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- 저자 : Mingai Huang (검색결과 5 건)
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Risk Assessment of Low-Level Cadmium and Arsenic on the Kidney
Huang, Mingai,Choi, Seong-Jin,Kim, Dong-Won,Kim, Na-Young,Park, Choong-Hee,Yu, Seung-Do,Kim, Dae-Seon,Park, Kyung-Su,Song, Jae-Seok,Kim, Heon,Choi, Byung-Sun,Yu, Il-Je,Park, Jung-Duck Informa UK (TaylorFrancis) 2009 Journal of toxicology and environmental health. Pa Vol.72 No.21
<P>Cadmium (Cd) and arsenic (As) are widely distributed in the environment and are known human carcinogens. Several studies reported that chronic exposure to Cd and As produced renal injuries in humans. As one of the mechanisms, oxidative stress was suggested to play a role in the early process of Cd- and/or As-induced tubular damage in the kidney. This study was performed to evaluate the significance of urinary biomarkers, role of oxidative stress, and effect of coexposure to environmental low-level exposure to Cd and/or As in the general population. Urine samples were collected from 290 adults (86 males and 204 females). Urinary concentrations of Cd and As were measured, and kidney biomarkers of toxicity such as ss(2)-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) activity determined in urine. Urinary malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured as oxidative stress indices. The mean concentration of Cd was 1.21 mug/L, 0.84 mug/g creatinine, and As was 5.7 mug/L, 3.95 mug/g creatinine in urine. NAG, MDA, and 8-OHdG were positively correlated with both Cd and As in urine. Positive correlations were also observed between NAG and oxidative indices. The effects of coexposure to Cd and As on biomarkers are more pronounced than for exposure to each metal alone. These findings suggest that chronic exposure to low levels of Cd and/or As might produce tubular damage in the kidney through oxidative stress in humans.</P>
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Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence
Doug-Young Ryu,Mingai Huang,Changbo Park,Soo Im Chang,Ruth Im,Seong-Jin Choi,Na-Young Kim,In Won Park,Byoung Whui Choi,Jae Yeol Kim,Jong Wook Shin,Jae Chul Choi,Byung-Sun Choi,Jung-Duck Park 한국독성학회 2008 Toxicological Research Vol.24 No.2
The G184C and G134A single nucleotide polymorphisms (SNPs) of the CYP1A1 gene result in Ala62Pro and Gly45Asp substitutions, respectively. Here, we tested whether these SNPs are associated with an alteration in lung cancer incidence. We examined 80 Korean subjects with lung cancer and 240 age- and sex-matched controls. For each subject, the CYP1A1 gene was PCR amplified and sequenced. We observed that the odds ratio (OR) for lung cancer was 3.37 higher in subjects with the G184C polymorphism than in controls (95% confidence interval (CI), 0.89~12.73, P = 0.07). In contrast, the OR for lung cancer was 1.23 in subjects with the G134A polymorphism compared to controls (95% CI, 0.68~2.20, P = 0.49). The G184C polymorphism exacerbated the effects of smoking on lung cancer development. Gene-smoking interaction analyses revealed that past or present smokers with the G184C polymorphism had a higher incidence of lung cancer (OR, 24.72; 95% CI, 4.48~136.31; P < 0.01) than control smokers (OR, 6.65; 95% CI, 2.72~16.28; P < 0.01). However, there was only a slight difference in the ORs for lung cancer between control smokers and smokers with the G134A polymorphism. These findings suggest that the G184C polymorphism, but not the G134A polymorphism, is associated with an increased risk of lung cancer.
