Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

Seo, Hee-Won,Kim, Eun-Jin,Na, Hyelin,Lee, Mi-Ock Elsevier 2009 FEBS letters Vol.583 No.1

<P><B>Abstract</B></P><P>The interplay between hypoxia-inducible factor-1α (HIF-1α) and histone deacetylase (HDACs) have been well studied; however, the mechanism of cross-talk is unclear. Here, we investigated the roles of HDAC4 and HDAC5 in the regulation of HIF-1α function and its associated mechanisms. HDAC4 and HDAC5 enhanced transactivation by HIF-1α without stabilizing HIF-1α. HDAC4 and HDAC5 physically associated with HIF-1α through the inhibitory domain (ID) that is the binding site for factor inhibiting HIF-1 (FIH-1). In the presence of these HDACs, binding of HIF-1α to FIH-1 decreased, whereas binding to p300 increased. These results indicate that HDAC4 and HDAC5 increase the transactivation function of HIF-1α by promoting dissociation of HIF-1α from FIH-1 and association with p300.</P><P><B>Structured summary:</B></P><P>MINT-6802187:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>FIH1</I> (uniprotkb:Q9NWT6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802058:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>pull down</I> (MI:0096)</P><P>MINT-6802021:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802036:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802102:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>pull down</I> (MI:0096)</P><P>MINT-6802121, MINT-6802156:</P><P><I>P300</I> (uniprotkb:Q09472) <I>physically interacts</I> (MI:0218) with <I>HIF1 alpha</I> (uniprotkb:Q16665) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P>

김순남

김미옥 민족음악학회 2003 음악과 민족 Vol.26 No.-

Soun-Nam Kim(1917-1983) was one of the first-generation Korean composers of the 20th century, and lived in North Korea after he crossed the border for political reasons in 1948 until his death. HIS activity as a composer in South Korea was confined to a little less than 4 years(194-1948), and much less, his works had been officially banned to be performed from 1948. In spite of this circumstances, as soon as the ban was lifted in 1988, researches on him and his works were prompted, in that he was a major historical figure who set forth music of a new mode which contains national traits and at the same time sounds modem for the new era(around the time of Liberation from Japanese colonial ruling). Though Soun-Nam Kim was well acquainted with Western music and learned it s compositional techniques in universities in Japan, he was, more than anyone else, eager to accommodate traditional Korean musical elements into the frame of Western music to shape the modernized Korean music. The purpose of this thesis is to trace his techniques of that accommodation in depth through the analysis of his entire works(published 41 pieces including 2 composed in the North). These are classified into four categories according to the genre with separate subtitles: monophonic song(%), art song(l31, instrumental music(2), and works for chorus and orchestra(1). And each of them are examined systematically focussing in turn on text(if it is the category of song or contains a text), mode, characteristics of melodic progression, tonality and harmony, meter and rhythm. The contents of the texts can be divided roughly into three: hear-stirring one with leftists ideology(monophonic songs; a work for chorus and orchestra), expressionistic one with tinge of that ideology and/or folklike atmosphere(4-5 art songs), lyrical one in Korean emotional manner(5; especially 3, lullaby(3). Concerning musical elements, Western ones employed are (modified) major/minor, chromaticism, skips with large intervals, structure organized by intervallic relationship(1ike Bartok), added harmony, cluster, thick texture, frequently shifted accents(in the manner of Stravinsky), importance of variational technique, etc. Upon this, Korean elements combined are pentatonic scale, a typical Korean scale often called saeya (upward progression of two intervals, the perfect 4th and the 2nd), ornamental formulae, typical beginning and ending intervals of the melody, traditional rhythmic patterns, etc. One of the most notable techniques he executed seems to be that the notes (especially from the 'saeya scale) he applied in the melody are frequently applied also as the essential notes of harmony so that added harmony or cluster are resulted in the Western manner.

수술환자에 있어 수술실내에서 수술대기 시간이 불안에 미치는 영향에 관한 연구

이혜원,이규정,김해옥,이해옥,김혜숙,이미경,송말순,Lee, Hea-Won,Lee, Kyu-Chung,Kim, Hae-Ock,Lee, Haik-Ock,Kim, Hea-Suk,Lee, Mi-Kyung,Song, Mal-Soon 대한간호협회 1990 대한간호 Vol.29 No.3

