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Malpani, Yashwardhan R.,Biswas, Bishyajit Kumar,Han, Hong Sik,Jung, Young-Sik,Han, Soo Bong American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.7
<P>The direct oxidative addition of CF<SUB>3</SUB> and H<SUB>2</SUB>O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various sizes containing CF<SUB>3</SUB> were synthesized from the α-CF<SUB>3</SUB>-substituted diketones obtained through the protocol, thereby demonstrating the versatile applicability of the method. Mechanistic studies of the reaction with isotopes provided insight into the reaction pathway.</P> [FIG OMISSION]</BR>
Oh, Se Hwan,Malpani, Yashwardhan R.,Ha, Neul,Jung, Young-Sik,Han, Soo Bong American Chemical Society 2014 ORGANIC LETTERS Vol.16 No.5
<P>Photoredox-catalyzed vicinal chlorotrifluoromethylation of alkene is described. In the presence of Ru(Phen)<SUB>3</SUB>Cl<SUB>2</SUB>, CF<SUB>3</SUB>SO<SUB>2</SUB>Cl was used as a source for the CF<SUB>3</SUB> radical and chloride ion under visible light irradiation. Various terminal and internal alkenes were transformed to their vicinal chlorotrifluoromethylated derivatives. Biologically active compounds were applied under the condition to obtain desired products, suggesting that the method could be feasible for late-stage modification in drug discovery.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2014/orlef7.2014.16.issue-5/ol403716t/production/images/medium/ol-2013-03716t_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol403716t'>ACS Electronic Supporting Info</A></P>
Kumar Biswas, Bishyajit,Malpani, Yashwardhan R.,Ha, Neul,Kwon, Do-Hyun,Soo Shin, Jin,Kim, Hae-Soo,Kim, Chonsaeng,Bong Han, Soo,Lee, Chong-Kyo,Jung, Young-Sik Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.15
<P><B>Abstract</B></P> <P>Members of a series of 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-<I>e</I>][1,2,4]triazolo[4,3-<I>a</I>]pyrimidin-5(4<I>H</I>)-ones (<B>1</B>, Fig. 2) were prepared and tested against representative enteroviruses including Human Coxsackievirus B1 (Cox B1), Human Coxsackievirus B3 (Cox B3), human Poliovirus 3 (PV3), human Rhinovirus 14 (HRV14), human Rhinovirus 21 (HRV 21) and human Rhinovirus 71 (HRV 71). The C-8-<I>tert</I>-butyl group on the tetrahydrobenzene ring in these substances was found to be crucial for their enterovirus activity. One member of this group, <B>1e</B>, showed single digit micromolar activities (1.6–8.85μM) against a spectrum of viruses screened, and the highest selectivity index (SI) values for Cox B1 (>11.2), for Cox B3 (>11.5), and for PV3 (>51.2), respectively<B>.</B> In contrast, <B>1p</B>, was the most active analog against the selected HRVs (1.8–2.6μM), and showed the highest selectivity indices among the group of compounds tested. The SI values for <B>1p</B> were 11.5 for HRV14, 8.4 for HRV21, and 12.1 for HRV71, respectively.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
트리아진 코어를 지니는 초분자 고분자의 광화학적 상전이 거동
오승환(Seungwhan Oh),Yashwardhan R. Malpani,정영식(Young-Sik Jung),김종만(Jong-Man Kim) 한국고분자학회 2016 폴리머 Vol.40 No.4
트리아진(triazine) 코어를 중심으로 아조벤젠을 말단기로 갖는 광 감응성 화합물을 합성하고, 초분자 구조체를 제조하여 용매에 따른 구조적 특성을 조사하였다. 트리아진 유도체 N2,N4,N6-tris(4-((E)-phenyldiazenyl) phenyl)-1,3,5-triazine-2,4,6-tricarboxamide(Azo-TA)를 디메틸설폭사이드와 디메틸포름아마이드 용매에 녹인 후, 증류수를 첨가해 섬유상의 초분자 고분자구조체를 만들었다. 아조벤젠의 광이성질화에 의해, 365 nm 파장의 자외선을 조사하면 초분자 구조의 분해가 일어나고, 400 nm 파장 이상의 가시광선을 조사하면 초분자 구조의 재조립이 일어나는 것을 확인하였다. A photoresponsive azobenzene derivative having a triazine core moiety was prepared. Self-assembly of the triazine containing azobenzene derivative (Azo-TA) in aqueous dimethylsulfoxide and N,N-dimethylformamide afforded fibrous supramolecular polymers. Melting and regeneration of the supramolecular polymer were observed with alternative 365 nm UV and visible light irradiation by reversible cis-trans isomerization of azobenzene moieties.
