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흉부 X-선상 활동성 미정으로 판독된 경증 폐결핵 환자에서 활동성 판정에 대한 67Ga 평면영상과 SPECT의 비교분석
안민 ( An Min ),장원규 ( Jang Won Gyu ),김경곤 ( Kim Gyeong Gon ),김성민 ( Kim Seong Min ),김윤권 ( Kim Yun Gwon ),김소연 ( Kim So Yeon ),김영중 ( Kim Yeong Jung ),박병익 ( Park Byeong Ig ),조민구 ( Jo Min Gu ),이권전 ( Lee Gwon 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.6
Gwon, Wi-Gyeong,Lee, Bonggi,Joung, Eun-Ji,Choi, Min-Woo,Yoon, Nayoung,Shin, Taisun,Oh, Chul-Woong,Kim, Hyeung-Rak American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.41
<P>Sargaquinoic acid (SQA) has been known for its antioxidant and anti-inflammatory properties. This study investigated the effects of SQA isolated from <I>Sargassum serratifolium</I> on the inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to human umbilical vein endothelial cells (HUVECs). SQA decreased the expression of cell adhesion molecules such as intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 as well as chemotactic cytokines such as interleukin-8 and monocyte chemoattractant protein-1 in TNF-α-treated HUVECs. As a result, SQA prevented monocyte adhesion to TNF-α-induced adhesion. SQA also inhibited TNF-α-induced nuclear factor kappa B (NF-κB) translocation into the nucleus by preventing proteolytic degradation of inhibitor κB-α. Overall, SQA protects against TNF-α-induced vascular inflammation through inhibition of the NF-κB pathway in HUVECs. These data suggest that SQA may be used as a therapeutic agent for vascular inflammatory diseases such as atherosclerosis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-41/acs.jafc.5b04050/production/images/medium/jf-2015-04050n_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf5b04050'>ACS Electronic Supporting Info</A></P>
Gwon, Wi-Gyeong,Lee, Min-Sup,Kim, Jong-Soon,Kim, Jae-Il,Lim, Chi-Won,Kim, Nam-Gil,Kim, Hyeung-Rak Institute for Advanced Research in Asian Science a 2013 The American journal of Chinese medicine Vol.41 No.3
<P>Sargassum fulvellum (Turner) C. Agardh has been used to treat various inflammatory diseases, including lump, dropsy, swollen and painful scrotum, and urination problems for several centuries with no side effects. This study aims to investigate the anti-inflammatory effect of the hexane fraction of S. fulvellum (HFS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and phorbol 12-myristate 13-acetate (PMA)-induced mouse-ear edema. The anti-inflammatory activity of HFS in LPS-stimulated RAW 264.7 cells was investigated by assessing the inhibition of nitric oxide (NO) and pro-inflammatory cytokine production during Griess reaction and enzyme-linked immunosorbent assay (ELISA), respectively. The molecular mechanisms that underlie the anti-inflammatory action of HFS were investigated by analyzing the activation of transcription factor and its upstream signaling proteins. Additionally, an in vivo study of the anti-inflammatory effect of HFS was carried out using PMA-induced mouse-ear edema. HFS inhibited LPS-induced NO production in a dose-dependent manner and suppressed the expression of inducible NO synthase (iNOS) in the RAW 264.7 cells. Further, HFS reduced the production of pro-inflammatory cytokines in the LPS-stimulated RAW 264.7 cells. HFS significantly inhibited LPS-induced nuclear factor kappa B (NF-κB) transcriptional activity and NF-κB translocation into the nucleus by preventing degradation of inhibitor κB-α. Moreover, HFS inhibited the activation of Akt and mitogen-activated protein kinases (MAPKs) in the LPS-stimulated RAW 264.7 cells. Furthermore, HFS suppressed PMA-induced mouse-ear edema. The above data indicate that the anti-inflammatory effects of HFS on LPS-stimulated cells are associated with the suppression of NF-κB through the inhibition of MAPKs and Akt phosphorylation.</P>
IoT 기반 운동프로그램이 경도 인지 장애 환자의 인지기능 및 신체기능에 미치는 영향
김권민(Kim, Gwon-Min),양자경(Yang, Ja-Gyeong),박현태(Park, Hyun-Tae) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.1
This study aimed to determine the interventions that resulted in delaying physical and cognitive decline in older population with mild cognitive impairment (MCI). Thirty older adults diagnosed with mild cognitive impairment based on the Peterson criteria (mean age 73 years) consented to and completed a 12-week twice weekly exercise intervention. The SDST score showed a difference between pre and post-test in the group of ≥ 72 years. During TMT test, the score of reaction time in the group of ≥72 years was significantly faster than in the group of < 72 years. During TMT B test, the score of reaction time in the ≥ 72 year group was significantly faster than in the < 72 year group. These findings help to establish the beneficial effects of IoT based exercise and cognitive combined intervention and identify key areas for future research strategies in the continued effort to improve human cognition and delaying onset of dementia.
Kwan-Sik Min,Munkhzaya Byambaragchaa,Seung-Hee Choi,Hyo-Eun Joo,Sang-Gwon Kim,Yean-Ji Kim,Gyeong-Eun Park 한국동물생명공학회(구 한국동물번식학회) 2021 Journal of Animal Reproduction and Biotechnology Vol.36 No.4
Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors.
확장성을 고려한 웹 기반 SNMP 망 관리 시스템의 구현
민경주,권택근,Min, Gyeong-Ju,Gwon, Taek-Geun 한국정보처리학회 2002 정보처리학회논문지 C : 정보통신,정보보안 Vol.9 No.3
SNMP는 네트워크의 장비들 사이에서 관리 정보를 주고받는 응용 계층 프로토콜로 동작 방법은 매우 간단하다. SNMP는 PDU를 통해서 관리 정보의 이름과 값을 서로 교환한다. 지금까지 네트워크 관리는 SNMP를 이용해 콘솔 기반으로 관리되었기 때문에 매우 불편했다. 이 논문에서는 새롭게 디자인된 사설 MIB와 GUI를 통한 웹 기반 SNMP 망 관리 시스템을 구현한다. 또한 확장성 문제를 해결하기 위해 가상 에이전트를 제안하고 구현한다. 제안된 가상 에이전트를 사용함으로써, 무분별한 트랩 발생에 대한 필터링과 계층적인 망 관리가 가능하게 된다. SNMP is a simple, application layer protocol and that is sending and receiving the management information among network devices. It exchanges the management information by the PDUs that have the management information names and values. Until now, network management is so inconvenience because of console-based management by using SNMP. This paper shows the Web-based SNMP network management system that is using the designed private MIB and GUI. In this paper, we have proposed a virtual SNMP agent supporting scalability of network management. With the virtual agent, large-scale network can be managed simply by trap filtering and hierarchical management.