This study was attempted to provide us with basic information on how to improve understanding with patients for operation, and to offer then better nursing and treatment. This kind of study will help scientific application to nursing practice and operating room. The data was collected by interviewing 29 patients who underwent the elective surgery under the general anesthesia at Y hospital in Seoul. The interview ran from October 15 to December 15, 1989. The research instrument was a anxiety measurement device (SAAI) originally developed by Spielberger, et al and modified by Jung-Tack Kim. 1. Hypothesis Testing Hypothesis one was that there would be a difference in state anxiety level according to a time difference in watiting for operation. This hypothesis was rejected(state.anxiety level one hour before operation P>.05, r-.747, State anxiety level half an hour before operation P>.05, r-.1550, state anxiety level just before operation, P>.05, r=.1099). However, state anxiety, evel appeared to be associated with a longer watiting period, like one day before operation (P<.05, r-.4628). Hypothesis two was that there would be a difference according to state anxiety level of patients for operation. This was rejected. (Change of blood perssure in systolie P>.05 r=.1082, Change of blood pressure in diastolic P>.05, r=.088, Change of pulse rate, P>.05, r-1.909) 2. Examining trait anxiety and state anxiety levels, the average level of trait anxiety was 42.034, and the average level of state anxiety one day before operation was 43,000. The average level of state anxiety was averaged 42.356 in a waiting room for operation. 3. Examining the state anxiety level by time period, the one hour before was 42.379 the level half an hour before 42.276, and the level just before operation 42.414. The low level of state anxiety was due to the fact that premedication was not eliminated. 4. Age and time period like one day before operation was related to state anxiety level (F=5.271, P<.0.01) and blood pressure in waiting room for operation. That is, state anxiety level and blood pressure of patients one day before operation appeared high. Sex was relation to changes of blood pressure ; the blood pressure of male patients appeard higer than of female patients. A marital status was also related anxiety level one hour before operation the married patient for operation showed a higher state anxiety level than that of the unmarried patient for operation. Education was similarily related to trait anxiety level in which highly educated patients show lower levels of trait anxiety than poorly educated ones. Motive for hospitalization was related to state anxiety level for patient one hour before operation (F=6.464, P<.05) likewise, patients who are supposed to undergo operation hastily showed higher levels of anxiety than patients who expect elective surgeries.

초등학교 성교육의 현황

김정휘,안창선,조동섭,심미옥 춘천교육대학교 초등교육연구소 2002 敎育硏究 Vol.19 No.-

르네상스 화성과 조성에 관한 최근의 이론적 논쟁 고찰

金美玉 漢陽大學校 音樂硏究所 1993 音樂論壇 Vol.7 No.-

강원초등 교육의 실태 : 도시아동을 중심으로

김정휘,안창선,심미옥 춘천교육대학교 학생생활연구소 1992 學生生活硏究 Vol.17 No.-

무지카 픽타의 이론적 제 규명

김미옥 민족음악학회 2003 음악과 민족 Vol.25 No.-

This study deals with the subject of musica ficta together with diverse theoretical clarifications made by early theorists and recent scholars, since it has been one of the most puzzling topics in the twentieth century in relation to the examination of Medieval and Renaissance music, and since clarifications of some problems are necessary. Musica ficta, originally a by-product of the hexachord which was designed for monophonic plainsong, began to be taken for granted in polyphonic music for a number of melodic and harmonic reasons from the 13th century. Influenced by this change, early theorists became attentive to clarify its functions theoretically. And in some cases, they even went too far to reconcile with other independent theories, especially the church modes. In result, diverse interpretations on the use of musica ficta came out and in turn they caused much of the recent debate on the same subject. Diverse theoretical clarifications on the use of it in early and recent times can be summarized in 3 ways as follows: 1) Explanations on the function of musica ficta made by early theorists which are easily understandable: correction of dim,/aug. intervals, best contrapunctal progressions in the cadence, leading tone, transposition of melody, and so on. 2) contentions on the function of musica ficta suggested by recent scholars, due to the lack of theoretical explanations in early treatises: mutation of the hexachords, cases when accidentals do not mean the alteration of notes, rhetorical means, partial signatures, etc. 3) Interpretations made by early theorists which also caused the recent debate, due to their diverse views or joining with other independent theories: the role of accidental signatures, relationship between the church modes and the hexachord, rejection of the concept of the church modes in polyphony with musica ficta. In spite of the heated debate, scholars generally agree on that almost all the functions of musica ficta came from the importance of linear structure, and that, from the 15th century, the "modern Meaning" of accidentals(alteration of individual pitches, rhetorical means) began to take precedence over other traditional one, in accordance with the growing felling for the simultaneous control of sonority. These agreements can be supported by new theoretical suggestions made around that time(an octave scale with new syllables or with twelve modern chromatic steps, appearances of A^#, newly coined terms for musica ficta, etc.) and stylistic changes in music itself(the change in the pattern of partial signatures, and decline on the use of itself).