Stimulus-Responsive Azobenzene Supramolecules: Fibers, Gels, and Hollow Spheres
Lee, Sumi,Oh, Seungwhan,Lee, Joosub,Malpani, Yashwardhan,Jung, Young-Sik,Kang, Baotao,Lee, Jin Yong,Ozasa, Kazunari,Isoshima, Takashi,Lee, Sang Yun,Hara, Masahiko,Hashizume, Daisuke,Kim, Jong-Man American Chemical Society 2013 Langmuir Vol.29 No.19
<P>Novel, stimulus-responsive supramolecular structures in the form of fibers, gels, and spheres, derived from an azobenzene-containing benzenetricarboxamide derivative, are described. Self-assembly of tris(4-((<I>E</I>)-phenyldiazenyl)phenyl)benzene-1,3,5-tricarboxamide (<B>Azo-1</B>) in aqueous organic solvent systems results in solvent dependent generation of microfibers (aq DMSO), gels (aq DMF), and hollow spheres (aq THF). The results of a single crystal X-ray diffraction analysis of <B>Azo-1</B> (crystallized from a mixture of DMSO and H<SUB>2</SUB>O) reveal that it possesses supramolecular columnar packing along the <I>b</I> axis. Data obtained from FTIR analysis and density functional theory (DFT) calculation suggest that multiple hydrogen bonding modes exist in the <B>Azo-1</B> fibers. UV irradiation of the microfibers, formed in aq DMSO, causes complete melting while regeneration of new fibers occurs upon visible light irradiation. In addition to this photoinduced and reversible phase transition, the <B>Azo-1</B> supramolecules display a reversible, fiber-to-sphere morphological transition upon exposure to pure DMSO or aq THF. The role played by amide hydrogen bonds in the morphological changes occurring in <B>Azo-1</B> is demonstrated by the behavior of the analogous, ester-containing tris(4-((<I>E</I>)-phenyldiazenyl)phenyl)benzene-1,3,5-tricarboxylate (<B>Azo-2</B>) and by the hydrogen abstraction in the presence of fluoride anions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2013/langd5.2013.29.issue-19/la400159m/production/images/medium/la-2013-00159m_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la400159m'>ACS Electronic Supporting Info</A></P>
Experimental study of graphene oxide on wollastonite induced cement mortar
Sairam, V.,Shanmugapriya, T.,Jain, Chetan,Agrahari, Himanshu Kumar,Malpani, Tanmay Techno-Press 2021 Advances in concrete construction Vol.12 No.6
Present research is mainly focused on, microstructural and durability analysis of Graphene Oxide (GO) in Wollastonite (WO) induced cement mortar with silica fume. The study was conducted by evaluating the mechanical properties (compressive and flexural strength), durability properties (water absorption, sorptivity and sulphate resistance) and microstructural analysis by SEM. Cement mortar mix prepared by replacing 10% ordinary portland cement with SF was considered as the control mix. Wollastonite replacement level varied from 0 to 20% by weight of cement. The optimum replacement of wollastonite was found to be 15% and this was followed by four sets of mortar specimens with varying substitution levels of cementitious material with GO at dosage rates of 0.1%, 0.2%, 0.3% and 0.4% by weight. The results indicated that the addition of up to 15%WO and 0.3% GO improves the hydration process and increase the compressive strength and flexural strength of the mortar due to the pore volume reduction, thereby strengthening the mortar mix. The resistance to water penetration and sulphate attack of mortar mixes were generally improved with the dosage of GO in presence of 15% Wollastonite and 10% silica fume content in the mortar mix. Furthermore, FE-SEM test results showed that the WO influences the lattice framework of the cement hydration products increasing the bonding between silica fume particles and cement. The optimum mix containing 0.3% GO with 15% WO replacement exhibited extensive C-S-H formation along with a uniform densified structure indicating that calcium meta-silicate has filled the pores.
Hahyeon Kim,Jonghyun Lee,Seung Jae Lee,오정은,김수동,Yashwardhan R. Malpani,황예진,박보영 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
A clog-free sustainable method for the synthesis of ursodeoxycholic acid through selective hydrogenationwas developed using Raney nickel in a continuous flow process. To increase the sustainability and safetyof the continuous flow system, water as a green solvent was used to remove the salt compound causingserious clogging problems and to generate hydrogen gas by electrolysis. Furthermore, a real-time monitoringsystem was installed in the flow system to check the system pressure and collective volume of thereaction solution, allowing immediate confirmation of blockages. Eventually, the continuous flow systemwas successfully developed with a short residence time of 4 min, almost full conversion, and high selectivityof 94.0% dr. This continuous flow system lasts 10 consecutive days with lower catalyst loading (theratio of Raney nickel to 7-oxo-LCA = 4.44 w/w) without clogging problems.
Cement Augmentation of Vertebral Compression Fractures May Be Safely Considered in the Very Elderly
Anoop R. Galivanche,Courtney Toombs,Murillo Adrados,Wyatt B. David,Rohil Malpani,Comron Saifi,Peter G. Whang,Jonathan N. Grauer,Arya G. Varthi 대한척추신경외과학회 2021 Neurospine Vol.18 No.1
Objective: The objective of the current study was to perform a retrospective review of a national database to assess the safety of cement augmentation for vertebral compression fractures in geriatric populations in varying age categories. Methods: The 2005–2016 National Surgical Quality Improvement Program databases were queried to identify patients undergoing kyphoplasty or vertebroplasty in the following age categories: 60–69, 70–79, 80–89, and 90+ years old. Demographic variables, comorbidity status, procedure type, provider specialty, inpatient/outpatient status, number of procedure levels, and periprocedure complications were compared between age categories using chi-square analysis. Multivariate logistic regressions controlling for patient and procedural variables were then performed to assess the relative periprocedure risks of adverse outcomes of patients in the different age categories relative to those who were 60–69 years old. Results: For the 60–69, 70–79, 80–89, and 90+ years old cohorts, 486, 822, 937, and 215 patients were identified, respectively. After controlling for patient and procedural variables, 30-day any adverse events, serious adverse events, reoperation, readmission, and mortality were not different for the respective age categories. Cases in the 80- to 89-year-old cohort were at increased risk of minor adverse events compared to cases in the 60- to 69-year-old cohort. Conclusion: As the population ages, cement augmentation is being considered as a treatment for vertebral compression fractures in increasingly older patients. These results suggest that even the very elderly may be appropriately considered for these procedures (level of evidence: 3).