueous solution. The products were characterized using UV-vis spectroscopy, X-ray powder diffraction, fluorescence spectroscopy, and Fourier transform infrared spectroscopy. The transmission electron microscopy (TEM) tests indicated that our nano-composite products are highly stable with homogeneous particle size and great monodispersity. Quercetin coated nano-composite CdSe/CdS/NAC/Quercetin showed different fluorescence behavior from that of CdSe/CdS/NAC. Most amazingly, the synthesized CdSe/CdS/NAC/Quercetin nano-composite exhibits strong antibacterial activity. The combination of the strong fluorescence and its antibacterial activity makes the quercetin modified quantum dots as a potential candidate for cancer targeted therapy and other cancer treatments.

Malnutrition worsens fluorosis-induced damage in hypothalamic-pituitary-ovarian axis of rats

Yongmei Liu,Ling Li,Jingfeng Xu,Siwen Yu,Shijun Wang,Maojuan Yu,Wenbing Zou,Mingliang Cheng,Shuhua Xia 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.2

Backgrounds: This study aimed to evaluate the effects of malnutrition on the hypothalamic-pituitary-ovarian axis (HPOA) sex hormones in female rats with coal burning-type fluorosis. Methods: Female rats were divided into four groups: control, malnutrition, fluorosis, and fluorosis with malnutrition. Rats in the control and malnutrition groups were fed pollution-free corn with either regular or low protein content. Rats in the fluorosis and fluorosis with malnutrition groups were fed corn roasted with coals from the fluorosis endemic areas of Zhijin, China,with either regular or low protein content. Results: Results revealed that the body weight of rats with protein malnutrition was significantly reduced compared with that of the control and fluorosis rats. Urinary fluoride was significantly decreased and bone fluoride was significantly increased in the fluorosis with malnutrition group compared to the fluorosis group. Moreover, protein malnutrition significantly enhanced the effect of fluoride on gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, and testosterone. Histological and ultrastructural analyses revealed that protein malnutrition intensified fluoride-induced ovary damage. Conclusion: Malnourishment could promote the abnormal secretion of HPOA sex hormones in females with fluorosis.

Cloning and Characterization of Ginsenoside-Hydrolyzing β-Glucosidase from Lactobacillus brevis That Transforms Ginsenosides Rb1 and F2 into Ginsenoside Rd and Compound K

( Fei-liang Zhong ),( Rui Ma ),( Mingliang Jiang ),( Wei-wei Dong ),( Jun Jiang ),( Songquan Wu ),( Donghao Li ),( Lin-hu Quan ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.10

The ginsenoside-hydrolyzing β-glucosidase gene (bgy2) was cloned from Lactobacillus brevis. We expressed this gene in Escherichia coli BL21(DE3), isolated the resulting protein, and then utilized the enzyme for the biotransformation of ginsenosides. The bgy2 gene contains 2,223 bp, and encodes a protein of 741 amino acids that is a member of glycosyl hydrolase family 3. β-Glucosidase (Bgy2) cleaved the outer glucose moieties of ginsenosides at the C-20 position, and the inner glucose at the C-3 position. Under optimal conditions (pH 7.0, 30˚C), we used 0.1 mg/ml Bgy2 in 20 mM sodium phosphate buffer (PBS) for enzymatic studies. In these conditions, 1.0 mg/ml ginsenoside Rb1 and ginsenoside F2 were converted into 0.59 mg/ml ginsenoside Rd and 0.72mg/ml compound K, with molar conversion productivities of 69% and 91%, respectively. In pharmaceutical and commercial industries, this recombinant Bgy2 would be suitable for producting ginsenoside Rd and compound K.

