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Superconducting MgB2 Films as Radiation Detectors
Takekazu Ishida,Daisuke Fujiwara,Hisashi Shimakage,Kazuo Satoh,Masahiko Machida,Masaru Kato,Masatoshi Nishikawa,Shigehito Miki,Tsutomu Yotsuya,Zhen Wang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
The thermal response of a membrane-structured MgB2 film can be used to detect various sorts of radiations. High-quality MgB2 films were prepared by a sputtering technique. The MgB2 radiation detector consisted of an MgB2 thin-film meander line on a 0.5-μm-thick SiN membrane. The detector devices were placed in a 4 K refrigerator, and the operating temperature was controlled at a certain temperature below Tc. Light from a 20-ps pulsed laser directly irradiated the MgB2 device; the end of the optical fiber was fixed in front of the device. An erbium-doped fiber amplifier (EDFA) and a GP-IB attenuator were used to control the laser power, and the output voltage was observed through a low-noise amplifier by using a digital oscilloscope. The output signals caused by thermal response were clearly observed. Systematic studies of the output signals were conducted, and effects of device design, dc bias conditions, bias temperature, and input laser power were considered. We report the out-of-equilibrium thermodynamics, which was investigated by means of extensive computer simulations based on the time-dependent Ginzburg-Landau equations, thermodynamics, and electrodynamics. Large-scale calculations were carried out under the realistic conditions of actual devices by using an Earth Simulator (ES). One attractive application is to use the device as a novel neutron detector by employing the 10B(n,)7Li nuclear reaction with a local energy release of 2.3 MeV.
Lee, Jin-Yong,Tokumoto, Maki,Hattori, Yuta,Fujiwara, Yasuyuki,Shimada, Akinori,Satoh, Masahiko Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.1
Chronic exposure to cadmium (Cd) is known to adversely affect renal function. Our previous studies indicated that Cd induces p53-dependent apoptosis by inhibiting gene expression of the ubiquitin-conjugating enzyme (Ube) 2d family in both human and rat proximal tubular cells. In this study, the effects of Cd on protein expression of p53 and apoptotic signals in the kidney and liver of mice exposed to Cd for 12 months were examined, as well as the effects of Cd on p53 protein levels and gene expression of the Ube2d family in various cell lines. Results showed that in the kidney of mice exposed to 300 ppm Cd for 12 months, there was overaccumulation of p53 proteins in addition to the induction of apoptosis, which was triggered specifically in the proximal tubules. Interestingly, the site of apoptosis was the same as that of p53 accumulation in the proximal tubules. In the liver of mice chronically exposed to Cd, gene expression of the Ube2d family tended to be slightly decreased, together with slight apoptosis without the accumulation of p53 protein. In rat small intestine epithelial (IEC-6) cells, Cd decreased not only the p53 protein level but also gene expression of Ube2d1, Ube2d2 and Ube2d4. In human brain microvascular endothelial cells (HBMECs), Cd did not suppress gene expression of the Ube2d family, but increased the p53 protein level. In human brain astrocytes (HBASTs), Cd only increased gene expression of UBE2D3. These results suggest that Cd-induced apoptosis through p53 protein is associated with renal toxicity but not hepatic toxicity, and the modification of p53 protein by Cd may vary depending on cell type.
Satoru Kikuchi,Tetsushi Kubota,Shinji Kuroda,Masahiko Nishizaki,Shunsuke Kagawa,Hironari Kato,Hiroyuki Okada,Toshiyoshi Fujiwara 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.4
Endoscopic ultrasound (EUS)-guided transgastric drainage has been performed as a less invasive procedure for pancreatic fistulasand intra-abdominal abscesses occurring after surgery in recent years. However, there are no reports of EUS-guided transgastricdrainage of intra-abdominal abscesses following gastrectomy. This case report describes 2 patients who developed an intra-abdominalabscess following gastrectomy and underwent EUS-guided transgastric drainage. Both patients underwent laparoscopy-assisted distalgastrectomy with Billroth-I reconstruction for gastric cancer. The intra-abdominal abscesses were caused by postoperative pancreaticfistula that developed following gastrectomy. One patient underwent naso-cystic drainage and the other underwent only a needlepuncture of the abscess cavity. EUS-guided drainage was performed safely and effectively, although 1 patient developed gastroduodenalanastomotic leakage related to this procedure. In summary, EUS-guided transgastric drainage is safe and technically feasible evenin post-gastrectomy patients. However, it is necessary to be careful if this procedure is performed in the early period followinggastrectomy.