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어촌, 농촌, 도시 지역별 주민의 식품을 통한 다이옥신의 섭취량 추정
박정덕(Jung-Duck Park),황명애(Mingai Huang),임룻(Ruth Im),최병선(Byung-Sun Choi),양재호(Jae-Ho Yang),배윤정(Yun-Jung Bae),전예숙(Ye-Sook Jun),최미경(Mi-Kyeong Choi) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.3
본 연구에서는 식생활 양상이 서로 다를 것으로 생각되는 어촌, 농촌, 도시 지역별 각각 213명, 193명, 187명을 대상으로 직접면담과 24시간 회상법에 의한 식사섭취조사를 실시한 후 35가지 식품 중 다이옥신 함량 자료를 이용하여 추정한 다이옥신 섭취상태를 비교·평가하였다. 지역별 조사대상자의 평균 연령은 어촌 61.5세, 농촌 57.6세, 도시 49.4세순으로 유의하게 높았으며, 신장은 도시 대상자가 160.0 ㎝로 어촌의 158.1 ㎝나 농촌의 157.7 ㎝보다 유의하게 높았다. 지역별 남녀 성별 분포는 유의한 차이가 없었다. 1일 에너지 섭취량은 농촌 1707.7 ㎉, 도시 1596.5 ㎉, 어촌 1493.8 ㎉로 농촌이 어촌보다 유의하게 높았다. 1일 총 식품섭취량은 지역별 유의한 차이가 없었으나 어패류는 어촌지역이, 곡류, 채소류, 육류, 조미료류는 농촌지역이, 당류, 두류, 난류, 해조류, 우유류, 유지류는 도시지역이 가장 높았다. 35종 식품의 다이옥신 함량자료를 이용하여 평가한 어촌, 농촌, 도시 대상자의 1일 다이옥신 섭취량은 어촌이 0.70 pgTEQ/㎏/day로 농촌의 0.32 pgTEQ/㎏/day나 도시의 0.46 pgTEQ/㎏/day보다 유의하게 높았다. 곡류, 두류, 채소류, 어패류를 통한 다이옥신 섭취량은 어촌이, 난류와 우유류를 통한 다이옥신 섭취량은 도시가 가장 높았다. 전체 대상자의 다이옥신 섭취량은 육류, 난류, 어패류, 유지류, 조미료류 및 총 식품섭취량과 각각 유의한 정의 상관관계를 보였다. 이상의 연구결과를 종합할 때 식품을 통한 다이옥신 섭취량은 어촌 지역이 농촌이나 도시보다 높고 어패류나 동물성식품을 통한 섭취가 높았으나, 세 지역 모두 우리나라 내용(耐容) 1일 섭취량보다 낮아 안전한 수준이었다. The human population is mainly exposed to dioxins through the diet. The purpose of this study was to estimate the daily dietary intake of PCDDs and PCDFs in Korean adults residing in different regions. Subjects were recruited and divided into three groups according to the districts where they lived: rural (n=213), coastal (n=193), and urban district (n=187). Subjects were interviewed using a general questionnaire and 24-hour recall for dietary intake. The daily intake of dioxins was estimated through the use of the database of dioxins contents in 35 Korean foods. The average age of the subjects were 61.5 years for coastal district, 57.6 years for rural district, and 49.4 years for urban district. Daily energy intake was 1707.7 ㎉ for rural district, 1596.5 ㎉ for urban district, and 1493.8 ㎉ for coastal district. There was no significant difference in total food intake by regions. The intakes from fishes of coastal district, those from cereals, vegetables, meats, and seasonings of rural district, and those from sugars, pulses, eggs, seaweeds, milks, oils of urban area were higher than those of the other two districts. The daily dioxins intake of coastal district (0.70 pgTEQ/㎏/day) was significantly higher than those of rural district (0.32 pgTEQ/㎏/day) and urban district (0.46 pgTEQ/㎏/day). The dioxins intake from cereals, pulses, vegetables, fishes of coastal district and those from eggs and milks of urban area were the highest among the districts. The daily dioxins intake was positively correlated with the intakes of meats, eggs, fishes, oils, and seasonings. Therefore, it could be concluded that the daily dioxins intake of coastal district is higher than that in other districts and the fish is one of the main sources in dioxin intakes. However, daily dioxins intakes of the three regions were below the level of tolerable daily intake (TDI).
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Effects of Repeated Seafood Consumption on Urinary Excretion of Arsenic Species by Volunteers
Choi, Byung-Sun,Choi, Seong-Jin,Kim, Dong-Won,Huang, Mingai,Kim, Na-Young,Park, Kyung-Su,Kim, Choong-Yong,Lee, Hyo-Min,Yum, Young-Na,Han, Eui-Sik,Kang, Tae-Seok,Yu, Il-Je,Park, Jung-Duck Springer-Verlag 2010 Archives of environmental contamination and toxico Vol.58 No.1
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