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Shunsuke Ohnishi,Hidemichi Watari,Maki Kanno,Yoko Ohba,Satoshi Takeuchi,Tempei Miyaji,Shunsuke Oyamada,Eiji Nomura,Hidenori Kato,Toru Sugiyama,Masahiro Asaka,Noriaki Sakuragi,Takuhiro Yamaguchi,Yasuhi 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: Rikkunshito, an herbal medicine, is widely prescribed in Japan for the treatmentof anorexia and functional dyspepsia, and has been reported to recover reductions in foodintake caused by cisplatin. We investigated whether rikkunshito could improve chemotherapyinducednausea and vomiting (CINV) and anorexia in patients treated with cisplatin. Methods: Patients with uterine cervical or corpus cancer who were to receive cisplatin (50 mg/m2day 1) and paclitaxel (135 mg/m2day 0) as first-line chemotherapy were randomly assignedto the rikkunshito group receiving oral administration on days 0–13 with standard antiemetics,or the control group receiving antiemetics only. The primary endpoint was the rate of completecontrol (CC: no emesis, no rescue medication, and no significant nausea) in the overall phase(0–120 hours). Two-tailed p<0.20 was considered significant in the planned analysis. Results: The CC rate in the overall phase was significantly higher in the rikkunshito groupthan in the control group (57.9% vs. 35.3%, p=0.175), as were the secondary endpoints:the CC rate in the delayed phase (24–120 hours), and the complete response (CR) rates(no emesis and no rescue medication) in the overall and delayed phases (63.2% vs. 35.3%, p=0.095; 84.2% vs. 52.9%, p=0.042; 84.2% vs. 52.9%, p=0.042, respectively), and time totreatment failure (p=0.059). Appetite assessed by visual analogue scale (VAS) appeared to besuperior in the rikkunshito group from day 2 through day 6. Conclusion: Rikkunshito provided additive effect for the prevention of CINV and anorexia
Grain size distribution and chemistry of the brackish Lake sediment in Korea
I Chan Shin,Tetsuji Akatsuka,Hisayuki Azumi,Lan Ao,Nozomi Amahashi,Maki Oyagi,Noriko Ishida,Naoshige Goto,Masahiro Maruo,Akihiko Yagi,Yashshi Seike,Seung Hyun Lee,Sung Ae Yoon,Jun Kil Choi,Young Woong 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.5
To determine the grain size distribution and chemical characteristics of bottom surface sediments in shallow brackish lagoons, we studied sediment samples collected from the entire horizontal lake area and in vertical profiles from three stations in Lakes Youngrang and Hwajinpo, on the eastern coast of Korea. Vertical and horizontal grain size distributions of the bottom sediments indicated predominantly sand- and silt in both lakes. The vertical distribution of C/N ratios ranged from 6.14 to 11.92 in Lake Youngrang, and 6.74 to 12.34 in Lake Hwajinpo. The horizontal distribution of C/N ratios in Lake Youngrang ranged from 6.1 to 17.6, whereas they ranged from 4.4 to 12.1 in Lake Hwajinpo. C/N ratios showed locally different responses to the origin of allochthonous (partial region) and autochthonous (entire region) organic materials. Horizontally, bottom sediment with low δ<SUP>13</SUP>C and high δ<SUP>15</SUP>N in Lake Youngrang were likely to be influenced by autochthonous organic material derived from primary production, and would be affected by N inputs from sources. In contrast, high δ<SUP>13</SUP>C and low δ<SUP>15</SUP>N sediments in Lake Hwajinpo were likely to be influenced by cyanobacteria.
Association between Osteoporosis and Skeletal Muscle Mass in Men
Mizutani Masaya,Eguchi Yawara,Toyoguchi Toru,Orita Sumihisa,Inage Kazuhide,Shiga Yasuhiro,Maki Satoshi,Nakamura Junichi,Hagiwara Shigeo,Aoki Yasuchika,Inoue Masahiro,Koda Masao,Takahashi Hiroshi,Akaza 대한척추외과학회 2024 Asian Spine Journal Vol.18 No.1
Study Design: Cross-sectional study.Purpose: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced glycation end products (AGEs).Overview of Literature: Fewer studies have reported the correlation between BMD and skeletal muscle mass in women. Moreover, a few studies have examined the relationship between osteoporosis and skeletal muscle mass.Methods: This study included 99 men (mean age, 74.9 years; range, 28–93 years) who visited Qiball Clinic for BMD and body composition examinations. The osteoporosis group consisted of 24 patients (mean age, 72.5 years; range, 44–92 years), and the control group consisted of 75 individuals (mean age, 74.9 years; range, 28–93 years). Whole-body skeletal muscle mass was measured using a bioelectrical impedance analyzer. BMD was measured by dual X-ray absorptiometry. Skin autofluorescence (SAF), a marker of dermal AGE accumulation, was measured using a spectroscope. Osteoporosis was defined as a bone density T score of –2.5 or less. Physical findings, skeletal muscle mass, BMD, grip strength, and SAF were compared between the osteoporosis and control groups.Results: The osteoporosis group had significantly lower trunk muscle mass (23.1 kg vs. 24.9 kg), lower leg muscle mass (14.4 kg vs. 13.0 kg), and skeletal mass index (7.1 kg/m<sup>2</sup> vs. 6.7 kg/m<sup>2</sup>) than the control group (all <i>p</i><0.05). Lower limb muscle mass was identified as a risk factor for osteoporosis in men (odds ratio, 0.64; <i>p</i>=0.03).Conclusions: Conservative treatment of osteoporosis in men will require an effective approach that facilitates the maintenance or strengthening of skeletal muscle mass, including exercise therapy with a focus on lower extremities and nutritional supplementation.