Suzuki Tetsuya,Tsuji Osahiko,Ichikawa Masahiko,Ishii Ryota,Nagoshi Narihito,Kawakami Michiyuki,Watanabe Kota,Matsumoto Morio,Tsuji Tetsuya,Fujiwara Toshiyuki,Nakamura Masaya 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.2
Study Design: This is a single-center retrospective cohort study with a university hospital setting.Purpose: This study aims to evaluate the short-term course of physical function and walking ability after intramedullary spinal cord tumor (ISCT) resection and predict walking independence 1 year after surgery.Overview of Literature: Although several reports have shown the postoperative functional prognosis of spinal intramedullary tumors with long-term follow-up, no reports have identified the predictors associated with the functional outcome at an early stage. Methods: A total of 79 individuals who underwent ISCT resection at our institute between 2014 and 2019 were enrolled in the study, whose preoperative walking state was independent ambulator regardless of cane support with the Functional Independence Measure Locomotor Scale (FIM-L) score of ≥6. The FIM-L, the American Spinal Injury Association (ASIA) motor and sensory scores in the lower extremities, and the Walking Index for Spinal Cord Injury II (WISCI II) were assessed for walking independence, lower-limb function, and walking ability, respectively. These evaluations were performed at 4 time points: preoperatively, 1 week (1W), 2 weeks (2W), and 1 year after surgery.Results: In the early phase after surgery, 71% and 43% of the participants were nonindependent ambulators at 1W and 2W, respectively. Histopathology indicated that patients with solid tumors (ependymoma, astrocytoma, or lipoma) showed significantly lower indices at 1W and 2W than those with vascular tumors (hemangioblastoma or cavernous hemangioma). Regarding tumor location, thoracic cases exhibited poorer lower-limb function at 1W and 2W and poorer walking ability at 2W than cervical cases. According to the receiver operating characteristic (ROC) analysis, 2 WISCI II points at 2W had the highest sensitivity (100%) and specificity (92.2%) in predicting the level of walking independence at 1 year postoperatively (the area under the ROC curve was 0.99 (95% confidence interval, 0.93–1.00).Conclusions: The higher the lower-limb function scores in the early phase, the better the improvement in walking ability is predicted 1 year after ISCT resection.
Jin-Yong Lee,Maki Tokumoto,Yuta Hattori,Yasuyuki Fujiwara,Akinori Shimada,Masahiko Satoh 한국독성학회 2016 Toxicological Research Vol.32 No.1
Chronic exposure to cadmium (Cd) is known to adversely affect renal function. Our previous studies indicated that Cd induces p53-dependent apoptosis by inhibiting gene expression of the ubiquitin-conjugating enzyme (Ube) 2d family in both human and rat proximal tubular cells. In this study, the effects of Cd on protein expression of p53 and apoptotic signals in the kidney and liver of mice exposed to Cd for 12 months were examined, as well as the effects of Cd on p53 protein levels and gene expression of the Ube2d family in various cell lines. Results showed that in the kidney of mice exposed to 300 ppm Cd for 12 months, there was overaccumulation of p53 proteins in addition to the induction of apoptosis, which was triggered specifically in the proximal tubules. Interestingly, the site of apoptosis was the same as that of p53 accumulation in the proximal tubules. In the liver of mice chronically exposed to Cd, gene expression of the Ube2d family tended to be slightly decreased, together with slight apoptosis without the accumulation of p53 protein. In rat small intestine epithelial (IEC-6) cells, Cd decreased not only the p53 protein level but also gene expression of Ube2d1, Ube2d2 and Ube2d4. In human brain microvascular endothelial cells (HBMECs), Cd did not suppress gene expression of the Ube2d family, but increased the p53 protein level. In human brain astrocytes (HBASTs), Cd only increased gene expression of UBE2D3. These results suggest that Cd-induced apoptosis through p53 protein is associated with renal toxicity but not hepatic toxicity, and the modification of p53 protein by Cd may vary depending on cell type.