<바그너>의 종합예술작품 이론에 대한 비판과 현대적 수용들

김미옥 漢陽大學校 音樂硏究所 1998 音樂論壇 Vol.12 No.-

채동선의 삶과 음악

김미옥 민족음악학회 2004 음악과 민족 Vol.28 No.-

Chae-Dong Sun(1901-1953) was one of the first-generation Korean composers of the 20th century. Though he started and was active thereafter as a violinist. he has been remembered mainly by his compositions(chamber music, choral music, cantatas, monophonic patriotic songs, art songs, transcription and editing of Korean traditional music), especially, art songs. But his works had been officially banned to be performed from 1950 because of the political reasons concerning a poet whose poems were adopted as the texts of his many songs. In 1960s, some of his songs began to be published with texts changed to other poems. But it was only after 1988 when the ban was lifted his songs with original texts finally came out in public. Due to this circumstances, researches on him and analysis of his works began recently, thus remain rare at present. Though Chae-Dong Sun was well acquainted with Western music and studied in universities in Japan and Germany, he was eager to shape the modernized Korean music. And his achievement on this with his songs are significant in that he accommodated national trait and affection into the frame of Western music. His intention can clearly be seen most of all in his choice of texts. majority(8/12) of his texts are those which is regarded as the first modern Korean poems with those characteristics. And Chae-Dong Sun experimented especially with the musical form in accordance with that new type of poems. 7/12 is in through-composed form, and also most of songs have formal sophistication reminding Debussy. The role of melody and rhythm also include some new aspects. That is, besides various characteristics in relation to text expression(stepwise motion, leap, melisma, consistent rhythmic pattern for maintaining the mood, etc.), they also accomodate free rhyme of the texts exquisitely by recitative-like flow, fermata, and so on. They say Chae-Dong Sun's harmony is least original among his treatment of musical elements in that it is in the strict frame of Western Classical music. But this aspect might also have contributed th the appeal of his songs to various classes of Korean people.

GIC를 활용한 도로중심의 건물주소 부여시스템

이미란,김부영,옥철영 울산대학교 1999 공학연구논문집 Vol.30 No.1

현행 국내 건물주소는 토지지번 중심으로 구축되어 교통 및 산업구조에서 물류비용을 증가시키는 요인이 되어 왔다. 내무부에서는 이러한 문제를 극복하기 위해 도로중심의 건물주소체계를 구축하고자 1997년부터 서울 강남구와 안양시를 대상으로 시범사업을 수행하였다. 시범사업에서는 먼저 도로의 길이를 건물수로 나눈 기초간격에 따라 기초번호를 구하고, 기초번호에 근거하여 수작업으로 건물주소를 부여하였다. 그러나, 이러한 방법에서는 기초간격이 도로길이와 건물수에 의해 산출됨으로써 도로사정에 따라 다르고, 수작업으로 부여한 도로중심의 주소체계를 검증하는 수단이 없었다. 본 논문에서는 시범사업에서 나타난 문제점을 해결하고 새로운 건물주소를 자동적으로 부여하기 위해 GIS를 활용한 도로중심의 건물주소 부여시스템을 제시했다. 이를 위해 시스템 설계의 기본원칙을 새롭게 설정하고, 공간정보와 속성정보가 구축된 GIS를 활용하여 시스템을 구현한다. 본 시스템에서 도로의 인접한 건물은 도로의 기점에서부터 건물까지의 도로경로거리와 방향에 따라서 건물주소가 부여되고, 골목길에 인접한 건물은 골목길의 시작점에 가상건물번호(X)를 부여하고, 골목길의 시작점에서부터 건물까지의 거리와 방향에 따라서 가상건물번호의 하위번호(n)를 부여하여 'Ⅹ-n'형태의 건물주소를 부여한다. 이와 같이, 도로에 인접한 건물과 골목길에 인접한 건물에 대해 서로 다른 방식으로 건물주소를 부여함으로써 차별화된 도로방식의 주소체계를 구축한다. 본 시스템은 일괄적으로 주소변환작업을 수행하며, 현재 사용하고 있는 토지지번 중심의 현주소와 도로중심의 신주소를 동시에 검색한다. Current lot-based building address system caused to increase the distribution cost of industry. Thus in order to decrease the cost, the Ministry of Home Affairs began to design and implement a pilot system for a road-based building address at KangNamGu and AnYang city in 1997. The pilot system calculated a basic number which was obtained from dividing the length of road by the number of building and assigned manually a road-based building address. But the basic length is different according to the length of road and the number of building and there is no verifying means of manually assigned address. This thesis presents a road-based building address assignment system using GIS that solves various problems in the pilot system and assigns a new building address automatically. This thesis establishes fundamental principles for the system design and implements the system using GIS in which spatial and attribute data are stored. In the system, the building address of road is assigned according to the direction and road path-distance from starting point of the road. The system assigns a virtual building address(X) to the cross point of adjacent road and alley, and assigns the building address(X-n) of alley to sub number(n) of the virtual building number according to the direction and distance from starting point of the alley. It assigns the building address of road and alley in different way so that it produces a distinctive road-based address organization. This system assigns a new building address in batch and searches current lot-based and new road-based address simultaneously.