Sulforaphane kills Mycobacterium tuberculosis H37Ra and Mycobacterium smegmatis mc2155 through a reactive oxygen species dependent mechanism

Zhao Yongjie,Shang Shengwen,Song Ya,Li Tianyue,Han Mingliang,Qin Yuexuan,Wei Meili,Xi Jun,Tang Bikui 한국미생물학회 2022 The journal of microbiology Vol.60 No.11

Mycobacterium tuberculosis (M. tuberculosis) is a highly pathogenic intracellular pathogen that causes tuberculosis (TB), the leading cause of mortality from single infections. Redox homeostasis plays a very important role in the resistance of M. tuberculosis to antibiotic damage and various environmental stresses. The antioxidant sulforaphane (SFN) has been reported to exhibit anticancer activity and inhibit the growth of a variety of bacteria and fungi. Nonetheless, it remains unclear whether SFN exhibits anti-mycobacterial activity. Our results showed that the SFN against M. tuberculosis H37Ra exhibited bactericidal activity in a time and dose-dependent manner. The anti-tubercular activity of SFN was significantly correlated with bacterial reactive oxygen species (ROS) levels. In addition, SFN promoted the bactericidal effect of macrophages on intracellular bacteria in a dose-dependent manner, mediated by increasing intracellular mitochondrial ROS levels and decreasing cytoplasmic ROS levels. Taken together, our data revealed the previously unrecognized antimicrobial functions of SFN. Future studies focusing on the mechanism of SFN in macrophages against M. tuberculosis are essential for developing new host-directed therapeutic approaches against TB.

Integrated fault location method for distribution networks based on IACO‑PS

Shuqing Zhang,Xiaowen Zhang,Anqi Jiang,Liguo Zhang,Mingliang Li 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.1

This paper develops a new hybrid method based on an improved ant colony optimization algorithm that incorporates pattern search (IACO-PS) for determining the location of faults in a distribution network. The performance of the conventional ant colony optimization (ACO) algorithm is improved using the opposite-based learning strategy to generate the initial population and adding a weight coefficient into the pheromone update mechanism to dynamically adjust the pheromone volatilization factor. The hybrid IACO-PS algorithm combines the individual strengths of ACO and PS. In addition, the fitness function is constructed by counting the false and missing fault information into the fault variable. In optimizing benchmark function experiments, the proposed hybrid IACO-PS presents a superior performance when compared to other improved versions of ACO. The effectiveness of the proposed approach is corroborated by tests performed on an IEEE 134-bus network. Simulation results show that the proposed hybrid IACO-PS method can determine the location of a fault even in the presence of fault distortion. In addition, it is immune to noise and data loss errors. Finally, the method proposed in this paper significantly outperforms other published fault location methods, and it can accurately locate faults and identify the type of distortion.

Excessive Startle with Novel GLRA1 Mutations in 4 Chinese Patients and a Literature Review of GLRA1-Related Hyperekplexia

Feixia Zhan,Chao Zhang,Shige Wang,Zeyu Zhu,Guang-Chen Jiao,Mingliang Zhao,Li Cao 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.2

Background and Purpose Hyperekplexia (HPX), a rare neurogenetic disorder, is classically characterized by neonatal hypertonia, exaggerated startle response provoked by the sudden external stimuli and followed by a shortly general stiffness. Glycine receptor alpha 1 (GLRA1) is the major pathogenic gene of the disease. We described the clinical manifestations of genetically confirmed HPX patients and made a literature review of GLRA1-related HPX to improve the early recognition and prompt the management of the disorder. Methods Extensive clinical evaluations were analyzed in 4 Chinese HPX patients from two unrelated families. Next generation sequencing was conducted in the probands. Sanger sequence and segregation analysis were applied to confirm the findings. Results All four patients including 3 males and 1 female presented with excessive startle reflex, a cautious gait and recurrent falls. Moreover, startle episodes were dramatically improved with the treatment of clonazepam in all cases. Exome sequencing revealed 2 homozygous GLRA1 mutations in the patients. The mutation c.1286T>A p.I429N has been previously reported, while c.754delC p.L252* is novel. Conclusions HPX is a treatable disease, and clonazepam is the drug of choice. By studying and reviewing the disorder, we summarized the phenotype, expanded the genotype spectrum, and discussed the possible pathogenic mechanisms to enhance the understanding and recognition of the disease. Early awareness of the disease is crucial to the prompt and proper administration, as well as the genetic counseling.